Inflammatory And Hemostasis Blood Biomarkers Predict The Clinical Outcome Of Stroke Patients Treated By Thrombolysis Thrombectomy

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INFLAMMATORY AND HEMOSTASIS BLOOD BIOMARKERS PREDICT THE CLINICAL OUTCOME OF STROKE PATIENTS TREATED BY THROMBOLYSIS/THROMBECTOMY.

Author : S andrine Delbosc
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis INFLAMMATORY AND HEMOSTASIS BLOOD BIOMARKERS PREDICT THE CLINICAL OUTCOME OF STROKE PATIENTS TREATED BY THROMBOLYSIS/THROMBECTOMY. by : S andrine Delbosc

Download or read book INFLAMMATORY AND HEMOSTASIS BLOOD BIOMARKERS PREDICT THE CLINICAL OUTCOME OF STROKE PATIENTS TREATED BY THROMBOLYSIS/THROMBECTOMY. written by S andrine Delbosc and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction In ischemic stroke, the lack of blood flow triggers local inflammation and vascular injury, which further promotes tissue remodeling and angiogenesis. The aim of the present study was to investigate whether biomarkers of inflammation, hemostasis, vascular injury, and tissue remodeling measured in the plasma of stroke patients could stratify stroke patients concerning their clinical outcome. MethodsWe included 153 patients consecutively admitted for ischemic stroke treated by thrombolysis with or without thrombectomy. Blood was sampled at admission and 21 biomarkers related to inflammation (MPO, Osteopontin, CCL2/MCP-1, Adiponectin, Resistin, CD40L), hemostasis (uPA/Urokinase, alpha 2-macroglobulin, Serpin C1/Antithrombin-III, Serpin E1/PAI-1, Kallikrein 6/Neurosin, CD40L), endothelium activation (VCAM-1, ICAM-1 , CD31/PECAM-1, CD40L, Neuropilin-1), and tissue remodeling (Osteopontin, MMP-2, MMP-3, MMP-9, MMP-13, Cathepsin S, Cystatin C, Neuropilin-1) were assayed by a quantitative Luminex multiplex technic. ResultsPatients with higher NIHSS at admission presented higher levels of the inflammatory biomarker MPO, the hemostasis biomarker uPA/Urokinase and the endothelial activation biomarker VCAM. Logistic regression analyses correlated levels of uPA/Urokinase to NIHSS at arrival (p=0.0037), suggesting the major role of hemostasis in initial stroke gravitymRS>1 at 3 months was correlated to higher levels of MPO, the endothelial activation biomarkers ICAM-1, VCAM-1 and the tissue remodeling biomarkers Osteopontin, Cathepsine S, and lower levels of MMP-13. Logistic regression analyses correlated mRS 0-1 at three months to levels of Cathepsine S (p=0.0201) and VCAM-1 (p=0.0048). The area under ROC curve of both biomarkers was 0.75. Symptomatic hemorrhagic transformation, defined according to ECASS-3 criteria, was correlated to MMP-9 (p=0.0382)ConclusionsAs expected, initial NIHSS was related to early hemostasis response. Importantly, initial inflammatory response, endothelial activation and tissue remodeling biomarkers significantly impact the three-month outcome and the hemorrhagic transformation.

Neuroinflammation in Stroke

Author : Ulrich Dirnagl
Publisher : Springer Science & Business Media
ISBN 13 : 3662054264
Total Pages : 248 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Neuroinflammation in Stroke by : Ulrich Dirnagl

Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Biomarkers for Stroke Recovery

Author : Pradeep Kumar
Publisher : Frontiers Media SA
ISBN 13 : 2832519741
Total Pages : 221 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Biomarkers for Stroke Recovery by : Pradeep Kumar

Download or read book Biomarkers for Stroke Recovery written by Pradeep Kumar and published by Frontiers Media SA. This book was released on 2023-04-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Management of Acute Pulmonary Embolism

Author : Stavros V. Konstantinides
Publisher : Springer Science & Business Media
ISBN 13 : 1597452874
Total Pages : 273 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Management of Acute Pulmonary Embolism by : Stavros V. Konstantinides

Download or read book Management of Acute Pulmonary Embolism written by Stavros V. Konstantinides and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.

