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Glucose Sensing Receptor In Pancreatic Beta Cells
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Book Synopsis Glucose-sensing Receptor in Pancreatic Beta-cells by : Itaru Kojima
Download or read book Glucose-sensing Receptor in Pancreatic Beta-cells written by Itaru Kojima and published by Springer. This book was released on 2018-05-31 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.
Book Synopsis Glucose Sensing by : Chris D. Geddes
Download or read book Glucose Sensing written by Chris D. Geddes and published by Springer Science & Business Media. This book was released on 2007-12-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.
Download or read book The Pancreatic Beta Cell written by and published by Academic Press. This book was released on 2014-02-20 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. - Expertise of the contributors - Coverage of a vast array of subjects - In depth current information at the molecular to the clinical levels - Three-dimensional structures in color - Elaborate signaling pathways
Book Synopsis Functional Significance of the Extracelluar Calcium Sensing Receptor on Pancreatic Beta Cells by : Elizabeth Gray
Download or read book Functional Significance of the Extracelluar Calcium Sensing Receptor on Pancreatic Beta Cells written by Elizabeth Gray and published by . This book was released on 2004 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Basis of Pancreas Development and Function by : Joel F. Habener
Download or read book Molecular Basis of Pancreas Development and Function written by Joel F. Habener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.
Book Synopsis Role of Peroxisomal Proliferator-activated Receptor Alpha-linked Functions in Relation to Pancreatic Beta Cell Glucose Sensing and Insulin Secretion by :
Download or read book Role of Peroxisomal Proliferator-activated Receptor Alpha-linked Functions in Relation to Pancreatic Beta Cell Glucose Sensing and Insulin Secretion written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Islets of Langerhans, 2. Ed by : Shahidul Islam
Download or read book Islets of Langerhans, 2. Ed written by Shahidul Islam and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recueil factice d'articles de presse et documents concernant Prosper Joseph Julien Gothi by :
Download or read book Recueil factice d'articles de presse et documents concernant Prosper Joseph Julien Gothi written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Bernhelm Booß-Bavnbek Publisher :Springer Science & Business Media ISBN 13 :144196956X Total Pages :558 pages Book Rating :4.4/5 (419 download)
Download or read book BetaSys written by Bernhelm Booß-Bavnbek and published by Springer Science & Business Media. This book was released on 2011-03-02 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: BetaSys uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.
Book Synopsis Pancreatic Beta Cell in Health and Disease by : Susumu Seino
Download or read book Pancreatic Beta Cell in Health and Disease written by Susumu Seino and published by Springer Science & Business Media. This book was released on 2008-04-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Book Synopsis Sweet Sensing Mechanisma in the Rat Retina by : Jaeyoung Yang
Download or read book Sweet Sensing Mechanisma in the Rat Retina written by Jaeyoung Yang and published by . This book was released on 2011 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucose is the major energy source in most organisms. Glucose level is tightly regulated in the body. Increases in blood glucose can produce a response in pancreatic beta cells that includes an elevation in intracellular free calcium, increased cAMP production, and augmented insulin release (Gerich et al., 1976). There are also glucose sensing neurons in the hypothalamus, which can be divided into Glucose-Excited (GE) or Glucose-Inhibited (GI) based on their firing rate in response to a change in extracellular glucose. These responses depend, respectively, on the closing of a potassium channel or the opening of a chloride channel. In both cases these channels are gated by ATP, and thus indirectly detect glucose by the effects of glucose metabolism on intracellular levels of ATP (Song et al., 2001). In both types of hypothalamic neurons the responses are slow and require large, maintained changes in glucose concentration. In this study we examined whether the nervous system might also possess a receptor based system for detection of extracellular glucose. After the sweet taste receptor (T1R2) was cloned from the tongue, it was suggested that it might be the mediator of responses to extracellular glucose. T1R2 knockout mice are deficient in tasting sweet chemicals such as sucrose, maltose, and saccharin (Zhao et al., 2003). Sweet taste receptor (T1R2) is a member of taste receptor type1 G-protein coupled receptor group consisting of T1R1, T1R2 and T1R3. Functional expression studies in heterologous cells revealed that T1R3 combines with T1R2 to form functional sweet taste receptors (Chandrashekar et al., 2006). It has been reported that sweet taste receptor (T1R2) is expressed in multiple organs such as pancreas, brain, and gut. Artificial sweeteners can induce insulin secretion through T1R2 expressed in pancreatic cells (Nakagawa et al., 2009). Dietary sugar and artificial sweeteners can increase SGLT1 mRNA and protein expression, and glucose absorptive capacity in wild-type mice, but not in knockout mice lacking T1R3 or alpha-gustducin (Margolskee et al., 2007). Food deprivation or low glucose culture media can significantly increase T1R2 expression in brain and in a hypothalamic cell line (Ren et al., 2009). These studies raise the possibility that T1R2 is involved in glucose detection in many different organs. We report that retinal neurons respond to a variety of sweeteners including glucose, aspartame, saccharin, and D-amino acids. We also find that T1R2 mRNA is expressed in retinal neurons. Surprisingly, based on siRNA experiments, T1R2 mediates part of the neuronal response to sacharrin but is not important in the responses to aspartame. We found instead that cellular responses to both glucose and aspartame depend on TRPV1 channels or endocannabinoid receptors. Part of the response to saccharin also depends on the TRPV1 channel. Thus, retinal neurons possess two distinct sweet tastant receptor systems. One involves the canonical T1R2 subunit. The other is an alternate sweet sensing pathway consisting of ionotropic (TRPV1 variant) and metabotropic (CB endocannabinoid) amandamide receptor. This alternate pathway can alter synaptic transmission at the first synapse in the retina.
