Heart Cell Coupling And Impulse Propagation In Health And Disease

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Heart Cell Coupling and Impulse Propagation in Health and Disease

Author : Walmor C. de Mello
Publisher : Springer Science & Business Media
ISBN 13 : 1461511550
Total Pages : 475 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Heart Cell Coupling and Impulse Propagation in Health and Disease by : Walmor C. de Mello

Download or read book Heart Cell Coupling and Impulse Propagation in Health and Disease written by Walmor C. de Mello and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field. The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.

Renin Angiotensin System and the Heart

Author : Walmor C. De Mello
Publisher : John Wiley & Sons
ISBN 13 : 0470862947
Total Pages : 256 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Renin Angiotensin System and the Heart by : Walmor C. De Mello

Download or read book Renin Angiotensin System and the Heart written by Walmor C. De Mello and published by John Wiley & Sons. This book was released on 2005-10-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research

The Local Cardiac Renin-Angiotensin Aldosterone System

Author : Edward D. Frohlich
Publisher : Springer Science & Business Media
ISBN 13 : 0387278265
Total Pages : 231 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis The Local Cardiac Renin-Angiotensin Aldosterone System by : Edward D. Frohlich

Download or read book The Local Cardiac Renin-Angiotensin Aldosterone System written by Edward D. Frohlich and published by Springer Science & Business Media. This book was released on 2006-01-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Gap Junctions: Molecular Basis of Cell Communication in Health and Disease

Author : Dale J. Benos
Publisher : Gulf Professional Publishing
ISBN 13 : 9780125506458
Total Pages : 692 pages
Book Rating : 4.5/5 (64 download)

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Book Synopsis Gap Junctions: Molecular Basis of Cell Communication in Health and Disease by : Dale J. Benos

Download or read book Gap Junctions: Molecular Basis of Cell Communication in Health and Disease written by Dale J. Benos and published by Gulf Professional Publishing. This book was released on 1999-12-14 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.

Heart Cell Communication in Health and Disease

Author : Walmor C. de Mello
Publisher : Springer
ISBN 13 : 9781461555261
Total Pages : 295 pages
Book Rating : 4.5/5 (552 download)

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Book Synopsis Heart Cell Communication in Health and Disease by : Walmor C. de Mello

Download or read book Heart Cell Communication in Health and Disease written by Walmor C. de Mello and published by Springer. This book was released on 2011-09-15 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Heart Cell Communication in Health and Disease an extensive review of different aspects of heart cell communication is presented. The book starts with the fundamental concept that cardiac cells are communicated, and then proceeds to the role of gap junctions in heart development, the molecular biology of gap junctions, the biophysics of the intercellular channels, the control of junctional conductance and the influence of gap junctions on impulse propagation. This is the first time that a single volume has described cell communication in the normal heart and under different pathological conditions such as heart failure, coronary disease, myocardial ischemia and cardiac arrhythmias. In this way the process of cell communication is analyzed at different levels of complexity, providing the reader with a wide view of this field and its relevance to cardiology.

Renin Angiotensin System and Cardiovascular Disease

Author : Walmor C. DeMello
Publisher : Springer Science & Business Media
ISBN 13 : 1607611864
Total Pages : 249 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Renin Angiotensin System and Cardiovascular Disease by : Walmor C. DeMello

Download or read book Renin Angiotensin System and Cardiovascular Disease written by Walmor C. DeMello and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.

Heart Cell Communication in Health and Disease

Author : Walmor C. de Mello
Publisher : Springer Science & Business Media
ISBN 13 : 1461555256
Total Pages : 322 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Heart Cell Communication in Health and Disease by : Walmor C. de Mello

Download or read book Heart Cell Communication in Health and Disease written by Walmor C. de Mello and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Heart Cell Communication in Health and Disease an extensive review of different aspects of heart cell communication is presented. The book starts with the fundamental concept that cardiac cells are communicated, and then proceeds to the role of gap junctions in heart development, the molecular biology of gap junctions, the biophysics of the intercellular channels, the control of junctional conductance and the influence of gap junctions on impulse propagation. This is the first time that a single volume has described cell communication in the normal heart and under different pathological conditions such as heart failure, coronary disease, myocardial ischemia and cardiac arrhythmias. In this way the process of cell communication is analyzed at different levels of complexity, providing the reader with a wide view of this field and its relevance to cardiology.

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

Author : George E. Billman
Publisher : Frontiers Media SA
ISBN 13 : 288919647X
Total Pages : 143 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias by : George E. Billman

Download or read book Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias written by George E. Billman and published by Frontiers Media SA. This book was released on 2015-09-25 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Advances in Electrocardiograms

Author : Richard Millis
Publisher : BoD – Books on Demand
ISBN 13 : 9533079029
Total Pages : 343 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Advances in Electrocardiograms by : Richard Millis

Download or read book Advances in Electrocardiograms written by Richard Millis and published by BoD – Books on Demand. This book was released on 2012-01-25 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrocardiograms have become one of the most important, and widely used medical tools for diagnosing diseases such as cardiac arrhythmias, conduction disorders, electrolyte imbalances, hypertension, coronary artery disease and myocardial infarction. This book reviews recent advancements in electrocardiography. The four sections of this volume, Cardiac Arrhythmias, Myocardial Infarction, Autonomic Dysregulation and Cardiotoxicology, provide comprehensive reviews of advancements in the clinical applications of electrocardiograms. This book is replete with diagrams, recordings, flow diagrams and algorithms which demonstrate the possible future direction for applying electrocardiography to evaluating the development and progression of cardiac diseases. The chapters in this book describe a number of unique features of electrocardiograms in adult and pediatric patient populations with predilections for cardiac arrhythmias and other electrical abnormalities associated with hypertension, coronary artery disease, myocardial infarction, sleep apnea syndromes, pericarditides, cardiomyopathies and cardiotoxicities, as well as innovative interpretations of electrocardiograms during exercise testing and electrical pacing.

Cardiovascular Gap Junctions

Author : Stefan Dhein
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805580770
Total Pages : 307 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Cardiovascular Gap Junctions by : Stefan Dhein

Download or read book Cardiovascular Gap Junctions written by Stefan Dhein and published by Karger Medical and Scientific Publishers. This book was released on 2006-01-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, gap junction research in the cardiovascular system has considerably improved the understanding of cardiac function and the vasculature in health and disease. The present book focuses on the communication of intercellular gap junctions in

Gap Junctions in Development and Disease

Author : Elke Winterhager
Publisher : Springer Science & Business Media
ISBN 13 : 3540286217
Total Pages : 289 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Gap Junctions in Development and Disease by : Elke Winterhager

Download or read book Gap Junctions in Development and Disease written by Elke Winterhager and published by Springer Science & Business Media. This book was released on 2005-11-04 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

Cardiovascular Applications of Stem Cells

Author : Khawaja H. Haider
Publisher : Springer Nature
ISBN 13 : 9819907225
Total Pages : 517 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Cardiovascular Applications of Stem Cells by : Khawaja H. Haider

Download or read book Cardiovascular Applications of Stem Cells written by Khawaja H. Haider and published by Springer Nature. This book was released on 2023-07-05 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.

Biomedical Index to PHS-supported Research

Author :
Publisher :
ISBN 13 :
Total Pages : 1398 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1987 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

Author :
Publisher :
ISBN 13 :
Total Pages : 1398 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by :

Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1994 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease E-Book

Author : Ziad Issa
Publisher : Elsevier Health Sciences
ISBN 13 : 1455737682
Total Pages : 746 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease E-Book by : Ziad Issa

Download or read book Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease E-Book written by Ziad Issa and published by Elsevier Health Sciences. This book was released on 2012-04-24 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its unique, singular focus on the clinical aspect of cardiac arrhythmias, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease makes it easy to apply today's most up-to-date guidelines for diagnosis and treatment. An expert author team provides clear, clinically focused guidance on all types of cardiac arrhythmias, including practical techniques for managing complex patients. Find the information you need quickly with a consistent organization in all chapters, written to a template that shows every arrhythmia type in a similar manner. Access the fully searchable contents online at www.expertconsult.com, in addition to downloadable images and dynamic video clips. Fully understand the rationale for treatment of specific arrhythmias with practical techniques that are grounded in the most recent basic science. Stay up to date with new chapters on molecular mechanisms of cardiac electrical activity, cardiac ion channels, ventricular tachycardia in nonischemic dilated cardiomyopathy, epicardial ventricular tachycardia, ventricular arrhythmias in hypertrophic cardiomyopathy, ventricular arrhythmias in inherited channelopathies, ventricular arrhythmias in congenital heart disease, atrial arrhythmias in congenital heart disease, and complications of catheter ablation of cardiac arrhythmias. View videos of 27 key techniques online, including optical mapping of reentrant ventricular arrhythmias, 3-dimensional mapping of arrhythmias using different mapping and navigation modalities, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, atrial septal puncture, and pericardial access. Gain a new understanding of hot topics such as mechanisms of arrhythmias, electrophysiologic testing, mapping and navigation modalities, ablation energy sources, sinus node dysfunction, conduction disturbances, atrial tachyarrhythmias, preexcitation syndromes and all types of ventricular and supraventricular tachycardias.

Molecular Mechanisms of Cardiac Hypertrophy and Failure

Author : Richard A. Walsh
Publisher : CRC Press
ISBN 13 : 0203503244
Total Pages : 812 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Molecular Mechanisms of Cardiac Hypertrophy and Failure by : Richard A. Walsh

Download or read book Molecular Mechanisms of Cardiac Hypertrophy and Failure written by Richard A. Walsh and published by CRC Press. This book was released on 2005-11-29 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.

Cardiac Electrophysiology: From Cell to Bedside E-Book

Author : Douglas P. Zipes
Publisher : Elsevier Health Sciences
ISBN 13 : 1455770108
Total Pages : 1397 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Cardiac Electrophysiology: From Cell to Bedside E-Book by : Douglas P. Zipes

Download or read book Cardiac Electrophysiology: From Cell to Bedside E-Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2013-10-11 with total page 1397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.