Genetic Variation Among Influenza Viruses

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Genetic Variation Among Influenza Viruses

Author : Debi P. Nayak
Publisher : Academic Press
ISBN 13 : 1483274748
Total Pages : 695 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Genetic Variation Among Influenza Viruses by : Debi P. Nayak

Download or read book Genetic Variation Among Influenza Viruses written by Debi P. Nayak and published by Academic Press. This book was released on 2013-09-24 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Variation Among Influenza Viruses documents the proceedings of ICN-UCLA symposium held in Salt Lake City, Utah, 8-13 March 1981. The symposium brought together people from different disciplines working with the common objective of reducing the ravages of influenza and to expose them to the totality of the problem of influenza. The papers presented at the meeting included nearly all major aspects of influenza in which important advances are being made. Because of recombinant DNA technology and rapid DNA sequencing, a number of genes of influenza virus from a number of strains have been either completely or partially sequenced. Among these, the gene coding for hemagglutinin (HA) has been most intensively studied and the HA of one or more strains from each subtype (H1, H2, H3) has been completely sequenced. Other topics discussed include the question of drift and shift at the genomic level; the role of the capped host mRNA is the process of initiation of transcription; and the regulation of viral transcription. This volume also includes papers presented by the speakers of the plenary sessions and that of keynote speaker, Sir Charles Stuart-Harris as well as the selected papers presented in the poster sessions.

Genetics of Influenza Viruses

Author : P. Palese
Publisher : Springer Science & Business Media
ISBN 13 : 3709187060
Total Pages : 375 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Genetics of Influenza Viruses by : P. Palese

Download or read book Genetics of Influenza Viruses written by P. Palese and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of genetic engineering methods and improved biochemical tech niques, much has been learned about the replication of influenza viruses, their structure and their epidemiology. It appears that the time is ripe to review these efforts and to provide a molecular perspective of influenza virology. It is hoped that this book will stimulate our thinking, help us in designing new experiments, and possibly show avenues leading to the control of the diseases associated with influenza viruses. Peter Palese, New York, N. Y. August 1983 David W. Kingsbury, Memphis, Tenn. Contents List of Contributors. . . . . . . . . . . . . . . . . XV 1. The Evolution of Influenza Viral Genetics - A Perspective. By E. D. Kilbourne. . . . . . . . . . . . . . . . 1 I. Introduction. . . . . . . . . . . . . . . . . 1 II. The Development of Modern Influenza Viral Genetics 2 A. Early Evidence of Genetic Variation in the Laboratory 2 B. Application of Formal Genetic Techniques to Studies of Influenza Virus . . . . . . . 3 C. Genetic Markers. . . . . . . . . 3 D. Development of Plaquing Systems. . . 4 E. The Use of Conditional Lethal Mutants 5 F. New Approaches in Influenza Virus Genetics. 6 1. The Biochemical Identification of Viral Gene Products in the Unambiguous Definition of Viral Inheritance . . . 6 2. Mapping of the Influenza Virus Genome by Correlative Physico-Chemical and Biological Techniques. . . . . . 7 3. The Application of Molecular Biological Techniques to the Study of Viral Genetic Variation. . . . . . . . . 8 4. Oligonucleotide Mapping of Viral RNA's . . . . . . . 8 5. Contribution of Protein and RNA Sequencing to Influenza Viral Genetics-Intragenic Mapping . . . . . . . 8 III. Viral Genetics and the Understanding of Viral Virulence and Pathogenicity . . . . . . . . . . . . . . . . . . .

