Identification Of Portal Mesenchymal Stem Cells And Derived Myofibroblasts In Liver Fibrosis

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Identification of Portal Mesenchymal Stem Cells and Derived Myofibroblasts in Liver Fibrosis

Author : Lin Lei (auteur d'une thèse en biologie).)
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Identification of Portal Mesenchymal Stem Cells and Derived Myofibroblasts in Liver Fibrosis by : Lin Lei (auteur d'une thèse en biologie).)

Download or read book Identification of Portal Mesenchymal Stem Cells and Derived Myofibroblasts in Liver Fibrosis written by Lin Lei (auteur d'une thèse en biologie).) and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous work has demonstrated that portal myofibroblasts (PMFs) significantly contributed to liver fibrogenesis and modulated angiogenesis in liver fibrosis. The main aim of this thesis was to elucidate the landscape of portal mesenchymal cells, with a particular focus on a portal mesenchymal stem cell niche. We characterized the murine normal liver portal mesenchymal cell landscape. Importantly, we revealed a portal mesenchymal cell population with the features of mesenchymal stem cells (MSCs), designated portal mesenchymal stem cells (PMSCs) that possessed the ability to give rise to PMFs in vitro. Furthermore, we identified Slit2 as a new marker of PMSCs based on scRNA-seq and bulk RNA-seq analysis. In vivo, we observed PMSC expansion (measured by the expression of Slit2) in liver from both animal fibrosis models (DDC and CDAA) and patients with chronic liver disease (NASH, PSC and other liver disease). Notably, we defined the specific gene signatures for PMSCs and hepatic stellate cells (HSCs), respectively. By using these markers, we provide further evidence indicating that PMSCs expand in correlation with fibrogenesis and angiogenesis in different murine and human liver diseases, whereas the HSCs gene signatures did not vary. In conclusion, our work collectively offers insights into the components and functions of the mammalian liver portal mesenchymal cell populations, and in particular, identify and characterize PMSCs and their derived myofibroblasts, opening up the possibility for the development of novel targeted drugs or biomarkers of clinical significance with increased precision.

Liver Myofibroblasts

Author : Jiri Kanta
Publisher : Frontiers Media SA
ISBN 13 : 2889199894
Total Pages : 101 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Liver Myofibroblasts by : Jiri Kanta

Download or read book Liver Myofibroblasts written by Jiri Kanta and published by Frontiers Media SA. This book was released on 2016-10-25 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.

Stellate Cells in Health and Disease

Author : Chandrashekhar Gandhi
Publisher : Academic Press
ISBN 13 : 0128005440
Total Pages : 335 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Stellate Cells in Health and Disease by : Chandrashekhar Gandhi

Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Liver Disease in Children

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Author : Denis Corbeil
Publisher : Springer Science & Business Media
ISBN 13 : 1461458943
Total Pages : 255 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by : Denis Corbeil

Download or read book Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology written by Denis Corbeil and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Cholestatic Liver Disease

Author : Elizabeth J. Carey
Publisher : Springer
ISBN 13 : 1493910132
Total Pages : 265 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Cholestatic Liver Disease by : Elizabeth J. Carey

Download or read book Cholestatic Liver Disease written by Elizabeth J. Carey and published by Springer. This book was released on 2014-07-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.

Liver, Lung and Heart Regeneration

Author : Phuc Van Pham
Publisher : Springer
ISBN 13 : 3319466933
Total Pages : 220 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Liver, Lung and Heart Regeneration by : Phuc Van Pham

Download or read book Liver, Lung and Heart Regeneration written by Phuc Van Pham and published by Springer. This book was released on 2016-12-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Tissue Repair and Fibrosis

Author : Alexis Desmouliere
Publisher : Springer Science & Business Media
ISBN 13 : 364258456X
Total Pages : 358 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Tissue Repair and Fibrosis by : Alexis Desmouliere

Download or read book Tissue Repair and Fibrosis written by Alexis Desmouliere and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Canine and Feline Gastroenterology - E-Book

Author : Robert J. Washabau
Publisher : Elsevier Health Sciences
ISBN 13 : 143770302X
Total Pages : 1024 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Canine and Feline Gastroenterology - E-Book by : Robert J. Washabau

