Genetic Immunization

Download Genetic Immunization full books in PDF, epub, and Kindle. Read online Genetic Immunization ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Genetic Immunization

Author : Adrian Bot
Publisher : Springer Science & Business Media
ISBN 13 : 1475731639
Total Pages : 185 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!

Book Synopsis Genetic Immunization by : Adrian Bot

Download or read book Genetic Immunization written by Adrian Bot and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

DNA Vaccination/Genetic Vaccination

Author : Hilary Koprowski
Publisher : Springer Science & Business Media
ISBN 13 : 3642804756
Total Pages : 215 pages
Book Rating : 4.6/5 (428 download)

DOWNLOAD NOW!

Book Synopsis DNA Vaccination/Genetic Vaccination by : Hilary Koprowski

Download or read book DNA Vaccination/Genetic Vaccination written by Hilary Koprowski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

Immunization Safety Review

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309169887
Total Pages : 152 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Immunization Safety Review by : Institute of Medicine

Download or read book Immunization Safety Review written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-02 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.

Toll-Like Receptors (TLRs) and Innate Immunity

Author : Stefan Bauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540721673
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

DOWNLOAD NOW!

Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Gene Therapy of Cancer

Author : Stanton L. Gerson
Publisher : Elsevier
ISBN 13 : 0080491367
Total Pages : 555 pages
Book Rating : 4.0/5 (84 download)

DOWNLOAD NOW!

Book Synopsis Gene Therapy of Cancer by : Stanton L. Gerson

Download or read book Gene Therapy of Cancer written by Stanton L. Gerson and published by Elsevier. This book was released on 2002-04-04 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Provides in-depth description of targeted systems and treatment strategies Explains the underlying cancer biology necessary for understanding a given therapeutic approach Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses Presents translational focus with emphasis on requirements for clinical implementation Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

DNA Vaccines

Author : Douglas B. Lowrie
Publisher : Springer Science & Business Media
ISBN 13 : 1592596886
Total Pages : 530 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis DNA Vaccines by : Douglas B. Lowrie

Download or read book DNA Vaccines written by Douglas B. Lowrie and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications. In a separate and important line of experimentation, Tang, De Vit, and Johnston announced in 1992 that it was indeed possible to obtain humoral immune responses against proteins encoded by DNA delivered to the skin by a biolistic device, which has colloquially become known as the “gene gun. ” The year 1993 saw the publication of further improvements in the me- ods of naked DNA delivery and, above all, the first demonstrations by several groups of the induction of humoral and cytotoxic immune responses to viral antigens expressed from injected plasmid DNA. In some cases, protection against challenge with the pathogen was obtained. The latter result was - questionably the touchstone of a method of vaccination worthy of the name.

Adverse Effects of Vaccines

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309214351
Total Pages : 894 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!

Book Synopsis Adverse Effects of Vaccines by : Institute of Medicine

Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Gene Vaccination: Theory and Practice

Author : Eyal Raz
Publisher : Springer Science & Business Media
ISBN 13 : 3642468675
Total Pages : 182 pages
Book Rating : 4.6/5 (424 download)

DOWNLOAD NOW!

Book Synopsis Gene Vaccination: Theory and Practice by : Eyal Raz

Download or read book Gene Vaccination: Theory and Practice written by Eyal Raz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.

Immunization Safety Review

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309076366
Total Pages : 137 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Immunization Safety Review by : Institute of Medicine

Download or read book Immunization Safety Review written by Institute of Medicine and published by National Academies Press. This book was released on 2001-12-29 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this report, the Immunization Safety Review committee examines the hypothesis of whether or not the use of vaccines containing the preservative thimerosal can cause neurodevelopmental disorders (NDDs), specifically autism, attention deficit/hyperactivity disorder (ADHD), and speech or language delay.

DNA Vaccines

Author : Hildegund C. J. Ertl
Publisher : Springer Science & Business Media
ISBN 13 : 9780306474446
Total Pages : 374 pages
Book Rating : 4.4/5 (744 download)

DOWNLOAD NOW!

Book Synopsis DNA Vaccines by : Hildegund C. J. Ertl

Download or read book DNA Vaccines written by Hildegund C. J. Ertl and published by Springer Science & Business Media. This book was released on 2003 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Vaccines: An Introduction; M.R. Hilleman. Architecture of a DNA vaccine; G. Pavlakis. DNA vaccine delivery; S. Kaufmann. Adjuvanticity of DNA vaccines; A. Krieg. Immune responses to DNA vaccines: Antigen presentation; R. Steinman. Immune responses to DNA vaccines: Antigen processing; J. Yewdell. Immune responses to DNA vaccines: Induction of B cells; G. Kelsoe. Immune responses to DNA vaccines: Induction of CD4+ T cells; E. Shevach. Immune responses to DNA vaccines: Induction of CD8+ T cells; L. Whitton. Immune responses to DNA vaccines: Cytokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; H. Ertl. Immune responses to DNA vaccines: Chemokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; P. Murphy. DNA Vaccines to infectious agents: RNA viruses; J. Ulmer. DNA Vaccines to infectious agents: HIV/SIV; B. Wahren. DNA Vaccines to infectious agents: DNA viruses; B. Rouse. DNA Vaccines to infectious agents: Tumor-associated viruses (excluding HBV); R. Kennedy. DNA Vaccines to infectious agents: Bacteria; D. Lowrie. DNA Vaccines to infectious agents: Parasites; S. Hoffman. Use of DNA vaccines for neonatal/early childhood immunization; C.-A. Siegrist. The potential of DNA vaccines for developing countries; H. Wilde. DNA vaccines and their potential to counterbalance biological warfare/bioterrorism; A. Schmaljohn. DNA vaccines to cancer associated/specific antigens; DNA vaccines to autoimmune diseases; H. Wigzell. DNA vaccines to allergic diseases; Yan Chuah, P. Holt. DNA vaccines for gene therapy; K. High. Safety concerns for DNA; D. Klinman. DNA vaccines: Summary.

Gene Vaccines

Author : Josef Thalhamer
Publisher : Springer Science & Business Media
ISBN 13 : 3709104394
Total Pages : 332 pages
Book Rating : 4.7/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Gene Vaccines by : Josef Thalhamer

Download or read book Gene Vaccines written by Josef Thalhamer and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

DNA Vaccines

Author : Mark W. Saltzman
Publisher : Springer Science & Business Media
ISBN 13 : 1597451681
Total Pages : 382 pages
Book Rating : 4.5/5 (974 download)

DOWNLOAD NOW!

Book Synopsis DNA Vaccines by : Mark W. Saltzman

Download or read book DNA Vaccines written by Mark W. Saltzman and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an immunological response. Once it was observed that plasmid DNA delivered in vivo led to production of an encoded transgene (1), two ground-breaking studies demonstrated that immunological responses could be generated against antigenic transgenes via plasmid DNA delivered by DNA vaccination (as this approach is called) (2,3). The appe- ance of this new vaccination strategy coincided with advances in molecular biology, which provided new tools to study and manipulate the basic elements of an organism’s genome and also could also be applied to the design and production of DNA vaccines. DNA Vaccines is a major updated and enhancement of the first edition. It reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current appli- tions, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Medicine series, these chapters contain detailed practical procedures on the latest DNA vaccine technology. The enthusiasm for DNA vaccine technology is made clear by the number of research studies published on this topic since the mid-1990s.

Gulf War and Health

Author : Committee on Health Effects Associated with Exposures During the Gulf War
Publisher : National Academies Press
ISBN 13 : 0309171628
Total Pages : 426 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Gulf War and Health by : Committee on Health Effects Associated with Exposures During the Gulf War

Download or read book Gulf War and Health written by Committee on Health Effects Associated with Exposures During the Gulf War and published by National Academies Press. This book was released on 2000-12-12 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: The men and women who served in the Gulf War theater were potentially exposed to a wide range of biological and chemical agents. Gulf War and Health: Volume 1 assesses the scientific literature concerning the association between these agents and the adverse health effects currently experienced by a large number of veterans.

Vaccines for Biodefense and Emerging and Neglected Diseases

Author : Alan D.T. Barrett
Publisher : Academic Press
ISBN 13 : 0080919022
Total Pages : 1519 pages
Book Rating : 4.0/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Vaccines for Biodefense and Emerging and Neglected Diseases by : Alan D.T. Barrett

Download or read book Vaccines for Biodefense and Emerging and Neglected Diseases written by Alan D.T. Barrett and published by Academic Press. This book was released on 2009-03-05 with total page 1519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace Each chapter will include a map of the world showing where that particular disease is naturally found

The Ethics of Vaccination

Author : Alberto Giubilini
Publisher : Springer
ISBN 13 : 3030020681
Total Pages : 126 pages
Book Rating : 4.0/5 (3 download)

DOWNLOAD NOW!

Book Synopsis The Ethics of Vaccination by : Alberto Giubilini

Download or read book The Ethics of Vaccination written by Alberto Giubilini and published by Springer. This book was released on 2018-12-28 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book discusses individual, collective, and institutional responsibilities with regard to vaccination from the perspective of philosophy and public health ethics. It addresses the issue of what it means for a collective to be morally responsible for the realisation of herd immunity and what the implications of collective responsibility are for individual and institutional responsibilities. The first chapter introduces some key concepts in the vaccination debate, such as ‘herd immunity’, ‘public goods’, and ‘vaccine refusal’; and explains why failure to vaccinate raises certain ethical issues. The second chapter analyses, from a philosophical perspective, the relationship between individual, collective, and institutional responsibilities with regard to the realisation of herd immunity. The third chapter is about the principle of least restrictive alternative in public health ethics and its implications for vaccination policies. Finally, the fourth chapter presents an ethical argument for unqualified compulsory vaccination, i.e. for compulsory vaccination that does not allow for any conscientious objection. The book will appeal to philosophers interested in public health ethics and the general public interested in the philosophical underpinning of different arguments about our moral obligations with regard to vaccination.

Vaccine Development and Manufacturing

Author : Emily P. Wen
Publisher : John Wiley & Sons
ISBN 13 : 1118870905
Total Pages : 452 pages
Book Rating : 4.1/5 (188 download)

DOWNLOAD NOW!

Book Synopsis Vaccine Development and Manufacturing by : Emily P. Wen

Download or read book Vaccine Development and Manufacturing written by Emily P. Wen and published by John Wiley & Sons. This book was released on 2014-10-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Immunobiology of Dendritic Cells Part A

Author :
Publisher : Academic Press
ISBN 13 : 0128183527
Total Pages : 314 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Immunobiology of Dendritic Cells Part A by :

Download or read book Immunobiology of Dendritic Cells Part A written by and published by Academic Press. This book was released on 2019-10-04 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of Dendritic Cells Part A, Volume 348 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters on the Origin and Development of Dendritic Cells, Dendritic Cell Subsets and Locations, Antigen Processing and Presentation, The Interaction of Dendritic Cells With Cancer Cells, The Role of Dendritic Cells in Human Diseases, and Dendritic Cells-based Vaccines for Cancer Therapy. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Cell and Molecular Biology series Includes the latest information on the Immunobiology of Dendritic Cells, Part A