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Influence Of Biomechanical Force And Mass Transfer On The Progression Of Atherosclerosis In Human Carotid Arteries
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Book Synopsis Influence of Biomechanical Force and Mass Transfer on the Progression of Atherosclerosis in Human Carotid Arteries by : Sungho Kim
Download or read book Influence of Biomechanical Force and Mass Transfer on the Progression of Atherosclerosis in Human Carotid Arteries written by Sungho Kim and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis is a vascular degenerative disease leading to progressive thickening in the intima of large and medium sized arteries through the formation of plaque that is very rich with cholesterol. The cholesterol is carried by LDL (low density lipoprotein) particles which pass through the endothelium and accumulate in the intima. The passage of LDL is influenced by wall shear stress which activates physiological responses of the endothelium. However, the causal relationship between the physiological responses and their effect on LDL mass transport is not fully understood. To obtain blood flow patterns in human carotid arteries, a fluid structure interaction (FSI) computational approach is employed, based on the in-vivo arterial geometry constructed from black blood magnetic resonance images (BBMRI) and flow rate boundary conditions obtained from phase contrast images (PC). Wall shear stress (WSS) on the luminal surface is computed, and this variable is related to the formation of leaky junctions, which is a major transendothelial pathway for LDL. A model for the fraction of leaky junction at a surface is incorporated into the overall computational scheme for mass transport, along with pore theory.
Book Synopsis Quantitative Models in Decision-Making (UUM Press) by : Nazrina Aziz
Download or read book Quantitative Models in Decision-Making (UUM Press) written by Nazrina Aziz and published by UUM Press. This book was released on 2024-05-19 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a must-have for students, academics, and practitioners looking for simple yet effective solutions to real-world problems. The nine chapters of this book discuss current trends in applied and related quantitative sciences, with an emphasis on techniques and modeling in real-world problems. By employing appropriate quantitative models and interpreting numerical results, this book provides useful information and guidance in understanding real-world problems.
Book Synopsis The Role of Fluid Flow and Mass Transfer in the Atherosclerosis of the Human Carotid Artery Under Pulsatile Flow Conditions by :
Download or read book The Role of Fluid Flow and Mass Transfer in the Atherosclerosis of the Human Carotid Artery Under Pulsatile Flow Conditions written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomechanical Behavior of Carotid Atherosclerosis by : Lina Zouggari
Download or read book Biomechanical Behavior of Carotid Atherosclerosis written by Lina Zouggari and published by . This book was released on 2019 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerical fluid biomechanics has proven to be an efficient tool for understanding vascular diseases including atherosclerosis. Studying mechanical phenomena taking place in carotid artery remains a scientifically relevant problem and can help clarify the association between blood flow behavior and the formation and rupture of atheromas. The presence of atheromas, usually in regions of high curvatures, led to a widely accepted hypothesis that local loads of hemodynamics play an important role in atherogenesis. It also causes alterations to the systemic behavior such as perturbations to the flow, stress distributions at the wall and particularly the Wall Shear Stress (WSS). In other words, hemodynamics influences the progression of atherosclerosis. In order to study the behavior of carotid artery, both CFD simulations and FSI simulations were performed on multiple geometrical models. The viscosity model and boundary conditions for the fluid domain were chosen by a preliminary analysis. Five structure models are taken into account: rigid walls with and without plaque, hyperelastic arterial structure without plaque and with a plaque simulated by a geometry restriction, hyperelastic structure with elastic plaque. The effects of the presence and absence of the plaque and of different geometry configurations was analyzed. WSS and blood flow parameters (pressure-velocity) were investigated at different locations of the vasculature with a special focus at the plaque and after plaque areas. Finally, a full FSI analysis was performed on a patient specific geometry and compared with the rigid wall results. The comparison between healthy and stenosed arteries showed different flow disruptions near the stenosis area resulting in a higher shear stress at the plaque zone and lower shear stress after-plaque zone. This result was observed both in the generic simplified geometry and in the patient specific geometry. The analysis of the structural response of the arterial tissue showed different displacement amplitudes between healthy and diseased arteries. It also showed a high frequency Fourier component of the displacement signal of the models stenosed artery: this signal slightly changes when the plaque mechanical properties are modified. The plaque rupture depends among others on the local WSS and the local strength of the tissue. On one hand LWSS zones are areas of vivid proliferation of atherosclerosis plaques, on the other hand the LWSS can promote inflammations and cause plaque instability too. The assessment of the vibrational behavior of the artery shows the emergence of low frequency modes when the plaque is present. The method proposed in this project is aimed to provide useful information for the future assessments of the dynamic response of carotid artery when more patient specific data is available and in-vivo experimental investigations are carried out.
Book Synopsis The Role of Fluid Flow and Mass Transfer on Atherosclerosis in the Human Carotid Bifurcation by : Pingping Ma
Download or read book The Role of Fluid Flow and Mass Transfer on Atherosclerosis in the Human Carotid Bifurcation written by Pingping Ma and published by . This book was released on 1992 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Book Synopsis Analysis of Flow and Biomechanical Stresses in Atherosclerotic Human Carotid Arteries by :
Download or read book Analysis of Flow and Biomechanical Stresses in Atherosclerotic Human Carotid Arteries written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Blood Flow in Atherogenesis by : Y. Yoshida
Download or read book Role of Blood Flow in Atherogenesis written by Y. Yoshida and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been recognized that atherosclerosis tends to develop in certain areas of the artery. Blood flow is thus considered to play an important role in such development. However, the direct mechanisms of the influence of blood flow on atherosclerosis are controversial. Recently, a number of active studies in this field have been carried out around the world. This volume consists of the contributions to a symposium held on the subject and offers a report of latest findings.
Book Synopsis Analysing of Flow and Biomechanical Stresses in Atherosclerotic Human Carotid Arteries by : Giulia Soloperto
Download or read book Analysing of Flow and Biomechanical Stresses in Atherosclerotic Human Carotid Arteries written by Giulia Soloperto and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Developments in Atherosclerosis Research by : Misra Schoenhagen
Download or read book Current Developments in Atherosclerosis Research written by Misra Schoenhagen and published by Nova Publishers. This book was released on 2005 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood's flow through an artery. Two things that can happen where plaques occur are: bleeding (haemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque's surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to new breakthroughs in molecular medicine.
Book Synopsis Blood Flow in Large Arteries by : Dieter W. Liepsch
Download or read book Blood Flow in Large Arteries written by Dieter W. Liepsch and published by S. Karger AG (Switzerland). This book was released on 1990 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomechanics of Coronary Atherosclerotic Plaque by : Jacques Ohayon
Download or read book Biomechanics of Coronary Atherosclerotic Plaque written by Jacques Ohayon and published by Elsevier. This book was released on 2020-03-17 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, Fourth Edition summarizes all biomechanical aspects of each living organ in one comprehensive reference. The first two volumes introduce Continuum Fluid and Solid Biomechanics approaches, with each subsequent volume covering the important biomechanical and clinical aspects. The key thought leaders in the field of Biomechanics of Living Organs have gathered together their expertise in this series, making it an essential reference for anyone working in this research area. This book presents the first such resource to cover fluid and solid biomechanical studies conducted in this last decade to increase our understanding of plaque initiation, growth and rupture and improve the design of medical devices and clinical interventions, including surgical procedures. Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations Highlights the correlation between plaque initiation regions and blood shear stress amplitude Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)
Book Synopsis Mass Transport and Shear Stress Within the Carotid Artery Bifurcation by : Riley Gorder
Download or read book Mass Transport and Shear Stress Within the Carotid Artery Bifurcation written by Riley Gorder and published by . This book was released on 2010 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mass Transfer in Atherosclerotic Arteries: a Theoretical Model by : Julie Tsing Yung
Download or read book Mass Transfer in Atherosclerotic Arteries: a Theoretical Model written by Julie Tsing Yung and published by . This book was released on 1974 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The influence of minor stenoses on carotid artery flow by : Daniëlle Elisabeth Maria Palmen
Download or read book The influence of minor stenoses on carotid artery flow written by Daniëlle Elisabeth Maria Palmen and published by . This book was released on 1994 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Introductory Biomechanics by : C. Ross Ethier
Download or read book Introductory Biomechanics written by C. Ross Ethier and published by Cambridge University Press. This book was released on 2007-03-12 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.
Book Synopsis PanVascular Medicine by : Peter Lanzer
Download or read book PanVascular Medicine written by Peter Lanzer and published by Springer. This book was released on 2015-03-30 with total page 5004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.