Book Synopsis Analysis of Theoretical Models Describing in Vitro Oscillations of Insulin Secretion by : Laura B. Maki
Download or read book Analysis of Theoretical Models Describing in Vitro Oscillations of Insulin Secretion written by Laura B. Maki and published by . This book was released on 1994 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nutrient Regulation of Insulin Secretion by : Peter R. Flatt
Download or read book Nutrient Regulation of Insulin Secretion written by Peter R. Flatt and published by Ashgate Publishing. This book was released on 1992 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms of release of insulin in response to the body's intake of nutrients has long been one of the central problems of research into diabetes. This book presents the latest findings on the topic from the leading laboratories in the field.
Book Synopsis Feedback Systems by : Karl Johan Åström
Download or read book Feedback Systems written by Karl Johan Åström and published by Princeton University Press. This book was released on 2021-02-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The essential introduction to the principles and applications of feedback systems—now fully revised and expanded This textbook covers the mathematics needed to model, analyze, and design feedback systems. Now more user-friendly than ever, this revised and expanded edition of Feedback Systems is a one-volume resource for students and researchers in mathematics and engineering. It has applications across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. Features a new chapter on design principles and tools, illustrating the types of problems that can be solved using feedback Includes a new chapter on fundamental limits and new material on the Routh-Hurwitz criterion and root locus plots Provides exercises at the end of every chapter Comes with an electronic solutions manual An ideal textbook for undergraduate and graduate students Indispensable for researchers seeking a self-contained resource on control theory
Book Synopsis Handbook of Diabetes by : Rudy Bilous
Download or read book Handbook of Diabetes written by Rudy Bilous and published by John Wiley & Sons. This book was released on 2021-04-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: HANDBOOK OF DIABETES The Handbook of Diabetes provides concise and efficient coverage of the diagnosis, epidemiology, and management of diabetes and its complications. Containing hundreds of attractive colour diagrams, illustrations, and clinical photographs, this popular quick-reference guide focuses on the management and measurement of diabetes mellitus with highly visual references. Now in its fifth edition, this market-leading book aligns with the most recent guidelines from the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), Diabetes UK, and the National Institute for Health and Care Excellence (NICE), presenting authoritative clinical coverage of diabetes in an accessible format with rich pedagogical features. Five new chapters provide detailed coverage of liver disease, diabetes education, bariatric surgery, diabetes and cancer, and the use of incretin-based therapies and SGLT2 Inhibitors in the management of Type II diabetes Updated and expanded topics include the relation between hypoglycaemia and dementia, anxiety and depression, the NICE Quality and Outcomes Framework (QOF), and the impacts of diabetes to self-care, mental health, and decision-making Provides a wealth of pedagogical features such as vignettes and case histories, important learning points, summaries of key clinical trials, and links to further readings Handbook of Diabetes, remains the essential practical companion for all health professionals involved in managing patients with diabetes, and an up-to-date reference for diabetes and endocrinology researchers, scientists, and academics.
Author :Franz M. Matschinsky Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805577443 Total Pages :417 pages Book Rating :4.8/5 (55 download)
Book Synopsis Glucokinase and Glycemic Diseases by : Franz M. Matschinsky
Download or read book Glucokinase and Glycemic Diseases written by Franz M. Matschinsky and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus. The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs). This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists.
Book Synopsis Metformin: Beyond Diabetes by : Frederic Bost
Download or read book Metformin: Beyond Diabetes written by Frederic Bost and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
