Immunopharmacology Of Free Radical Species

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Immunopharmacology of Free Radical Species

Author :
Publisher : Elsevier
ISBN 13 : 9780080534541
Total Pages : 301 pages
Book Rating : 4.5/5 (345 download)

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Book Synopsis Immunopharmacology of Free Radical Species by :

Download or read book Immunopharmacology of Free Radical Species written by and published by Elsevier. This book was released on 1995-05-15 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

Free Radicals and Inflammation

Author : Paul G. Winyard
Publisher : Springer
ISBN 13 : 3034884826
Total Pages : 260 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Free Radicals and Inflammation by : Paul G. Winyard

Download or read book Free Radicals and Inflammation written by Paul G. Winyard and published by Springer. This book was released on 2013-03-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in so many fields of scientific endeavour following the molecular biology revo lution, our knowledge of the role of radicals not only in pathological states, but in basic physiology has developed exponentially. Indeed, our evolving concepts have, like so many political parties, been forced into dramatic "V-turns" and contortions. Within our working lives, we have had to debate whether radicals made any con tribution to any pathology, whilst now it is difficult not to entertain the view that every physiological process is pivotally controlled by exquisitely sensitive radical reactions. Inflammation is, of course, an example of pathology evolving from physiology, and in this book we have called upon both scientists and clinicians who have research interests in the complex switching mechanisms that sustain these transi tions. The book as a whole explores, from a physiological standpoint, how deter ministic radical systems sensitive to their initial conditions can interdigitate, iterate and feed back to control diverse cellular processes that create the inflammatory response. Whilst systems such as these to a mathematician would provide the basis for a chaotic response, one is forced to marvel how, for all stages of an inflammatory reaction, this system appears exquisitely controlled, making therapeutic manipula tion both possible and, to some extent, predictable.

Immunopharmacology of the Gastrointestinal System

Author : John L. Wallace
Publisher : Academic Press
ISBN 13 : 1483289338
Total Pages : 213 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Immunopharmacology of the Gastrointestinal System by : John L. Wallace

Download or read book Immunopharmacology of the Gastrointestinal System written by John L. Wallace and published by Academic Press. This book was released on 1993-03-01 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

Immunopharmacology of Platelets

Author : M. Joseph
Publisher : Academic Press
ISBN 13 : 0080534562
Total Pages : 267 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Immunopharmacology of Platelets by : M. Joseph

Download or read book Immunopharmacology of Platelets written by M. Joseph and published by Academic Press. This book was released on 1995-07-05 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.

Immunopharmacology of Epithelial Barriers

Author : Roy Goldie
Publisher : Elsevier
ISBN 13 : 9780122880308
Total Pages : 304 pages
Book Rating : 4.8/5 (83 download)

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Book Synopsis Immunopharmacology of Epithelial Barriers by : Roy Goldie

Download or read book Immunopharmacology of Epithelial Barriers written by Roy Goldie and published by Elsevier. This book was released on 1994-04-05 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.

Immunotoxicology and Immunopharmacology

Author : Robert V. House
Publisher : CRC Press
ISBN 13 : 1420005448
Total Pages : 676 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Immunotoxicology and Immunopharmacology by : Robert V. House

Download or read book Immunotoxicology and Immunopharmacology written by Robert V. House and published by CRC Press. This book was released on 2006-12-26 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history,

Antioxidants in Diabetes Management

Author : Peter Rosen
Publisher : CRC Press
ISBN 13 : 9780824788445
Total Pages : 380 pages
Book Rating : 4.7/5 (884 download)

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Book Synopsis Antioxidants in Diabetes Management by : Peter Rosen

Download or read book Antioxidants in Diabetes Management written by Peter Rosen and published by CRC Press. This book was released on 2000-02-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes current understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complications, and presents results of studies aimed at regulating oxidatively induced complications through the use of antioxidants. Examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications! Designed to stimulate scientific discussion and curiosity about the causes of diabetes, with contributions from nearly 65 clinicians and researchers who cite more than 1300 sources, Antioxidants in Diabetes Management focuses on stringent control of hyperglycemia to prevent or modify onset and progression promotes the development of intervention strategies because of the therapeutic limitations of hypoglycemic therapy emphasizes the potential synergistic effects of an interlinked antioxidant network investigates the controversy surrounding the significance of oxidative stress markers in diabetes highlights oxidative stress and antioxidant treatment in animal models for juvenile and adult onset diabetes explores the hypothesis that ischemic reperfusion is the primary cause of diabetic polyneuropathy links protein kinase C activation to the development of diabetic vascular complications and the effectiveness of vitamin E in preventing these abnormalities spotlights recent clinical trials of therapeutic effects of antioxidants to reduce insulin resistance and much more! Illustrating the therapeutic potential of antioxidants for the treatment of diabetes, Antioxidants in Diabetes Management is an unparalleled reference for endocrinologists, nutritionists and dietitians, cell biologists and biochemists, cardiologists, pathologists, and graduate and medical school students in these disciplines.

