Hydrolases In Organic Synthesis

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Hydrolases in Organic Synthesis

Author : Uwe Theo Bornscheuer
Publisher : John Wiley & Sons
ISBN 13 : 3527607129
Total Pages : 368 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Hydrolases in Organic Synthesis by : Uwe Theo Bornscheuer

Download or read book Hydrolases in Organic Synthesis written by Uwe Theo Bornscheuer and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.

Hydrolases in Organic Synthesis

Author : Uwe Theo Bornscheuer
Publisher :
ISBN 13 : 9780013206705
Total Pages : 355 pages
Book Rating : 4.2/5 (67 download)

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Book Synopsis Hydrolases in Organic Synthesis by : Uwe Theo Bornscheuer

Download or read book Hydrolases in Organic Synthesis written by Uwe Theo Bornscheuer and published by . This book was released on 2006 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organic Synthesis with Enzymes in Non-Aqueous Media

Author : Giacomo Carrea
Publisher : John Wiley & Sons
ISBN 13 : 3527621733
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Organic Synthesis with Enzymes in Non-Aqueous Media by : Giacomo Carrea

Download or read book Organic Synthesis with Enzymes in Non-Aqueous Media written by Giacomo Carrea and published by John Wiley & Sons. This book was released on 2008-04-09 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Asymmetric Organic Synthesis with Enzymes

Author : Vicente Gotor
Publisher : John Wiley & Sons
ISBN 13 : 9783527318254
Total Pages : 348 pages
Book Rating : 4.3/5 (182 download)

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Book Synopsis Asymmetric Organic Synthesis with Enzymes by : Vicente Gotor

Download or read book Asymmetric Organic Synthesis with Enzymes written by Vicente Gotor and published by John Wiley & Sons. This book was released on 2008-03-31 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Enzyme Handbook

Author : Dietmar Schomburg
Publisher : Springer Science & Business Media
ISBN 13 : 3642764630
Total Pages : 836 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Enzyme Handbook by : Dietmar Schomburg

Download or read book Enzyme Handbook written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes are applied in organic synthesis and in analytical chemistry, in industrial production processes of pharmaceuticals and in food processing. Finding a suitable enzyme for a desired transformation or with a de- fined specificity is not always an easy task. More than 3000 enzymes are well described to date. The Enzyme Handbook provides all the information for selecting the proper enzyme to perform defined transformations in a given environment. The Enzyme Handbook devotes a variable number of pages for each enzyme, depending on the amount of information available with the EC number as ordering criterion within a volume. Revised data sheets can be released for individual enzymes and newly characterized enzymes and they can easily be sorted into the binders at the appropriate place. Each data sheet is divided into 7 sections: - Nomenclature (EC number, Systematic name, Recommended name, Synonyms, CAS Reg. No.). - Reaction and specificity (Catalysed reaction, Reaction type, Natural substrates, Substrate spectrum, Product spectrum, Inhibitors, Cofactors/prosthetic groups, Metal compounds/ salts, Turnover number, Specific activity, KM-value, pH-optimum, pH-range, Temperature optimum, Temperature range). - Enzyme structure (Molecular weight, Subunits, Glyco-/Lipoprotein). - Isolation/Preparation (Source organism, Source tissue, Localisation in source, Purification, Crystallization, Cloned, Renatured). - Stability (pH, Temperature, Oxidation, Organic solvent, General stability information, Storage). - Cross-References (to Structure Data Banks). - Literature references.

Enzymatic Reactions in Organic Media

Author : A. Koskinen
Publisher : Springer Science & Business Media
ISBN 13 : 9401106118
Total Pages : 327 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Enzymatic Reactions in Organic Media by : A. Koskinen

Download or read book Enzymatic Reactions in Organic Media written by A. Koskinen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Enzyme-Based Organic Synthesis

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
ISBN 13 : 1118995155
Total Pages : 719 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Enzyme-Based Organic Synthesis by : Cheanyeh Cheng

Download or read book Enzyme-Based Organic Synthesis written by Cheanyeh Cheng and published by John Wiley & Sons. This book was released on 2022-02-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Enzyme Handbook