Antiplatelet Agents in Stroke Prevention

Author : Gergely Feher
Publisher : Frontiers Media SA
ISBN 13 : 2889716805
Total Pages : 106 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Antiplatelet Agents in Stroke Prevention by : Gergely Feher

Download or read book Antiplatelet Agents in Stroke Prevention written by Gergely Feher and published by Frontiers Media SA. This book was released on 2021-11-24 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hemostasis and Stroke

Author : Zsuzsa Bagoly
Publisher : Frontiers Media SA
ISBN 13 : 2889714292
Total Pages : 171 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Hemostasis and Stroke by : Zsuzsa Bagoly

Download or read book Hemostasis and Stroke written by Zsuzsa Bagoly and published by Frontiers Media SA. This book was released on 2021-09-30 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acute Ischemic Stroke

Author : R. Gilberto González
Publisher : Springer Science & Business Media
ISBN 13 : 3642127517
Total Pages : 299 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Acute Ischemic Stroke by : R. Gilberto González

Download or read book Acute Ischemic Stroke written by R. Gilberto González and published by Springer Science & Business Media. This book was released on 2010-10-05 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.

Precision Medicine in Stroke

Author : Ana Catarina Fonseca
Publisher : Springer Nature
ISBN 13 : 303070761X
Total Pages : 339 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Precision Medicine in Stroke by : Ana Catarina Fonseca

Download or read book Precision Medicine in Stroke written by Ana Catarina Fonseca and published by Springer Nature. This book was released on 2021-05-04 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.

Toole's Cerebrovascular Disorders

Author : E. Steve Roach
Publisher : Cambridge University Press
ISBN 13 : 1139855581
Total Pages : 445 pages
Book Rating : 4.1/5 (398 download)

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Book Synopsis Toole's Cerebrovascular Disorders by : E. Steve Roach

Download or read book Toole's Cerebrovascular Disorders written by E. Steve Roach and published by Cambridge University Press. This book was released on 2010-02-15 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toole's Cerebrovascular Disorders was the first modern book devoted to care of the stroke, originally published more than 40 years ago. This is a completely revised and updated sixth edition of the highly respected standard for stroke diagnosis and treatment. Dr James Toole has stayed on as a consultant for the text, and Drs E. Steve Roach, Kerstin Bettermann, and Jose Biller have reworked Dr Toole's book to include chapters on genetics, pregnancy-related stroke, and acute treatments. The practical focus of the book has not changed, retaining its emphasis on bedside diagnosis and treatment. Easily accessible both for stroke specialists and residents, the sixth edition has been modernized to keep pace with the rapid expansion of knowledge in stroke care and includes evidence-based recommendations, the latest technology and imaging, and risk factors. The text is supplemented with more than 200 images, many in color.

Textbook of Stroke Medicine

Author : Michael Brainin
Publisher : Cambridge University Press
ISBN 13 : 1107047498
Total Pages : 425 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Textbook of Stroke Medicine by : Michael Brainin

Download or read book Textbook of Stroke Medicine written by Michael Brainin and published by Cambridge University Press. This book was released on 2014-09-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.

Intracranial Bleeding after Reperfusion Therapy in Acute Ischemic Stroke

Author : Nishant K. Mishra
Publisher : Frontiers Media SA
ISBN 13 : 2889715086
Total Pages : 210 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Intracranial Bleeding after Reperfusion Therapy in Acute Ischemic Stroke by : Nishant K. Mishra

Download or read book Intracranial Bleeding after Reperfusion Therapy in Acute Ischemic Stroke written by Nishant K. Mishra and published by Frontiers Media SA. This book was released on 2021-10-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coronary Microvascular Obstruction in Acute Myocardial Infarction

Author : Giampaolo Niccoli
Publisher : Academic Press
ISBN 13 : 0128133619
Total Pages : 400 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Coronary Microvascular Obstruction in Acute Myocardial Infarction by : Giampaolo Niccoli

