Identification Of Coq11 A New Coenzyme Q Biosynthetic Protein In The Coq Synthome In Saccharomyces Cerevisiae

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Coenzyme Q in Aging

Author : Guillermo López Lluch
Publisher : Springer Nature
ISBN 13 : 3030456420
Total Pages : 367 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Coenzyme Q in Aging by : Guillermo López Lluch

Download or read book Coenzyme Q in Aging written by Guillermo López Lluch and published by Springer Nature. This book was released on 2020-08-06 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

Molecular Basis for Mitochondrial Signaling

Author : Tatiana K. Rostovtseva
Publisher : Springer
ISBN 13 : 3319555391
Total Pages : 388 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Molecular Basis for Mitochondrial Signaling by : Tatiana K. Rostovtseva

Download or read book Molecular Basis for Mitochondrial Signaling written by Tatiana K. Rostovtseva and published by Springer. This book was released on 2017-05-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

Coenzyme Q in Aging

Author : Guillermo López Lluch
Publisher : Springer
ISBN 13 : 9783030456412
Total Pages : 0 pages
Book Rating : 4.4/5 (564 download)

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Book Synopsis Coenzyme Q in Aging by : Guillermo López Lluch

Download or read book Coenzyme Q in Aging written by Guillermo López Lluch and published by Springer. This book was released on 2020-08-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

Biotechnology of Isoprenoids

Author : Jens Schrader
Publisher : Springer
ISBN 13 : 3319201077
Total Pages : 470 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Biotechnology of Isoprenoids by : Jens Schrader

Download or read book Biotechnology of Isoprenoids written by Jens Schrader and published by Springer. This book was released on 2015-05-19 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Coenzyme Q

Author : Giorgio Lenaz
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Coenzyme Q by : Giorgio Lenaz

Download or read book Coenzyme Q written by Giorgio Lenaz and published by John Wiley & Sons. This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming increasingly apparent that Coenzyme Q (Ubiquinone) is a major component of the electron transfer chains within aerobic micro-oganisms, photo-synthetic micro-organisms and mitochondria of eukaryotes. In particular, the proposal by Nobel laureate, Peter Mitchell, that Coenzyme Q possibly acts as a proton translocator within a proton motive Q-cycle, thus establishing an electrochemical membrane potential which in turn drives ATP synthesis, has received wide attention. This exhaustive, inter-disciplinary study discusses Ubiquinone's chemical and physical properties, metabolism, and function in different organisms.

Microbial Respiration

Author : Walter P. Hempfling
Publisher : Hutchinson Ross Publishing Company
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microbial Respiration by : Walter P. Hempfling

Download or read book Microbial Respiration written by Walter P. Hempfling and published by Hutchinson Ross Publishing Company. This book was released on 1979 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Diseases

Author : Placido Navas
Publisher :
ISBN 13 : 9783030701482
Total Pages : 0 pages
Book Rating : 4.7/5 (14 download)

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Book Synopsis Mitochondrial Diseases by : Placido Navas

Download or read book Mitochondrial Diseases written by Placido Navas and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 431 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Proteases in Human Diseases

Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 9811031622
Total Pages : 516 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Proteases in Human Diseases by : Sajal Chakraborti

Download or read book Proteases in Human Diseases written by Sajal Chakraborti and published by Springer. This book was released on 2017-07-13 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Genetic Diseases of the Kidney

Author : Richard P. Lifton
Publisher : Academic Press
ISBN 13 : 0080924271
Total Pages : 895 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Genetic Diseases of the Kidney by : Richard P. Lifton

Download or read book Genetic Diseases of the Kidney written by Richard P. Lifton and published by Academic Press. This book was released on 2009-02-25 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic "disturbance to the systemic appearance of disease. - Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics - Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes - World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Mitochondrial Case Studies

Author : Russell Saneto
Publisher : Academic Press
ISBN 13 : 0128011491
Total Pages : 340 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mitochondrial Case Studies by : Russell Saneto

