Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

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Publisher : National Academies Press
ISBN 13 : 0309157277
Total Pages : 335 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by : Institute of Medicine

Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Biomarkers in Cardiovascular Disease

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323548369
Total Pages : 199 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Biomarkers in Cardiovascular Disease by : Vijay Nambi

Download or read book Biomarkers in Cardiovascular Disease written by Vijay Nambi and published by Elsevier Health Sciences. This book was released on 2018-11-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. - Covers lab standards and statistical interpretation of biomarkers with a clinical focus. - Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. - Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. - Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.

Mechanisms of Vascular Disease

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Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Pediatric Heart Failure

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Publisher : CRC Press
ISBN 13 : 9780367393243
Total Pages : 928 pages
Book Rating : 4.3/5 (932 download)

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Book Synopsis Pediatric Heart Failure by : Robert Shaddy

Download or read book Pediatric Heart Failure written by Robert Shaddy and published by CRC Press. This book was released on 2019-08-30 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book of its kind, this reference describes current diagnostic and treatment strategies for acute and chronic heart failure in the fetus, neonate, child, and young adult-encompassing every aspect of pediatric heart failure including historical perspectives, the latest technologies in mechanical circulatory support, and recent information on the psychosocial aspects of heart failure in children.

Acute Heart Failure

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Publisher : Springer Science & Business Media
ISBN 13 : 1846287820
Total Pages : 922 pages
Book Rating : 4.8/5 (462 download)

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Book Synopsis Acute Heart Failure by : Alexandre Mebazaa

Download or read book Acute Heart Failure written by Alexandre Mebazaa and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

Women in Science: Genetics

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Publisher : Frontiers Media SA
ISBN 13 : 2832505260
Total Pages : 220 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Women in Science: Genetics by : Rana Dajani

Download or read book Women in Science: Genetics written by Rana Dajani and published by Frontiers Media SA. This book was released on 2022-11-11 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chronic Graft Versus Host Disease

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Publisher : Cambridge University Press
ISBN 13 : 1139478893
Total Pages : 427 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Chronic Graft Versus Host Disease by : Georgia B. Vogelsang

Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

The Detection of Biomarkers

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Publisher : Academic Press
ISBN 13 : 0128230754
Total Pages : 615 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Detection of Biomarkers by : Sibel A. Ozkan

Download or read book The Detection of Biomarkers written by Sibel A. Ozkan and published by Academic Press. This book was released on 2021-12-05 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. - Locates biomarker detection in its research context, setting out present and future prospects - Allows clinical researchers to compare various biomarker assays systematically - Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical - Gives innovative biomarker assays that are viable alternatives to current complex methods - Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Genetic Cardiomyopathies

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Publisher : Springer Science & Business Media
ISBN 13 : 8847027578
Total Pages : 170 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Genetic Cardiomyopathies by : Gianfranco Sinagra

Download or read book Genetic Cardiomyopathies written by Gianfranco Sinagra and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, genetics has been emerging as a primary issue in the diagnosis and management of cardiomyopathies. This book is intended to be a state-of-the-art monograph on these diseases, describing their genetic causes, defining the molecular basis and presenting extensive descriptions of genotype–phenotype correlations. Other chapters are focused on the role of clinical observation, on ECG and echocardiography. With its highlight on the most recent discoveries in the field of molecular genetics as well as on the correct clinical approach to patients with heart muscle disease, the book is aimed at physicians and clinical cardiologists with a particular interest in myocardial diseases and in their genetic causes.

Novel Biomarkers for Heart Disease

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Publisher : MDPI
ISBN 13 : 3039438832
Total Pages : 420 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Novel Biomarkers for Heart Disease by : Michael Lichtenauer

Download or read book Novel Biomarkers for Heart Disease written by Michael Lichtenauer and published by MDPI. This book was released on 2020-12-28 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.

Proteomics Mass Spectrometry Methods

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Publisher : Elsevier
ISBN 13 : 0323906524
Total Pages : 242 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Proteomics Mass Spectrometry Methods by : Paula Meleady

Download or read book Proteomics Mass Spectrometry Methods written by Paula Meleady and published by Elsevier. This book was released on 2024-02-13 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers. - Explores the most common questions new researchers have - Guides readers to properly design the workflow for successful integration of mass spectrometry into protein biochemical analyses - Provides examples of sample preparation for a number of different materials, mammalian cells, and others

Circulating MicroRNAs

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Publisher : Humana Press
ISBN 13 : 9781627034524
Total Pages : 0 pages
Book Rating : 4.0/5 (345 download)

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Book Synopsis Circulating MicroRNAs by : Takahiro Ochiya

Download or read book Circulating MicroRNAs written by Takahiro Ochiya and published by Humana Press. This book was released on 2013-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.

Novel biomarkers and risk factors associated with cardiometabolic dysfunction in heart failure

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832519040
Total Pages : 168 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Novel biomarkers and risk factors associated with cardiometabolic dysfunction in heart failure by : Yuli Huang

Download or read book Novel biomarkers and risk factors associated with cardiometabolic dysfunction in heart failure written by Yuli Huang and published by Frontiers Media SA. This book was released on 2023-03-27 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Monitoring Metabolic Status

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Publisher : National Academies Press
ISBN 13 : 0309091594
Total Pages : 469 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Monitoring Metabolic Status by : Institute of Medicine

Download or read book Monitoring Metabolic Status written by Institute of Medicine and published by National Academies Press. This book was released on 2004-08-29 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.

Pericardial Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9400904819
Total Pages : 254 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Pericardial Disease by : J. Soler-Soler

Download or read book Pericardial Disease written by J. Soler-Soler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November 1986, I was invited to attend a symposium held in Barcelona on Diseases of the Pericardium. The course was directed by Dr. J. Soler-Soler, director of Cardiology at Hospital General Vall d'Hebron in Barcelona. During my brief but delightful visit to this institution, my appreciation of the depth and breadth of study into pericardial diseases, carried out by Dr. Soler and his group, grew into the conviction that these clinical investigators have accumulated a wealth of information concerning pericardial diseases, and that investigators and clinicians practicing in English speaking countries would greatly profit from ready access to the results of the clinical investiga tions into pericardial disease carried out in Barcelona. The proceedings of the Barcelona conference were published in a beauti fully executed volume in the Spanish language edited by Dr. Soler and pro duced by Ediciones Doyma. Because I believe that this work should be brought to the attention of the English speaking scientific and clinical com munities, I encouraged Dr. Soler to have the book translated into English. I knew that this task could be accomplished and that the book would be trans lated into good English without change of its content. My confidence was based upon a translation of my own book, The Pericardium, into Spanish undertaken by Dr. Permanyer, who is a contributor and co-editor of the pre sent volume.

Improving Early Detection and Risk Prediction in Heart Failure

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Publisher : Frontiers Media SA
ISBN 13 : 2889763226
Total Pages : 139 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Improving Early Detection and Risk Prediction in Heart Failure by : Vinicius Tragante

Download or read book Improving Early Detection and Risk Prediction in Heart Failure written by Vinicius Tragante and published by Frontiers Media SA. This book was released on 2022-06-03 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dilated Cardiomyopathy

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Author :
Publisher : Springer
ISBN 13 : 303013864X
Total Pages : 239 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Dilated Cardiomyopathy by : Gianfranco Sinagra

Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.