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Author : J. M. Parry
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (166 download)
Download or read book Guidance on a Strategy for Testing of Chemicals for Mutagenicity written by J. M. Parry and published by . This book was released on 2000 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ashutosh Kumar
Publisher : Academic Press
ISBN 13 : 0128092602
Total Pages : 352 pages
Book Rating : 4.1/5 (28 download)
Download or read book Mutagenicity: Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Author : Great Britain. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.F/5 ( download)
Download or read book Guidelines for the Testing of Chemicals for Mutagenicity written by Great Britain. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment and published by . This book was released on 1989 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : DNH & W/DOE Environmental Contaminants Advisory Committee on Mutagenesis (Canada)
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.E/5 ( download)
Download or read book Guidelines on the Use of Mutagenicity Tests in the Toxicological Evaluation of Chemicals written by DNH & W/DOE Environmental Contaminants Advisory Committee on Mutagenesis (Canada) and published by . This book was released on 1986 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David J. Kirkland
Publisher : Cambridge University Press
ISBN 13 : 9780521450737
Total Pages : 176 pages
Book Rating : 4.4/5 (57 download)
Download or read book Supplementary Mutagenicity Tests written by David J. Kirkland and published by Cambridge University Press. This book was released on 1993-11-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1993, this volume describes a complementary selection of tests to those described in the companion volume Basic Mutagenicity Tests (Cambridge University Press, 1990). These supplementary tests were used to assess risks of in vitro mutagenicity in those instances where the basic tests were inconclusive. As such, these tests had an important role in the assessment of the safety of compounds, drugs and chemicals. These supplementary test and guidelines, originally drawn up by the United Kingdom Environmental Mutagen Society (UKEMS) were fully revised in this publication to take full account of different regulatory guidelines and scientific advances. This volume will be of value to anyone with aninterest in regulatory affairs, mutagenicity testing and the registration of chemical products in the UK and Europe.
Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 1461589665
Total Pages : 410 pages
Book Rating : 4.4/5 (615 download)
Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: As editor I want especially to thank Dr. Ernst Freese for helpful co operation in preparing these volumes, and to express my appreclatlOn to Drs. Kurt Hirschhorn and Marvin Legator, the other members of the editorial board. Alexander Hollaender January 1971 Preface The purpose of these volumes is to encourage the development and ap plication of testing and monitoring procedures to avert significant human exposure to mutagenic agents. The need for protection against exposure to possibly mutagenic chemicals is only now coming to be generally realized. The recently issued Report of the Secretary's Commission on Pesticides and Their Possible Effects on Health (the Mrak Report-U.S. Department of Health, Education and Welfare, December 1969) has made an important start. Its Panel on Mutagenicity recommends that all currently used pesticides be tested for mutagenicity in several recently developed and relatively simple systems. Whether recommendations such as these are actually put into effect will depend on convincing government, industry, and the public that the problem is important, that the proposed tests would be effective, and that they can be conducted at a cost that is not prohibitive. Why is it important to screen environmental agents for mutagenic activity? To those who will read this book, the answer is self-evident. The sine qua non of all that we value and all that we are is our genetic heritage.
Author :
Publisher :
ISBN 13 : 9789282700815
Total Pages : 0 pages
Book Rating : 4.7/5 (8 download)
Download or read book Methods and Testing Strategies for Evaluating the Genotoxic Properties of Chemicals written by and published by . This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this document, current methods and testing strategies for evaluating the genotoxic effects of chemicals are reviewed. Following an overview of both somatic and germ cell mutagenesis, model organisms and tests in current use are described. Correlations of short-term tests with carcinogenicity and germ cell mutagenicy data are assessed and the two main genotoxicity testing strategies - the tier approach and the battery approach - are described. Guidelines currently recommended at international (CEC and OECD), national (the UK, Italy, Japan, Canada, and the U.S.A.), and industry (European Chemical Industry Ecology and Toxicology Centre) levels are described. It is concluded that, given technological progress, there is scope for improvement of current practices and methodologies. Recommendations for future research and development are given both for in vitro and in vivo genotoxicity tests and for ecosystems and environmental compartments. -- Summary.
Author : Andrew Teasdale
Publisher : John Wiley & Sons
ISBN 13 : 1119551218
Total Pages : 548 pages
Book Rating : 4.1/5 (195 download)
Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Author : Great Britain. Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment
Publisher :
ISBN 13 :
Total Pages : 74 pages
Book Rating : 4.:/5 ( download)
Download or read book Guidelines for the Testing of Chemicals for Toxicity written by Great Britain. Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment and published by . This book was released on 1982 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alok Dhawan
Publisher : Humana Press
ISBN 13 : 9781627035286
Total Pages : 0 pages
Book Rating : 4.0/5 (352 download)
Download or read book Genotoxicity Assessment written by Alok Dhawan and published by Humana Press. This book was released on 2013-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264243178
Total Pages : 13 pages
Book Rating : 4.2/5 (642 download)
Download or read book Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Author : David J. Kirkland
Publisher : Cambridge University Press
ISBN 13 : 9780521116961
Total Pages : 178 pages
Book Rating : 4.1/5 (169 download)
Download or read book Supplementary Mutagenicity Tests written by David J. Kirkland and published by Cambridge University Press. This book was released on 2011-06-09 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1993, this volume describes a complementary selection of tests to those described in the companion volume Basic Mutagenicity Tests (Cambridge University Press, 1990). These supplementary tests were used to assess risks of in vitro mutagenicity in those instances where the basic tests were inconclusive. As such, these tests had an important role in the assessment of the safety of compounds, drugs and chemicals. These supplementary test and guidelines, originally drawn up by the United Kingdom Environmental Mutagen Society (UKEMS) were fully revised in this publication to take full account of different regulatory guidelines and scientific advances. This volume will be of value to anyone with aninterest in regulatory affairs, mutagenicity testing and the registration of chemical products in the UK and Europe.
Author : Canada. Environmental Contaminants Advisory Committee on Mutagenesis
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.:/5 (427 download)
Download or read book Guidelines on the Use of Mutagenicity Tests in the Toxicological Evaluation of Chemicals written by Canada. Environmental Contaminants Advisory Committee on Mutagenesis and published by . This book was released on 1986 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : World Health Organization WHO.
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)
Download or read book Guide to short-term tests for detecting mutagenic and carcinogenic chemicals written by World Health Organization WHO. and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Canada. Health Protection Branch
Publisher :
ISBN 13 : 9780662206248
Total Pages : 23 pages
Book Rating : 4.2/5 (62 download)
Download or read book The Assessment of Mutagenicity written by Canada. Health Protection Branch and published by . This book was released on 1993-01-01 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Health Protection Branch (HPB) Executive Committee established the Branch Genotoxicity Committee to develop recommendations on a branch-wide approach to the use of genotoxicity test results in toxicological assessment. This report, endorsed by the HPB Executive Committee, addresses the mandate under seven headings, namely: genotoxicity tests; mutagenicity testing strategy; genotoxicity tests as predictors of carcinogenicity; germ cell and somatic cell mutation; validation of genotoxicity tests; and, epidemiological extension of the regulatory process.
Author : Organisation for Economic Co-operation and Development
Publisher : Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN 13 : 9789264122215
Total Pages : pages
Book Rating : 4.1/5 (222 download)
Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Institute for Occupational Safety and Health. Division of Criteria Documentation and Standards Development
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (319 download)
Download or read book Occupational Exposure to Allyl Chloride written by National Institute for Occupational Safety and Health. Division of Criteria Documentation and Standards Development and published by . This book was released on 1977 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
