Guide To Paediatric Clinical Research

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Guide to Paediatric Clinical Research

Author : Klaus Rose
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805582013
Total Pages : 164 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Guide to Paediatric Clinical Research by : Klaus Rose

Download or read book Guide to Paediatric Clinical Research written by Klaus Rose and published by Karger Medical and Scientific Publishers. This book was released on 2007 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: As off-label use of medicines in children is no longer acceptable today, paediatric drug development is currently in transition from an almost exclusive academic specialty towards an integrated part of the global process that drives the development of new pharmaceuticals. US and EU governments have made it mandatory for the pharmaceutical industry to investigate medicines in children, thus exposing a multitude of different institutions to paediatric research. Written by exponents of the academia as well as the pharmaceutical industry, regulators and patient advocacy groups, this book explains the background of the US and EU paediatric legislations, gives an analysis of their probable short-, mid- and long-term impact, addresses key operational challenges in paediatric research, and develops a tentative vision where paediatric drug development needs to go. Helping to understand the role of the different stakeholders, the spectrum of readers to profit from this book ranges from paediatricians, general medical personnel and pharmacologists to those involved in regulatory affairs and clinical trials, pharmaceutical company management, patient advocacy groups, ethical committees, politicians and interested lay persons.

Guide to Paediatric Drug Development and Clinical Research

Author : Klaus Rose
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805593627
Total Pages : 240 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Guide to Paediatric Drug Development and Clinical Research by : Klaus Rose

Download or read book Guide to Paediatric Drug Development and Clinical Research written by Klaus Rose and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better understanding of how the child's body develops as well as recent legislation in the USA and in Europe, this comprises dosing, ethics, age-appropriate pharmaceutical forms and clinical trials, to name just a few aspects.A wide spectrum of readers will profit from this book, including paediatricians, pharmacists, general practitioners and health care professionals involved in child care and paediatric research, clinical trial personnel, patient advocacy groups, ethics committees, politicians, parents and interested lay persons.

Ethical Conduct of Clinical Research Involving Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309133386
Total Pages : 445 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Ethical Conduct of Clinical Research Involving Children by : Institute of Medicine

Download or read book Ethical Conduct of Clinical Research Involving Children written by Institute of Medicine and published by National Academies Press. This book was released on 2004-07-09 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.

Clinical Research in Paediatric Psychopharmacology

Author : Philippe Auby
Publisher : Elsevier
ISBN 13 : 9781908818607
Total Pages : 0 pages
Book Rating : 4.8/5 (186 download)

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Book Synopsis Clinical Research in Paediatric Psychopharmacology by : Philippe Auby

Download or read book Clinical Research in Paediatric Psychopharmacology written by Philippe Auby and published by Elsevier. This book was released on 2015-01-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical research in pediatric psychopharmacology covers ethical, regulatory, clinical, scientific, intercultural and practical aspects of clinical research in child and adolescent psychopharmacology. Clinical Research in Paediatric Psychopharmacology: A Practical Guide is written and organized with the aim of being a practical guide, providing both an overview of clinical research in pediatric psychopharmacology and practical points to consider when developing clinical research in this field. Covers both theoretical and practical aspects Includes the regulatory framework and the patient perspective Priovides real insight rather than tips

Drug Discovery and Development

Author : Omboon Vallisuta
Publisher : BoD – Books on Demand
ISBN 13 : 9535121286
Total Pages : 332 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Drug Discovery and Development by : Omboon Vallisuta

Download or read book Drug Discovery and Development written by Omboon Vallisuta and published by BoD – Books on Demand. This book was released on 2015-06-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Pediatric Critical Care Study Guide

Author : Steven E. Lucking
Publisher : Springer Science & Business Media
ISBN 13 : 0857299239
Total Pages : 971 pages
Book Rating : 4.8/5 (572 download)

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Book Synopsis Pediatric Critical Care Study Guide by : Steven E. Lucking

Download or read book Pediatric Critical Care Study Guide written by Steven E. Lucking and published by Springer Science & Business Media. This book was released on 2012-04-10 with total page 971 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive study guide covering all aspects of pediatric critical care medicine. It fills a void that exists in learning resources currently available to pediatric critical care practitioners. The major textbooks are excellent references, but do not allow concise reading on specific topics and are not intended to act as both text and study guide. There are also several handbooks available, but these are usually written for general pediatric residents and lack the advanced physiology and pathophysiology required for the higher level pediatric critical care practitioner

Safe and Effective Medicines for Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309225493
Total Pages : 432 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Safe and Effective Medicines for Children by : Institute of Medicine

Download or read book Safe and Effective Medicines for Children written by Institute of Medicine and published by National Academies Press. This book was released on 2012-10-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

Unofficial Guide to Paediatrics

Author : Zeshan Qureshi
Publisher : Elsevier Health Sciences
ISBN 13 : 9780957149953
Total Pages : 0 pages
Book Rating : 4.1/5 (499 download)

