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Identification Of A Chaperonin Protein Hsp60 Associated With Alanine Resistance And Increased A System Transport Activity And The Solubilization And Reconstitution Of A System Amino Acid Transport In Chinese Hamster Ovary Cells
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Book Synopsis Identification of a Chaperonin Protein (hsp60) Associated with Alanine Resistance and Increased A System Transport Activity and the Solubilization and Reconstitution of A System Amino Acid Transport in Chinese Hamster Ovary Cells by : Michael Kennis Jones
Download or read book Identification of a Chaperonin Protein (hsp60) Associated with Alanine Resistance and Increased A System Transport Activity and the Solubilization and Reconstitution of A System Amino Acid Transport in Chinese Hamster Ovary Cells written by Michael Kennis Jones and published by . This book was released on 1992 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Hsp60 Chaperonin by : Peter Bross
Download or read book The Hsp60 Chaperonin written by Peter Bross and published by Springer. This book was released on 2015-12-08 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1992 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1993-03 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :American Chemical Society. Committee on Professional Training Publisher : ISBN 13 :9780841227231 Total Pages :1700 pages Book Rating :4.2/5 (272 download)
Book Synopsis ACS Directory of Graduate Research 1993 by : American Chemical Society. Committee on Professional Training
Download or read book ACS Directory of Graduate Research 1993 written by American Chemical Society. Committee on Professional Training and published by . This book was released on 1993 with total page 1700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda
Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling
Book Synopsis GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity by : Denis J. Dupré
Download or read book GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity written by Denis J. Dupré and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
Book Synopsis Inclusions in Prokaryotes by : Jessup M. Shively
Download or read book Inclusions in Prokaryotes written by Jessup M. Shively and published by Springer Science & Business Media. This book was released on 2006-05-04 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this first volume, "Inclusions in Prokaryotes", the components, labeled inclusions, are defined as discrete bodies resulting from synthesis of a metabolic product. Research on the biosynthesis and reutilization of the accumulated materials is still in progress, and interest in the inclusions is growing. This comprehensive volume provides historical background and comprehensive reviews of eight well-known prokaryotic inclusions.
Book Synopsis Cancer Therapeutics by : Beverly A. Teicher
Download or read book Cancer Therapeutics written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 1997 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive review of existing and potential anticancer drugs and therapies by leading researchers from academia, government laboratories, and pharmaceutical companies offers essential insight into what has been accomplished and where the experimental therapy of cancer is going. The authoritative contributors illuminate the current status of the major molecules of cancer treatment, ranging from the nitrogen mustards through platinum complexes to interferons, cytokines, growth factors and their inhibitors, and on to immunotoxins, antisense oligonucleotides, and gene therapy. A companion volume by the same editor (Anticancer Drug Development Guide: Preclinical and Clinical Screening and Approval) details the processes by which new anticancer drugs are approved. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.
Book Synopsis Cell-Free Protein Production by : Yaeta Endo
Download or read book Cell-Free Protein Production written by Yaeta Endo and published by Humana Press. This book was released on 2009-12-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade as the data on gene sequences and expression patterns rapidly accumulated, cell-free protein synthesis technology has also experienced a revolution, becoming a powerful tool for the preparation of proteins for their functional and structural analysis. In Cell-Free Protein Production: Methods and Protocols, experts in the field contribute detailed techniques, the uses of which expand deep into the studies of biochemistry, molecular biology, and biotechnology. Beginning briefly with basic methods and historical aspects, the book continues with thorough coverage of protein preparation methods, the preparation of proteins that are generally difficult to prepare in their functional forms, applications of the cell-free technologies to protein engineering, as well as some methods that are expected to constitute a part of future technologies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell-Free Protein Production: Methods and Protocols aims to help researchers continue the growth of the vital exploration of cell-free sciences and technologies in order to better understand the dynamic lives of cells.
Book Synopsis The Biogenesis of Cellular Organelles by : Chris Mullins
Download or read book The Biogenesis of Cellular Organelles written by Chris Mullins and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.
Book Synopsis New Developments in Lipid-Protein Interactions and Receptor Function by : K.W.A. Wirtz
Download or read book New Developments in Lipid-Protein Interactions and Receptor Function written by K.W.A. Wirtz and published by Springer. This book was released on 2012-10-24 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced Study Institute on "New Developments in Lipid-Protein Interactions and Receptor Function" was held on the Island of Spetsai, Greece, from August 16-27, 1992. This Institute was organized to bring together researchers in the field of membrane organization and dynamics with those actively involved in studies on receptor function, signal transduction mechanisms and gene regulation. 2 Presentations and discussions focussed on the regulation of intracellular Ca +-levels, on the second messengers derived from inositol lipids and on the specific phospholipase C isozymes involved in these processes. A major focus was on G-proteins and the effect of lipid anchors on their function. These principles of regulation were further discussed in the context of receptors for acetylcholine, lysophosphatidic acid and low-density lipoproteins. In addition, various aspects of the genomic regulation of cell growth and differentiation by transcription factors were presented. These topics were put into perspective by discussing the most recent developments in lipid-protein interactions, protein insertion into membranes, membrane lipid organization and lipid dynamics as mediated by phospholipid transfer proteins. This book presents the content of the major lectures and a selection of the most relevant of the most important topics posters. These proceedings offer a comprehensive account presented during the course of the Institute. The book is intended to make these proceedings accessible to a large audience.
Book Synopsis Genetic Enhancement of Crops for Tolerance to Abiotic Stress: Mechanisms and Approaches, Vol. I by : Vijay Rani Rajpal
Download or read book Genetic Enhancement of Crops for Tolerance to Abiotic Stress: Mechanisms and Approaches, Vol. I written by Vijay Rani Rajpal and published by Springer. This book was released on 2019-04-24 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abiotic stresses such as drought (water deficit), extreme temperatures (cold, frost and heat), salinity (sodicity) and mineral (metal and metalloid) toxicity limit productivity of crop plants worldwide and are big threats to global food security. With worsening climate change scenarios, these stresses will further increase in intensity and frequency. Improving tolerance to abiotic stresses, therefore, has become a major objective in crop breeding programs. A lot of research has been conducted on the regulatory mechanisms, signaling pathways governing these abiotic stresses, and cross talk among them in various model and non-model species. Also, various ‘omics’ platforms have been utilized to unravel the candidate genes underpinning various abiotic stresses, which have increased our understanding of the tolerance mechanisms at structural, physiological, transcriptional and molecular level. Further, a wealth of information has been generated on the role of chromatin assembly and its remodeling under stress and on the epigenetic dynamics via histones modifications. The book consolidates outlooks, perspectives and updates on the research conducted by scientists in the abovementioned areas. The information covered in this book will therefore interest workers in all areas of plant sciences. The results presented on multiple crops will be useful to scientists in building strategies to counter these stresses in plants. In addition, students who are beginners in the areas of abiotic stress tolerance will find this book handy to clear their concepts and to get an update on the research conducted in various crops at one place
Book Synopsis Pharmacoepigenetics by : Ramón Cacabelos
Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2024-09-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics, Second Edition, Volume Ten in the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development. Here, leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. This new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges are also discussed.
Book Synopsis Proteases in Physiology and Pathology by : Sajal Chakraborti
Download or read book Proteases in Physiology and Pathology written by Sajal Chakraborti and published by Springer. This book was released on 2017-09-14 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
Book Synopsis The Parathyroids by : John P. Bilezikian
Download or read book The Parathyroids written by John P. Bilezikian and published by Elsevier. This book was released on 2001-07-21 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders
Book Synopsis Plant Transcription Factors by : Daniel H Gonzalez
Download or read book Plant Transcription Factors written by Daniel H Gonzalez and published by Academic Press. This book was released on 2015-07-07 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the important aspects and unifying themes to understanding transcription factors and the important roles of particular families in specific processes. Provides an entry point for transcription factor literature Offers compilation of information into one single resource for rapid consultation on different plant transcription factor features Integrates the knowledge about different transcription factors, along with cross-referencing Provides information on the unique aspects surrounding plant transcription factors
