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Histamine In The Brain
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Book Synopsis Histamine in the brain by : Jian-Sheng Lin
Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Book Synopsis Histamine in Inflammation by : Robin Thurmond
Download or read book Histamine in Inflammation written by Robin Thurmond and published by Springer Science & Business Media. This book was released on 2011-06-29 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Book Synopsis Histamine Receptors by : Patrizio Blandina
Download or read book Histamine Receptors written by Patrizio Blandina and published by Springer. This book was released on 2016-11-07 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
Book Synopsis The 4-Phase Histamine Reset Plan by : Dr. Becky Campbell
Download or read book The 4-Phase Histamine Reset Plan written by Dr. Becky Campbell and published by Page Street Publishing. This book was released on 2019-12-10 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uncover the Root Cause of Your Health Issues and Heal Your Body for Life Millions of people suffer from allergies, migraines, skin issues, sleep disturbances, digestive ailments or anxiety due to undiagnosed histamine intolerance. Dr. Becky Campbell, who has years of experience in the field and who suffers from histamine intolerance herself, has created a revolutionary four-phase program to heal your body naturally. What makes her approach different—and more effective for lifelong results—is that it looks for root causes and offers a well-rounded, holistic treatment plan that addresses diet, environmental toxins, lifestyle and more. To help you uncover why your body is not processing histamine correctly, Dr. Campbell explains the eight most common factors and how to address them. Then she gives you a plan that includes a low-histamine diet, liver care, gut support and direction on how to safely reintroduce the foods that were once making you sick. Along with her wealth of delicious recipes, she also includes information on supplements, ways to reduce stress and much more. Invest in your health and use The 4-Phase Histamine Reset Plan to heal your body for good.
Book Synopsis The Functional Roles of Histamine Receptors by : Kazuhiko Yanai
Download or read book The Functional Roles of Histamine Receptors written by Kazuhiko Yanai and published by Springer Nature. This book was released on 2022-09-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.
Book Synopsis Histaminergic Neurons by : Takehiko Watanabe
Download or read book Histaminergic Neurons written by Takehiko Watanabe and published by CRC Press. This book was released on 1991-02-22 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the histaminergic neuron system in the brain for neuroscience, anatomy, pharmacology, biochemistry, and medical researchers. Topics discussed include the biochemistry of enzymes; histamine receptors (H1, H2, and H3); morphology, coexistance, and development of the histaminergic neuron system; electrophysiological studies on vertebrate and invertebrate neurons; as well as the functions of the histamine neurons.
Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Book Synopsis What HIT Me? Living with Histamine Intolerance by : Genny Masterman
Download or read book What HIT Me? Living with Histamine Intolerance written by Genny Masterman and published by Createspace Independent Publishing Platform. This book was released on 2013-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIT - Histamine Intolerance - is a condition that affects many people but remains largely undiagnosed. The symptoms of histamine intolerance (HIT) are caused by the inability of the body to break down histamine sufficiently. These symptoms can appear very like an allergy and can cause stomach and intestinal complaints, migraine, tiredness and skin problems, to name but a few. This is in most cases because of the reduced activity or low presence of an enzyme called diamine oxidase (DAO), which is mainly responsible for breaking down histamine and other biogenic amines ingested through food. Foods that are known culprits include: red wine, ready meals, cured meats, mature cheeses, tomatoes and aubergines. It can make people's lives a total misery. But it CAN be brought under control with the RIGHT DIAGNOSIS and the RIGHT DIET. This book is a guide to how to achieve both. It helps both health professionals and patients gain insight. After the great success of the first edition, this second edition contains a new section on the different points of view about diagnosis as well as a second food list - a tolerance index which resulted from a survey of 800 participants who judged 109 foods according to their individual threshold - side by side with the scientifically based food list. CONTENTS Introduction Histamine Intolerance - In a nutshell How do I find out if I have HIT? Other intolerances -DAO and its closest friends and helpers What HIT is not Specially for the ladies - HIT's favourite targets How do I find out what to eat or not? What do I need to do at home? How do I keep the family happy? How can I deal with this at work? What do I need to keep in mind when shopping? What consequences are there for my social life? Meat - the good...the bad and the ugly Fish - the good... and the ugly Milk and Dairy Products - essentials Fruit & Vegetables - the little labyrinth Bread & Baking The problem with alcohol! Pharmaceuticals, food additives, E-numbers and other culprits Food lists and supplements Short summary of therapy options Recipes The Food Diary
Book Synopsis Pharmacology of Histamine Receptors by : C. R. Ganellin
Download or read book Pharmacology of Histamine Receptors written by C. R. Ganellin and published by Elsevier. This book was released on 2013-10-22 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.