Download or read book Coronary Microvascular Obstruction in Acute Myocardial Infarction written by Giampaolo Niccoli and published by Academic Press. This book was released on 2018-07-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon

Deep Vein Thrombosis and Pulmonary Embolism

Author : Edwin J. R. van Beek
Publisher : John Wiley & Sons
ISBN 13 : 9780470744994
Total Pages : 584 pages
Book Rating : 4.7/5 (449 download)

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Book Synopsis Deep Vein Thrombosis and Pulmonary Embolism by : Edwin J. R. van Beek

Download or read book Deep Vein Thrombosis and Pulmonary Embolism written by Edwin J. R. van Beek and published by John Wiley & Sons. This book was released on 2009-03-12 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dedicated to dealing with a challenging disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients. - Latest publication in a fast-moving area of keen clinical interest - Authored by leading international authorities - Builds on success of a respected first edition - Incorporates new data on latest imaging technologies and therapies - Covers both the science and clinical aspects, including presentation, surgical intervention and drug therapy - Includes coverage of both Pulmonary Embolism and Deep Vein Thrombosis

Stroke

Author : Jens Minnerup
Publisher : Biota Publishing
ISBN 13 : 1615045872
Total Pages : 102 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Stroke by : Jens Minnerup

Download or read book Stroke written by Jens Minnerup and published by Biota Publishing. This book was released on 2013-08-01 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.

The Right Heart

Author : Sean P. Gaine
Publisher : Springer
ISBN 13 : 1447123980
Total Pages : 326 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis The Right Heart by : Sean P. Gaine

Download or read book The Right Heart written by Sean P. Gaine and published by Springer. This book was released on 2014-05-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heart and lung are intricately linked. When the heart is affected by disease, the lungs will often show some related pathological or clinical conditions and vice versa. Pulmonary heart disease is by definition a condition when the lungs cause the heart to fail. The left ventricle in combination with the other structures in the “left heart” pumps blood throughout the body. The right ventricle (and structures of the “right heart”) pumps blood to the lungs where it is oxygenated and returned to the left heart for distribution. In normal circumstances, the right heart pumps blood into the lungs without any resistance. The lungs usually have minimal pressure and the right heart easily pumps blood through. However when there is lung disease present, like emphysema, chronic obstructive lung disease (COPD) or pulmonary hypertension- the small blood vessels become very stiff and rigid. The right ventricle is no longer able to push blood into the lungs and eventually fails. This is known as pulmonary heart disease. Pulmonary heart disease is also known as right heart failure or cor pulmonale. The chief cause of right heart failure is the increase in blood pressure in the lungs (pulmonary artery).

Acute Pulmonary Embolism

Author : A. Geibel
Publisher : Springer Science & Business Media
ISBN 13 : 3642511902
Total Pages : 202 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Acute Pulmonary Embolism by : A. Geibel

Download or read book Acute Pulmonary Embolism written by A. Geibel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The value of echocardiography in the diagnostic work-up of patients with suspected acute pulmonary embolism.- New developments in the thrombolytic therapy of venous thrombosis.- Mechanism of blood coagulation. Newer aspects of anticoagulant and antithrombotic therapy.MR-angiography in the diagnosis of pulmonary embolism.Scintigraphy-ventilation/perfusion scanning and imaging of the embolus.- Clinical course and prognosis of acute pulmonary embolism.- The molecular mechanisms of inherited thombophilia.

Vascular Medicine: A Companion to Braunwald's Heart Disease

Author : Mark Creager
Publisher : Elsevier Health Sciences
ISBN 13 : 0323636012
Total Pages : 963 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Vascular Medicine: A Companion to Braunwald's Heart Disease by : Mark Creager

Download or read book Vascular Medicine: A Companion to Braunwald's Heart Disease written by Mark Creager and published by Elsevier Health Sciences. This book was released on 2019-05-22 with total page 963 pages. Available in PDF, EPUB and Kindle. Book excerpt: With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients’ cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. Incorporates technologic advances in vascular imaging – including ultrasound, MRI, CTA, and catheter-based angiography – along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today’s best surgical treatments for vascular diseases. Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice.