Genetics Of Human Infertility

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Genetics of Human Infertility

Author : P.H. Vogt
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318060984
Total Pages : 178 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Genetics of Human Infertility by : P.H. Vogt

Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

The Genetics of Male Infertility

Author : Douglas T. Carrell
Publisher : Springer Science & Business Media
ISBN 13 : 1597451762
Total Pages : 337 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Genetics of Male Infertility by : Douglas T. Carrell

Download or read book The Genetics of Male Infertility written by Douglas T. Carrell and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Human Reproductive and Prenatal Genetics

Author : Peter C.K. Leung
Publisher : Elsevier
ISBN 13 : 0323913814
Total Pages : 930 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Reproductive and Prenatal Genetics by : Peter C.K. Leung

Download or read book Human Reproductive and Prenatal Genetics written by Peter C.K. Leung and published by Elsevier. This book was released on 2023-03-22 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Reproductomics

Author : José A. Horcajadas
Publisher : Academic Press
ISBN 13 : 0128126760
Total Pages : 425 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Reproductomics by : José A. Horcajadas

Download or read book Reproductomics written by José A. Horcajadas and published by Academic Press. This book was released on 2018-07-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Textbook of Human Reproductive Genetics

Author : Stéphane Viville
Publisher : Cambridge University Press
ISBN 13 : 100919772X
Total Pages : 255 pages
Book Rating : 4.0/5 (91 download)

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Book Synopsis Textbook of Human Reproductive Genetics by : Stéphane Viville

Download or read book Textbook of Human Reproductive Genetics written by Stéphane Viville and published by Cambridge University Press. This book was released on 2022-12-31 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Genetics of Male Infertility

Author : Mohamed Arafa
Publisher : Springer Nature
ISBN 13 : 3030379728
Total Pages : 374 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Genetics of Male Infertility by : Mohamed Arafa

Download or read book Genetics of Male Infertility written by Mohamed Arafa and published by Springer Nature. This book was released on 2020-03-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Textbook of Human Reproductive Genetics

Author : Stéphane Viville
Publisher : Cambridge University Press
ISBN 13 : 100919769X
Total Pages : 255 pages
Book Rating : 4.0/5 (91 download)

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Book Synopsis Textbook of Human Reproductive Genetics by : Stéphane Viville

Download or read book Textbook of Human Reproductive Genetics written by Stéphane Viville and published by Cambridge University Press. This book was released on 2022-12-31 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: A basic understanding of human genetics is vital for all those working in the field of assisted human reproduction. Genetic makeup can hamper reproduction and insight into this is making genetic diagnosis and counselling increasingly important. This fully updated textbook continues the clear structure of the original edition, beginning with a chapter on the basics of genetics and cytogenetics. Genetic causes of infertility and the effect of epigenetics and transposons on fertility are discussed in detail. Several new chapters are included in this edition, reflecting the advances of the field, including preconception genetic analysis and screening in IVF and mitochondrial genetics. Combining genetics, reproductive biology and medicine, this is an essential text for practitioners in reproductive medicine and geneticists involved in the field looking to improve their knowledge of the subject and provide outstanding patient care.

Towards Reproductive Certainty: Fertility and Genetics Beyond 1999: The Plenary Proceedings of the 11th World Congress

Author : R. Jansen
Publisher : CRC Press
ISBN 13 : 9781850700845
Total Pages : 556 pages
Book Rating : 4.7/5 (8 download)

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Book Synopsis Towards Reproductive Certainty: Fertility and Genetics Beyond 1999: The Plenary Proceedings of the 11th World Congress by : R. Jansen

Download or read book Towards Reproductive Certainty: Fertility and Genetics Beyond 1999: The Plenary Proceedings of the 11th World Congress written by R. Jansen and published by CRC Press. This book was released on 1999-04-15 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a forward-looking clinical reference of definitive authority on today's headline controversies surrounding in vitro fertilization (IVF) and reproductive genetics. Written by leading experts from medicine, education, psychology, ethics, counseling, and other disciplines studying fertility and genetics, the book contains nearly 70 chapters in seven sections. The introductory section deals with biology, business, morality and society in IVF and reproductive genetics; other sections focus on IVF outcomes, personal ethics and business, biology of the egg, sperm and embryo, implantation, IVF and society, and such 21st century topics as space travel and human reproduction, the disappearing male,and the future of motherhood. Includes bibliographic references and index.

