Human Pluripotent Stem Cell Derived Organoid Models

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Human Pluripotent Stem Cell Derived Organoid Models

Author :
Publisher : Academic Press
ISBN 13 : 0128215321
Total Pages : 338 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Human Pluripotent Stem Cell Derived Organoid Models by :

Download or read book Human Pluripotent Stem Cell Derived Organoid Models written by and published by Academic Press. This book was released on 2020-06-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Pluripotent Stem Cell Derived Organoid Models, Volume 159 highlights recent and emerging advances that describe organoid differentiation protocols for the different organ systems that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, development and evolution. Specific chapters in this new release include Pluripotent stem cell derived gastric organoids, Pluripotent stem cell derived esophageal organoids, Pluripotent stem cell derived small intestinal organoids, Pluripotent stem cell derived colonic organoids, Pluripotent stem cell intestinal organoids with an Enteric Nervous System, Pluripotent stem cell derived airway organoids, Pluripotent stem cell derived alveolar organoids, and much more. Provides the first comprehensive collection of pluripotent stem cell derived organoid protocols Includes cutting-edge methods Presents methods that generate organoids from many organ systems

Human Gastrointestinal Development

Author : Emanuel Lebenthal
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Gastrointestinal Development by : Emanuel Lebenthal

Download or read book Human Gastrointestinal Development written by Emanuel Lebenthal and published by Raven Press (ID). This book was released on 1989 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 225 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Organoid Technology for Disease Modelling and Personalized Treatment

Author : Badrul Hisham Yahaya
Publisher : Springer Nature
ISBN 13 : 3030930564
Total Pages : 209 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Organoid Technology for Disease Modelling and Personalized Treatment by : Badrul Hisham Yahaya

Download or read book Organoid Technology for Disease Modelling and Personalized Treatment written by Badrul Hisham Yahaya and published by Springer Nature. This book was released on 2022-02-14 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.

Intestinal Stem Cell Niche

Author :
Publisher : Academic Press
ISBN 13 : 9780128134818
Total Pages : 150 pages
Book Rating : 4.1/5 (348 download)

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Book Synopsis Intestinal Stem Cell Niche by :

Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Self-assembling Human Pluripotent Stem Cell-derived Heart Organoids for the Study of Heart Development and Congenital Heart Disease

Download Self-assembling Human Pluripotent Stem Cell-derived Heart Organoids for the Study of Heart Development and Congenital Heart Disease PDF Online Free

Author : Yonatan Raz Lewis Israeli
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.3/5 (776 download)

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Book Synopsis Self-assembling Human Pluripotent Stem Cell-derived Heart Organoids for the Study of Heart Development and Congenital Heart Disease by : Yonatan Raz Lewis Israeli

Download or read book Self-assembling Human Pluripotent Stem Cell-derived Heart Organoids for the Study of Heart Development and Congenital Heart Disease written by Yonatan Raz Lewis Israeli and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Congenital heart defects (CHD) constitute the most common birth defect in humans, affecting approximately 1% of all live births. Our ability to understand how these disorders originate is hindered by our limited ability to model the complexity of the human heart in vitro. There is a pressing need to develop more representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. This dissertation outlines a novel method to generate physiologically relevant human heart organoids by self-assembly using pluripotent stem cells. This method is fully defined, highly efficient, scalable, exhibits high reproducibility, and is compatible with screening and high-content approaches. Human heart organoids (hHOs) are generated through a three-step Wnt signaling modulation strategy using a combination of chemical inhibitors and growth factors in completely defined culture conditions. hHOs recapitulate aspects of human cardiac development and are comparable to age-matched fetal cardiac tissues at the transcriptomic, structural, and cellular levels. hHOs develop sophisticated internal chambers with well-organized multi-lineage cell type regional identities reminiscent of the heart fields and the atrial and ventricular chambers, as well as the epicardium, endocardium, and vasculature, and exhibit robust functional activity. Finally, hHOs can recreate complex metabolic disorders associated with CHD by establishing the first in vitro human heart organoid model of pregestational diabetes (PGD) to study embryonic CHD. Our heart organoid model constitutes a powerful novel tool for translational studies in human cardiac development and disease.

Pluripotent Stem Cell Biology

Author : Craig Atwood
Publisher : BoD – Books on Demand
ISBN 13 : 9535115901
Total Pages : 244 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Pluripotent Stem Cell Biology by : Craig Atwood

Download or read book Pluripotent Stem Cell Biology written by Craig Atwood and published by BoD – Books on Demand. This book was released on 2014-07-02 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pluripotent stem cells have the potential to revolutionize treatment options for a range of diseases and conditions. This book presents recent advances in our understanding of the biological mechanisms of stem cell self-renewal, reprograming and regeneration. Also covered are novel methodological advances in the culture, purification and use of stem cells, as well as the ethical and moral dilemmas of embryo donation and adoption. These advances will shape the utilization of stem cells for future basic and applied applications.

Pluripotent Stem Cells

Author : Minoru Tomizawa
Publisher : BoD – Books on Demand
ISBN 13 : 9535124714
Total Pages : 534 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Pluripotent Stem Cells by : Minoru Tomizawa

Download or read book Pluripotent Stem Cells written by Minoru Tomizawa and published by BoD – Books on Demand. This book was released on 2016-07-20 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Human Induced Pluripotent Stem Cells

Author : Baojin Ding
Publisher : Springer Nature
ISBN 13 : 1071639994
Total Pages : 256 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Human Induced Pluripotent Stem Cells by : Baojin Ding

Download or read book Human Induced Pluripotent Stem Cells written by Baojin Ding and published by Springer Nature. This book was released on with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Impact of Food Bioactives on Health

Author : Kitty Verhoeckx
Publisher : Springer
ISBN 13 : 3319161040
Total Pages : 341 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Impact of Food Bioactives on Health by : Kitty Verhoeckx

Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Human Adult Stem Cells

Author : John Masters
Publisher : Springer
ISBN 13 : 9789048122684
Total Pages : 208 pages
Book Rating : 4.1/5 (226 download)

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Book Synopsis Human Adult Stem Cells by : John Masters

Download or read book Human Adult Stem Cells written by John Masters and published by Springer. This book was released on 2009-06-04 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of volume 7 of Human Cell Culture is to provide clear and precise methods for growing primary cultures of adult stem cells from various human tissues and describe culture conditions in which these adult stem cells differentiate along their respective lineages. The book will be of value to biomedical scientists and of special interest to stem cell biologists and tissue engineers. Each chapter is written by experts actively involved in growing human adult stem cells.

Stem Cells and Regenerative Medicine

Author : Walter C. Low
Publisher : World Scientific
ISBN 13 : 9812775773
Total Pages : 571 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Stem Cells and Regenerative Medicine by : Walter C. Low

Download or read book Stem Cells and Regenerative Medicine written by Walter C. Low and published by World Scientific. This book was released on 2008 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Human Retinal Organoids - Exploration of a Human Induced Pluripotent Stem Cell-derived in Vitro Model

Author : Kevin Achberger
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Human Retinal Organoids - Exploration of a Human Induced Pluripotent Stem Cell-derived in Vitro Model by : Kevin Achberger

Download or read book Human Retinal Organoids - Exploration of a Human Induced Pluripotent Stem Cell-derived in Vitro Model written by Kevin Achberger and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Embryonic Stem Cells

Author : Arlene Chiu
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Embryonic Stem Cells by : Arlene Chiu

Download or read book Human Embryonic Stem Cells written by Arlene Chiu and published by Springer Science & Business Media. This book was released on 2003-08 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Induced Pluripotent Stem Cells and Human Disease

Author : Kursad Turksen
Publisher : Springer Nature
ISBN 13 : 1071625853
Total Pages : 426 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Induced Pluripotent Stem Cells and Human Disease by : Kursad Turksen

Download or read book Induced Pluripotent Stem Cells and Human Disease written by Kursad Turksen and published by Springer Nature. This book was released on 2022-07-02 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells (iPS cells) and corresponding human disease models. Reflecting the latest technology for generating induced pluripotent stem cells (iPS cells) and their initial characterization, the book explores techniques invaluable both for studies of disease-specific cell types and for their potential applications in regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols serves as a vital guide that is valuable for not only experts but also novices in the stem cell field.

The International after 150 Years

Author : George Comninel
Publisher : Routledge
ISBN 13 : 1317487966
Total Pages : 311 pages
Book Rating : 4.3/5 (174 download)

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Book Synopsis The International after 150 Years by : George Comninel

Download or read book The International after 150 Years written by George Comninel and published by Routledge. This book was released on 2017-10-02 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Workingmen’s Association was the prototype of all organizations of the Labour movement and the 150th anniversary of its birth (1864-2014) offers an important opportunity to rediscover its history and learn from its legacy. The International helped workers to grasp that the emancipation of labour could not be won in a single country but was a global objective. It also spread an awareness in their ranks that they had to achieve the goal themselves, through their own capacity for organization, rather than by delegating it to some other force; and that it was essential to overcome the capitalist system itself, since improvements within it, though necessary to pursue, would not eliminate exploitation and social injustice. This book reconsider the main issues broached or advanced by the International – such as labor rights, critiques of capitalism and the search for international solidarity – in light of present-day concerns. With the recent crisis of capitalism, that has sharpened more than before the division between capital and labour, the political legacy of the organization founded in London in 1864 has regained profound relevance, and its lessons are today more timely than ever. This book was published as a special issue of Socialism and Democracy.