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Hydrophilic Interaction Liquid Chromatography Hilic And Advanced Applications
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Book Synopsis Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications by : Perry G. Wang
Download or read book Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications written by Perry G. Wang and published by CRC Press. This book was released on 2011-02-17 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to pr
Book Synopsis Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications by : Perry G. Wang
Download or read book Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications written by Perry G. Wang and published by CRC Press. This book was released on 2011-02-17 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President's Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.
Book Synopsis Hydrophilic Interaction Chromatography by : Bernard A. Olsen
Download or read book Hydrophilic Interaction Chromatography written by Bernard A. Olsen and published by John Wiley & Sons. This book was released on 2013-01-22 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how to use HILIC to analyze and better understand polar compounds An increasingly popular analytical method, hydrophilic interaction chromatography (HILIC) has the ability to retain and separate polar compounds that are often difficult to analyze by reversed-phase high-performance liquid chromatography (HPLC) or other analytical methods. Offering a comprehensive review, this book enables readers to develop a fundamental understanding of how HILIC works and then apply that knowledge to develop and implement a variety of practical applications. Hydrophilic Interaction Chromatography begins with discussions of HILIC retention mechanisms, stationary phases, and general method development. This sets the foundation for the book's extensive coverage of applications. The authors address unique separation challenges for bioanalytical, environmental, pharmaceutical, and biochemical applications. Moreover, there is a thorough discussion of HILIC in two-dimensional chromatography. With contributions from leading analytical scientists who have extensive experience in HILIC as well as HPLC, Hydrophilic Interaction Chromatography serves as a practical guide for researchers, featuring: Detailed examples of HILIC methods and development approaches Thorough explanations of retention mechanisms and the impact of stationary phase and mobile phase properties on separations Step-by-step guidance for developing efficient, sensitive, and robust HILIC methods References to the primary literature at the end of each chapter Hydrophilic Interaction Chromatography is written for scientists who use or develop analytical methods for the separation of polar compounds. In particular, these researchers will discover how HILIC can be used to analyze and better understand the composition of pharmaceutical, bioanalytical, biochemical, chemical, food, and environmental samples.
Book Synopsis Handbook of Advanced Chromatography /Mass Spectrometry Techniques by : Michal Holcapek
Download or read book Handbook of Advanced Chromatography /Mass Spectrometry Techniques written by Michal Holcapek and published by Elsevier. This book was released on 2017-09-07 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques. Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research
Book Synopsis Gradient HPLC for Practitioners by : Stavros Kromidas
Download or read book Gradient HPLC for Practitioners written by Stavros Kromidas and published by John Wiley & Sons. This book was released on 2019-04-04 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide for analytical scientists explains the use of gradients in liquid chromatography. The fundamentals of gradient separations, as well as the most common application scenarios are addressed, from LC-MS coupling to biochromatography to the separation of ionic substances. Throughout, this handy volume provides detailed hands-on information for practitioners, enabling them to use gradient separation methods reliably and efficiently.
Book Synopsis The Combination of Hydrophilic Interaction Liquid Chromatography and High Resolution Mass Spectrometry (HILIC-HRMS) by : Muhammad Anas Kamleh
Download or read book The Combination of Hydrophilic Interaction Liquid Chromatography and High Resolution Mass Spectrometry (HILIC-HRMS) written by Muhammad Anas Kamleh and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Supercritical Fluid Chromatography by : Gregory K. Webster
Download or read book Supercritical Fluid Chromatography written by Gregory K. Webster and published by CRC Press. This book was released on 2014-02-04 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today's pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by provi
Book Synopsis High-performance Liquid Chromatography (HPLC) by : Yuegang Zuo
Download or read book High-performance Liquid Chromatography (HPLC) written by Yuegang Zuo and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes bibliographical references and index.
Download or read book Liquid Chromatography written by Ya Zhang and published by . This book was released on 2014 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Chromatography (IC) is a powerful technique in the separation and analysis of inorganic ions and small charged organic molecules. Meanwhile, Hydrophilic Interaction Liquid Chromatography (HILIC) enables the separation of polar hydrophilic compounds. Although their retention mechanisms are different, the same goal applies. Chromatographers want a fast and thorough separation. This thesis focuses on improving separations in both modes. Injection solvent mismatch in Reversed Phase Liquid Chromatography (RPLC) leads to peak broadening and even distortion. In this thesis, systematic studies on IC columns showed that the characteristics of injection solvent mismatch broadening are very different than in RPLC. Also, IC is much more tolerant to high matrix concentration. The sensitivity parameter for evaluating RPLC injection solvent response was applied in the IC column studied for the comparison and can be further used in evaluating other IC columns. In modern IC, suppressors are widely used. Injection system peaks are usually neglected because they are eliminated by the suppressor. However this thesis showed that the system peak strongly affects the nearby analyte peak shape and retention. Porous Graphitic Carbon (PGC) is popular in some RPLC applications due to its excellent pH and temperature stability. This stability would also be attractive for HILIC applications. However, the hydrophobic character of PGC makes it incompatible with HILIC separations. In this thesis, PGC was converted into a hydrophilic phase by attaching acetanilide to the surface. The new Amide-PGC shows unique selectivity among 37 stationary phases under HILIC mode. The thesis demonstrates its potential in separating nucleobases, carboxylic acids and pharmaceuticals. Retention is shown to be due to both HILIC partitioning and adsorption on the PGC surface. In summary, this thesis improves liquid chromatography in two aspects: IC separations through an understanding of injection broadening; and HILIC through the development of a new stationary phase which enables unique HILIC selectivity.
Book Synopsis Encyclopedia of Analytical Science by :
Download or read book Encyclopedia of Analytical Science written by and published by Elsevier. This book was released on 2019-04-02 with total page 5142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of the Encyclopedia of Analytical Science, Ten Volume Set is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science, Ten Volume Set provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher
Book Synopsis High-Throughput Analysis for Food Safety by : Perry G. Wang
Download or read book High-Throughput Analysis for Food Safety written by Perry G. Wang and published by John Wiley & Sons. This book was released on 2014-09-15 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIGH THROUGHPUT ANALYSIS FOR FOOD SAFETY MEETS FSMA REQUIREMENTS WITH THE LATEST ADVANCES IN HIGH-THROUGHPUT SCREENING High-Throughput Analysis for Food Safety addresses the fundamental concepts involved in the rapid screening for contaminants, including residual veterinary drugs, proteins, metals, hormones, pesticides, and adulterants. Addressing the need for—and requirements of—rapid screening tests, the book includes discussions of regulations and compliance issues from perspectives of both domestic and global industry and government contributors. The latest developments and most common techniques are focused on, with an emphasis on the applicability of both stand-alone mass spectrometry methods and coupled techniques. Beginning with a review of high-throughput analysis basics, the authors conduct a full exploration of mass spectrometry applications allowing readers to: Survey GC-MS, LC-MS, stand-alone MS, and tandem MS methods in foodanalysis and contaminant screening Review quality control standards, method validation, and ongoing analyticalcontrol Examine the current methods used to detect veterinary medicinal productresidues in food, as well as future directionsRecent Recent incidents around the globe have turned the food industry toward high-throughput analysis, and the Food Safety Modernization Act has made it a legal requirement in the US. This resource provides an in-depth discussion of the latest advances in methods and instrumentation.
Book Synopsis Software-assisted Method Development In High Performance Liquid Chromatography by : Szabolcs Fekete
Download or read book Software-assisted Method Development In High Performance Liquid Chromatography written by Szabolcs Fekete and published by World Scientific. This book was released on 2018-08-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'The book is a useful contribution in the field of HPLC, and may represent a valuable tool for chromatography practitioners in different fields, as well as teachers and instructors. The 12 chapters provide comprehensive insights of current day retention and resolution modelling in HPLC, and its applications for small and large molecule analysis. It may be a useful reference for specialists in pharmaceuticals but not limited to … It may be a valuable resource to assist scientists involved in method development, aiming to achieve the best results with reduced costs, time, and efforts.'Analytical and Bioanalytical ChemistryThis handbook gives a general overview of the possibilities in recent developments in chromatographic retention modeling. As a result of the latest developments in modeling software, several new features are now accessible, opening a new level in HPLC method development.Many of these current possibilities in software assisted liquid chromatographic method modeling for analytical purposes are presented. Several modes of chromatography, including Reversed-Phase Liquid Chromatography (RPLC), Ion Exchange Chromatography (IEX), Hydrophobic Interaction Chromatography (HIC), and Hydrophilic Interaction Liquid Chromatography (HILIC) are explained in detail. For all these chromatographic modes, the most important variables for tuning retention and selectivity are exposed.Beside the industrial and practical benefits of retention modeling, the possibilities in teaching and education are also illustrated. Finally, numerous representative industrial examples are shown, to highlight the benefits, time and cost savings offered by state-of-the-art software assisted HPLC method development.