Book Synopsis Traumatic Brain Edema by : F. Cohadon
Download or read book Traumatic Brain Edema written by F. Cohadon and published by . This book was released on 1987 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Third Histamine Receptor by : Divya Vohora
Download or read book The Third Histamine Receptor written by Divya Vohora and published by CRC Press. This book was released on 2008-11-14 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and DisordersThe H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer's disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodege
Book Synopsis The Beginner's Guide to Histamine Intolerance by : Janice M. Vickerstaff Joneja
Download or read book The Beginner's Guide to Histamine Intolerance written by Janice M. Vickerstaff Joneja and published by . This book was released on 2017-09 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you're struggling with your health, but the doctor can't find anything actually wrong with you, then perhaps you have Histamine Intolerance. It's a condition with a range of unpleasant symptoms, which can include headaches, flushing, itching, hives, swollen facial tissues, racing heart, digestive problems, irritability and more. Many doctors don't know much about Histamine Intolerance, although it's estimated that 1% of the world's population suffers from it. If you're one of them, you'll know first-hand how distressing and frustrating the disorder can be.Dr Janice Vickerstaff Joneja saw the misery that this condition caused sufferers, and made it the focus of her research work; she's been studying the condition and helping patients since the 1990s. She's now created this easy-to-read guide--which will help you understand if you have Histamine Intolerance, and what you can do about it--with clear advice and explanations, lots of interesting real-life cases, plus diet and treatment recommendations. If you wonder if your symptoms could be caused by Histamine Intolerance--or if you believe they are and want to know what to do about it--this book is for you.
Book Synopsis Histamine Intolerance by : Reinhart Jarisch
Download or read book Histamine Intolerance written by Reinhart Jarisch and published by Springer. This book was released on 2014-11-10 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.
Download or read book Dirty Genes written by Ben Lynch and published by HarperCollins. This book was released on 2018-01-30 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Instant National Bestseller After suffering for years with unexplainable health issues, Dr. Ben Lynch discovered the root cause—“dirty” genes. Genes can be “born dirty” or merely “act dirty” in response to your environment, diet, or lifestyle—causing lifelong, life-threatening, and chronic health problems, including cardiovascular disease, autoimmune disorders, anxiety, depression, digestive issues, obesity, cancer, and diabetes. Based on his own experience and successfully helping thousands of clients, Dr. Lynch shows you how to identify and optimize both types of dirty genes by cleaning them up with targeted and personalized plans, including healthy eating, good sleep, stress relief, environmental detox, and other holistic and natural means. Many of us believe our genes doom us to the disorders that run in our families. But Dr. Lynch reveals that with the right plan in place, you can eliminate symptoms, and optimize your physical and mental health—and ultimately rewrite your genetic destiny.
Book Synopsis The Histamine H3 Receptor by : R. Leurs
Download or read book The Histamine H3 Receptor written by R. Leurs and published by Elsevier. This book was released on 1998-12-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive. The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues. In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.
Book Synopsis Successful Drug Discovery, Volume 3 by : J¿nos Fischer
Download or read book Successful Drug Discovery, Volume 3 written by J¿nos Fischer and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
