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Author : Veronika Mantziou
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (128 download)
Download or read book In Vitro Teratogenicity Testing Using a 3D, Embryo-like Gastruloid System written by Veronika Mantziou and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajin Park
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Comparison of In-vitro 3D Human Embryoids with Current Models for Gastrulation written by Ajin Park and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrulation is an early morphogenetic process that is conserved across most metazoans and lays out the future body plan through the formation and shaping of the three germ layers: endoderm, mesoderm, and ectoderm. Despite its importance, not much is known about the events surrounding human gastrulation that occurs in utero due to ethical and technical limitations on studying human embryos. Therefore, many researchers have devised protocols for creating in vitro models of gastrulation using embryonic stem cells. Initially starting with mouse embryonic stem cells, the field of in vitro embryo models has advanced rapidly, with protocols using human embryonic stem cells being only recently published in 2020. However, validation of these models through comparison with other in vitro models or with animal gastrulae has only started. As such, this study investigates one of the first 3D gastruloid protocol using human embryonic stem cells to create an optimized protocol using the H1 embryonic stem cell line, which is then validated with immunofluorescent staining for germ layer markers. And lastly, cells from 3D gastruloids generated from H1 and RUES2-GRL cell lineswere tested for the ability to self-aggregate through a dissociation and reseeding experiment onto 2D micropatterns. Whereas cells from dissociated RUES2-GRL 3D gastruloids showed clear evidence of self-aggregation comparable to what was reported in a similar experiment with 2D gastruloids, cells from H1 3D gastruloids did not. However, further optimization of the protocol is needed. Overall, the results reported in this thesis have identified conditions to generate in vitro H1 3D elongating gastruloids with three germ layers, as well as showing the evolutionarily conserved sorting ability of 3D RUES2-GRL gastruloid cells.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author : Luís Félix
Publisher : Humana
ISBN 13 : 9781493993147
Total Pages : 614 pages
Book Rating : 4.9/5 (931 download)
Download or read book Teratogenicity Testing written by Luís Félix and published by Humana. This book was released on 2019-06-27 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
Author : Viktor Hamburger
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Heritage of Experimental Embryology written by Viktor Hamburger and published by . This book was released on 1988 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a critical account of the experimental work of German biologist and Nobel laureate Hans Spemann, one of the founders of experimental embryology. The author, a distinguished developmental biologist, spent almost a decade in Spemann's laboratory. He examines Spemann's work and traces the different lines of investigation which emerged from his mentor's seminal research, and laid the foundation for modern cellular and developmental biology.
Author : Michael Cross
Publisher : Cambridge University Press
ISBN 13 : 0521770505
Total Pages : 547 pages
Book Rating : 4.5/5 (217 download)
Download or read book Pattern Formation and Dynamics in Nonequilibrium Systems written by Michael Cross and published by Cambridge University Press. This book was released on 2009-07-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: An account of how complex patterns form in sustained nonequilibrium systems; for graduate students in biology, chemistry, engineering, mathematics, and physics.
Author : Hans Driesch
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Science and Philosophy of the Organism written by Hans Driesch and published by . This book was released on 1908 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sir Gavin De Beer
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.:/5 (318 download)
Download or read book Embryos and Ancestors written by Sir Gavin De Beer and published by . This book was released on 1958 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Toni Cade Bambara
Publisher : Vintage
ISBN 13 : 0307778010
Total Pages : 305 pages
Book Rating : 4.3/5 (77 download)
Download or read book The Salt Eaters written by Toni Cade Bambara and published by Vintage. This book was released on 2011-02-16 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A community of Black faith healers witness an event that will change their lives forever in this "hard-nosed, wise, funny" novel (Los Angeles Times). Set in a fictional city in the American South, the novel also "inhabits the nonlinear, sacred space and sacred time of traditional African religion” (The New York Times Book Review). Though they all united in their search for the healing properties of salt, some of them are centered, some are off-balance; some are frightened, and some are daring. From the men who live off welfare women to the mud mothers who carry their children in their hides, the novel brilliantly explores the narcissistic aspect of despair and the tremendous responsibility that comes with physical, spiritual, and mental well-being.
Author : Patrick P. L. Tam
Publisher :
ISBN 13 : 9781936113248
Total Pages : 0 pages
Book Rating : 4.1/5 (132 download)
Download or read book Mammalian Development written by Patrick P. L. Tam and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A subject collection from Cold Spring Harbor perspectives in biology."
Author : Rudolf A. Raff
Publisher : University of Chicago Press
ISBN 13 : 022625657X
Total Pages : 545 pages
Book Rating : 4.2/5 (262 download)
Download or read book The Shape of Life written by Rudolf A. Raff and published by University of Chicago Press. This book was released on 2012-12-14 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development. Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms. Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.
Author : Alessandro Minelli
Publisher : Oxford University Press
ISBN 13 : 0199671427
Total Pages : 299 pages
Book Rating : 4.1/5 (996 download)
Download or read book Towards a Theory of Development written by Alessandro Minelli and published by Oxford University Press. This book was released on 2014 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the foundations of ontogeny by asking how the development of living things should be understood. It explores key concepts of developmental biology, asks whether general principles of development can be discovered, and what the role of models and theories is in developmental biology.