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Book Synopsis Unofficial Guide to Paediatrics by : Zeshan Qureshi

Download or read book Unofficial Guide to Paediatrics written by Zeshan Qureshi and published by Elsevier Health Sciences. This book was released on 2017-05-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Unofficial Guide to Paediatrics is unique in that it is the only textbook that covers core subject summaries, examination practice, practical skills, career opportunities and clinical cases all in one place. It does this through 1000+ color images and illustrations, 200+ multiple choice questions, and 60+ real life clinical cases to bring paediatrics to life. The contributors range from Professors of Paediatrics, to medical students, to teachers, nurses, and midwifes, meaning the book has influences from a truly multidisciplinary team at all stages of training. This book has relevance beyond examinations, for post graduate further education and as a day-to-day reference for professionals. With extensive collaboration from renowned academics and specialists, the content is reliable and based on up-to-date evidence.

Pediatric Board Study Guide

Author : Osama Naga
Publisher : Springer
ISBN 13 : 3319101153
Total Pages : 614 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Pediatric Board Study Guide by : Osama Naga

Download or read book Pediatric Board Study Guide written by Osama Naga and published by Springer. This book was released on 2015-03-27 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the most frequently asked and tested points on the pediatric board exam. Each chapter offers a quick review of specific diseases and conditions clinicians need to know during the patient encounter. Easy-to-use and comprehensive, clinicians will find this guide to be the ideal final resource needed before taking the pediatric board exam.

The Science of Paediatrics: MRCPCH Mastercourse

Author : Tom Lissauer
Publisher : Elsevier Health Sciences
ISBN 13 : 0702066125
Total Pages : 874 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis The Science of Paediatrics: MRCPCH Mastercourse by : Tom Lissauer

Download or read book The Science of Paediatrics: MRCPCH Mastercourse written by Tom Lissauer and published by Elsevier Health Sciences. This book was released on 2016-03-21 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is “innovative and original in assisting the reader to apply the principles of science to paediatric practice . Professor Neena Modi, President, Royal College of Paediatrics and Child Health. The Science of Paediatrics, MRCPCH Mastercourse, provides essential background preparation for the MRCPCH Theory and Science examination. It contains an up-to-date review of the application of science to everyday paediatric clinical practice, whether it is interpreting clinical signs or investigations, prescribing drugs or identifying best management. Although this understanding is essential in order to make informed clinical decisions, it is diffi cult to obtain as it is not usually covered in clinical textbooks. Key features • MRCPCH exam-format questions embedded in each chapter to test understanding • Emphasis on embryology to explain many congenital abnormalities • An overview of the relevant anatomy and physiology • Focus on the application and interpretation of investigations • Examples of recent advances in science and clinical research that have benefi tted the children’s care • All clinical specialties covered by paediatric specialists. • Chapters covering evidence-based paediatrics, statistics, ethics and quality improvement.

Clinical Guide to Paediatrics

Author : Rachel Varughese
Publisher : John Wiley & Sons
ISBN 13 : 1119539110
Total Pages : 626 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Clinical Guide to Paediatrics by : Rachel Varughese

Download or read book Clinical Guide to Paediatrics written by Rachel Varughese and published by John Wiley & Sons. This book was released on 2022-07-25 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Guide to Paediatrics enables rapid reference to the common paediatric conditions, symptoms, and practical concerns seen in day-to-day practice. Focused on making differential diagnoses in acute settings, this comprehensive resource offers step-by-step guidance on clinical decision-making, investigations, and interventions. Junior doctors and medical students are provided with a clear and up-to-date evidence base supported by numerous diagnostic algorithms, diagrams, tables and bullet points throughout. Organised into systems-based sections, the guide covers paediatric history taking, examination techniques, pharmacology, safeguarding, and a range of different diagnoses for presenting complaints in cardiology, infection and immunology, neurology, gastroenterology, accidents, poisoning, and more. Succinct chapters are logically structured to allow easy access to important concepts, key clinical details, and plans of investigation. Designed to complement the doctor-patient interaction in clinical practice, this valuable guide: Covers the most common presenting complaints encountered in acute paediatrics Provides evidence-based information on symptoms, disorders, and issues faced in paediatric medicine Addresses topics from the perspective of presenting complaints to provide a unique, highly practical approach to the subject Includes access to a companion website containing images and clinical photos, audio podcasts, clinical case studies, and self-assessment exercises Clinical Guide to Paediatrics is essential reading for junior doctors, medical students, nurses and specialist trainees working on paediatric wards or emergency departments.