Author : Dietmar Schomburg
Publisher : Springer
ISBN 13 : 9783540542094
Total Pages : 0 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Enzyme Handbook by : Dietmar Schomburg

Download or read book Enzyme Handbook written by Dietmar Schomburg and published by Springer. This book was released on 1991-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes are applied in organic synthesis and in analytical chemistry, in industrial production processes of pharmaceuticals and in food processing. Finding a suitable enzyme for a desired transformation or with a de- fined specificity is not always an easy task. More than 3000 enzymes are well described to date. The Enzyme Handbook provides all the information for selecting the proper enzyme to perform defined transformations in a given environment. The Enzyme Handbook devotes a variable number of pages for each enzyme, depending on the amount of information available with the EC number as ordering criterion within a volume. Revised data sheets can be released for individual enzymes and newly characterized enzymes and they can easily be sorted into the binders at the appropriate place. Each data sheet is divided into 7 sections: - Nomenclature (EC number, Systematic name, Recom- mended name, Synonyms, CAS Reg. No.) - Reaction and specificity (Catalysed reaction, Reaction type, Natural substrates, Substrate spectrum, Product spectrum, Inhibitors, Cofactors/prosthetic groups, Metal compounds/salts, Turnover number, Specific activity, KM-value, pH-optimum, pH-range, Tem- perature optimum, Temperature range) - Enzyme structure (Molecular weight, Subunits, Glyco-/Lipoprotein) - Isolation/Preparation (Source organism, Source tissue, Localisation in source, Purification, Crystallization, Cloned, Renatured) - Stability (pH, Temperature, Oxidation, Organic sol- vent, General stability information, Storage) - Cross-References (to Structure Data Banks) - Literature references

Principles of Organic Synthesis, 3rd Edition

Author : Richard O.C. Norman
Publisher : CRC Press
ISBN 13 : 9780748761623
Total Pages : 850 pages
Book Rating : 4.7/5 (616 download)

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Book Synopsis Principles of Organic Synthesis, 3rd Edition by : Richard O.C. Norman

Download or read book Principles of Organic Synthesis, 3rd Edition written by Richard O.C. Norman and published by CRC Press. This book was released on 1993-09-16 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject. The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In Part II these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex, naturally occurring compounds.

Organic Synthesis Highlights

Author : Johann Mulzer
Publisher : Verlag Chemie
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Organic Synthesis Highlights by : Johann Mulzer

Download or read book Organic Synthesis Highlights written by Johann Mulzer and published by Verlag Chemie. This book was released on 1991 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like its predecessor, Organic Synthesis Highlights II surveys recent accomplishments and current trends in synthetic organic chemistry. Part I describes new methods and reagents including asymmetric carbon-carbon bond formation with metallocenes and with enzymes, via temporary silicon connections, and by means of carbohydrate complexes. Part II describes landmarks in the synthesis of natural products and surveys synthetic strategies to different classes of natural products. The forty essays in this volume bear witness to the creativity and talent which have led to the recent advances in the field. Both advanced students and researchers active in the field will welcome this as a source of ideas and inspiration.

Selective Biocatalysis

Author : László Poppe
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Selective Biocatalysis by : László Poppe

Download or read book Selective Biocatalysis written by László Poppe and published by Wiley-VCH. This book was released on 1992-07-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: László Poppe, Lajos Novák Selective Biocatalysis A Synthetic Approach This stimulating monograph is a much needed response to the increasing use of biocatalysts in organic synthesis. In over 300 well-referenced pages, it reviews in detail applications and other aspects of the most widely used enzymes (e.g. hydrolases, oxidoreductases, and baker’s yeast) illustrates with examples the potential in biocatalysis of other, less frequently used enzymes and microorganisms discusses general problems of biocatalysis (e.g. stereochemistry of transformations, methods of influencing selectivity) indicates future trends in biocatalysis Researchers and students in prcparative organic chemistry. biotechnology and biochemistry will find this up-to-date monograph highly valuable in their daily work.

