Histone Variants

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Histone Variants

Author : Guillermo A. Orsi
Publisher : Humana
ISBN 13 : 9781493993581
Total Pages : 359 pages
Book Rating : 4.9/5 (935 download)

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Book Synopsis Histone Variants by : Guillermo A. Orsi

Download or read book Histone Variants written by Guillermo A. Orsi and published by Humana. This book was released on 2019-08-17 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume compiles methodologies used for detailed studies of histone variants, from their basic properties to their functional roles in chromatin and as vectors of epigenetic information. Its four sections cover experimental approaches to probe the biochemistry of histone variants and variant nucleosomes; their dynamics throughout the cell cycle and at specific genomic locations; their functional impact on chromosome organization and genome stability; and their importance in development, disease and evolution. Written in the highly successful Methods in Molecular Biology series format, chapters include lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, illustrations on the expected results, and tips on troubleshooting and avoiding known pitfalls. This anthology brings together contributions from many of the most highly recognized investigators in this community. Cutting-edge and thorough, Histone Variants: Methods and Protocols is a valuable resource for anyone interested in exploring the experimental and collaborative possibilities in this evolving field.

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Chromatin Regulation and Dynamics

Author : Anita Göndör
Publisher : Academic Press
ISBN 13 : 0128034025
Total Pages : 498 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chromatin Regulation and Dynamics by : Anita Göndör

Download or read book Chromatin Regulation and Dynamics written by Anita Göndör and published by Academic Press. This book was released on 2016-10-25 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. - Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective - Promotes crosstalk between basic sciences and their applications in medicine - Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles - Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Histones and Other Basic Nuclear Proteins

Author : Gary S. Stein
Publisher : CRC Press
ISBN 13 : 9780849355158
Total Pages : 426 pages
Book Rating : 4.3/5 (551 download)

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Book Synopsis Histones and Other Basic Nuclear Proteins by : Gary S. Stein

Download or read book Histones and Other Basic Nuclear Proteins written by Gary S. Stein and published by CRC Press. This book was released on 1989-06-30 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.

Histone Genes

Author : Gary S. Stein
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Histone Genes by : Gary S. Stein

Download or read book Histone Genes written by Gary S. Stein and published by Wiley-Interscience. This book was released on 1984 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Structure and Function of Chromatin

Author : David W. FitzSimons
Publisher : John Wiley & Sons
ISBN 13 : 0470717785
Total Pages : 192 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis The Structure and Function of Chromatin by : David W. FitzSimons

Download or read book The Structure and Function of Chromatin written by David W. FitzSimons and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Epigenetics

Author : C. David Allis
Publisher : CSHL Press
ISBN 13 : 0879697245
Total Pages : 503 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Epigenetics by : C. David Allis

Download or read book Epigenetics written by C. David Allis and published by CSHL Press. This book was released on 2007 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Histone Mutations and Cancer

Author : Dong Fang
Publisher : Springer Nature
ISBN 13 : 9811581045
Total Pages : 102 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Histone Mutations and Cancer by : Dong Fang

Download or read book Histone Mutations and Cancer written by Dong Fang and published by Springer Nature. This book was released on 2020-11-06 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

Fundamentals of Chromatin

Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 1461486246
Total Pages : 594 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Fundamentals of Chromatin by : Jerry L. Workman

Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Lewin's Essential Genes

Author : Jocelyn E. Krebs
Publisher : Jones & Bartlett Publishers
ISBN 13 : 1449612652
Total Pages : 874 pages
Book Rating : 4.4/5 (496 download)

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Book Synopsis Lewin's Essential Genes by : Jocelyn E. Krebs

Download or read book Lewin's Essential Genes written by Jocelyn E. Krebs and published by Jones & Bartlett Publishers. This book was released on 2013 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt: Condensed ed. of: Genes X / Benjamin Lewin. c2011.

Epigenetics and Chromatin

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 9783540233725
Total Pages : 288 pages
Book Rating : 4.2/5 (337 download)

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Book Synopsis Epigenetics and Chromatin by : Philippe Jeanteur

Download or read book Epigenetics and Chromatin written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2005-01-10 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on chromatin structure and function in combination with an epigenetic view. It offers an updated collection of papers treating epigenetic phenomena in mammals, insects and plants.

Nucleosomes, Histones and Chromatin Part A

Author : Carl Wu
Publisher : Academic Press
ISBN 13 : 0123919401
Total Pages : 408 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Nucleosomes, Histones and Chromatin Part A by : Carl Wu

Download or read book Nucleosomes, Histones and Chromatin Part A written by Carl Wu and published by Academic Press. This book was released on 2012-08-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins. Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field The first of 2 volumes covering nucleosomes, histones and chromatin Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

Nucleosomes, Histones and Chromatin Part A

Author :
Publisher : Academic Press
ISBN 13 : 012391941X
Total Pages : 407 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Nucleosomes, Histones and Chromatin Part A by :

Download or read book Nucleosomes, Histones and Chromatin Part A written by and published by Academic Press. This book was released on 2012-12-31 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins. - Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field - The first of 2 volumes covering nucleosomes, histones and chromatin - Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

Introduction to Epigenetics

Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Introduction to Epigenetics by : Renato Paro

Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

DNA Damage, DNA Repair and Disease

Author : Miral Dizdaroglu
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162562
Total Pages : 509 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis DNA Damage, DNA Repair and Disease by : Miral Dizdaroglu

Download or read book DNA Damage, DNA Repair and Disease written by Miral Dizdaroglu and published by Royal Society of Chemistry. This book was released on 2020-11-11 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications

Author : Raúl Alvarez-Venegas
Publisher : Springer
ISBN 13 : 3319079719
Total Pages : 158 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications by : Raúl Alvarez-Venegas

Download or read book Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications written by Raúl Alvarez-Venegas and published by Springer. This book was released on 2014-07-22 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decades, chromatin remodelling has emerged as an important regulator of gene expression and plant defense. This book provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity. New approaches of this kind and the development of new technologies will certainly increase our knowledge of currently known post-translational modifications and facilitate the understanding of their roles in, for example, host-pathogen interactions and crop productivity. Furthermore, we provide important insight on how the plant epigenome changes in response to developmental or environmental stimuli, how chromatin modifications are established and maintained, to which degree they are used throughout the genome, and how chromatin modifications influence each another.

A Clinician's Guide to Sperm DNA and Chromatin Damage

Author : Armand Zini
Publisher : Springer
ISBN 13 : 3319718150
Total Pages : 598 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis A Clinician's Guide to Sperm DNA and Chromatin Damage by : Armand Zini

Download or read book A Clinician's Guide to Sperm DNA and Chromatin Damage written by Armand Zini and published by Springer. This book was released on 2018-03-05 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.