Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Ige Receptor Fcri Function In Mast Cells And Basophils
Download Ige Receptor Fcri Function In Mast Cells And Basophils full books in PDF, epub, and Kindle. Read online Ige Receptor Fcri Function In Mast Cells And Basophils ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis IgE Receptor (FcεRI) Function in Mast Cells and Basophils by : Majed M. Hamawy
Download or read book IgE Receptor (FcεRI) Function in Mast Cells and Basophils written by Majed M. Hamawy and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
Book Synopsis IGE Receptor (FceRI) Function in Mast Cells and Basophils by : Majed M. Hamawy
Download or read book IGE Receptor (FceRI) Function in Mast Cells and Basophils written by Majed M. Hamawy and published by . This book was released on 1997-01-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis IgE, Mast Cells and the Allergic Response by : Derek J. Chadwick
Download or read book IgE, Mast Cells and the Allergic Response written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique in the IgE field for its breadth of coverage and interdisciplinary nature, and it shows the benefits from the current rapid expansion of knowledge in cell biology, immunology, and molecular genetics, as well as the potential clinical significance of this research to clinical immunologists and allergologists.
Book Synopsis Mast Cells and Basophils by : Derek J. Chadwick
Download or read book Mast Cells and Basophils written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-01-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
Book Synopsis Immunopharmacology of Mast Cells and Basophils by : John C. Foreman
Download or read book Immunopharmacology of Mast Cells and Basophils written by John C. Foreman and published by Academic Press. This book was released on 1993-11-29 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.
Book Synopsis IGE Receptor (FceRI) Function in Mast Cells and Basophils by : Majed M. Hamawy
Download or read book IGE Receptor (FceRI) Function in Mast Cells and Basophils written by Majed M. Hamawy and published by Springer Science & Business Media. This book was released on 1997-01-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
Book Synopsis Mast Cells and Basophils by : Gianni Marone
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Book Synopsis Novel Insights into Inflammatory Roles of Mast Cells and Basophils by : Satoshi Tanaka
Download or read book Novel Insights into Inflammatory Roles of Mast Cells and Basophils written by Satoshi Tanaka and published by Frontiers Media SA. This book was released on 2023-04-20 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mast Cells in Allergic Diseases by : Hirohisa Saito
Download or read book Mast Cells in Allergic Diseases written by Hirohisa Saito and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the editors have focused on the roles of mast cells in allergic diseases and discuss the future direction of discovering drugs. Another implication of this book is to understand mast cells at the system level. System biology is a research category to understand biology at the system level by examining the structure and dynamics of cellular and organismal functions, rather than the characteristics of isolated parts of a cell or organism.
Book Synopsis Mast Cells, Mediators and Disease by : S. T. Holgate
Download or read book Mast Cells, Mediators and Disease written by S. T. Holgate and published by Springer. This book was released on 1988-09-30 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.
Book Synopsis Deciphering new molecular mechanisms of mast cell activation by : Ulrich Blank
Download or read book Deciphering new molecular mechanisms of mast cell activation written by Ulrich Blank and published by Frontiers E-books. This book was released on 2014-03-20 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells are tissue-localized cells that play an important role in immunity and inflammation. Following an offensive event they act as cellular sensors that via the activation of cell surface receptors launch a cellular response culminating in the release of a whole set of inflammatory mediators and products. This response is initially destined to restore tissue homeostasis, but in case of chronic injury or deregulation also promotes pathology. To further understand the action of mast cells in their environmental context it is necessary to decipher the molecular mechanisms of their activation as well as the ensuing cellular responses. This will allow identification of new strategies to promote their beneficial actions or, at the contrary, to interfere with their pathological consequences. While in the past many studies have focused on responses engaged by high affinity IgE receptor because of its implication in the allergic response, it has become clear that mast cells can be activated by multiple types of receptors initiating an intense molecular crosstalk between receptors and signaling pathways that can either synergize, antagonize and in some cases produce new types of responses. Mast cells can indeed react with an astounding diverse array of cellular responses that sometimes are engaged selectively. This Research Topic will focus on selected articles that shed some new light on the molecular mechanisms of mast cell activation, the possible crosstalk between signaling pathways and the ensuing cellular responses that allow mast cells to act as cellular sensors in tissues.