Organic Synthesis via Examination of Selected Natural Products

Author :
Publisher :
ISBN 13 : 9814464562
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Organic Synthesis via Examination of Selected Natural Products by :

Download or read book Organic Synthesis via Examination of Selected Natural Products written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organic Synthesis with Oxidative Enzymes

Author : Herbert L. Holland
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Organic Synthesis with Oxidative Enzymes by : Herbert L. Holland

Download or read book Organic Synthesis with Oxidative Enzymes written by Herbert L. Holland and published by Wiley-VCH. This book was released on 1992 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Class 3.1 Hydrolases IV

Author : Dietmar Schomburg
Publisher : Springer Science & Business Media
ISBN 13 : 9783540439820
Total Pages : 592 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Class 3.1 Hydrolases IV by : Dietmar Schomburg

Download or read book Class 3.1 Hydrolases IV written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2002-11-13 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.

Some Modern Methods of Organic Synthesis

Author : W. Carruthers
Publisher : Cambridge University Press
ISBN 13 : 9780521311175
Total Pages : 550 pages
Book Rating : 4.3/5 (111 download)

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Book Synopsis Some Modern Methods of Organic Synthesis by : W. Carruthers

Download or read book Some Modern Methods of Organic Synthesis written by W. Carruthers and published by Cambridge University Press. This book was released on 1986 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general plan of the book follows that of the second edition, but the opportunity has been taken to bring the book up to date and to take account of advances in knowledge and of new reactions which have come into use since publication of the earlier editions.

Protective Groups in Organic Synthesis

Author : Theodora W. Greene
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 824 pages
Book Rating : 4.3/5 (97 download)

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Book Synopsis Protective Groups in Organic Synthesis by : Theodora W. Greene

Download or read book Protective Groups in Organic Synthesis written by Theodora W. Greene and published by Wiley-Interscience. This book was released on 1999-04-23 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the reviews of the previous editions: * "For completeness, the authors . . . include protective groups and techniques for formation and cleavage that are seldom used as well as those that are more common. . . . Anyone who does organic synthesis must have convenient access to this book." -Journal of the American Chemical Society. * "Essential to the modern synthetic organic chemist . . . should be in the libraries of all academic, governmental, and industrial organizations concerned with organic synthesis." -Polymer News. Reflecting the latest advances in protective group methodology, this Third Edition of the proven laboratory reference is expanded by more than 50%, providing readers with a comprehensive compendium of 1,050 of the most useful protective groups as well as 5,350 references to original publications. Protective groups are organized by six major organic functional groups: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate groups (the last new to this edition). Also added in this edition are protection of the alkyne-CH, expanded coverage of protection of all groups, and many new enzymatic methods of protection and deprotection. Each chapter briefly describes the classes of available protective groups, followed by an in-depth look at the chemistry of individual protective groups, their properties, and the best methods of formation and cleavage. Ten reactivity charts with more than 28,000 entries summarize the relative reactivities of 270 commonly used protective groups with 108 reagents. This book will be an indispensable reference for synthetic chemists and students.

Enzymatic Transformation

Author : Soundar Divakar
Publisher : Springer Science & Business Media
ISBN 13 : 8132208730
Total Pages : 284 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Enzymatic Transformation by : Soundar Divakar

Download or read book Enzymatic Transformation written by Soundar Divakar and published by Springer Science & Business Media. This book was released on 2012-12-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transformations using enzymes have been extensively investigated in the last two decades and the results promise great potential for this growing field, especially in the area of synthetic organic chemistry mainly due to of its many advantages. Accordingly, this book has attempted to bring out the advantages of using enzymes involving complex underivatized and unprotected substrates in non-polar media under homogenous and heterogeneous reaction conditions. Merits and demerits of using enzymes in terms of yields and selectivity/specificity are presented without any prejudice. Almost all the reactions dealt with are from the author’s laboratory comprising diverse substrates, and the catalysis involves two important hydrolyzing enzymes, extensively examined for the reverse reactions. Thus, esterification involving lipses and glycosylation involving glycosidases were investigated with respect to various strategies like optimization of reaction conditions, response surface methodology and kinetics, carrying out reactions under solvent, non-solvent and super critical carbon dioxide conditions. In short, the work presented is to ensure the comprehension of the problems faced by the researchers in this area so as to work out further efficient strategies for carrying out enzymatic transformations in the laboratory successfully with better yields and specificity.