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Author :
Publisher :
ISBN 13 : 9789402803853
Total Pages : 241 pages
Book Rating : 4.8/5 (38 download)
Download or read book Gene Hunting in Complex Traits written by and published by . This book was released on 2017 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D.C. Rao
Publisher : Academic Press
ISBN 13 : 0080569110
Total Pages : 788 pages
Book Rating : 4.0/5 (85 download)
Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Author : Nicholas W. Gillham
Publisher : FT Press
ISBN 13 :
Total Pages : 353 pages
Book Rating : 4./5 ( download)
Download or read book Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine written by Nicholas W. Gillham and published by FT Press. This book was released on 2011 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This readable overview covers the rise of medical genetics through the past century, and the eugenic impulses it has inspired. Nicholas Gillham reviews the linkages between genes and disease; ethnic groups & rsquo; differential susceptibility to genetic traits and disorders; personalized medicine; and crucial social and ethical issues arising from the field & rsquo;s progress.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309108675
Total Pages : 429 pages
Book Rating : 4.3/5 (91 download)
Download or read book Biosocial Surveys written by National Research Council and published by National Academies Press. This book was released on 2008-01-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosocial Surveys analyzes the latest research on the increasing number of multipurpose household surveys that collect biological data along with the more familiar interviewerâ€"respondent information. This book serves as a follow-up to the 2003 volume, Cells and Surveys: Should Biological Measures Be Included in Social Science Research? and asks these questions: What have the social sciences, especially demography, learned from those efforts and the greater interdisciplinary communication that has resulted from them? Which biological or genetic information has proven most useful to researchers? How can better models be developed to help integrate biological and social science information in ways that can broaden scientific understanding? This volume contains a collection of 17 papers by distinguished experts in demography, biology, economics, epidemiology, and survey methodology. It is an invaluable sourcebook for social and behavioral science researchers who are working with biosocial data.
Author :
Publisher : Academic Press
ISBN 13 : 0123808634
Total Pages : 211 pages
Book Rating : 4.1/5 (238 download)
Download or read book Computational Methods for Genetics of Complex Traits written by and published by Academic Press. This book was released on 2010-11-10 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics reasearch. This thematic volume of Advances in Genetics looks at Computational Methods for Genetics of Complex traits. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Author : Andrew H. Paterson
Publisher : CRC Press
ISBN 13 : 9781420049381
Total Pages : 328 pages
Book Rating : 4.0/5 (493 download)
Download or read book Molecular Dissection of Complex Traits written by Andrew H. Paterson and published by CRC Press. This book was released on 2019-09-17 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Author : Andrew Robert Wood
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (855 download)
Download or read book Next Generation Genome-wide Association Studies in Complex Human Quantitative Traits written by Andrew Robert Wood and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 2005, genome-wide association (GWA) studies have dominated the field of complex traits. Genetic and environmental factors play a role in causing disease and influencing the variance of a quantitative trait. GWA is a hypothesis-free approach that follows on from candidate gene and linkage studies and has markedly increased the number of loci associated with complex traits. Despite the relative success of GWA studies in identifying several hundreds of phenotypic associations, the genetic component of most complex traits remains largely unaccounted for. The field has now begun to focus its, efforts on the "missing heritability" to enhance the understanding of genetics and the associated biological pathways that underlie the aetiology of complex phenotypes. This thesis presents a series of studies that attempt to address this issue by exploring other sources of variation and statistical models that have not been extensively addressed in GWA studies to date. Chapter 1 is an introduction to genome-wide association studies. In particular it describes the origins of these studies, what we have learnt from them as well as their limitations. Chapter 2 describes a study that shows how multiple signals within a single locus can explain more of the genetic component of a complex trait, using gene expression as a model trait. 2 Chapter 3 describes a study that tests for deviation from additivity (additivity is an assumption of most GWA studies to date) through dominant, recessive and gene-gene interaction analyses using height, body mass index, and waist-hip ratio (adjusted for BMI) as model phenotypes. Chapter 4 describes a study that examines how more signals may be identified by increasing the density of variants through 1000 Genomes based imputation compared to HapMap based imputation. I use 93 phenotypes, all circulating factors, including proteins, ions and vitamins. Chapter 5 describes a study that tests whether more association signals can be discovered through low-coverage whole-genome sequencing. In particular, I compare association testing based on 1000 Genomes based imputation and sequencing. I use gene expression as a model trait. Chapter 6 discusses the research findings from the previous chapters, presents conclusions, and describes future research plans in the field of complex traits for a fuller understanding of the role of genetics. 3.