Author :Collegium Internationale Allergologicum. Symposium Publisher :S. Karger AG (Switzerland) ISBN 13 : Total Pages :332 pages Book Rating :4.:/5 (318 download)
Book Synopsis Progress in Clinical Immunology by : Collegium Internationale Allergologicum. Symposium
Download or read book Progress in Clinical Immunology written by Collegium Internationale Allergologicum. Symposium and published by S. Karger AG (Switzerland). This book was released on 1983 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis IgE Antibodies: Generation and Function by : Juan J. Lafaille
Download or read book IgE Antibodies: Generation and Function written by Juan J. Lafaille and published by Springer. This book was released on 2015-01-02 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.
Book Synopsis Understanding IgE Receptor Signaling Through Computational Modeling and Quantitative Experiments by : Lily Ann Chylek
Download or read book Understanding IgE Receptor Signaling Through Computational Modeling and Quantitative Experiments written by Lily Ann Chylek and published by . This book was released on 2016 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fc[epsilon]RI is a multi-subunit receptor found on the surface of mast cells and basophils and binds immunoglobulin E (IgE) with high affinity. Stimulation of this receptor, typically via antigen-mediated crosslinking of IgE, can lead to release of histamine and other mediators that are involved in the allergic immune response. Thus, understanding the workings of Fc[epsilon]RI-mediated signaling brings us closer to understanding one of the most widespread health conditions in the developed world. Fc[epsilon]RI-mediated signaling processes are inherently complex, involving highly interconnected systems in which quantitative factors can play a decisive role. Such systems can be difficult to decipher using intuition alone, but computational models can extend our reasoning abilities and enable us to develop nontrivial hypotheses that generate experimentally testable predictions. To develop a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated to impact cellular decisionmaking, we developed a computational interaction library. The library consists of executable rules for protein-protein and protein-lipid interactions. The library is visualized to facilitate understanding of network circuitry and identification of network motifs. Using this library, we investigated branching pathways from the adaptor protein Lat, which influence production of the phospholipid phosphatidylinositol (3,4,5)trisphosphate (PIP3) at the plasma membrane and the soluble second messenger inositol trisphosphate (IP3). We found that inclusion of a positive feedback loop gives rise to a bistable switch, which may ensure robust responses to stimulation above a threshold level. Such robustness has been observed experimentally for some readouts. We also developed a model that proposes an explanation for experimentally observed oscillations in Ca2+ concentration, which is an important outcome of Fc[epsilon]RI stimulation. To investigate Fc[epsilon]RI signaling from another angle, we modeled interactions between the receptor and a structurally defined ligand for IgE. We parameterized the model for consistency with kinetic fluorescence data as well as super-resolution imaging measurements of antigen-induced receptor aggregation. To facilitate this study, we developed a specialized tool for fitting biochemical models to experimental data. Finally, we examined how patterns of exposure to stimulatory and non-stimulatory ligands affect mast cells' secretory responses. Through iterative modeling and experimental tests, we learned that a tug-of-war between positive signals from the tyrosine kinase Syk and negative signals from the lipid phosphatase Ship-1 govern the magnitude of responses, with the adaptor protein Shc1 influencing how the balance of positive and negative signals changes with time.
Book Synopsis IgE Antibody Dynamics and Its Role in Receptor Binding and Inhibition by : Beomkyu Kim
Download or read book IgE Antibody Dynamics and Its Role in Receptor Binding and Inhibition written by Beomkyu Kim and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: IgE antibodies interact with the high affinity IgE Fc receptor (Fc [epsilon] RI) expressed on mast cells and basophils, and the low affinity IgE Fc receptor (CD23) on B cells. These interactions are directly involved in triggering the allergen-specific activation of inflammatory responses. The IgE-Fc region, comprising the C-terminal domains of the IgE heavy chain, binds Fc [epsilon] RI and the crystal structures of the human IgE-Fc alone and IgE-Fc complexes exhibited IgE-Fc conformational flexibility. In addition, the crystal structure of IgE-Fc bound to CD23 indicated a preference of CD23 for a closed conformation of the IgE-Fc incompatible with Fc [epsilon] RI binding. These observations suggested the importance of IgE conformational dynamics for its receptor binding mechanism and the potential to identify non-classical or allosteric inhibitors for IgE-receptor interactions. To investigate IgE dynamics and its role in receptor binding and inhibition, I have employed 5 experimental approaches: 1) IgE-Fc mutants trapped by an engineered disulfide bond, blocking Fc [epsilon] RI but not IgE inhibitor binding, 2) a fluorescence assay for IgE-Fc:Fc [epsilon] RI binding and inhibition that can distinguish IgE-inhibitors based on their proximity to the Fc [epsilon] RI binding site, 3) the determination of the E2_79 crystal structure showing that the IgE inhibitor E2_79 binds IgE-Fc outside the Fc [epsilon] RI-binding site and acts through a facilitated dissociation mechanism to block receptor binding, 4) the development of a TR-FRET assay suitable for high-throughput screening for small molecule inhibitors of IgE-receptor binding, and 5) a single-molecule FRET approach to characterize the conformational states of the IgE-Fc3-4 and observe changes upon Fc [epsilon] RI, CD23, and E2_79. These experiments revealed different conformational requirements for IgE binding, identified a disruptive inhibitor that actively dissociates preformed receptor complexes, and provided direct observation of receptor binding-induced IgE-Fc conformational changes. This work provides a new perspective on the role of IgE dynamics in receptor binding and inhibition, and makes possible the development of new disruptive inhibitors for IgE-receptor binding acting through non-classical or allosteric mechanisms.
