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Genome Mapping And Genomics In Human And Non Human Primates
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Book Synopsis Genome Mapping and Genomics in Human and Non-Human Primates by : Ravindranath Duggirala
Download or read book Genome Mapping and Genomics in Human and Non-Human Primates written by Ravindranath Duggirala and published by Springer. This book was released on 2015-03-25 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented. Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.
Book Synopsis Monkeys, Apes, and Humans by : Michael A. Huffman
Download or read book Monkeys, Apes, and Humans written by Michael A. Huffman and published by Springer Science & Business Media. This book was released on 2012-10-20 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: (tentative) What bring about biodiversity are not always genes. As is the case with humans, cultural diversity of non-human animals has also been found. Most of well-known examples of animal cultures are those of food acquisition behaviors, such as sweet-potato-washing by Japanese macaques and nut-cracking by chimpanzees. First author, Naofumi Nakagawa, introduces cultural diversity of social behaviors in wild Japanese macaques, such as the embracing behaviors between adult females in a wild group in each population of Yakushima, Kinkazan, and Shimokita. The subtle local difference in embracing can be identified as the first evidence for social customs in wild Japanese macaques. The next author, Michael A. Huffman, introduces the self-medicative behavior in non-human primates, which is a relatively new study in primatology. Parasites cause a variety of diseases that affect the behavior and reproductive fitness of an individual. He classifies health maintenance and self-medicative behaviors observed in non-human primates into four levels. Not only humans but also apes and monkeys are maintaining their health. The third authors, Hiroo Imai, Masaki Tomonaga, and Yasuhiro Go, are promoting comparative cognitive sciences of primates including human and chimpanzees. Recently, human personal genome projects progresses as related to the phenotypes including cognition, while there was no similar project for non-human primates. They started personal genome and transcriptome projects of chimpanzees in Primate Research Institute, Kyoto University, years ago. They introduce recent progresses of the project and related results based on the primate genome sciences.
Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author :Eugene E. Harris (Professor) Publisher :Oxford University Press, USA ISBN 13 :0199978034 Total Pages :249 pages Book Rating :4.1/5 (999 download)
Book Synopsis Ancestors in Our Genome by : Eugene E. Harris (Professor)
Download or read book Ancestors in Our Genome written by Eugene E. Harris (Professor) and published by Oxford University Press, USA. This book was released on 2015 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.
Book Synopsis Heritable Human Genome Editing by : The Royal Society
Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Book Synopsis Exploring Horizons for Domestic Animal Genomics by : National Research Council
Download or read book Exploring Horizons for Domestic Animal Genomics written by National Research Council and published by National Academies Press. This book was released on 2002-08-27 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the important contributions that genomic analysis can make to agriculture, production and companion animal science, evolutionary biology, and human health with respect to the creation of models for genetic disorders, the National Academies convened a group of individuals to plan a public workshop that would: (1) assess these contributions; (2) identify potential research directions for existing genomics programs; and (3) highlight the opportunities of a coordinated, multi-species genomics effort for the science and policymaking communities. Their efforts culminated in a workshop sponsored by the U.S. Department of Agriculture, Department of Energy, National Science Foundation, and the National Institutes of Health. The workshop was convened on February 19, 2002. The goal of the workshop was to focus on domestic animal genomics and its integration with other genomics and functional genomics projects.
Author :National Research Council (U.S.). Committee on Mapping and Sequencing the Human Genome Publisher : ISBN 13 : Total Pages :0 pages Book Rating :4.:/5 (135 download)
Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council (U.S.). Committee on Mapping and Sequencing the Human Genome
Download or read book Mapping and Sequencing the Human Genome written by National Research Council (U.S.). Committee on Mapping and Sequencing the Human Genome and published by . This book was released on 1988 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Committee on Mapping and Sequencing the Human Genome Publisher :National Academies Press ISBN 13 :9780309074629 Total Pages :106 pages Book Rating :4.0/5 (746 download)
Book Synopsis Mapping and Sequencing the Human Genome by : Committee on Mapping and Sequencing the Human Genome
Download or read book Mapping and Sequencing the Human Genome written by Committee on Mapping and Sequencing the Human Genome and published by National Academies Press. This book was released on 1988-01-15 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Book Synopsis Chimpanzees in Biomedical and Behavioral Research by : National Research Council
Download or read book Chimpanzees in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2012-01-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Download or read book The Human Genome written by Paul F. Kisak and published by Createspace Independent Publishing Platform. This book was released on 2016-04-27 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome is the complete set of nucleic acid sequence for humans (Homo sapiens), encoded as DNA within the 23chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells (the egg and spermgamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNAbase pairs, while diploid genomes (found in somatic cells) have twice the DNA content. While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4%) and bonobos. The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution. There are an estimated 20,000-25,000 human protein-coding genes. The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further. Protein-coding sequences account for only a very small fraction of the genome (approximately 1.5%), and the rest is associated with non-coding RNA molecules, regulatory DNA sequences, LINEs, SINEs, introns, and sequences for which as yet no function has been determined. The total length of the human genome is over 3 billion base pairs. The genome is organized into 22 paired chromosomes, plus the X chromosome (one in males, two in females) and, in males only, one Y chromosome. These are all large linear DNA molecules contained within the cell nucleus. The genome also includes the mitochondrial DNA, a comparatively small circular molecule present in each mitochondrion. Basic information about these molecules and their gene content, based on a reference genome that does not represent the sequence of any specific individual, are provided in the following table. This book is an excellent overview of the human genome, the genetics involved and DNA.
Book Synopsis Primate Cytogenetics by : Stefan Müller
Download or read book Primate Cytogenetics written by Stefan Müller and published by S Karger Ag. This book was released on 2005 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primate molecular genetics, cytogenetics and genomics currently form a highly dynamic field of research. This has not occurred simply because of advances in technology. It is largely a consequence of the key insight that many aspects of human genome functioning can be better understood when knowledge about the conservation of, and changes in, genome organization during the course of evolution is integrated. Studies of our closest phylogenomic relatives, the nonhuman primates, can provide detailed information on the molecular mechanisms that shape the human genome. Consequently the chimpanzee genome project put forth the first chimpanzee draft sequence and its alignment with the human reference sequence in December 2003. Including review articles and original investigations, this Cytogenetic and Genome Research single topic issue bundles various different perspectives and provides a broad overview of the present knowledge about molecular cytogenetics, genome organization and evolution of primates. It will be of great interest to researchers and geneticists in the fields of primatology, anthropology, molecular phylogeny, evolution, human genetics and genome research.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309488516 Total Pages :123 pages Book Rating :4.3/5 (94 download)
Book Synopsis Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research by : National Academies of Sciences, Engineering, and Medicine
Download or read book Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-08-26 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Genome Mapping and Genomics in Arthropods by : Wayne Hunter
Download or read book Genome Mapping and Genomics in Arthropods written by Wayne Hunter and published by Springer Science & Business Media. This book was released on 2007-12-10 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series "Genome Mapping and Genomics in Animals" provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. The huge amount of information hitherto dispersed in journals is now available in this clearly structured reference work. Arthropods covered here include honeybee, bumblebee, the parasitic Jewel Wasp, silkworm, pea aphid, mosquito, Hessian fly and tick.
Book Synopsis Genome Mapping and Genomics in Fishes and Aquatic Animals by : Thomas D. Kocher
Download or read book Genome Mapping and Genomics in Fishes and Aquatic Animals written by Thomas D. Kocher and published by Springer Science & Business Media. This book was released on 2008-06-07 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, function, expression and regulation of academically and economically important genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. This volume summarizes the first era of genomic studies of aquaculture species, in which the tools and resources necessary to support whole-genome sequencing were developed. These tools will enhance efforts toward selective breeding of aquaculture species. Included in this volume are summaries of work on salmonids, cyprinids, catfish, tilapias, European sea bass, Japanese flounder, shrimps and oysters.
Book Synopsis Mapping our genes : the genome projects : how big, how fast? by :
Download or read book Mapping our genes : the genome projects : how big, how fast? written by and published by DIANE Publishing. This book was released on 1988 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genome written by Matt Ridley and published by Harper Collins. This book was released on 2013-03-26 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
