Growth Factors And Cytokines In Skeletal Muscle Development Growth Regeneration And Disease

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Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease

Author : Jason White
Publisher : Springer
ISBN 13 : 3319275119
Total Pages : 197 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease by : Jason White

Download or read book Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease written by Jason White and published by Springer. This book was released on 2016-03-22 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.

Skeletal Muscle Repair and Regeneration

Author : Stefano Schiaffino
Publisher : Springer Science & Business Media
ISBN 13 : 1402067682
Total Pages : 385 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Skeletal Muscle Repair and Regeneration by : Stefano Schiaffino

Download or read book Skeletal Muscle Repair and Regeneration written by Stefano Schiaffino and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. It provides up-to-date coverage and presents a broad range of topics.

The Role of Growth Factors in Skeletal Muscle Regeneration

Author : John Basil Kurek
Publisher :
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.:/5 (221 download)

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Book Synopsis The Role of Growth Factors in Skeletal Muscle Regeneration by : John Basil Kurek

Download or read book The Role of Growth Factors in Skeletal Muscle Regeneration written by John Basil Kurek and published by . This book was released on 1996 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Author : Pura Muñoz-Cánoves
Publisher : Frontiers Media SA
ISBN 13 : 2889198669
Total Pages : 222 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease by : Pura Muñoz-Cánoves

Download or read book Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease written by Pura Muñoz-Cánoves and published by Frontiers Media SA. This book was released on 2016-06-29 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.

Non-viral Gene Transfer of Growth Factors in Skeletal Muscle

Author : Jonathan David Schertzer
Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.:/5 (225 download)

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Book Synopsis Non-viral Gene Transfer of Growth Factors in Skeletal Muscle by : Jonathan David Schertzer

Download or read book Non-viral Gene Transfer of Growth Factors in Skeletal Muscle written by Jonathan David Schertzer and published by . This book was released on 2006 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Growth Factors, Differentiation Factors, and Cytokines

Author : Andreas Habenicht
Publisher : Springer Science & Business Media
ISBN 13 : 3642748562
Total Pages : 484 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Growth Factors, Differentiation Factors, and Cytokines by : Andreas Habenicht

Download or read book Growth Factors, Differentiation Factors, and Cytokines written by Andreas Habenicht and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading international experts contribute to this selection of reviews covering the merging fields of growth factors, differentiation factors, and cytokines. These appear to play fundamental roles in a wide variety of physiological and pathophysiological processes that include the regulation of growth in normal and malignant cells, embryogenesis, the immune response, wound healing, inflammation, and atherogenesis. The major aspects of recent research and development are discussed, providing an important update in this pioneering field.

Skeletal Muscle Plasticity in Health and Disease

Author : Roberto Bottinelli
Publisher : Springer Science & Business Media
ISBN 13 : 1402051778
Total Pages : 372 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Skeletal Muscle Plasticity in Health and Disease by : Roberto Bottinelli

Download or read book Skeletal Muscle Plasticity in Health and Disease written by Roberto Bottinelli and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes and mechanisms which form the background of muscle adaptation. This book aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.

The Role of Transforming Growth Factor Beta-extracellular Matrix Signaling in Skeletal Muscle Growth and Development

Author : Xuehui Li
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 (263 download)

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Book Synopsis The Role of Transforming Growth Factor Beta-extracellular Matrix Signaling in Skeletal Muscle Growth and Development by : Xuehui Li

Download or read book The Role of Transforming Growth Factor Beta-extracellular Matrix Signaling in Skeletal Muscle Growth and Development written by Xuehui Li and published by . This book was released on 2008 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Muscle development is a highly organized process, regulated by interactions between muscle cells and their extracellular matrix (ECM) environment. The ECM through its regulation of growth factors plays a pivotal role in muscle growth and development. Transforming growth factor-[beta]1 (TGF-[beta]1) is a potent inhibitor of muscle cell proliferation and differentiation. Decorin, one of components in the ECM, binds to TGF-[beta]1 and modulates muscle cell responsiveness to TGF-[beta]1. The TGF-[beta]1 signal is carried by Smad proteins into the cell nucleus, resulting in an inhibition of the expression of certain myogenic regulatory factors. In addition, TGF-[beta]1 affects expression of cell [beta]1 integrin adhesion receptor that is involved in cell adhesion and survival. However, the mechanism by which these factors interact and the signaling pathway is largely unknown. To address this mechanism, both in vitro and in vivo studies were preformed. In vitro studies showed that TGF-[beta]1 reduced both decorin and [beta]1 integrin expression, and altered the localization of [beta]1 integrin in satellite cells. Decorin plays a negative role in the TGF-[beta]1-dependent signaling pathway in terms of inhibiting satellite cell responsiveness to TGF-[beta]1, resulting in enhanced cell proliferation and differentiation. Decreased expression of [beta]1 integrin is likely involved in the programmed cell death or apoptotic effect of TGF-[beta]1 on muscle cells through regulating focal adhesion kinase signaling pathway. The expression of myogenic regulatory factors, MyoD and myogenin, was inhibited by TGF-[beta]1 through Smad3-mediated pathway, resulting in decreased satellite cell proliferation and differentiation. In vivo studies investigated the function of TGF-[beta]1 on the expression and localization of [beta]1 integrin and decorin during muscle formation by injection of TGF-[beta]1 into the developing chicken embryo. In addition, the muscle cells from Low Score Normal (LSN) chicken, genetic muscle weakness, showed a different cellular responsiveness to TGF-[beta]1 compared to the normal, which suggests a complex mechanism involved in the LSN condition. This study provides new information on the role of the TGF-[beta]1-ECM signaling pathway in muscle growth and development, which will not only be critical to the domestic animal industries, but also benefit human health in terms of the repair and regeneration of muscle with age.