Book Synopsis IgE and Anti-IgE Therapy in Asthma and Allergic Disease by : Robert Fick
Download or read book IgE and Anti-IgE Therapy in Asthma and Allergic Disease written by Robert Fick and published by CRC Press. This book was released on 2002-04-24 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders. Compiles previously unpublished data from the first extensive scientific investigations of Xolair! IgE and Anti-IgE Therapy in Asthma and Allergic Disease reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe offers novel methods for the design and formulation of monoclonal antibodies discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications examines the role of IgE in food and parasitic allergies and covers the pathogenesis of atopic dermatitis and urticaria novel strategies to target mast cells and basophils murine models of allergic pulmonary inflammation the pathophysiology of allergic rhinitis Supplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.
Book Synopsis Investigating Cytoskeletal Regulation of IgE Receptor Signaling by Micropatterned Ligand Arrays by : Alexis J Torres
Download or read book Investigating Cytoskeletal Regulation of IgE Receptor Signaling by Micropatterned Ligand Arrays written by Alexis J Torres and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high affinity immunoglobulin E (IgE ) receptor (Fc[epsilon]RI) is a member of a family of related antigen receptors with conserved structure and similar roles in initiating intracellular signaling in response to an outside stimulus. In mammalian cells, Fc[epsilon]RI is found primarily on the surface of mast cells and basophils. Activation of this receptor by multivalent antigen triggers a series of intracellular signaling events that ultimately lead to the secretion of preformed mediators, such as histamine and serotonin, which are responsible for allergic reactions. Our recent efforts in the study of immunoreceptor signaling have focused on the participation of the plasma membrane and the actin cytoskeleton. However, tools for investigating biomolecular dynamics and interactions that occur within close proximity to the plasma membrane of living cells are somewhat limited. Micro-fabricated surfaces have been used for applications in cell and tissue engineering, although their full potential has not been explored, particularly in the area of molecular cell biology. We have recently developed a polymer lift-off method for localizing the initial stimulus to micron size patches of antigens such that assembly of signaling components could be visualized with selective fluorescent labeling and confocal microscopy. Employing these technologies we have investigated fundamental mechanisms in immune cell signaling, specifically IgE receptor (Fc[epsilon]RI) signaling involved in allergic responses on mast cells. In past years, our group has observed spatially and temporally resolved responses, including receptor phosphorylation, selective accumulation of Lyn kinase and other membrane components. In this work, I have applied these tools to investigate functional and structural implications of the actin cytoskeleton regulation of Fc[epsilon]RI signaling and the cytoskeletal dependence of activated receptor internalization. I have shown that particular actin binding proteins, paxillin, talin and vinculin co-redistribute at the patterned antigen and clustered receptors in a similar time course as polymerized actin. These proteins have been extensively characterized in the context of integrin signaling and focal adhesion assembly, but little is known about their involvement in immune cell signaling. Our biochemical data suggests that these proteins have functional relevance in some of the early and late events of the signaling cascade. In addition, I show that the GTPase dynamin 2, which is commonly associated with receptor endocytosis, is selectively recruited to the sites of receptor clustering. Protein knockdown of dynamin 2 decreases the accumulation of F-actin at the clustered receptors, implicating dynamin in the regulation of Fc[epsilon]RI mediated actin redistribution. These results point a possible role for dynamin-actin interactions in regulating activated IgEFc[epsilon]RI internalization.