Author : James W. Valentine
Publisher : University of Chicago Press
ISBN 13 : 0226845486
Total Pages : 639 pages
Book Rating : 4.2/5 (268 download)
Download or read book On the Origin of Phyla written by James W. Valentine and published by University of Chicago Press. This book was released on 2004-06-18 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Owing its inspiration and title to On the Origin of Species, James W. Valentine's ambitious book synthesizes and applies the vast treasury of theory and research collected in the century and a half since Darwin's time. By investigating the origins of life's diversity, Valentine unlocks the mystery of the origin of phyla. One of the twentieth century's most distinguished paleobiologists, Valentine here integrates data from molecular genetics, evolutionary developmental biology, embryology, comparative morphology, and paleontology into an analysis of interest to scholars from any of these fields. He begins by examining the sorts of evidence that can be gleaned from fossils, molecules, and morphology, then reviews and compares the basic morphology and development of animal phyla, emphasizing the important design elements found in the bodyplans of both living and extinct phyla. Finally, Valentine undertakes the monumental task of developing models to explain the origin and early diversification of animal phyla, as well as their later evolutionary patterns. Truly a magnum opus, On the Origin of Phyla will take its place as one of the classic scientific texts of the twentieth century, affecting the work of paleontologists, morphologists, and developmental, molecular, and evolutionary biologists for decades to come. "A magisterial compendium . . . . Valentine offers a judicious evaluation of an astonishing array of evidence."—Richard Fortey, New Scientist "Truly a magnum opus, On the Origin of Phyla has already taken its place as one of the classic scientific texts of the twentieth century, affecting the work of paleontologists, morphologists, and developmental, molecular, and evolutionary biologists for decades to come."—Ethology, Ecology & Evolution "Valentine is one of the Renaissance minds of our time. . . . Darwin wisely called his best-known work On the Origin of the Species; the origin of the phyla is an even stickier problem, and Valentine deserves credit for tackling it at such breadth . . . . A magnificient book."—Stefan Bengtson, Nature
Author : Ludwig Von Bertalanffy
Publisher :
ISBN 13 : 9781614277408
Total Pages : 222 pages
Book Rating : 4.2/5 (774 download)
Download or read book Modern Theories of Development: An Introduction to Theoretical Biology written by Ludwig Von Bertalanffy and published by . This book was released on 2014-11-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2014 Reprint of Original 1962 American Edition. Exact facsimile of the original edition, not reproduced with Optical Recognition Software. This important introduction to theoretical biology is a classic work in its field. Already in the 1930's Bertalanffy formulated the organismic system theory that later became the kernel of the GST (General Systems Theory]. GST is an interdisciplinary practice that describes systems with interacting components, applicable to biology, cybernetics, and other fields. Bertalanffy proposed that the classical laws of thermodynamics applied to closed systems, but not necessarily to "open systems," such as living things. His mathematical model of an organism's growth over time is still in use today.
Author : Sally C. Clarke
Publisher : Department of Health and Ters for Disease Company
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.3/5 ( download)
Download or read book Birth and Fertility Rates for States written by Sally C. Clarke and published by Department of Health and Ters for Disease Company. This book was released on 1994 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : C.H. Waddington
Publisher : Routledge
ISBN 13 : 1317657543
Total Pages : 231 pages
Book Rating : 4.3/5 (176 download)
Download or read book The Strategy of the Genes written by C.H. Waddington and published by Routledge. This book was released on 2014-04-29 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1957, this essential classic work bridged the gap between analytical and theoretical biology, thus setting the insights of the former in a context which more sensitively reflects the ambiguities surrounding many of its core concepts and objectives. Specifically, these five essays are concerned with some of the major problems of classical biology: the precise character of biological organisation, the processes which generate it, and the specifics of evolution. With regard to these issues, some thinkers suggest that biological organisms are not merely distinguishable from inanimate ‘things’ in terms of complexity, but are in fact radically different qualitatively: they exemplify some constitutive principle which is not elsewhere manifested. It is the desire to bring such ideas into conformity with our understanding of analytical biology which unifies these essays. They explore the contours of a conceptual framework sufficiently wide to embrace all aspects of living systems.
Author : Fotinos Panagakos
Publisher : BoD – Books on Demand
ISBN 13 : 9533073764
Total Pages : 250 pages
Book Rating : 4.5/5 (33 download)
Download or read book Gingival Diseases written by Fotinos Panagakos and published by BoD – Books on Demand. This book was released on 2011-09-22 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gingival diseases are a family of distinct pathological entities that involve the gingival tissues. These signs and symptoms of these diseases are so prevalent in populations around the world that they are often considered to be "normal" features. The diseases are now classified into two main groups namely: Plaque-Induced and Non-Plaque Induced Gingival Diseases. This book provides dentists, dental hygienists, dental therapists and students with a comprehensive review of gingival diseases, their aetiology and treatment.