Book Synopsis Applications of Hydrophilic Interation Chromatography in the Analysis of Drugs and Metabolites by : Saud Bawazeer
Download or read book Applications of Hydrophilic Interation Chromatography in the Analysis of Drugs and Metabolites written by Saud Bawazeer and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrophilic interaction liquid chromatography (HILIC) has grown in popularity during the last ten years. It is somewhere between normal phase and reverse phase liquid chromatography in terms of its mode of action. HILIC involves the separation of polar analytes through their partitioning into a water rich layer that is formed on the surface of the stationary phase. However, there are also additional mechanisms involved in HILIC including ion exchange interactions. There are an increasing number of HILIC columns on the market. A number of different factors can be set to control the separation of compounds in HILIC mode including column temperature, mobile phase composition, pH and buffer type and concentration. In the current study a cyanopropyl (CN) HPLC column was used for the separation of some basic compounds in HILIC mode. Good separation of a test mix of basic compounds was obtained with a mobile phase consisting of acetonitrile/water (95:5) containing 3.25mM ammonium acetate. The retention times of the basic compounds decreased with increased ionic strength or with increased water content in the mobile phase. The effect of the size of the basic centre, pH, and buffer concentration was also studied using a series of model bases. The utility of the column for impurity profiling of two basic drugs was tested. The CN column showed reasonable stability although there appeared to be loss of stationary phase with time. The retention properties of a silica gel column and a type C silica (silicon hydride) column for bases, sugars and polar acids were compared in HILIC mode with formic acid or ammonium acetate as aqueous phase modifiers. Seven different HILIC stationary phases were characterised with regard to their retention properties for 100 metabolite standards. In addition three of these phases were evaluated with regard to their ability to profile metabolites in urine. Finally a HILIC method was developed in order to determine the level of nicotine exposure in companion animals resulting from passive smoking.
Book Synopsis Liquid Chromatography by : Salvatore Fanali
Download or read book Liquid Chromatography written by Salvatore Fanali and published by Newnes. This book was released on 2013-01-08 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity Chapters written by authoritative and visionary experts in the field provide an overview and focused treatment of a single topic Comprehensive coverage of modern liquid chromatography from theory, to methods, to selected applications Thorough selected references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision making Extensive original tables and figures, placing recent research developments into a general context Worked examples, intuitive explanations, and clear figures reinforce learning
Book Synopsis Selection of the HPLC Method in Chemical Analysis by : Serban C. Moldoveanu
Download or read book Selection of the HPLC Method in Chemical Analysis written by Serban C. Moldoveanu and published by Elsevier. This book was released on 2016-11-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selection of the HPLC Method in Chemical Analysis serves as a practical guide to users of high-performance liquid chromatography and provides criteria for method selection, development, and validation. High-performance liquid chromatography (HPLC) is the most common analytical technique currently practiced in chemistry. However, the process of finding the appropriate information for a particular analytical project requires significant effort and pre-existent knowledge in the field. Further, sorting through the wealth of published data and literature takes both time and effort away from the critical aspects of HPLC method selection. For the first time, a systematic approach for sorting through the available information and reviewing critically the up-to-date progress in HPLC for selecting a specific analysis is available in a single book. Selection of the HPLC Method in Chemical Analysis is an inclusive go-to reference for HPLC method selection, development, and validation. Addresses the various aspects of practice and instrumentation needed to obtain reliable HPLC analysis results Leads researchers to the best choice of an HPLC method from the overabundance of information existent in the field Provides criteria for HPLC method selection, development, and validation Authored by world-renowned HPLC experts who have more than 60 years of combined experience in the field
Book Synopsis Handbook of Ion Chromatography by : Joachim Weiss
Download or read book Handbook of Ion Chromatography written by Joachim Weiss and published by John Wiley & Sons. This book was released on 2016-06-24 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume handbook is the standard reference in the field, unparalleled in its comprehensiveness. It covers every conceivable topic related to the expanding and increasingly important field of ion chromatography. The fourth edition is completely updated and revised to include the latest developments in the instrumentation, now stretching to three volumes to reflect the current state of applications. Ion chromatography is one of the most widely used separation techniques of analytical chemistry with applications in fields such as medicinal chemistry, water chemistry and materials science. Consequently, the number of users of this method is continuously growing, underlining the need for an up-to-date reference. A true pioneer of this method, Joachim Weiss studied chemistry at the Technical University of Berlin (Germany), where he also received his PhD degree in Analytical Chemistry. In 2002, he did his habilitation in Analytical Chemistry at the Leopold-Franzens University in Innsbruck (Austria), where he is also teaching liquid chromatography. Since 1982, Dr. Weiss has worked at Dionex (now being part of Thermo Fisher Scientific), where he currently holds the position of Technical Director for Dionex Products within the Chromatography and Mass Spectrometry Division (CMD) of Thermo Fisher Scientific, located in Dreieich (Germany).
Book Synopsis Organic Trace Analysis by : Reinhard Nießner
Download or read book Organic Trace Analysis written by Reinhard Nießner and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-08-07 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Organic Trace Analysis" presents the basics of trace analysis, from sample preparation to the measurement: Students are introduced to statistical evaluation, quality control technologies, sampling and preparation of organic traces, as well as to enrichment and separation of samples. Spectroscopic techniques as chromatography, capillary electrophoresis, mass spectrometry, and receptor-based bioanalysis are presented in detail.
