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Genetic Polymorphisms And Susceptibility To Disease
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Book Synopsis Genetic Polymorphisms and Susceptibility to Disease by : Mark Steven Miller
Download or read book Genetic Polymorphisms and Susceptibility to Disease written by Mark Steven Miller and published by CRC Press. This book was released on 2000-04-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, on
Book Synopsis Genetic Polymorphism and Disease by : Syed Sameer Aga
Download or read book Genetic Polymorphism and Disease written by Syed Sameer Aga and published by CRC Press. This book was released on 2022-12-06 with total page 1256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics
Book Synopsis Genetic Polymorphism and cancer susceptibility by : Aga Syed Sameer
Download or read book Genetic Polymorphism and cancer susceptibility written by Aga Syed Sameer and published by Springer Nature. This book was released on 2021-04-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
Book Synopsis Genetic Polymorphisms by : Narasimha Reddy Parine
Download or read book Genetic Polymorphisms written by Narasimha Reddy Parine and published by BoD – Books on Demand. This book was released on 2017-09-06 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.
Book Synopsis Genetic Diversity and Disease Susceptibility by : Yamin Liu
Download or read book Genetic Diversity and Disease Susceptibility written by Yamin Liu and published by BoD – Books on Demand. This book was released on 2018-10-17 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
Book Synopsis Genetic Diversity and Disease Susceptibility by : Yamin Liu
Download or read book Genetic Diversity and Disease Susceptibility written by Yamin Liu and published by . This book was released on 2018 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
Book Synopsis Genetic Susceptibility to Infectious Diseases by : Richard A. Kaslow
Download or read book Genetic Susceptibility to Infectious Diseases written by Richard A. Kaslow and published by Oxford University Press. This book was released on 2008 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other work on the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.
Book Synopsis Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment by : Necla Benlier
Download or read book Human Genetic Polymorphisms Associated with Susceptibility to COVID-19 Infection and Response to Treatment written by Necla Benlier and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinicians and researchers observing the natural history of endemic and epidemic infections have always been fascinated by the vagaries of these diseases, in terms of both the changing nature of the disease severity and phenotype over time and the variable susceptibility of hosts within exposed populations. SARS-CoV-2, the virus that causes COVID-19 and is believed to originate from bats, quickly transformed into a global pandemic. The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the global health in many aspects. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Comprehensive understanding of the biology of SARS-CoV-2 and its interaction with hosts is fundamentally important in the fight against SARS-CoV-2. Advanced age, male sex, and comorbidities such as hypertension and cardiovascular disease as well as diabetes and obesity have been identified as risk factors for more severe COVID-19. However, which and to what extent specific genetic factors may account for the predisposition of individuals to develop severe disease or to contract the infection remains elusive. The increasing availability of data from COVID-19 patient populations is allowing for potential associations to be established between specific gene loci and disease severity, susceptibility to infection, and response to current/future drugs.
Book Synopsis Genetic Polymorphisms by : Mahmut Çalışkan
Download or read book Genetic Polymorphisms written by Mahmut Çalışkan and published by BoD – Books on Demand. This book was released on 2022-05-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a glimpse into the dynamic process of genetic polymorphism by presenting studies carried out on different kinds of organisms at the DNA level or gene expression level. Chapters address such topics as genetic polymorphism in animals, gametocyte biomarkers, thrombotic disorders, prostate cancer, and more.
Book Synopsis The Recent Topics in Genetic Polymorphisms by : Mahmut Çalışkan
Download or read book The Recent Topics in Genetic Polymorphisms written by Mahmut Çalışkan and published by BoD – Books on Demand. This book was released on 2020-05-13 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book in your hands presents chapters revealing the magnitude of genetic polymorphisms that exist in different kinds of living beings. Natural populations contain a considerable amount of genetic change, which provides a genomic flexibility that can be used as a raw material for adaptation to changing environmental conditions. The analysis of genetic polymorphisms provides information about DNA sequence changes at a given locus. The increasing availability of PCR-based molecular markers allows for the detailed analyses and the detection of genetic changes influencing some important traits. The purpose of this book is to provide a glimpse into the dynamic process of genetic polymorphisms by presenting the thoughts of scientists engaged in the generation of new ideas and techniques employed for the assessment of genetic polymorphisms. The book should prove useful to students, researchers and experts in the area of molecular genetics.
Book Synopsis Genes, Behavior, and the Social Environment by : Institute of Medicine
Download or read book Genes, Behavior, and the Social Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-12-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
Book Synopsis Genetics of Infectious Disease Susceptibility by : Tjeerd G. Kimman
Download or read book Genetics of Infectious Disease Susceptibility written by Tjeerd G. Kimman and published by Springer Science & Business Media. This book was released on 2001-07-31 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Progress in the molecular analysis of genetic susceptibility to human and animal infectious diseases has been very rapid over the last few years. Several genes involved in resistance to HIV/AIDS, tuberculosis, malaria, viral hepatitis, herpesvirus infections, prion diseases, and several others have now been identified, and their functions have partly or completely been elucidated." "This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights into understanding and combating them."--BOOK JACKET.
Book Synopsis The Effect of Genetic Polymorphisms in Activating NK Cell Receptors on the Susceptibility to Disease by : Rachel Thomas
Download or read book The Effect of Genetic Polymorphisms in Activating NK Cell Receptors on the Susceptibility to Disease written by Rachel Thomas and published by . This book was released on 2009 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by : National Research Council
Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Book Synopsis Gene-Environment Interactions by : Lucio G. Costa
Download or read book Gene-Environment Interactions written by Lucio G. Costa and published by John Wiley & Sons. This book was released on 2005-12-16 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.
Book Synopsis Metabolic Polymorphisms and Susceptibility to Cancer by : Paolo Vineis
Download or read book Metabolic Polymorphisms and Susceptibility to Cancer written by Paolo Vineis and published by . This book was released on 1999 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of interactions between genes and environmental exposures ha s expanded considerably in recent years. Highly penetrant genes that a re involved in familial cancer have been identified, but are likely to account for a relatively small proportion of total cancers. Other pre disposing genes have low penetrance, resulting in a moderate increase in the risk of specific cancers, but are widespread in the general pop ulation. This is the case for so-called metabolic polymorphisms. Scien tific interest in metabolic polymorphisms is based on the possibility of identifying subgroups of the population which are at elevated risk of developing environmentally-induced cancer. However, such studies ra ise a series of problems that are methodological - related to the stud y design and analysis - and ethical - related to the practical use tha t can be made of genetic information. This volume deals thoroughly wit h such problems.
Book Synopsis Association of Cytokine Gene Polymorphisms with Susceptibility and Disease Progression in Chronic Hepatitis B Virus (Hbv) Infection by : Wing-Yan Lee
Download or read book Association of Cytokine Gene Polymorphisms with Susceptibility and Disease Progression in Chronic Hepatitis B Virus (Hbv) Infection written by Wing-Yan Lee and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Association of Cytokine Gene Polymorphisms With Susceptibility and Disease Progression in Chronic Hepatitis B Virus (HBV) Infection" by Wing-yan, Lee, 李穎欣, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: DOI: 10.5353/th_b3955695 Subjects: Hepatitis B virus Cytokines Genetic polymorphisms