The Threat of Pandemic Influenza

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309095042
Total Pages : 431 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Threat of Pandemic Influenza by : Institute of Medicine

Download or read book The Threat of Pandemic Influenza written by Institute of Medicine and published by National Academies Press. This book was released on 2005-04-09 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Virus as Populations

Author : Esteban Domingo
Publisher : Academic Press
ISBN 13 : 0128163321
Total Pages : 426 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Virus as Populations by : Esteban Domingo

Download or read book Virus as Populations written by Esteban Domingo and published by Academic Press. This book was released on 2019-11-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes

Genetic Variation of Viruses

Author : Peter Palese
Publisher :
ISBN 13 :
Total Pages : 528 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Genetic Variation of Viruses by : Peter Palese

Download or read book Genetic Variation of Viruses written by Peter Palese and published by . This book was released on 1980 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Perspectives on Research with H5N1 Avian Influenza

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309267781
Total Pages : 132 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Perspectives on Research with H5N1 Avian Influenza by : National Research Council

Download or read book Perspectives on Research with H5N1 Avian Influenza written by National Research Council and published by National Academies Press. This book was released on 2013-04-04 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: When, in late 2011, it became public knowledge that two research groups had submitted for publication manuscripts that reported on their work on mammalian transmissibility of a lethal H5N1 avian influenza strain, the information caused an international debate about the appropriateness and communication of the researchers' work, the risks associated with the work, partial or complete censorship of scientific publications, and dual-use research of concern in general. Recognizing that the H5N1 research is only the most recent scientific activity subject to widespread attention due to safety and security concerns, on May 1, 2012, the National Research Council's Committee on Science, Technology and Law, in conjunction with the Board on Life Sciences and the Institute of Medicine's Forum on Microbial Threats, convened a one-day public workshop for the purposes of 1) discussing the H5N1 controversy; 2) considering responses by the National Institute of Allergy and Infectious Diseases (NIAID), which had funded this research, the World Health Organization, the U.S. National Science Advisory Board for Biosecurity (NSABB), scientific publishers, and members of the international research community; and 3) providing a forum wherein the concerns and interests of the broader community of stakeholders, including policy makers, biosafety and biosecurity experts, non-governmental organizations, international organizations, and the general public might be articulated. Perspectives on Research with H5N1 Avian Influenza: Scientific Enquiry, Communication, Controversy summarizes the proceedings of the workshop.

The Influenza Viruses

Author : Robert M Krug
Publisher :
ISBN 13 : 9781461308126
Total Pages : 452 pages
Book Rating : 4.3/5 (81 download)

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Book Synopsis The Influenza Viruses by : Robert M Krug

Download or read book The Influenza Viruses written by Robert M Krug and published by . This book was released on 1989-09-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Viruses and Man: A History of Interactions

Author : Milton W. Taylor
Publisher : Springer
ISBN 13 : 3319077589
Total Pages : 430 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Viruses and Man: A History of Interactions by : Milton W. Taylor

Download or read book Viruses and Man: A History of Interactions written by Milton W. Taylor and published by Springer. This book was released on 2014-07-21 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.

Vaccines for the 21st Century

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309174985
Total Pages : 476 pages
Book Rating : 4.1/5 (749 download)

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Book Synopsis Vaccines for the 21st Century by : Institute of Medicine

Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Antiviral Drug Resistance

Author : Douglas D. Richman
Publisher : Wiley
ISBN 13 : 9780471961208
Total Pages : 324 pages
Book Rating : 4.9/5 (612 download)

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Book Synopsis Antiviral Drug Resistance by : Douglas D. Richman

Download or read book Antiviral Drug Resistance written by Douglas D. Richman and published by Wiley. This book was released on 1996-12-02 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy.

Textbook of Influenza

Author : Robert G. Webster
Publisher : John Wiley & Sons
ISBN 13 : 111863683X
Total Pages : 684 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Textbook of Influenza by : Robert G. Webster

Download or read book Textbook of Influenza written by Robert G. Webster and published by John Wiley & Sons. This book was released on 2014-01-06 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

Molecular Virology of Human Pathogenic Viruses

Author : Wang-Shick Ryu
Publisher : Academic Press
ISBN 13 : 0128009993
Total Pages : 440 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Virology of Human Pathogenic Viruses by : Wang-Shick Ryu

Download or read book Molecular Virology of Human Pathogenic Viruses written by Wang-Shick Ryu and published by Academic Press. This book was released on 2016-03-30 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Influenza