IAP Clinical Examination in Pediatrics

Author : Baldev Prajapati
Publisher : Jaypee Brothers Medical Publishers
ISBN 13 : 9389776376
Total Pages : 539 pages
Book Rating : 4.3/5 (897 download)

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Book Synopsis IAP Clinical Examination in Pediatrics by : Baldev Prajapati

Download or read book IAP Clinical Examination in Pediatrics written by Baldev Prajapati and published by Jaypee Brothers Medical Publishers. This book was released on 2021-01-31 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate diagnosis of paediatric illness is, at times, more challenging than diagnosis of adult illness because children, especially those of a very young age, are often unable to describe or illustrate their symptoms. This book is a practical guide to clinical examination of children for diagnosis of diseases and disorders. Beginning with an introduction to communication skills with both children and their parents, the next chapters discuss the importance of history taking and offer guidance on general physical examination techniques. The following sections cover more specific examination for each system of the body – respiratory, nervous, gastrointestinal, musculoskeletal, eyes, skin and more. The book concludes with discussion on ethical and legal matters, diagnosis of death, and common procedures in paediatrics. Clinical photographs, illustrations and tables for quick and easy reference, further enhance the comprehensive text. Key points Comprehensive guide to paediatric clinical examination techniques Emphasis on importance of communication skills and accurate history taking Covers all systems of the body Highly illustrated with clinical photographs, diagrams and tables

Essential Clinical Skills in Pediatrics

Author : Anwar Qais Saadoon
Publisher : Springer
ISBN 13 : 3319924265
Total Pages : 237 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Essential Clinical Skills in Pediatrics by : Anwar Qais Saadoon

Download or read book Essential Clinical Skills in Pediatrics written by Anwar Qais Saadoon and published by Springer. This book was released on 2018-09-03 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise learning guide dedicated to the full scope of pediatric history-taking and clinical examination, for use in OSCEs as well as clinical life. It guides the reader simply and methodically through what to ask when taking a history, and how to perform a comprehensive physical examination. The book contains more than 30 “History Stations” covering the most common pediatric cases, as well as 10 “Examination Stations” covering examinations of the different body system. It provides students and resident doctors worldwide with the necessary core information for pediatric history-taking and clinical examination, all in a brief and interesting format. The book adopts a reader-friendly format through a lecture-note style and the use of Key Points, Clinical Tips, Notes, Tables, and Boxes listing the most important features. It is also richly illustrated, demonstrating the correct way to perform clinical examinations. Written “by a resident, for residents and medical students,” this book has been revised, foreworded, and peer-reviewed by fourteen prominent authorities in the field of Pediatrics from various parts of the world (including the United States, United Kingdom, Australia, Italy, Canada, and India), and from different universities (Illinois, Pennsylvania, Washington, Oxford, Edinburgh, Keele, Melbourne, Toronto, Parma, and Florence Universities). These experts recommend this book for medical students, pediatric residents, and pediatric practitioners, as well as pediatricians.

Ethical Conduct of Clinical Research Involving Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309091810
Total Pages : 446 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Ethical Conduct of Clinical Research Involving Children by : Institute of Medicine

Download or read book Ethical Conduct of Clinical Research Involving Children written by Institute of Medicine and published by National Academies Press. This book was released on 2004-08-09 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.

Pediatric Formulations

Author : Daniel Bar-Shalom
Publisher : Springer Science & Business Media
ISBN 13 : 1489980113
Total Pages : 429 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Pediatric Formulations by : Daniel Bar-Shalom

Download or read book Pediatric Formulations written by Daniel Bar-Shalom and published by Springer Science & Business Media. This book was released on 2014-01-30 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.

The Management of Clinical Trials

Author : Hesham Abdeldayem
Publisher : BoD – Books on Demand
ISBN 13 : 1789232384
Total Pages : 91 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis The Management of Clinical Trials by : Hesham Abdeldayem

Download or read book The Management of Clinical Trials written by Hesham Abdeldayem and published by BoD – Books on Demand. This book was released on 2018-06-06 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise book is addressed to researchers, clinical investigators, as well as practicing physicians and surgeons who are interested in the fields of clinical research and trials. It covers some important topics related to clinical trials including an introduction to clinical trials, some aspects concerning clinical trials in pediatric age group, and the unique aspects of the design of clinical trials on stem cell therapy.

Paediatric Parenteral Nutrition

Author : Kathrin Krohn
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 380558606X
Total Pages : 71 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Paediatric Parenteral Nutrition by : Kathrin Krohn

Download or read book Paediatric Parenteral Nutrition written by Kathrin Krohn and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parenteral nutrition in general is required if nutritional needs cannot be met by oral or enteral feeding. In the paediatric patient, its initiation depends both on individual circumstances and the age and size of the infant or child. This compact reference work on parenteral nutrition in children is based on the 'Guidelines for Paediatric Parenteral Nutrition' that have been developed jointly by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), in collaboration with the European Society for Paediatric Research (ESPR).These guidelines were based on systematic literature reviews as well as a formal consensus process of a multidisciplinary panel of professionals. However, as a result of the scarcity of good quality clinical trials in children, many of the recommendations were extrapolated from adult studies and based on expert opinion. A detailed analysis of the available data was performed, and for each statement, the level of evidence and grade of recommendation was assessed. This reference guide has been conceived as an aid for the treating physician to assist him in the decision process, thus being a valuable companion in clinical practice.