Phosphodiesterase Inhibitors

Author :
Publisher : Elsevier
ISBN 13 : 0080538819
Total Pages : 247 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Phosphodiesterase Inhibitors by :

Download or read book Phosphodiesterase Inhibitors written by and published by Elsevier. This book was released on 1996-08-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike

The Kinin System

Author : Stephen G. Farmer
Publisher : Academic Press
ISBN 13 : 0080542522
Total Pages : 371 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Kinin System by : Stephen G. Farmer

Download or read book The Kinin System written by Stephen G. Farmer and published by Academic Press. This book was released on 1997-04-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.

Lipid Mediators

Author : Fiona M. Cunningham
Publisher : Elsevier
ISBN 13 : 1483217639
Total Pages : 395 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Lipid Mediators by : Fiona M. Cunningham

Download or read book Lipid Mediators written by Fiona M. Cunningham and published by Elsevier. This book was released on 2016-10-27 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.

Antioxidant Methodology

Author : Okezie I. Aruoma
Publisher : The American Oil Chemists Society
ISBN 13 : 9780935315790
Total Pages : 264 pages
Book Rating : 4.3/5 (157 download)

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Book Synopsis Antioxidant Methodology by : Okezie I. Aruoma

Download or read book Antioxidant Methodology written by Okezie I. Aruoma and published by The American Oil Chemists Society. This book was released on 1997 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals and other reactive oxygen species are constantly formed in the human body and have been implicated in human diseases such as cancer, atherosclerosis, rheumatoid arthritis, Parkinson's disease, and malaria. This observation has raised the possibility that antioxidants could act as prophylactic agents. However, it remains to be fully established whether oxidative stress makes a significant contribution to the pathology of a given disease or whether it is an epiphenomenon. Indeed, development of specific assays applicable to humans would greatly contribute to our understanding of the role played by free radicals and their modulation by antioxidants in normal physiology and in human diseases. This book addresses the key methodological questions.

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Author : Luc Montagnier
Publisher : CRC Press
ISBN 13 : 9781420002928
Total Pages : 578 pages
Book Rating : 4.0/5 (29 download)

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Book Synopsis Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases by : Luc Montagnier

Download or read book Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases written by Luc Montagnier and published by CRC Press. This book was released on 1997-10-06 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Environmental Stressors in Health and Disease

Author : Jürgen Fuchs
Publisher : CRC Press
ISBN 13 : 0824746007
Total Pages : 571 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Environmental Stressors in Health and Disease by : Jürgen Fuchs

Download or read book Environmental Stressors in Health and Disease written by Jürgen Fuchs and published by CRC Press. This book was released on 2001-07-20 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.

Handbook of Nanophysics

Author : Klaus D. Sattler
Publisher : CRC Press
ISBN 13 : 1420075497
Total Pages : 888 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Nanophysics by : Klaus D. Sattler

Download or read book Handbook of Nanophysics written by Klaus D. Sattler and published by CRC Press. This book was released on 2010-09-17 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tools of nanodiagnostics, nanotherapy, and nanorobotics are expected to revolutionize the future of medicine, leading to presymptomatic diagnosis of disease, highly effective targeted treatment therapy, and minimum side effects. Handbook of Nanophysics: Nanomedicine and Nanorobotics presents an up-to-date overview of the application of nan

Wound Closure Biomaterials and Devices

Author : Chih-Chang Chu
Publisher : CRC Press
ISBN 13 : 1351404008
Total Pages : 416 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Wound Closure Biomaterials and Devices by : Chih-Chang Chu

Download or read book Wound Closure Biomaterials and Devices written by Chih-Chang Chu and published by CRC Press. This book was released on 2018-05-04 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Virtually every wound, whether surgical or traumatic, needs to be closed to promote wound healing and prevent infection. Increasingly sophisticated and effective materials for the crucial surgical treatment of wound closure are being developed continuously. Keep up with the most recent research progress and future trends in this complex and rapidly changing field with Wound Closure Biomaterial and Devices. This state-of-the-art book provides detailed information and critical discussions on: ï

Antioxidants in Disease Mechanisms and Therapy

Author :
Publisher : Academic Press
ISBN 13 : 0080581307
Total Pages : 734 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Antioxidants in Disease Mechanisms and Therapy by :

Download or read book Antioxidants in Disease Mechanisms and Therapy written by and published by Academic Press. This book was released on 1996-12-10 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. Contains cutting-edge information on focused topics written by expert scientists Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines Attempts molecular pathophysiology which links basic science and the clinic Presents critical assessment of controversial topics

Preventive Nutrition

Author : Adrianne Bendich
Publisher : Springer Science & Business Media
ISBN 13 : 1475762429
Total Pages : 624 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Preventive Nutrition by : Adrianne Bendich

Download or read book Preventive Nutrition written by Adrianne Bendich and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading medical authorities and clinicians comprehensively review and critically assess the newest nutritional approaches to preventing or delaying disease processes to create the single most comprehensive resource for health professionals seeking to improve individual health outcomes through nutrition. Along the way these distinguished scientists develop specific nutrient recommendations and illuminate not only the relationship between diet on the one hand and cancer, cardiovascular disease, and diabetes on the other, but also the dietary prevention of cataracts, osteoporosis, and immune dysfunction. In addition, they examine the exciting current research linking nutritional status with the prevention of birth defects, as well as with the optimization of the health and intellectual capacity of children. Their pathbreaking reviews clearly spell out the public health implications of preventive nutrition strategies for the US and Europe, as well as emerging nations and developing countries worldwide.