Download or read book Mitochondrial Case Studies written by Russell Saneto and published by Academic Press. This book was released on 2015-11-24 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments. - Reviews case studies as a helpful teaching tool to increase awareness and improve diagnosis - Provides information on underlying mechanisms of mitochondrial disease - Includes basic mitochondrial dysfunction research through patient case studies to best illustrate the entire disease process

The Structure and Function of Plastids

Author : Robert R. Wise
Publisher : Springer Science & Business Media
ISBN 13 : 9781402065705
Total Pages : 624 pages
Book Rating : 4.0/5 (657 download)

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Book Synopsis The Structure and Function of Plastids by : Robert R. Wise

Download or read book The Structure and Function of Plastids written by Robert R. Wise and published by Springer Science & Business Media. This book was released on 2007-09-13 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive look at the biology of plastids, the multifunctional biosynthetic factories that are unique to plants and algae. Fifty-six international experts have contributed 28 chapters that cover all aspects of this large and diverse family of plant and algal organelles. The book is divided into five sections: (I): Plastid Origin and Development; (II): The Plastid Genome and Its Interaction with the Nuclear Genome; (III): Photosynthetic Metabolism in Plastids; (IV): Non-Photosynthetic Metabolism in Plastids; (V): Plastid Differentiation and Response to Environmental Factors. Each chapter includes an integrated view of plant biology from the standpoint of the plastid. The book is intended for a wide audience, but is specifically designed for advanced undergraduate and graduate students and scientists in the fields of photosynthesis, biochemistry, molecular biology, physiology, and plant biology.

The Cerebellum: Disorders and Treatment

Author :
Publisher : Elsevier
ISBN 13 : 0444641904
Total Pages : 442 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis The Cerebellum: Disorders and Treatment by :

Download or read book The Cerebellum: Disorders and Treatment written by and published by Elsevier. This book was released on 2018-06-08 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. - Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases - Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases - Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases

DNA Methyltransferases - Role and Function

Author : Albert Jeltsch
Publisher : Springer
ISBN 13 : 3319436244
Total Pages : 537 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis DNA Methyltransferases - Role and Function by : Albert Jeltsch

Download or read book DNA Methyltransferases - Role and Function written by Albert Jeltsch and published by Springer. This book was released on 2016-11-08 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Proteases and Cancer

Author : Santiago Cal
Publisher : Humana Press
ISBN 13 : 9781493975945
Total Pages : 352 pages
Book Rating : 4.9/5 (759 download)

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Book Synopsis Proteases and Cancer by : Santiago Cal

Download or read book Proteases and Cancer written by Santiago Cal and published by Humana Press. This book was released on 2018-01-10 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography, angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Proteases and Cancer: Methods and Protocols is a valuable resource for clinical researchers across numerous fields such as molecular and cellular biology, oncology, biochemistry, and chemistry. This book is also useful for PhD students in the various disciples of health sciences.

Thiamine

Author : Frank Jordan
Publisher : CRC Press
ISBN 13 : 9780203913420
Total Pages : 646 pages
Book Rating : 4.9/5 (134 download)

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Book Synopsis Thiamine by : Frank Jordan

Download or read book Thiamine written by Frank Jordan and published by CRC Press. This book was released on 2003-12-11 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiling landmark research from those laying the foundation for medical science's next leap forward, Thiamine: Catalytic Mechanisms in Normal and Disease States fully explores the pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing brilliant new insights into neurogenerative diseases, this comprehensive volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states, and offers novel aspects of thiamine enzymes in chiral synthesis, as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.

Epigenetics, the Environment, and Children’s Health Across Lifespans

Author : David Hollar
Publisher : Springer
ISBN 13 : 3319253255
Total Pages : 399 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Epigenetics, the Environment, and Children’s Health Across Lifespans by : David Hollar

Download or read book Epigenetics, the Environment, and Children’s Health Across Lifespans written by David Hollar and published by Springer. This book was released on 2016-02-08 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.