Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Immunotherapy And Biomarkers In Neurodegenerative Disorders full books in PDF, epub, and Kindle. Read online Immunotherapy And Biomarkers In Neurodegenerative Disorders ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Lars Lannfelt
Publisher :
ISBN 13 : 9781493935604
Total Pages : 289 pages
Book Rating : 4.9/5 (356 download)
Download or read book Immunotherapy and Biomarkers in Neurodegenerative Disorders written by Lars Lannfelt and published by . This book was released on 2016 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yu-Hui Liu
Publisher : Frontiers Media SA
ISBN 13 : 2889713644
Total Pages : 124 pages
Book Rating : 4.8/5 (897 download)
Download or read book Immunological Mechanisms, Biomarkers and Immunotherapies of Alzheimer's Disease written by Yu-Hui Liu and published by Frontiers Media SA. This book was released on 2021-09-24 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Suman Dutta
Publisher : Frontiers Media SA
ISBN 13 : 2832518001
Total Pages : 273 pages
Book Rating : 4.8/5 (325 download)
Download or read book Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives written by Suman Dutta and published by Frontiers Media SA. This book was released on 2023-03-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sujata P. Sawarkar
Publisher : Springer Nature
ISBN 13 : 9811590389
Total Pages : 267 pages
Book Rating : 4.8/5 (115 download)
Download or read book Immunotherapy – A Novel Facet of Modern Therapeutics written by Sujata P. Sawarkar and published by Springer Nature. This book was released on 2020-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.
Author : Elizabeth A. Thomas
Publisher : Springer Nature
ISBN 13 : 3031328159
Total Pages : 476 pages
Book Rating : 4.0/5 (313 download)
Download or read book Biomarkers for Huntington's Disease written by Elizabeth A. Thomas and published by Springer Nature. This book was released on 2023-11-13 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
Author : Chaur-Jong Hu
Publisher : Frontiers Media SA
ISBN 13 : 2889458024
Total Pages : 83 pages
Book Rating : 4.8/5 (894 download)
Download or read book Risk Factors and Outcome Predicating Biomarker of Neurodegenerative Diseases written by Chaur-Jong Hu and published by Frontiers Media SA. This book was released on 2019-04-03 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers for risk detection and outcome prediction of neurodegenerative diseases become more and more important for the clinical practise and neuroscience research. This eBook presents novel findings in this field, including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease and application of neuroimaging, underlying mechanism of oxidative stress. The readers can catch new information about this emerging frontier of neurology with this eBook.
Author : Paul C. Guest
Publisher : Springer
ISBN 13 : 3030055426
Total Pages : 328 pages
Book Rating : 4.0/5 (3 download)
Download or read book Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders written by Paul C. Guest and published by Springer. This book was released on 2019-02-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Author : Manuel Menéndez-González
Publisher : Frontiers Media SA
ISBN 13 : 2889194000
Total Pages : 123 pages
Book Rating : 4.8/5 (891 download)
Download or read book Clinical use of biomarkers for neurodegenerative disorders written by Manuel Menéndez-González and published by Frontiers Media SA. This book was released on 2014-12-03 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.
Author : Ke Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889769755
Total Pages : 141 pages
Book Rating : 4.8/5 (897 download)
Download or read book Peripheral Immune System and Neurodegenerative Disease written by Ke Zhang and published by Frontiers Media SA. This book was released on 2022-09-15 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Philip Beart
Publisher : Springer
ISBN 13 : 3319571931
Total Pages : 546 pages
Book Rating : 4.3/5 (195 download)
Download or read book Neurodegenerative Diseases written by Philip Beart and published by Springer. This book was released on 2017-07-03 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.
Author : Jeffrey L. Cummings
Publisher : Oxford University Press
ISBN 13 : 0190233567
Total Pages : 361 pages
Book Rating : 4.1/5 (92 download)
Download or read book Neurodegenerative Diseases written by Jeffrey L. Cummings and published by Oxford University Press. This book was released on 2016-11-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a thorough examination of the unifying principles from the subcellular to the systems and clinical levels; Identifies common themes among molecular biology, genetics, physiology, pathology, biomarkers, behavior, and treatment strategies that are shared between neurodegenerative diseases; Enables better care of patients and help build collaboration across researchers in multiple specializations that could help advance future insights and facilitate novel therapies and enhancing basic scientific understanding of these diseases to a new generation.
Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author : Werner Poewe
Publisher : Cambridge University Press
ISBN 13 : 1139867628
Total Pages : 475 pages
Book Rating : 4.1/5 (398 download)
Download or read book Movement Disorders in Neurologic and Systemic Disease written by Werner Poewe and published by Cambridge University Press. This book was released on 2014-02-20 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement disorders - ranging from parkinsonism to a variety of hyperkinetic disorders, such as tremors, dystonic, chorea and myoclonus - can be the presenting or a prominent clinical feature in a broad spectrum of systemic conditions such as endocrine and metabolic disorders, autoimmune diseases, infections, intoxications, tumors and pareneoplastic syndromes, stroke and multiple sclerosis. The resulting clinical scenarios can be confusing and difficult to interpret by internists, generalists and neurologists. Movement Disorders in Neurologic and Systemic Disease provides comprehensive coverage of the most common movement disorders seen in systemic and general neurologic disease, as well as differential diagnostic and therapeutic algorithms. The chapters are written by internationally recognized experts and more than 50 illustrative videos highlight the phenomenology of some of the movement disorders and provide a useful 'bed-side' diagnostic tool. This book is a valuable resource for neurologists, physiatrists, psychiatrists, internists, primary care physicians and trainees in medicine and neurology.
Author : Erik D. Roberson
Publisher : Humana Press
ISBN 13 : 9781607617433
Total Pages : 0 pages
Book Rating : 4.6/5 (174 download)
Download or read book Alzheimer's Disease and Frontotemporal Dementia written by Erik D. Roberson and published by Humana Press. This book was released on 2010-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders.
Author : Otto Warburg
Publisher : EnCognitive.com
ISBN 13 : 1927091179
Total Pages : 419 pages
Book Rating : 4.9/5 (27 download)
Download or read book The Prime Cause of Cancer written by Otto Warburg and published by EnCognitive.com. This book was released on 2015-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is book 2 of 5 of the “Understand Cancer” series. It is based on the best-available science. The SECONDARY causes of cancer were discussed in book one. This book continues from book one and discusses the PRIME cause of cancer as discovered by Nobel Prize Laureate Dr. Otto Warburg—considered by many as the founder of modern biochemistry. “There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.” —Dr. Otto Warburg
Author : Michael S. Wolfe
Publisher : Academic Press
ISBN 13 : 0128113057
Total Pages : 561 pages
Book Rating : 4.1/5 (281 download)
Download or read book The Molecular and Cellular Basis of Neurodegenerative Diseases written by Michael S. Wolfe and published by Academic Press. This book was released on 2018-03-29 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts
Author :
Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)
Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