Heritable Human Genome Editing

Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

The Genetic Basis of Male Infertility

Author : Ken McElreavey
Publisher : Springer Science & Business Media
ISBN 13 : 3540484612
Total Pages : 306 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis The Genetic Basis of Male Infertility by : Ken McElreavey

Download or read book The Genetic Basis of Male Infertility written by Ken McElreavey and published by Springer Science & Business Media. This book was released on 2012-11-03 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Author : Sorin Hostiuc
Publisher : Academic Press
ISBN 13 : 0128137657
Total Pages : 431 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies by : Sorin Hostiuc

Download or read book Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies written by Sorin Hostiuc and published by Academic Press. This book was released on 2018-08-07 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Reproductive Endocrinology and Infertility

Author : Douglas T. Carrell
Publisher : Springer Science & Business Media
ISBN 13 : 1441914366
Total Pages : 812 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Reproductive Endocrinology and Infertility by : Douglas T. Carrell

Download or read book Reproductive Endocrinology and Infertility written by Douglas T. Carrell and published by Springer Science & Business Media. This book was released on 2010-03-23 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Management of the modern reproductive endocrinology and infertility clinic has become very complex. In addition to the medical and scientific aspects, it is crucial that the modern director be aware of of incongruent fields such as marketing, accounting, management, and regulatory issues. Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice was developed to assist the practicing reproductive endocrinologist and/or laboratory director by providing an overview of relevant scientific, medical, and management issues in a single volume. Experts in all pertinent areas present concise, practical, evidence-based summaries of relevant topics, producing a key resource for physicians and scientists engaged in this exciting field of medicine. As novel technologies continue to amplify, Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice offers insight into development, and imparts extra confidence to practitioners in handling the many demands presented by their work.

Infertility in the Male

Author : Larry I. Lipshultz
Publisher : Cambridge University Press
ISBN 13 : 9781139483247
Total Pages : pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Infertility in the Male by : Larry I. Lipshultz

Download or read book Infertility in the Male written by Larry I. Lipshultz and published by Cambridge University Press. This book was released on 2009-09-24 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.

Sperm Chromatin

Author : Armand Zini
Publisher : Springer Science & Business Media
ISBN 13 : 9781441968579
Total Pages : 512 pages
Book Rating : 4.9/5 (685 download)

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Book Synopsis Sperm Chromatin by : Armand Zini

Download or read book Sperm Chromatin written by Armand Zini and published by Springer Science & Business Media. This book was released on 2011-08-04 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Male Infertility: Understanding, Causes and Treatment

Author : RAJENDER SINGH
Publisher : Springer
ISBN 13 : 9811040176
Total Pages : 497 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Male Infertility: Understanding, Causes and Treatment by : RAJENDER SINGH

Download or read book Male Infertility: Understanding, Causes and Treatment written by RAJENDER SINGH and published by Springer. This book was released on 2017-06-17 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.

Assisted Reproduction Techniques

Author : Khaldoun Sharif
Publisher : John Wiley & Sons
ISBN 13 : 1444335553
Total Pages : 473 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Assisted Reproduction Techniques by : Khaldoun Sharif

Download or read book Assisted Reproduction Techniques written by Khaldoun Sharif and published by John Wiley & Sons. This book was released on 2012-03-26 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assisted reproduction techniques have led to the birth of 4 million babies worldwide Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges. Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient. Written by 122 internationally renowned experts, Assisted Reproduction Techniques follows the patient's journey throughout the whole ART process, with chapters on: Counseling and preparation Ovarian stimulation Oocyte retrieval Embryo transfer The luteal phase The ART laboratory The male patient The ART pregnancy Each of the 100 concise chapters includes clinical cases, background, evidence-based practical management options, preventive measures and key-point summaries of the important details. Assisted Reproduction Techniques gives a wide-ranging practical guide to all those wishing to support couples who cannot conceive naturally.

The End of Sex and the Future of Human Reproduction

Author : Henry T. Greely
Publisher : Harvard University Press
ISBN 13 : 0674728963
Total Pages : 392 pages
Book Rating : 4.6/5 (747 download)

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Book Synopsis The End of Sex and the Future of Human Reproduction by : Henry T. Greely

Download or read book The End of Sex and the Future of Human Reproduction written by Henry T. Greely and published by Harvard University Press. This book was released on 2016-05-30 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction...[It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today