Enzymatic Reactions in Organic Media

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Publisher : Springer Science & Business Media
ISBN 13 : 9401106118
Total Pages : 327 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Enzymatic Reactions in Organic Media by : A. Koskinen

Download or read book Enzymatic Reactions in Organic Media written by A. Koskinen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Enzymes in Nonaqueous Solvents

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592591124
Total Pages : 677 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Enzymes in Nonaqueous Solvents by : Evgeny N. Vulfson

Download or read book Enzymes in Nonaqueous Solvents written by Evgeny N. Vulfson and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic catalysis has gained considerable attention in recent years as an efficient tool in the preparation of natural products, pharmaceuticals, fine chemicals, and food ingredients. The high selectivity and mild reaction con- tions associated with enzymatic transformations have made this approach an attractive alternative in the synthesis of complex bioactive compounds, which are often difficult to obtain by standard chemical routes. However, the maj- ity of organic compounds are not very soluble in water, which was traditi- ally perceived as the only suitable reaction medium for the application of biocatalysts. The realization that most enzymes can function perfectly well under nearly anhydrous conditions and, in addition, display a number of useful properties, e. g. , highly enhanced stability and different selectivity, has d- matically widened the scope of their application to the organic synthesis. Another great attraction of using organic solvents rather than water as a reaction solvent is the ability to perform synthetic transformations with re- tively inexpensive hydrolytic enzymes. It is worth reminding the reader that in vivo, the synthetic and hydrolytic pathways are catalyzed by different enzymes. However, elimination of water from the reaction mixture enables the “reversal” of hydrolytic enzymes and thus avoids the use of the expensive cofactors or activated substrates that are required for their synthetic count- parts.

Organic Synthesis with Enzymes in Non-Aqueous Media

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527621733
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Organic Synthesis with Enzymes in Non-Aqueous Media by : Giacomo Carrea

Download or read book Organic Synthesis with Enzymes in Non-Aqueous Media written by Giacomo Carrea and published by John Wiley & Sons. This book was released on 2008-04-09 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Modern Biocatalysis

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014537
Total Pages : 594 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Modern Biocatalysis by : Gavin Williams

Download or read book Modern Biocatalysis written by Gavin Williams and published by Royal Society of Chemistry. This book was released on 2018-05-31 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Asymmetric Organic Synthesis with Enzymes

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Publisher : John Wiley & Sons
ISBN 13 : 3527622497
Total Pages : 340 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Asymmetric Organic Synthesis with Enzymes by : Vicente Gotor

Download or read book Asymmetric Organic Synthesis with Enzymes written by Vicente Gotor and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

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Author :
Publisher : Elsevier
ISBN 13 : 0080513360
Total Pages : 800 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by : Richard B. Silverman

Download or read book Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition written by Richard B. Silverman and published by Elsevier. This book was released on 2002-03-07 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Enzymatic Transformation

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 8132208730
Total Pages : 284 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Enzymatic Transformation by : Soundar Divakar

Download or read book Enzymatic Transformation written by Soundar Divakar and published by Springer Science & Business Media. This book was released on 2012-12-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transformations using enzymes have been extensively investigated in the last two decades and the results promise great potential for this growing field, especially in the area of synthetic organic chemistry mainly due to of its many advantages. Accordingly, this book has attempted to bring out the advantages of using enzymes involving complex underivatized and unprotected substrates in non-polar media under homogenous and heterogeneous reaction conditions. Merits and demerits of using enzymes in terms of yields and selectivity/specificity are presented without any prejudice. Almost all the reactions dealt with are from the author’s laboratory comprising diverse substrates, and the catalysis involves two important hydrolyzing enzymes, extensively examined for the reverse reactions. Thus, esterification involving lipses and glycosylation involving glycosidases were investigated with respect to various strategies like optimization of reaction conditions, response surface methodology and kinetics, carrying out reactions under solvent, non-solvent and super critical carbon dioxide conditions. In short, the work presented is to ensure the comprehension of the problems faced by the researchers in this area so as to work out further efficient strategies for carrying out enzymatic transformations in the laboratory successfully with better yields and specificity.

