Human Targets

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Author :
Publisher : University of Chicago Press
ISBN 13 : 022609099X
Total Pages : 220 pages
Book Rating : 4.2/5 (26 download)

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Book Synopsis Human Targets by : Victor M. Rios

Download or read book Human Targets written by Victor M. Rios and published by University of Chicago Press. This book was released on 2017-03-08 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Victor Rios has a vibrant reputation as America s leading ethnographer of Latino youth. His personal storygoing from drug pusher (selling heroin on the streets as a teenager) to a hard worker at a mechanic shop within a matter of weeksshows how he stands in the place of the Latino youths he studies. His story underscores the degree to which delinquent urban youths can become adaptable, fluid, amenable individuals, able to shift their views of the world as well as their actions. Rios rejects the old storyline that said gangs are bad and they do bad things because they are bad people. Kids on the street, he argues, can drift between different identities, indeed, they can shift seamlessly between responsible and deviant displays within a few hours time. The key to understanding gang-associated youth lies in analysis of the way authority figures (teachers and police officers) interact with young people. The kids need caring adults who offer tangible resources. Story and characters are always front-and-center in Rios s narrative: Jorge, Mark, Wilson, and others, are boys we get to know as they negotiate day-to-day life on the streets and across institutional settings. We learn a great deal about Cholo subculture, the clothing and hairstyles, and the argot that are adopted by Latino youth in response to the forces that seek to marginalize or punish them. The crisis of a perceived epidemic of police brutality in our post-Ferguson era is a product of culture in Rios s view: contested symbols, negative interactions, and day-to-day encounters that freeze youth identities as gang-associated, and that freeze authority identities as negative shapers of youth attitudes and actions are the dynamic. Fear of young males of color leads to police misreading and dehumanizing of young black and Latino men. Rios raises our awareness of how this dynamic operates by studying his subjects whole: following young gang members into their schools, their homes, their community organizations, their detention facilities, and watching them interact with police, watching them grow up to become fathers, get jobs, get rap sheets. Get killed. This book will be a landmark contribution to the social psychology of poverty and crime."

Human Drug Targets

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Publisher : John Wiley & Sons
ISBN 13 : 1118849833
Total Pages : 456 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Human Drug Targets by : Edward D. Zanders

Download or read book Human Drug Targets written by Edward D. Zanders and published by John Wiley & Sons. This book was released on 2015-12-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

New therapeutic targets for human placental angiogenesis diseases

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Publisher : Frontiers Media SA
ISBN 13 : 2889194612
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis New therapeutic targets for human placental angiogenesis diseases by : Carlos Alonso Escudero

Download or read book New therapeutic targets for human placental angiogenesis diseases written by Carlos Alonso Escudero and published by Frontiers Media SA. This book was released on 2015-04-15 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.

Eco Targets, Goal Functions, and Orientors

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9783540636793
Total Pages : 648 pages
Book Rating : 4.6/5 (367 download)

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Book Synopsis Eco Targets, Goal Functions, and Orientors by : Felix Müller

Download or read book Eco Targets, Goal Functions, and Orientors written by Felix Müller and published by Springer Science & Business Media. This book was released on 1998-04-08 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the proceedings of the International Workshop on Eco logical Goal Functions, held at the Schleswig-Holstein Cultural Center of Salzau, August 30 -September 4, 1996. The conference - first in a series - intended to be convened at Salzau at 1 -2 year intervals to address various aspects of theo retical and application-oriented ecology, was initiated, organized and carried out under the auspices of the Ecology Center of the Kiel University. It featured key note addresses, invited lectures, submitted papers, and posters. 32 contributions written by authors from eight countries, were selected to be presented in this book. From the very rich discussions of the workshop, some general characteristics emerged which might become important for a deeper understanding of the nature of evolving systems or, in other words, systems with a history, described by variables with a high degree of interdependence. These characteristics include the following: Speaking of 'goal functions' is a convenient 'fa~on de parler', since a logical analysis of the formal structure of teleological and causal explanations shows that both are analogous with regard to the inherent structural typology and the basic mode of explanation. Teleological interpretations introduce motives or objectives of actors into the set of 'antecedens' conditions relevant for system evolution, and are consequently a subset of causal interpretations.

Necessary Targets

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Publisher : Dramatists Play Service Inc
ISBN 13 : 9780822218951
Total Pages : 52 pages
Book Rating : 4.2/5 (189 download)

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Book Synopsis Necessary Targets by : Eve Ensler

Download or read book Necessary Targets written by Eve Ensler and published by Dramatists Play Service Inc. This book was released on 2003 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE STORY: In NECESSARY TARGETS, two American women, a Park Avenue psychiatrist and an ambitious young writer, travel to Bosnia to help women refugees confront their memories of war. Though the two have little in common beyond the methods they use

Deception in the Digital Age

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Author :
Publisher : Elsevier
ISBN 13 : 0124116396
Total Pages : 284 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Deception in the Digital Age by : Cameron H. Malin

Download or read book Deception in the Digital Age written by Cameron H. Malin and published by Elsevier. This book was released on 2017-06-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deception in the Digital Age: Exploiting and Defending Human Targets Through Computer-Mediated Communication guides readers through the fascinating history and principles of deception—and how these techniques and stratagems are now being effectively used by cyber attackers. Users will find an in-depth guide that provides valuable insights into the cognitive, sensory and narrative bases of misdirection, used to shape the targeted audience’s perceptions and beliefs. The text provides a detailed analysis of the psychological, sensory, sociological, and technical precepts that reveal predictors of attacks—and conversely postmortem insight about attackers—presenting a unique resource that empowers readers to observe, understand and protect against cyber deception tactics. Written by information security experts with real-world investigative experience, the text is the most instructional book available on the subject, providing practical guidance to readers with rich literature references, diagrams and examples that enhance the learning process. Deeply examines the psychology of deception through the lens of misdirection and other techniques used by master magicians Explores cognitive vulnerabilities that cyber attackers use to exploit human targets Dissects the underpinnings and elements of deception narratives Examines group dynamics and deception factors in cyber attacker underground markets Provides deep coverage on how cyber attackers leverage psychological influence techniques in the trajectory of deception strategies Explores the deception strategies used in today’s threat landscape—phishing, watering hole, scareware and ransomware attacks Gives unprecedented insight into deceptive Internet video communications Delves into the history and deception pathways of nation-state and cyber terrorism attackers Provides unique insight into honeypot technologies and strategies Explores the future of cyber deception

Therapeutic Targets

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Publisher : John Wiley & Sons
ISBN 13 : 1118185528
Total Pages : 503 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Therapeutic Targets by : Luis M. Botana

Download or read book Therapeutic Targets written by Luis M. Botana and published by John Wiley & Sons. This book was released on 2012-04-20 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.

Drugs from Nature: Targets, Assay Systems and Leads

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Author :
Publisher : Springer Nature
ISBN 13 : 9819991838
Total Pages : 572 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Drugs from Nature: Targets, Assay Systems and Leads by : Madhathilkovilakathu Haridas

Download or read book Drugs from Nature: Targets, Assay Systems and Leads written by Madhathilkovilakathu Haridas and published by Springer Nature. This book was released on with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Transporters as Drug Targets

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527333843
Total Pages : 354 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Transporters as Drug Targets by : Gerhard F. Ecker

Download or read book Transporters as Drug Targets written by Gerhard F. Ecker and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Targets for Cancer Chemotherapy

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Publisher : Springer Science & Business Media
ISBN 13 : 1592591531
Total Pages : 352 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Targets for Cancer Chemotherapy by : Nicholas B. La Thangue

Download or read book Targets for Cancer Chemotherapy written by Nicholas B. La Thangue and published by Springer Science & Business Media. This book was released on 2002-04-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.

Colorectal Cancer: Targets, Treatment and Prevention

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Publisher : Frontiers Media SA
ISBN 13 : 2889768759
Total Pages : 158 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Colorectal Cancer: Targets, Treatment and Prevention by : Mireille Alhouayek

Download or read book Colorectal Cancer: Targets, Treatment and Prevention written by Mireille Alhouayek and published by Frontiers Media SA. This book was released on 2022-08-31 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Soft Targets

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Publisher : Copper Canyon Press
ISBN 13 : 1619321963
Total Pages : 70 pages
Book Rating : 4.6/5 (193 download)

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Book Synopsis Soft Targets by : Deborah Landau

Download or read book Soft Targets written by Deborah Landau and published by Copper Canyon Press. This book was released on 2019-06-18 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starred Review in Publishers Weekly: "Through the cadence of these poems, which sometimes resemble lullabies in their dreaminess and gorgeous lyricism, Landau captures the ways humans persist, despite our collective anxiety, in our longing for 'something tender, something that might bloom.'” Deborah Landau’s fourth book of poetry, Soft Targets, draws a bullseye on humanity’s vulnerable flesh and corrupted world. In this ambitious lyric sequence, the speaker’s fear of annihilation expands beyond the self to an imperiled planet on which all inhabitants are “soft targets.” Her melancholic examinations recall life’s uncanny ability to transform ordinary places—subways, cafes, street corners—into sites of intense significance that weigh heavily on the modern mind. “O you who want to slaughter us, we’ll be dead soon/enough what’s the rush,” Landau writes, contemplating a world beset by political tumult, random violence, terror attacks, and climate change. Still there are the ordinary and abundant pleasures of day-to-day living, though the tender exchanges of friendship and love play out against a backdrop of 21st century threats with historical echoes, as neo-Nazis marching in the United States recall her grandmother’s flight from Nazi Germany.

The Human Target (2021-) #5

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Author :
Publisher : DC Comics
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.:/5 (21 download)

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Book Synopsis The Human Target (2021-) #5 by : Tom King

Download or read book The Human Target (2021-) #5 written by Tom King and published by DC Comics. This book was released on 2022-02-22 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christopher Chance, a.k.a. the Human Target, will be dead in a few days, but nothing will stop him from solving his own murder. His investigation into the JLI intensifies, and he sets his sights on the Martian Manhunter…but what piece does J’onn J’onzz add to the puzzle?

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387464018
Total Pages : 502 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by : Bharat B. Aggarwal

Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

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Author :
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 118 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

New Advances on Disease Biomarkers and Molecular Targets in Biomedicine

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1627034560
Total Pages : 284 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis New Advances on Disease Biomarkers and Molecular Targets in Biomedicine by : Nikki P. Lee

Download or read book New Advances on Disease Biomarkers and Molecular Targets in Biomedicine written by Nikki P. Lee and published by Springer Science & Business Media. This book was released on 2013-06-22 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includes concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. This book renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

Chronic Liver Disease: New Targets and New Mechanisms

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889767760
Total Pages : 186 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Chronic Liver Disease: New Targets and New Mechanisms by : Jinhang Gao

Download or read book Chronic Liver Disease: New Targets and New Mechanisms written by Jinhang Gao and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: