Handbook Of Glycomics

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Handbook of Glycomics

Author : Richard D. Cummings
Publisher : Academic Press
ISBN 13 : 9780080920054
Total Pages : 512 pages
Book Rating : 4.9/5 (2 download)

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Book Synopsis Handbook of Glycomics by : Richard D. Cummings

Download or read book Handbook of Glycomics written by Richard D. Cummings and published by Academic Press. This book was released on 2009-10-19 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans. Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

A Practical Guide to Using Glycomics Databases

Author : Kiyoko F. Aoki-Kinoshita
Publisher : Springer
ISBN 13 : 4431564543
Total Pages : 370 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis A Practical Guide to Using Glycomics Databases by : Kiyoko F. Aoki-Kinoshita

Download or read book A Practical Guide to Using Glycomics Databases written by Kiyoko F. Aoki-Kinoshita and published by Springer. This book was released on 2016-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides glycoscientists with a handbook of useful databases that can be applied to glycoscience research. Although many databases are now publicly available, one of the hurdles for their users is the learning curve required to effectively utilize those databases. Therefore, this book not only describes the existing databases, but also provides tips on how to obtain the target data. That is, because many databases provide a variety of data that could be obtained from different perspectives, each chapter provides users with potential biological questions that can be answered by a particular database and step-by-step instructions, with figures, on how to obtain that data. Troubleshooting tips are also provided to aid users encountering problems that can be predicted when using these databases. Moreover, contact information for each database is provided in case unexpected issues arise.

Glycomics

Author : Nicolle H. Packer
Publisher : Humana Press
ISBN 13 : 9781617377693
Total Pages : 0 pages
Book Rating : 4.3/5 (776 download)

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Book Synopsis Glycomics by : Nicolle H. Packer

Download or read book Glycomics written by Nicolle H. Packer and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the significant contributions of carbohydrates to the functional diversity of the cell, the challenging study of the glycome has expanded beyond the research of carbohydrate experts and into the wider scope of the life sciences. To aid all scientists now delving into this vital subject area, Glycomics: Methods and Protocols collects a compendium of detailed laboratory protocols reflecting the increasing availability of sample preparation, chromatographic, electrophoretic, mass spectrometric, and bioinformatic tools specifically designed for the analysis of glycosylation. Leading researchers in the field address subjects such as glycoprotein and proteoglycan analysis, glycosylation structure determination, as well as various approaches to investigate the interaction between glycans and a variety of carbohydrate-recognizing proteins in order to aid exploration into the functional significance of the oligosaccharides. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycomics: Methods and Protocols serves as a valuable guide for experimenters facing the challenges of glycan analysis in hope of providing further insights into the biology of cell-cell communication and interaction.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Handbook of Glycosyltransferases and Related Genes

Author : Naoyuki Taniguchi
Publisher : Springer Science & Business Media
ISBN 13 : 4431678778
Total Pages : 668 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Handbook of Glycosyltransferases and Related Genes by : Naoyuki Taniguchi

Download or read book Handbook of Glycosyltransferases and Related Genes written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Functional Glycomics

Author :
Publisher : Academic Press
ISBN 13 : 9780123809988
Total Pages : 496 pages
Book Rating : 4.8/5 (99 download)

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Book Synopsis Functional Glycomics by :

Download or read book Functional Glycomics written by and published by Academic Press. This book was released on 2010-10-25 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry

Glycomics

Author : Minoru Fukuda
Publisher : Elsevier
ISBN 13 : 0080549454
Total Pages : 461 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Glycomics by : Minoru Fukuda

Download or read book Glycomics written by Minoru Fukuda and published by Elsevier. This book was released on 2006-11-13 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the second of three in the Methods in Enzymology series, including Glycobiology (vol. 415) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.

Functional Glycomics

Author : Jianjun Li
Publisher : Humana
ISBN 13 : 9781493956975
Total Pages : 284 pages
Book Rating : 4.9/5 (569 download)

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Book Synopsis Functional Glycomics by : Jianjun Li

Download or read book Functional Glycomics written by Jianjun Li and published by Humana. This book was released on 2016-08-23 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of functional glycomics requires the continuous development of rapid and sensitive methods for the identification of glycan structures and integration to structure-function relationships. In Functional Glycomics: Methods and Protocols, a panel of world-renowned experts provide new developments and emerging glycomics techniques in the form of detailed protocols exploring the fundamental challenges and most cutting-edge novel applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters in this volume present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting key tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Functional Glycomics: Methods and Protocols serves as an ideal reference for scientists working in biochemistry, molecular biology, cell biology, immunology, microbiology, and virology and a guide to appropriate techniques and the design of achievable research plans in this vital field.

Bioinformatics for Glycobiology and Glycomics

Author : Claus-Wilhelm von der Lieth
Publisher : John Wiley & Sons
ISBN 13 : 9780470029602
Total Pages : 494 pages
Book Rating : 4.0/5 (296 download)

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Book Synopsis Bioinformatics for Glycobiology and Glycomics by : Claus-Wilhelm von der Lieth

Download or read book Bioinformatics for Glycobiology and Glycomics written by Claus-Wilhelm von der Lieth and published by John Wiley & Sons. This book was released on 2009-10-01 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Glycobiology

Author : Minoru Fukuda
Publisher : Elsevier
ISBN 13 : 0080468993
Total Pages : 424 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Glycobiology by : Minoru Fukuda

Download or read book Glycobiology written by Minoru Fukuda and published by Elsevier. This book was released on 2006-11-14 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the first of three in the Methods in Enzymology series, including Glycomics (vol. 416) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.

The Collagen Superfamily and Collagenopathies

Author : Florence Ruggiero
Publisher : Springer Nature
ISBN 13 : 3030675920
Total Pages : 343 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis The Collagen Superfamily and Collagenopathies by : Florence Ruggiero

Download or read book The Collagen Superfamily and Collagenopathies written by Florence Ruggiero and published by Springer Nature. This book was released on 2021-05-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as “collagenopathies” that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Sustainable Nanosystems Development, Properties, and Applications

Author : Putz, Mihai V.
Publisher : IGI Global
ISBN 13 : 1522504931
Total Pages : 794 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Sustainable Nanosystems Development, Properties, and Applications by : Putz, Mihai V.

Download or read book Sustainable Nanosystems Development, Properties, and Applications written by Putz, Mihai V. and published by IGI Global. This book was released on 2016-08-01 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global economic demands and population surges have led to dwindling resources and problematic environmental issues. As the climate and its natural resources continue to struggle, it has become necessary to research and employ new forms of sustainable technology to help meet the growing demand. Sustainable Nanosystems Development, Properties, and Applications features emergent research and theoretical concepts in the areas of nanotechnology, photovoltaics, electrochemistry, and materials science, as well as within the physical and environmental sciences. Highlighting progressive approaches and utilization techniques, this publication is a critical reference source for researchers, engineers, students, scientists, and academicians interested in the application of sustainable nanotechnology.

Handbook on Immunosenescence

Author : Tamas Fulop
Publisher : Springer Science & Business Media
ISBN 13 : 1402090633
Total Pages : 1693 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook on Immunosenescence by : Tamas Fulop

Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Glycomics

Author :
Publisher : Academic Press
ISBN 13 : 9780123810021
Total Pages : 664 pages
Book Rating : 4.8/5 (1 download)

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Book Synopsis Glycomics by :

Download or read book Glycomics written by and published by Academic Press. This book was released on 2010-10-25 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry

Handbook of Glycosyltransferases and Related Genes

Author : Naoyuki Taniguchi
Publisher : Springer
ISBN 13 : 9784431542391
Total Pages : 0 pages
Book Rating : 4.5/5 (423 download)

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Book Synopsis Handbook of Glycosyltransferases and Related Genes by : Naoyuki Taniguchi

Download or read book Handbook of Glycosyltransferases and Related Genes written by Naoyuki Taniguchi and published by Springer. This book was released on 2014-03-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook, now in a new, second edition, is an essential resource for scientists with an interest in the role of glycosyltransferases and related genes involved in the biosynthesis of glycoproteins, glycolipids, and proteoglycans. The first edition of the Handbook of Glycosyltransferases and Related Genes, published in 2002, contained descriptions of more than 100 mammalian genes by over 100 scientists who originally isolated and/or cloned these genes. Since then, there has been a growing body of evidence concerning the roles of glycosyltransferases, and additional glycosyltransferases have been identified. Now more than 200 glycosyltransferases have been isolated from mammalian tissue, corresponding to approximately 1–2% of the total human genome. Some have been found to be involved in development and reproduction, signal transduction, cell death, higher nervous functioning, immunity, and other important biological processes. Glycosyltransferases have also been implicated in the development of lifestyle diseases such as diabetes, cancer, chronic obstructive lung disease (COPD), neuromuscular diseases, and infectious diseases. A functional glycomics approach using gene targeting in mice and analytical methods utilizing glycan arrays, lectin arrays, HPLC, and mass spectrometry identified the target glycoprotein(s) on which glycans are attached by the catalytic reaction of glycosyltransferases. Most of the target proteins have been shown to be cell surface membrane proteins such as growth factor receptors and transporters. The three-dimensional structures of some glycosyltransferases have also been characterized, making it possible to classify them into retaining and inverting enzymes. Such structural information is also included in this invaluable new edition.

MALDI MS

Author : Franz Hillenkamp
Publisher : John Wiley & Sons
ISBN 13 : 3527333312
Total Pages : 0 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis MALDI MS by : Franz Hillenkamp

Download or read book MALDI MS written by Franz Hillenkamp and published by John Wiley & Sons. This book was released on 2013-12-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

The Handbook of Biomarkers

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1607616858
Total Pages : 492 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis The Handbook of Biomarkers by : Kewal K. Jain

Download or read book The Handbook of Biomarkers written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2010-02-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.