Download or read book Canine and Feline Gastroenterology - E-Book written by Robert J. Washabau and published by Elsevier Health Sciences. This book was released on 2012-09-02 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference standard for the discipline, Canine and Feline Gastroenterology covers the biology, pathobiology, and diagnosis and treatment of diseases of the gastrointestinal, pancreatic, and hepatobiliary systems. An international team of experts, including 85 authors from 17 different countries, led by Robert Washabau and Michael Day, covers everything from minor problems such as adverse food reactions to debilitating inflammatory, infectious, metabolic, and neoplastic diseases of the digestive system. This authoritative text utilizes an evidence-based approach to reflect the latest science and research, complemented by principles of problem solving, algorithms to improve clinical diagnoses, and extensive full-color illustrations. For generalists and specialists alike, this gastroenterology reference should be part of every serious practitioner's professional library. A comprehensive, 928-page reference standard covers the discipline of canine and feline gastroenterology. An international focus is provided by 85 authors from 17 different countries, including renowned experts in veterinary gastroenterology, internal medicine, pathology, clinical pathology, radiology, and infectious disease. Coverage of the entire breadth and depth of gastroenterology ranges from biology to pathobiology, as well as diagnosis and treatment of diseases of the gastrointestinal, pancreatic, and hepatobiliary systems. Current information on GI microflora, immunology, cellular growth, and systems integration provides a foundation for treating clinical problems. Coverage of diseases in dogs and cats includes the oral cavity, esophagus, stomach, small intestine, large intestine, colon, anorectum, liver and biliary tract, exocrine pancreas, peritoneum, and associated vasculature. A focus on patient management examines the full range of procedures and techniques essential to diagnosis and treatment from clinical signs and diagnosis to nutritional support and pharmacologic management of disease. Clear explanations of current diagnostic modalities include laboratory tests, molecular methods, diagnostic imaging, endoscopy, and histopathology, also showing how to interpret and utilize results. A strong clinical approach emphasizes need-to-know information for managing the common and not-so-common G.I. clinical problems of everyday practice. Full-color photographs and illustrations depict concepts, conditions, and procedures. An evidence-based medicine perspective reflects the latest research as well as the modern practice of veterinary medicine. Logical, coherent, and consistent internal organization makes this a reader-friendly edition. Problem-based algorithms help in diagnosing every G.I. clinical problem from A to Z. A stand-alone section on the pharmacologic approach to G.I. disease offers quick and easy drug reference.

Pericyte Biology in Different Organs

Author : Alexander Birbrair
Publisher : Springer
ISBN 13 : 3030110931
Total Pages : 277 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Pericyte Biology in Different Organs by : Alexander Birbrair

Download or read book Pericyte Biology in Different Organs written by Alexander Birbrair and published by Springer. This book was released on 2019-04-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Molecular Mechanisms of Cell Differentiation in Gonad Development

Author : Rafal P. Piprek
Publisher : Springer
ISBN 13 : 3319319736
Total Pages : 444 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Molecular Mechanisms of Cell Differentiation in Gonad Development by : Rafal P. Piprek

Download or read book Molecular Mechanisms of Cell Differentiation in Gonad Development written by Rafal P. Piprek and published by Springer. This book was released on 2016-06-14 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

Liver Immunology

Author : M. Eric Gershwin
Publisher : Springer Science & Business Media
ISBN 13 : 331902096X
Total Pages : 482 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Liver Immunology by : M. Eric Gershwin

Download or read book Liver Immunology written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.

Stem Cell Therapy for Vascular Diseases

Author : Tulio Pinho Navarro
Publisher : Springer Nature
ISBN 13 : 3030569543
Total Pages : 425 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Stem Cell Therapy for Vascular Diseases by : Tulio Pinho Navarro

Download or read book Stem Cell Therapy for Vascular Diseases written by Tulio Pinho Navarro and published by Springer Nature. This book was released on 2020-11-05 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Hepatocellular Carcinoma

Author : Yujin Hoshida
Publisher : Springer
ISBN 13 : 3030215407
Total Pages : 366 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Leong's Manual of Diagnostic Antibodies for Immunohistology

Author : Runjan Chetty
Publisher : Cambridge University Press
ISBN 13 : 1316592065
Total Pages : 525 pages
Book Rating : 4.3/5 (165 download)

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Book Synopsis Leong's Manual of Diagnostic Antibodies for Immunohistology by : Runjan Chetty

Download or read book Leong's Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.

Liver Cirrhosis

Author : Georgios Tsoulfas
Publisher : BoD – Books on Demand
ISBN 13 : 9535133098
Total Pages : 304 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Liver Cirrhosis by : Georgios Tsoulfas

Download or read book Liver Cirrhosis written by Georgios Tsoulfas and published by BoD – Books on Demand. This book was released on 2017-07-05 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver cirrhosis represents one of the major challenges for most physicians and surgeons on a global scale. This book provides practicing hepatologists, gastroenterologists and liver surgeons with a valuable tool in their efforts to understand the (molecular) mechanisms involved, be updated regarding the newest and less invasive diagnostic methods, and educate themselves about the challenges involved in the management of liver cirrhosis and its complications. The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of liver cirrhosis, giving us a well-rounded overview.