Gene Therapy of Autoimmune Disease

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387286705
Total Pages : 148 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Gene Therapy of Autoimmune Disease by : Gerald J. Prud'homme

Download or read book Gene Therapy of Autoimmune Disease written by Gerald J. Prud'homme and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Biologic and Gene Therapy of Autoimmune Disease

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805569491
Total Pages : 229 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Biologic and Gene Therapy of Autoimmune Disease by : C. Garrison Fathman

Download or read book Biologic and Gene Therapy of Autoimmune Disease written by C. Garrison Fathman and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Gene Therapy for Autoimmune and Inflammatory Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 3034601654
Total Pages : 249 pages
Book Rating : 4.0/5 (346 download)

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Book Synopsis Gene Therapy for Autoimmune and Inflammatory Diseases by : Yuti Chernajovsky

Download or read book Gene Therapy for Autoimmune and Inflammatory Diseases written by Yuti Chernajovsky and published by Springer Science & Business Media. This book was released on 2011-01-28 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Gene Therapy of Autoimmune Disease

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Author :
Publisher : Springer
ISBN 13 : 9780306479915
Total Pages : 149 pages
Book Rating : 4.4/5 (799 download)

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Book Synopsis Gene Therapy of Autoimmune Disease by : Gerald J. Prud'homme

Download or read book Gene Therapy of Autoimmune Disease written by Gerald J. Prud'homme and published by Springer. This book was released on 2005-07-13 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Gene Therapy for Autoimmune Disease

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Author :
Publisher :
ISBN 13 : 9781587062056
Total Pages : pages
Book Rating : 4.0/5 (62 download)

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Book Synopsis Gene Therapy for Autoimmune Disease by : Dagan (NA) Wells

Download or read book Gene Therapy for Autoimmune Disease written by Dagan (NA) Wells and published by . This book was released on 2003-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene Therapy in Inflammatory Diseases

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Author :
Publisher : Birkhäuser
ISBN 13 : 3034884788
Total Pages : 278 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Gene Therapy in Inflammatory Diseases by : Christopher H. Evans

Download or read book Gene Therapy in Inflammatory Diseases written by Christopher H. Evans and published by Birkhäuser. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Gene Therapy of Autoimmune Disease

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Author :
Publisher : Springer
ISBN 13 : 9780387500164
Total Pages : 0 pages
Book Rating : 4.5/5 (1 download)

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Book Synopsis Gene Therapy of Autoimmune Disease by : Gerald J. Prud'homme

Download or read book Gene Therapy of Autoimmune Disease written by Gerald J. Prud'homme and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

New Concepts in Pathology and Treatment of Autoimmune Disorders

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Publisher : Springer Science & Business Media
ISBN 13 : 3662044501
Total Pages : 158 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis New Concepts in Pathology and Treatment of Autoimmune Disorders by : C. Pozzilli

Download or read book New Concepts in Pathology and Treatment of Autoimmune Disorders written by C. Pozzilli and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Gene Therapy for Autoimmune Disease

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Publisher :
ISBN 13 :
Total Pages : 99 pages
Book Rating : 4.:/5 (548 download)

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Book Synopsis Gene Therapy for Autoimmune Disease by : Nicholas R. Lemoine

Download or read book Gene Therapy for Autoimmune Disease written by Nicholas R. Lemoine and published by . This book was released on 2003 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stem Cell Therapy for Autoimmune Disease

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Publisher : CRC Press
ISBN 13 : 1000716856
Total Pages : 512 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Stem Cell Therapy for Autoimmune Disease by : Richard K. Burt

Download or read book Stem Cell Therapy for Autoimmune Disease written by Richard K. Burt and published by CRC Press. This book was released on 2019-11-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Retroviral-based Gene Therapy in Autoimmune Disease

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Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.:/5 (245 download)

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Book Synopsis Retroviral-based Gene Therapy in Autoimmune Disease by : Gina Lynn Costa

Download or read book Retroviral-based Gene Therapy in Autoimmune Disease written by Gina Lynn Costa and published by . This book was released on 2000 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Treatment of Autoimmune Disorders

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Publisher : Springer Science & Business Media
ISBN 13 : 3709160162
Total Pages : 184 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Treatment of Autoimmune Disorders by : Michael Sticherling

Download or read book Treatment of Autoimmune Disorders written by Michael Sticherling and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.

Biological and Gene Therapy of Autoimmune Disease

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Publisher :
ISBN 13 :
Total Pages : 223 pages
Book Rating : 4.:/5 (641 download)

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Book Synopsis Biological and Gene Therapy of Autoimmune Disease by : C. G. Fathman

Download or read book Biological and Gene Therapy of Autoimmune Disease written by C. G. Fathman and published by . This book was released on 2000 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cytokine Gene Therapy of Autoimmune Disease

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Cytokine Gene Therapy of Autoimmune Disease by :

Download or read book Cytokine Gene Therapy of Autoimmune Disease written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Janeway's Immunobiology

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Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Autoimmune Disease

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Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781530457359
Total Pages : 0 pages
Book Rating : 4.4/5 (573 download)

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Book Synopsis Autoimmune Disease by : Mary Patterson

Download or read book Autoimmune Disease written by Mary Patterson and published by Createspace Independent Publishing Platform. This book was released on 2016-03-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gain Vitality, Energy and Happiness With Increased Autoimmune Health! Do you have an autoimmune disorder? Does a family member have this condition? How can you know if one of these diseases is affecting your life? If so, Autoimmune Disease: Discover The Symptoms & Treatment of Chronic Pain & Genetic Disease is the book for you! Mary Patterson explains the scientific background and root causes of autoimmune diseases so you know exactly what you're dealing with. You'll understand the basic processes underlying autoimmunity - and which symptoms you should look for in yourself and your loved ones! Discover The Details of A Number of Autoimmune Diseases: Thyroid Gland Disorders Rheumatoid Arthritis Systemic Lupus Erythematosus Multiple Sclerosis Type 1 Diabetes Mellitus and even Celiac Disease! With natural nutrition, a belief in healing and the functional treatments in this book, you can combat autoimmune diseases and feel great - TODAY!

Genes and Autoimmunity

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Publisher : BoD – Books on Demand
ISBN 13 : 9535110284
Total Pages : 280 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Genes and Autoimmunity by : Spaska Stanilova

Download or read book Genes and Autoimmunity written by Spaska Stanilova and published by BoD – Books on Demand. This book was released on 2013-03-13 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity.