Human Papillomavirus Hpv Associated Oropharyngeal Cancer

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Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

Author : Daniel L. Miller
Publisher : Springer
ISBN 13 : 3319211005
Total Pages : 316 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer by : Daniel L. Miller

Download or read book Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer written by Daniel L. Miller and published by Springer. This book was released on 2015-08-01 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.

The Current Situation of Human Papillomavirus (Hpv) Associated Oropharyngeal Cancer

Author : Wai-Hung Lam
Publisher : Open Dissertation Press
ISBN 13 : 9781361352946
Total Pages : pages
Book Rating : 4.3/5 (529 download)

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Book Synopsis The Current Situation of Human Papillomavirus (Hpv) Associated Oropharyngeal Cancer by : Wai-Hung Lam

Download or read book The Current Situation of Human Papillomavirus (Hpv) Associated Oropharyngeal Cancer written by Wai-Hung Lam and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "The Current Situation of Human Papillomavirus (HPV) Associated Oropharyngeal Cancer: a Multi-institutional Cohort Study in Hong Kong" by Wai-hung, Lam, 林偉雄, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Despite the advance in modern oncology, there was limited improvement over the survival outcome of head and neck cancers. Until the discovery of the etiological association between Human Papillomavirus (HPV) and oropharyngeal cancer, an accelerated evolution in the field of head and neck oncology began. This viral-related tumor has ignited tremendous effort in American and European countries to explore the optimal treatment approaches. In contrast, the paucity of comprehensive and robust studies commonly exists in many Chinese and Asian countries. Little is known about the current situation of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) in Hong Kong. This retrospective local multi-institutional study attempted to explore the HPV-associated OPSCC in Hong Kong from various aspects, including demographics, risk factors, clinical and histological features, molecular profile, as well as clinical outcomes. Finally, attempts were made to determine any predictive factors to stratify high-risk patients in this distinct disease entity and explore the most appropriate detection algorithm of the biologically active HPV infection in our locality. With the support from the Hong Kong Cancer Registry and nine public hospitals, 141 (43.3%) of 326 newly diagnosed OPSCC in the whole population of Hong Kong between 2005 and 2009 were recruited. Inclusion criteria were histologically proven OPSCC with tumor specimens available for prospective laboratory tests. Those with non-SCC, non-oropharyngeal in origin and incomplete clinical records were excluded. Prospective HPV PCR and genotyping, and immunohistochemical staining with p16, p53, cyclin D1 and HER-2 were performed. Univariate and multivariate analyses were performed to assess the correlations between various parameters and HPV-associated OPSCC. Epidemiologically, based on the combined positivity in HPV PCR and p16, the prevalence of HPV-associated OPSCC was 22%. Thirty (96.8%) of thirty one were HPV-16, the remaining one was HPV-18. In the univariate analysis, this cancer directly correlated with female gender (p=0.014), younger age (p=0.012), non-smoker (p=0.02), non-drinker (p=0.06) and early primary tumor (p=0.001). Histologically, basaloid differentiation (pSignificantly superior prognosis was demonstrated in HPV-associated OPSCC. The 5-year overall and disease specific survivals were 67.0% and 88.6% compared with 27.8% (p

Proton Therapy

Author : Steven J Frank
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733506
Total Pages : 422 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Proton Therapy by : Steven J Frank

Download or read book Proton Therapy written by Steven J Frank and published by Elsevier Health Sciences. This book was released on 2020-05-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.

HPV and Head and Neck Cancers

Author : Carole Fakhry
Publisher : Springer
ISBN 13 : 8132224132
Total Pages : 144 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis HPV and Head and Neck Cancers by : Carole Fakhry

Download or read book HPV and Head and Neck Cancers written by Carole Fakhry and published by Springer. This book was released on 2015-07-11 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves a snapshot of the current knowledge base in field. As human papillomavirus (HPV) causes a rising number of oropharyngeal cancers, understanding the biological, clinical and social implications of this infection has become increasingly important for head and neck practitioners. This book reflects the multidisciplinary nature of the scientific and clinical questions involved in this disease. Experts in epidemiology, diagnosis and treatment of HPV-related oropharyngeal cancer present in-depth reviews which will help to improve the reader’s understanding of this topic. The authors provide insight for answers of common patient and provider questions about HPV infection and related disease, and highlight remaining questions to be answered in the coming years.

Oral Cancer

Author : Tadaaki Kirita
Publisher : Springer
ISBN 13 : 4431549382
Total Pages : 427 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Oral Cancer by : Tadaaki Kirita

Download or read book Oral Cancer written by Tadaaki Kirita and published by Springer. This book was released on 2015-02-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral cancer is frequently diagnosed late, when the disease has advanced with lesions that are large and deeply invasive and with metastasis to regional lymph nodes, leading to increased mortality. Moreover, late diagnosis and treatment often result in considerable morbidity of oral and maxillofacial structures and poor appearance and function following therapy. This book provides head and neck oncologists, oral oncologists, oral and maxillofacial surgeons, medical oncologists, dentists and other members of dental teams furnishing supportive care with a systematic review of recent diagnostic and therapeutic advances in oral cancer. The various authoritative chapters are prepared by specialists who are active leaders in each basic and clinical field. All chapters address individual and collective issues that arise in managing oral cancer patients with difficult treatment problems and provide insight into the multiple valid management approaches available. The authors offer an extensive source of information about oral cancers and encourage the clinician to be flexible and innovative, giving physicians and medical personnel the background information to make the best, educated, responsible decisions for individual patients.

The Current Situation of Human Papillomavirus (HPV) Associated Oropharyngeal Cancer

Author : 林偉雄
Publisher :
ISBN 13 :
Total Pages : 141 pages
Book Rating : 4.:/5 (897 download)

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Book Synopsis The Current Situation of Human Papillomavirus (HPV) Associated Oropharyngeal Cancer by : 林偉雄

Download or read book The Current Situation of Human Papillomavirus (HPV) Associated Oropharyngeal Cancer written by 林偉雄 and published by . This book was released on 2014 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

HPV Infection in Head and Neck Cancer

Author : Wojciech Golusiński
Publisher : Springer
ISBN 13 : 3319435809
Total Pages : 257 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis HPV Infection in Head and Neck Cancer by : Wojciech Golusiński

Download or read book HPV Infection in Head and Neck Cancer written by Wojciech Golusiński and published by Springer. This book was released on 2016-10-03 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.

HPV and Cancer

Author : James A. Radosevich
Publisher : Springer Science & Business Media
ISBN 13 : 940075437X
Total Pages : 202 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis HPV and Cancer by : James A. Radosevich

Download or read book HPV and Cancer written by James A. Radosevich and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: “HPV and Cancer” is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes. We then look at the dynamic trends of this infectious agent in the human population, how it interacts with human cells, and the role it plays with other organisms to produce both benign and malignant tumors. Lastly, there is a discussion about a new vaccine for HPV and the hopes that are held by many to change the trends with this virus and the associated cancers it produces.

HPV and Head and Neck Cancer, An Issue of Otolaryngologic Clinics

Author : Sara I Pai
Publisher : Elsevier Health Sciences
ISBN 13 : 1455747459
Total Pages : 200 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis HPV and Head and Neck Cancer, An Issue of Otolaryngologic Clinics by : Sara I Pai

Download or read book HPV and Head and Neck Cancer, An Issue of Otolaryngologic Clinics written by Sara I Pai and published by Elsevier Health Sciences. This book was released on 2012-08-28 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPV is a growing epidemic in head and neck cancer and specialists working with these diseases are provided information on shifting trends in HPV in head and neck cancers along with challenges and controversies in treating this disease. With this virus related cancer, there is a different approach to managing this patient population. Novel therapeutic treatments are actively being developed for this type of head and neck cancer. Topics include: Epidemioloygy of HPV-head and neck cancer; Clinical detection of HPV; Clinical evaluation and disease patterns of HPV-related head and neck cancers; Impact of HPV-related head and neck cancer in clinical trials; Molecular biology of HPV and head and neck cancer and targeted therapies; Transoral robotic surgery: new surgical techniques for oropharyngeal cancers; Economic impact of HPV-related cancers; Rehabilitation needs of oropharyngeal cancer patients; Psychosocial care needs of HPV-head and neck cancer patients; and a Multi-disciplinary approach to head and neck cancers.

Human Papillomavirus Associated Oropharyngeal Carcinoma-Diagnosis and Management

Author : Kainickal Cessal Thommachan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Human Papillomavirus Associated Oropharyngeal Carcinoma-Diagnosis and Management by : Kainickal Cessal Thommachan

Download or read book Human Papillomavirus Associated Oropharyngeal Carcinoma-Diagnosis and Management written by Kainickal Cessal Thommachan and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck squamous cell carcinomas arise from the mucosa of the upper aerodigestive tract and is often driven by risk factors like tobacco and alcohol consumption. Most of the time patients present with locally advanced stages and the outcome is poor, despite recent advances in multi-modality treatment. The epidemiology of the disease has changed over the last decade with the introduction of a separate clinical entity; Human Papillomavirus (HPV) associated head and neck cancer. The tumorigenesis is different from that of tobacco and alcohol-driven malignancies. These tumors have a better response to treatment owing to their inherent genetic makeup and carry an excellent prognosis. The current school of thought is to reduce the long-term morbidities associated with various treatment modalities, as these patients tend to survive longer. The best management of HPV-associated oropharyngeal cancer is under active investigation.

Head and Neck Cancer

Author : Louis B. Harrison
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781771368
Total Pages : 1004 pages
Book Rating : 4.7/5 (713 download)

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Book Synopsis Head and Neck Cancer by : Louis B. Harrison

Download or read book Head and Neck Cancer written by Louis B. Harrison and published by Lippincott Williams & Wilkins. This book was released on 2009 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life. This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include a new chapter on reconstructive techniques; significant updates to all site-specific chapters; updates on chemoprevention and molecular targeting; and discussions of new imaging modalities such as fused PET/CT. A companion Website will offer the fully searchable text with all images.

Oral Cavity and Oropharyngeal Cancer, An Issue of Otolaryngologic Clinics

Author : Jeffrey N. Myers
Publisher : Elsevier Health Sciences
ISBN 13 : 0323186327
Total Pages : 280 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Oral Cavity and Oropharyngeal Cancer, An Issue of Otolaryngologic Clinics by : Jeffrey N. Myers

Download or read book Oral Cavity and Oropharyngeal Cancer, An Issue of Otolaryngologic Clinics written by Jeffrey N. Myers and published by Elsevier Health Sciences. This book was released on 2013-08-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: While cancers of the oral cavity and oropharynx were overwhelming found in smokers and drinkers, a dramatic shift is occurring with a dramatic rise in the incidence of HPV-associated oropharyngeal cancers while oral cavity cancers and HPV-negative oropharyngeal cancers appear to be declining in incidence, reflecting the reduction in cigarette smoking. These trends also have implications for how Otolaryngologists prevent, diagnose, workup, treat, and follow these patients. The focus of information in this issue is on oral cavity and oropharyngeal cancer and the implications of the HPV epidemic on this disease. Amongst the medical community during this period of trying to better grasp the association of HPV with oropharyngeal cancers, there are misconceptions and a lack of knowledge of these important shifts which are addressed by Guest Editors Jeffrey Myers and Erich Sturgis of the University of Texas, MD Anderson Cancer Center. Topics include: Epidemiology- Control of a tobacco epidemic? But emergence of a HPV epidemic?; Oral cavity and Oropharyngeal Cancer Genomics; Why Otolaryngologists need to be aware of Fanconi anemia; Impact on HPV on Orpharyngeal Cancer Biology and Response to Therapy-Implications for Treatment; Oral premalignancy- The roles of early detection and chemoprevention; Evaluation and staging- Limitations despite technological breakthroughs; 7) Surgical treatment innovations; Radiotherapy- The “Particle-rs of energy, dose, and delivery method; Systemic Treatment- Its role before, during, and after definitive treatment; How to maximize functional assessment/rehabilitation; Standardizing treatment for Cancers – An approach to cancer care or crisis?; Survivorship in Oral Cancer- Competing mortalities, morbidities, and second malignancies.

HIV/AIDS-Associated Viral Oncogenesis

Author : Craig Meyers
Publisher : Springer
ISBN 13 : 3030035026
Total Pages : 252 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis HIV/AIDS-Associated Viral Oncogenesis by : Craig Meyers

Download or read book HIV/AIDS-Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.

WHO Classification of Head and Neck Tumours

Author : Adel K. El-Naggar
Publisher : IARC Who Classification of Tum
ISBN 13 : 9789283224389
Total Pages : 347 pages
Book Rating : 4.2/5 (243 download)

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Book Synopsis WHO Classification of Head and Neck Tumours by : Adel K. El-Naggar

Download or read book WHO Classification of Head and Neck Tumours written by Adel K. El-Naggar and published by IARC Who Classification of Tum. This book was released on 2017-01-23 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 135 authors from 35 countries, contains more than 600 color images and tables, and more than 2700 references. This book is in the series commonly referred to as the "Blue Book" series.

Clinical, epidemiological, and tumor-specific investigations in human papillomavirus (HPV) associated oropharyngeal cancer

Author :
Publisher :
ISBN 13 : 9788794494588
Total Pages : 0 pages
Book Rating : 4.4/5 (945 download)

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Book Synopsis Clinical, epidemiological, and tumor-specific investigations in human papillomavirus (HPV) associated oropharyngeal cancer by :

Download or read book Clinical, epidemiological, and tumor-specific investigations in human papillomavirus (HPV) associated oropharyngeal cancer written by and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook of Oral Cancer

Author : Saman Warnakulasuriya
Publisher : Springer Nature
ISBN 13 : 3030323161
Total Pages : 449 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Textbook of Oral Cancer by : Saman Warnakulasuriya

Download or read book Textbook of Oral Cancer written by Saman Warnakulasuriya and published by Springer Nature. This book was released on 2020-02-22 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.

Practical Radiation Oncology

Author : Supriya Mallick
Publisher : Springer Nature
ISBN 13 : 9811500738
Total Pages : 282 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Practical Radiation Oncology by : Supriya Mallick

Download or read book Practical Radiation Oncology written by Supriya Mallick and published by Springer Nature. This book was released on 2019-11-25 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the most relevant aspects of radiation oncology in terms of technical integrity, dose parameters, machine and software specifications, as well as regulatory requirements. Radiation oncology is a unique field that combines physics and biology. As a result, it has not only a clinical aspect, but also a physics aspect and biology aspect, all three of which are inter-related and critical to optimal radiation treatment planning. In addition, radiation oncology involves a host of machines/software. One needs to have a firm command of these machines and their specifications to deliver comprehensive treatment. However, this information is not readily available, which poses serious challenges for students learning the planning aspect of radiation therapy. In response, this book compiles these relevant aspects in a single source. Radiation oncology is a dynamic field, and is continuously evolving. However, tracking down the latest findings is both difficult and time-consuming. Consequently, the book also comprehensively covers the most important trials. Offering an essential ready reference work, it represents a value asset for all radiation oncology practitioners, trainees and students.