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Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeffrey Alan Johnson
Publisher :
ISBN 13 :
Total Pages : 534 pages
Book Rating : 4.:/5 (89 download)
Download or read book Glutathione S-transferase Isoenzymes written by Jeffrey Alan Johnson and published by . This book was released on 1992 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas G. Pretlow
Publisher : Academic Press
ISBN 13 : 1483282058
Total Pages : 457 pages
Book Rating : 4.4/5 (832 download)
Download or read book Biochemical and Molecular Aspects of Selected Cancers written by Thomas G. Pretlow and published by Academic Press. This book was released on 2014-05-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.
Author :
Publisher :
ISBN 13 :
Total Pages : 1684 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 1684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Leopold Flohe
Publisher : CRC Press
ISBN 13 : 1351261746
Total Pages : 642 pages
Book Rating : 4.3/5 (512 download)
Download or read book Glutathione written by Leopold Flohe and published by CRC Press. This book was released on 2018-08-29 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
Author : Paul V. Woolley
Publisher : Elsevier
ISBN 13 : 1483220753
Total Pages : 417 pages
Book Rating : 4.4/5 (832 download)
Download or read book Mechanisms of Drug Resistance in Neoplastic Cells written by Paul V. Woolley and published by Elsevier. This book was released on 2013-10-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Author : Hildegard M. Schuller
Publisher : CRC Press
ISBN 13 : 9780849356629
Total Pages : 218 pages
Book Rating : 4.3/5 (566 download)
Download or read book Comparitive Ultrastructural Pathology of Selected Tumors in Man and Animals written by Hildegard M. Schuller and published by CRC Press. This book was released on 1989-08-31 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains comprehensive information on the morphology of tumors in the lungs, liver, pancreas, kidneys, and disperse neuroendocrine system of man and the most commonly used laboratory rodents. It serves as an indispensable reference for cancer researchers, diagnostic pathologists, and readers who are interested in the comparative as-pects of tumor pathology and car-cinogenesis.
Author : A. Columbano
Publisher : Springer Science & Business Media
ISBN 13 : 1461536944
Total Pages : 632 pages
Book Rating : 4.4/5 (615 download)
Download or read book Chemical Carcinogenesis 2 written by A. Columbano and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: "chemical carcinogenesis" is the general title of the series of international meetings which are held, biannually, in sardinia (Italy) since 1981. Despite the generality of the title, the main effort of the scientific Committee has been to pursue a coherent line around one of the most distinguishing features of carcinogenesis: the "multifasic" development of the process. Given that many chemical compounds are known to cause "experimental cancer", many questions still remain unresolved or are given too simplistic answers. The very first question concerning the interaction between the chemical carcinogen and the molecular target in the cell is a debatable one despite the overwhelming literature in this field. It is certain that chemical carcinogens are toxic to cells and cause DNA damage: however it is still an open question as to how to relate these changes to the different stages of carcinogenesis including initiation. We have not to forget that 1/3 to 2/3 of the average life time of a given species elapses between the experimental administration of the carcinogen and the appearance of "cancer". The experimental manipulation of carcinogenesis through the use of "adequate biological models" has not simplified the problems about cancer, but it has led us to face the complexity of otherwise elementary biological properties, cell proliferation and differentiation. The understanding of this biological complexity is not just theoretical, but it may give us those adequate conceptual tools to approach "cancer" also from a medical point of view.
Author : B. V. Rama Sastry
Publisher : CRC Press
ISBN 13 : 9781439805527
Total Pages : 312 pages
Book Rating : 4.8/5 (55 download)
Download or read book Placental Toxicology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1995-02-24 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in
Author : G. Gordon Gibson
Publisher : CRC Press
ISBN 13 : 9780203481516
Total Pages : 756 pages
Book Rating : 4.4/5 (815 download)
Download or read book Peroxisomes written by G. Gordon Gibson and published by CRC Press. This book was released on 2013-04-08 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
Author :
Publisher :
ISBN 13 :
Total Pages : 528 pages
Book Rating : 4.3/5 (91 download)
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1988 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jose Vina
Publisher : CRC Press
ISBN 13 : 1351364405
Total Pages : 392 pages
Book Rating : 4.3/5 (513 download)
Download or read book Glutathione (1990) written by Jose Vina and published by CRC Press. This book was released on 2017-11-22 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this important book is to present the reader with developments concerning glutathione research. This work focuses on the synthesis-degradation and oxidation-reduction cycles of glutathione, the physiological functions of glutathione (especially in mammalian cells), and the analytical methods used to accurately measure the glutathione status of cells. This resource addresses specific modification of glutathione metabolism that is of special interest in the treatment of some tumors. This rare volume also introduces some different, new techniques on how to accurately measure glutathione, specifically in its oxidized form. Anyone involved with biochemistry, physiology, toxicology, pharmacology, nutrition and radiation biology will find this publication interesting and filled with useful information. It is also a valuable reference for research scientists in such fields as aging, metabolism disorders, and glutathione research.
Author : F. Cimino
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110846519
Total Pages : 940 pages
Book Rating : 4.1/5 (18 download)
Download or read book Human Tumor Markers written by F. Cimino and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-07-22 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Human Tumor Markers".
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Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Author : Delbert M. Shankel
Publisher : Springer Science & Business Media
ISBN 13 : 1468451820
Total Pages : 573 pages
Book Rating : 4.4/5 (684 download)
Download or read book Antimutagenesis and Anticarcinogenesis Mechanisms written by Delbert M. Shankel and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frederick C. Kauffman
Publisher : Springer Science & Business Media
ISBN 13 : 3642784291
Total Pages : 544 pages
Book Rating : 4.6/5 (427 download)
Download or read book Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Author : William N. Hait
Publisher : Springer Science & Business Media
ISBN 13 : 1461312671
Total Pages : 421 pages
Book Rating : 4.4/5 (613 download)
Download or read book Drug Resistance written by William N. Hait and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.
