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Genome Integrity
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Book Synopsis Genome Integrity by : Dirk-Henner Lankenau
Download or read book Genome Integrity written by Dirk-Henner Lankenau and published by Springer Science & Business Media. This book was released on 2006-10-14 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease.
Book Synopsis Mechanistic Studies of Genome Integrity, Environmental Health, and Cancer Etiology by : Shan Yan
Download or read book Mechanistic Studies of Genome Integrity, Environmental Health, and Cancer Etiology written by Shan Yan and published by Frontiers Media SA. This book was released on 2022-11-10 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants by : Alma Balestrazzi
Download or read book Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants written by Alma Balestrazzi and published by Frontiers Media SA. This book was released on 2016-05-06 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.
Book Synopsis The Maintenance of Genome Integrity in Plants: Novel Challenges in Basic and Applied Research by : Alma Balestrazzi
Download or read book The Maintenance of Genome Integrity in Plants: Novel Challenges in Basic and Applied Research written by Alma Balestrazzi and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Origin and Evolution of Telomeres by : Jozef Nosek
Download or read book Origin and Evolution of Telomeres written by Jozef Nosek and published by CRC Press. This book was released on 2008-05-26 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes.Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller i
Book Synopsis Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants by :
Download or read book Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair. DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.
Book Synopsis Apoptosis, Genomic Integrity, and Cancer by : Julien L. Van Lancker
Download or read book Apoptosis, Genomic Integrity, and Cancer written by Julien L. Van Lancker and published by Jones & Bartlett Learning. This book was released on 2006 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the molecules involved in apoptosis and genomal integrity and considers the gain or loss of the functions that lead to cancer.
Book Synopsis Long Non-coding RNA by : Antonin Morillon
Download or read book Long Non-coding RNA written by Antonin Morillon and published by Elsevier. This book was released on 2018-02-01 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309391253 Total Pages :327 pages Book Rating :4.3/5 (93 download)
Book Synopsis Fostering Integrity in Research by : National Academies of Sciences, Engineering, and Medicine
Download or read book Fostering Integrity in Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-13 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices.
Book Synopsis The Airliner Cabin Environment and the Health of Passengers and Crew by : National Research Council
Download or read book The Airliner Cabin Environment and the Health of Passengers and Crew written by National Research Council and published by National Academies Press. This book was released on 2002-02-03 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although poor air quality is probably not the hazard that is foremost in peoples' minds as they board planes, it has been a concern for years. Passengers have complained about dry eyes, sore throat, dizziness, headaches, and other symptoms. Flight attendants have repeatedly raised questions about the safety of the air that they breathe. The Airliner Cabin Environment and the Health of Passengers and Crew examines in detail the aircraft environmental control systems, the sources of chemical and biological contaminants in aircraft cabins, and the toxicity and health effects associated with these contaminants. The book provides some recommendations for potential approaches for improving cabin air quality and a surveillance and research program.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309452880 Total Pages :329 pages Book Rating :4.3/5 (94 download)
Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine
Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Download or read book Genome Chaos written by Henry H. Heng and published by Academic Press. This book was released on 2019-05-25 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
Book Synopsis Chromatin and Genomic Instability in Cancer by :
Download or read book Chromatin and Genomic Instability in Cancer written by and published by Academic Press. This book was released on 2021-09-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects
Book Synopsis MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress by : Anca Macovei
Download or read book MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress written by Anca Macovei and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aerospace Health and Safety: Today and the Future by : Irina Mordukhovich
Download or read book Aerospace Health and Safety: Today and the Future written by Irina Mordukhovich and published by Frontiers Media SA. This book was released on 2023-11-20 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aviation plays vital roles in commerce, defense, science and leisure travel. Irrespective of the purpose of flight, crew and passengers are challenged by exposure to a variety of environmental conditions that can differ widely from work and travel environments on the surface of the Earth. With anticipated changes in aviation and space technology, new challenges to health and safety of crew and passengers can be expected. In this Research Topic, we welcome contributions from those whose work and interests are relevant to the health and safety of crew and passengers. This includes, but is not limited to, health and safety professionals, FAA examiners, corporate medical officers, aerospace and occupational physicians, physiologists, military and scientific team members, public health professionals, as well as engineers who are tasked with crew and passenger health and safety design projects. While 4.1 billion passengers fly on commercial airlines annually (and this figure is even higher when taking into account privately owned aircraft and military flight), for the most part aviation is safe. Passengers do arrive at their destinations with little concern to their own well-being and flight is generally well tolerated. However, older flyers, people with (diagnosed or undiagnosed) preexisting disease, and other vulnerable passengers (such as young children and pregnant women) may be at risk of complications and crew may be at special risk due to the frequency and duration of their many flight-related exposures. Health and safety issues for crew and passengers include but are not limited to: potentially severe circadian rhythm disruption, potential health effects of low-level cosmic ionizing radiation exposure at altitude, reduced oxygen delivery and tissue hypoxia at cabin pressurization, cabin air contamination by engine gases, toxic materials used in uniforms and some cabin seat materials, occupational noise, pesticides used for cabin disinsection, lack of adequate crew rest on layovers or between flights, cardiovascular demands of flight and effects of flight-related dehydration, the current absence of screening protocols especially in the context of a rising number of elderly and vulnerable flyers, lack of healthy nutrition at airports and in flight, availability of food and hydration as well as adequate cabin temperature under delay conditions, effects of alcohol use on flight-related physiological and behavioral health risks, anxiety and psychological distress associated with air travel, the effects of long-haul or ultra-long-haul flights on thromboembolic events as well as smoking cessation efforts and related psychological outcomes, job-related stress and harassment among crew. Cosmic ionizing and non-ionizing radiation exposure have drawn attention as have historic exposures of crew and passengers to second-hand cigarette smoke. The threat of political and interpersonal violence and altercations involving aviation cannot be overlooked. On-board medical emergencies run a wide gamut and the capacity to respond becomes more problematic as the duration of flights becomes longer or in the case of flight over oceans and the poles. In addition, in-flight and post flight embolisms and myocardial infarctions are more prevalent than might be expected. We hence encourage manuscripts that address in-flight medical response, including the capabilities on different types of aircraft on potential interventions by crew and medical volunteers. In addition, aviation as a vector for the carriage of disease is a significant concern to public health and security of populations world-wide, and we welcome submissions regarding infectious disease epidemiology and medicine as it relates to air travel. Insects and occasional unplanned travel by birds and rodents can present additional public health concerns. We are approaching an era where space travel may soon be increasingly common. Future flights for near-Earth orbit by leisure travelers and as well as travel to the moon and Mars raise a host of new questions with health and safety implications. What are the proposed health and safety accommodations going to be? Who will be allowed to travel? Perhaps the most interesting question is - who will make the rules?
Book Synopsis Genome Stability by : Igor Kovalchuk
Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Book Synopsis The Dictionary of Genomics, Transcriptomics and Proteomics by : Guenter Kahl
Download or read book The Dictionary of Genomics, Transcriptomics and Proteomics written by Guenter Kahl and published by John Wiley & Sons. This book was released on 2015-05-21 with total page 2742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.