Growth Factor and Steroid Regulation of Skeletal Muscle Growth and Development

Author : Randall Scott Frey
Publisher :
ISBN 13 :
Total Pages : 550 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Growth Factor and Steroid Regulation of Skeletal Muscle Growth and Development by : Randall Scott Frey

Download or read book Growth Factor and Steroid Regulation of Skeletal Muscle Growth and Development written by Randall Scott Frey and published by . This book was released on 1994 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Muscle Atrophy

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811314357
Total Pages : 618 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Muscle Atrophy by : Junjie Xiao

Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Muscle Regeneration

Author : Alexander Mauro
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Muscle Regeneration by : Alexander Mauro

Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Influence of Insulin-like Growth Factor-I on Skeletal Muscle Regeneration

Author : David Wayne Hammers
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (828 download)

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Book Synopsis Influence of Insulin-like Growth Factor-I on Skeletal Muscle Regeneration by : David Wayne Hammers

Download or read book Influence of Insulin-like Growth Factor-I on Skeletal Muscle Regeneration written by David Wayne Hammers and published by . This book was released on 2012 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle regeneration involves a tightly regulated coordination of cellular and signaling events to remodel and repair the site of injury. When this coordination is perturbed, the regenerative process is impaired. The expression of insulin-like growth factor-I (IGF-I) is robust in the typical muscle regenerative program, promoting cell survival and increasing myoblast activity. In this project, we found that severely depressed IGF-I expression and intracellular signaling in aged skeletal muscle coincided with impaired regeneration from ischemia/reperfusion (I/R). To hasten muscle regeneration, we developed the PEGylated fibrin gel (PEG-Fib) system as a means to intramuscularly deliver IGF-I in a controlled manner to injured muscle. This strategy resulted in greatly improved muscle function and histological assessment following 14 days of reperfusion, which are likely mediated by improved myofiber survival. Recent evidence suggests macrophages (MPs) are responsible for the upregulation of IGF-I following injury, therefore we developed a rapid, reproducible, and cost-effective model of investigating MP profiles in injured muscle via flow cytometry. Using information gathered from this model, we found that increasing the number of a non-inflammatory MP population improves the recovery of muscle from I/R. These data demonstrate that immunomodulatory therapies have the potential to greatly improve the recovery of skeletal muscle from injury.

The Role of Growth Factors in the Regeneration of Skeletal Muscle

Author : Sondra Powers Kirk
Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.:/5 (155 download)

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Book Synopsis The Role of Growth Factors in the Regeneration of Skeletal Muscle by : Sondra Powers Kirk

Download or read book The Role of Growth Factors in the Regeneration of Skeletal Muscle written by Sondra Powers Kirk and published by . This book was released on 2001 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insulin-Like Growth Factors in Development, Cancers and Aging

Author : Haim Werner
Publisher : MDPI
ISBN 13 : 3036507701
Total Pages : 196 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Insulin-Like Growth Factors in Development, Cancers and Aging by : Haim Werner

Download or read book Insulin-Like Growth Factors in Development, Cancers and Aging written by Haim Werner and published by MDPI. This book was released on 2021-08-30 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.

Peptide Growth Factors in the Regeneration of Skeletal Muscle

Author : Niels Robert Dugan
Publisher :
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.:/5 (429 download)

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Book Synopsis Peptide Growth Factors in the Regeneration of Skeletal Muscle by : Niels Robert Dugan

Download or read book Peptide Growth Factors in the Regeneration of Skeletal Muscle written by Niels Robert Dugan and published by . This book was released on 1990 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease by :

Download or read book Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.

The Role of Satellite Cells in Skeletal Muscle Revascularization: A Potential Factor in Muscular Dystrophy

Author :
Publisher :
ISBN 13 :
Total Pages : 370 pages
Book Rating : 4.:/5 (659 download)

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Book Synopsis The Role of Satellite Cells in Skeletal Muscle Revascularization: A Potential Factor in Muscular Dystrophy by :

Download or read book The Role of Satellite Cells in Skeletal Muscle Revascularization: A Potential Factor in Muscular Dystrophy written by and published by . This book was released on 2009 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle regeneration is a multifaceted process requiring the spatial and temporal coordination of myogenesis as well as angiogenesis. While these processes are often studied independently, recent evidence from our lab has shown that the resident adult stem cell population within skeletal muscle, called satellite cells, begins secreting soluble growth factors likely to contribute to the proangiogenic response. The overall aim of this study is to investigate the role of pro-angiogenic factors secreted by satellite cells during skeletal muscle regeneration. Results from the study indicate that Hepatocyte Growth Factor (HGF) is a critical protein for the proangiogenic effect of satellite cells. It was also shown that in hypoxic environments, such as those seen in an injury state, it appears that satellite cells decrease their proangiogenic effect if oxygen levels fall below a threshold level. This decrease in pro-angiogenic effect in the hypoxic environment appears to be due to the decrease in HGF expression and protein secretion and is not compensated for by the increase in Vascular Endothelial Growth Factor secretion also seen in the hypoxic response. Furthermore, the regulation of HGF in these hypoxic conditions appears to be in part due to increased levels of hypoxia inducible factor, which are acting on the hypoxia response element site found on the HGF promoter. In the last set of experiments, this injury response was further investigated as the effect of satellite cell mediated angiogenesis was examined in the disease state of muscular dystrophy. Here, we also observed a reduction in angiogenesis from media conditioned by satellite cells from dystrophic muscle compared to healthy muscle. Overall, this study further strengthens the case for satellite cells as important mediators of the angiogenic response in regenerating muscle and may serve as a potential site for therapeutic intervention in the future.