Genetically Modified Model Report On Toxicology Studies Of Bromodichloromethane Cas No 75 27 4 In Genetically Modified Fvb Tb Ac Hemizygous Mice Dermal Drinking Water And Gavage Studies And Carcinogenicity Studies Of Bromodichloromethane In Genetically Modified B6 129 Trp53tm1brd N5 Haploinsufficient Mice Drinking Water And Gavage Studies

Author : G. A. Boorman
Publisher :
ISBN 13 : 9781422315224
Total Pages : 227 pages
Book Rating : 4.3/5 (152 download)

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Download or read book Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromodichloromethane (BD) is a by-product of the chlorination of drinking water. It is formed by the halogen substitution & oxidation reactions of chlorine & naturally occurring organic matter (e.g., humic or fluvic acids) in water containing bromide. BD was nominated to the Nat. Toxicology Program for toxicology & carcinogenecity studies. Male & female Tb.AC hemizygous mice received bromodichloromethane (at least 99% pure) by dermal application for 26 or 39 weeks, in drinking water for 26 or 42 weeks, or by gavage for 26 or 41 weeks. p53 Haploinsufficient mice received BD in drinking water for 26 or 42 weeks or by gavage for 26 or 42 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.