Biocatalysis for Practitioners

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 352734683X
Total Pages : 54 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Biocatalysis for Practitioners by : Gonzalo de Gonzalo

Download or read book Biocatalysis for Practitioners written by Gonzalo de Gonzalo and published by John Wiley & Sons. This book was released on 2021-07-19 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Enzyme-Based Organic Synthesis

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118995155
Total Pages : 719 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Enzyme-Based Organic Synthesis by : Cheanyeh Cheng

Download or read book Enzyme-Based Organic Synthesis written by Cheanyeh Cheng and published by John Wiley & Sons. This book was released on 2022-02-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

The Influence of Temperature on Enzyme Selectivity in Organic Media

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Author :
Publisher :
ISBN 13 :
Total Pages : 122 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Influence of Temperature on Enzyme Selectivity in Organic Media by : Åsa Jönsson

Download or read book The Influence of Temperature on Enzyme Selectivity in Organic Media written by Åsa Jönsson and published by . This book was released on 1998 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Enzyme Biocatalysis

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1402083610
Total Pages : 398 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Enzyme Biocatalysis by : Andrés Illanes

Download or read book Enzyme Biocatalysis written by Andrés Illanes and published by Springer Science & Business Media. This book was released on 2008-06-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Hydrolases in Organic Synthesis

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527607129
Total Pages : 368 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Hydrolases in Organic Synthesis by : Uwe Theo Bornscheuer

Download or read book Hydrolases in Organic Synthesis written by Uwe Theo Bornscheuer and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.

Enzyme Technology

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Publisher : Springer Science & Business Media
ISBN 13 : 9780387292946
Total Pages : 774 pages
Book Rating : 4.2/5 (929 download)

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Book Synopsis Enzyme Technology by : Ashok Pandey

Download or read book Enzyme Technology written by Ashok Pandey and published by Springer Science & Business Media. This book was released on 2006-04-28 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Enzymes in Synthetic Organic Chemistry

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Author :
Publisher : Elsevier
ISBN 13 : 0080505821
Total Pages : 389 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Enzymes in Synthetic Organic Chemistry by : Wong

Download or read book Enzymes in Synthetic Organic Chemistry written by Wong and published by Elsevier. This book was released on 2013-10-22 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Enzymology and Enzyme Technology

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Author :
Publisher : S. Chand Publishing
ISBN 13 : 8121935849
Total Pages : 442 pages
Book Rating : 4.1/5 (219 download)

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Book Synopsis Enzymology and Enzyme Technology by : Bhatt S.M.

Download or read book Enzymology and Enzyme Technology written by Bhatt S.M. and published by S. Chand Publishing. This book was released on 2011 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme : An Introduction • Enzyme Structure • Enzyme Specificity & Catalysis • Purification & Characterization Of Enzymes • Enzyme Assay • Enzyme Engineering • Enzyme Microenvironment : Catalysis In Non-Aqueous Solvent • Bioenergetics • Introduction To Metabolism • Knzyme Kinetics • Single Substrate Enzyme Inhibition • Kinetics Of Multisubtrate Enzymes • Enzyme'S Regulation And Cooperativity • Enzymes Immbilsation Techniques• Enzyme Biosensor

Methods in Non-Aqueous Enzymology

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Author :
Publisher : Birkhäuser
ISBN 13 : 3034884729
Total Pages : 229 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Methods in Non-Aqueous Enzymology by : Munishwar N. Gupta

Download or read book Methods in Non-Aqueous Enzymology written by Munishwar N. Gupta and published by Birkhäuser. This book was released on 2013-12-01 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extending the range of enzymatic catalysis by using non-aqueous media has now developed into a powerful approach in biochemistry and biotechnology. One peculiar feature which distinguishes it from the conventional enzymology (carried out in aqueous buffers) is that the awareness of different parameters that control and influence the behaviour of enzymes in such environments has emerged rather slowly. Science is about being able to repeat what somebody else has done. Absence of knowledge about such well-defined parameters/fac tors has sometimes made some workers rather cautious and diffident about using this approach in their laboratories. But for this, non-aqueous enzymol ogy would be more widely practised. It is these thoughts that made me feel that the availability of some well-defined protocols for various applications invol ving enzymes in non-aqueous environments would further catalyze the growth of this area. Hence this book, in which each chapter has some protocols in a specific area. The protocols are preceded by brief background material. The early chapters, which are of general importance, concern control of water ac tivity and stabilization via immobilization. Some subsequent chapters provide the protocols for transformations involving lipids and carbohydrates, peptide synthesis, and preparation of chiral compounds. The disproportionate focus on lipases is not a coincidence; this class of enzymes has been used more often than others in non-aqueous enzymology.

Industrial Enzyme Applications

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527343857
Total Pages : 430 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Industrial Enzyme Applications by : Andreas Vogel

Download or read book Industrial Enzyme Applications written by Andreas Vogel and published by John Wiley & Sons. This book was released on 2019-10-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a "must-read": It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.