Author : E.D. Kilbourne
Publisher : Springer Science & Business Media
ISBN 13 : 1468452398
Total Pages : 370 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Influenza by : E.D. Kilbourne

Download or read book Influenza written by E.D. Kilbourne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: My lifetime encompasses the postwar subsidence in the early 1920s of the greatest influenza pandemic in history, direct encounters with FM1 virus at Fort Mon mouth in 1947, the care of influenza patients in the 1950s, the pursuit of the in fluenza virus through the modern pandemics of 1957 and 1968, and a present in which the genes of the virus have dissembled in the DNA of vaccinia virus and Escherichia coli through the wand of "high tech. " If my corpus could be fossilized for archival and archaeological purposes, it would be found to contain immune cells branded with the imprint of the "swine" influenza virus of post-1918 and brain cells no less imprinted with memories of the abortive return of its descendant during America's bicentennial. But before that unlikely event, I wanted to try to make some sense out of this baffling dis ease and its viruses-expecting no definitive revelations but hoping for a sharper definition of problems. Hence this book. It is an audacious act in these days of specialization to essay a book such as this singlehandedly, but I have done so for selfish reasons. I wanted to reexam ine old questions about the nature of influenza and its epidemics in the light of the dazzling advances in molecular biology of the past few years. No virus has been better studied, but few diseases are less well understood.

Virus Taxonomy

Author :
Publisher :
ISBN 13 : 9780122499517
Total Pages : 1259 pages
Book Rating : 4.4/5 (995 download)

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Book Synopsis Virus Taxonomy by :

Download or read book Virus Taxonomy written by and published by . This book was released on 2005 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I: Introduction to Universal Virus Taxonomy. Part II: The Viruses. A Glossary of Abbreviations and Terms. Taxa Listed by Nucleic Acid and Size of the Genome. The Virus Diagrams. The Virus Particle Structures. The Order of Presentation of the Viruses. The Double Stranded DNA Viruses. The Single Stranded DNA Viruses. The DNA and RNA Reverse Transcribing Viruses. The Double Stranded RNA Viruses. The Negative Sense Single Stranded RNA Viruses. The Positive Sense Single Stranded RNA Viruses. The Unassigned Viruses. The Subviral Agents. Viroids. Satellites. Vertebrate Prions. Fungal Prions. Part III: The International Committee on Taxonomy of Viruses. Officers and Members of the ICTV, 1999-2002. The Statutes of the ICTV, 1998. The Code of Virus Classification and Nomenclature,1998. Part IV: Indexs. Virus Indexs. Taxonomic Index.

Understanding Coronavirus

Author : Raul Rabadan
Publisher : Cambridge University Press
ISBN 13 : 1009086650
Total Pages : 167 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Understanding Coronavirus by : Raul Rabadan

Download or read book Understanding Coronavirus written by Raul Rabadan and published by Cambridge University Press. This book was released on 2021-10-14 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the identification of the first cases of the coronavirus in December 2019, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the virus, unproven therapies, and inconsistent public health measures, have all served to increase anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? In this concise and accessible introduction, a leading expert provides answers to these commonly asked questions. This revised and updated edition now also covers how the virus mutates, how important these mutations are, how vaccines work, and what we can expect in the near and long-term future.

Flu

Author : Gina Kolata
Publisher : Farrar, Straus and Giroux
ISBN 13 : 1429979356
Total Pages : 378 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Flu by : Gina Kolata

Download or read book Flu written by Gina Kolata and published by Farrar, Straus and Giroux. This book was released on 2011-04-01 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza

Author : World Health Organization
Publisher :
ISBN 13 : 9789241548090
Total Pages : 0 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza by : World Health Organization

Download or read book Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza written by World Health Organization and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "WHO has developed this manual in order to strengthen the laboratory diagnosis and virological surveillance of influenza infection by providing standard methods for the collection, detection, isolation and characterization of viruses."--Publisher's description.