Author : Nourollah Ahmadi
Publisher : Springer Nature
ISBN 13 : 1071622056
Total Pages : 651 pages
Book Rating : 4.0/5 (716 download)
Download or read book Genomic Prediction of Complex Traits written by Nourollah Ahmadi and published by Springer Nature. This book was released on 2022-04-22 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the conceptual framework and the practical issues related to genomic prediction of complex traits in human medicine and in animal and plant breeding. The book is organized into five parts. Part One reminds molecular genetics approaches intending to predict phenotypic variations. Part Two presents the principles of genomic prediction of complex traits, and reviews factors that affect its reliability. Part Three describes genomic prediction methods, including machine-learning approaches, accounting for different degree of biological complexity, and reviews the associated computer-packages. Part Four reports on emerging trends such as phenomic prediction and incorporation into genomic prediction models of “omics” data and crop growth models. Part Five is dedicated to lessons learned from cases studies in the fields of human health and animal and plant breeding, and to methods for analysis of the economic effectiveness of genomic prediction. Written in the highly successful Methods in Molecular Biology series format, the book provides theoretical bases and practical guidelines for an informed decision making of practitioners and identifies pertinent routes for further methodological researches. Cutting-edge and thorough, Complex Trait Predictions: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this important and developing field. Chapters 3, 9, 13, 14, and 21 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Mashaal Sohail
Publisher : Frontiers Media SA
ISBN 13 : 2889748715
Total Pages : 108 pages
Book Rating : 4.8/5 (897 download)
Download or read book Genetic Architecture and Evolution of Complex Traits and Diseases in Diverse Human Populations written by Mashaal Sohail and published by Frontiers Media SA. This book was released on 2022-03-31 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kathleen Steinhöfel
Publisher : Springer
ISBN 13 : 3540453229
Total Pages : 206 pages
Book Rating : 4.5/5 (44 download)
Download or read book Stochastic Algorithms: Foundations and Applications written by Kathleen Steinhöfel and published by Springer. This book was released on 2003-07-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: SAGA 2001, the ?rst Symposium on Stochastic Algorithms, Foundations and Applications, took place on December 13–14, 2001 in Berlin, Germany. The present volume comprises contributed papers and four invited talks that were included in the ?nal program of the symposium. Stochastic algorithms constitute a general approach to ?nding approximate solutions to a wide variety of problems. Although there is no formal proof that stochastic algorithms perform better than deterministic ones, there is evidence by empirical observations that stochastic algorithms produce for a broad range of applications near-optimal solutions in a reasonable run-time. The symposium aims to provide a forum for presentation of original research in the design and analysis, experimental evaluation, and real-world application of stochastic algorithms. It focuses, in particular, on new algorithmic ideas invo- ing stochastic decisions and exploiting probabilistic properties of the underlying problem domain. The program of the symposium re?ects the e?ort to promote cooperation among practitioners and theoreticians and among algorithmic and complexity researchers of the ?eld. In this context, we would like to express our special gratitude to DaimlerChrysler AG for supporting SAGA 2001. The contributed papers included in the proceedings present results in the following areas: Network and distributed algorithms; local search methods for combinatorial optimization with application to constraint satisfaction problems, manufacturing systems, motor control unit calibration, and packing ?exible - jects; and computational learning theory.
Author : Nicholas Wright Gillham
Publisher : FT Press
ISBN 13 : 0132623242
Total Pages : 353 pages
Book Rating : 4.1/5 (326 download)
Download or read book Genes, Chromosomes, and Disease written by Nicholas Wright Gillham and published by FT Press. This book was released on 2011-03-15 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.
Author : Holly K. Tabor
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (245 download)
Download or read book Candidate Gene Approaches for Studying the Genetics of Complex Traits written by Holly K. Tabor and published by . This book was released on 2002 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Donaldson
Publisher : Garland Science
ISBN 13 : 1317334256
Total Pages : 450 pages
Book Rating : 4.3/5 (173 download)
Download or read book Genetics of Complex Disease written by Peter Donaldson and published by Garland Science. This book was released on 2015-08-25 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest
Author : Segun Fatumo
Publisher : Frontiers Media SA
ISBN 13 : 2889744647
Total Pages : 123 pages
Book Rating : 4.8/5 (897 download)
Download or read book Genetics of Complex Traits & Diseases from Under-Represented Populations written by Segun Fatumo and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Aaron Garth Day-Wiliams
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.:/5 ( download)
Download or read book Efficient Use of Genetic Data for Mapping Complex Traits written by Aaron Garth Day-Wiliams and published by . This book was released on 2009 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James Tabery
Publisher : Knopf
ISBN 13 : 0525658203
Total Pages : 337 pages
Book Rating : 4.5/5 (256 download)
Download or read book Tyranny of the Gene written by James Tabery and published by Knopf. This book was released on 2023-08-15 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A revelatory account of how power, politics, and greed have placed the unfulfilled promise of personalized medicine at the center of American medicine The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen. In Tyranny of the Gene, James Tabery exposes the origin story of personalized medicine—essentially a marketing idea dreamed up by pharmaceutical executives—and traces its path from the Human Genome Project to the present, revealing how politicians, influential federal scientists, biotech companies, and drug giants all rallied behind the genetic hype. The result is a medical revolution that privileges the few at the expense of health care that benefits us all. Now American health care, driven by the commercialization of biomedical research, is shifting focus away from the study of the social and environmental determinants of health, such as access to fresh and nutritious food, exposure to toxic chemicals, and stress caused by financial insecurity. Instead, it is increasingly investing in “miracle pills” for leukemia that would bankrupt most users, genetic studies of minoritized populations that ignore structural racism and walk dangerously close to eugenic conclusions, and oncology centers that advertise the perfect gene-drug match, igniting a patient’s hope, and often dashing it later.Tyranny of the Gene sounds a warning cry about the current trajectory of health care and charts a path to a more equitable alternative.
Author :
Publisher :
ISBN 13 : 9789462956155
Total Pages : 200 pages
Book Rating : 4.9/5 (561 download)
Download or read book Using Genetic Methods to Get Insights Into Human Complex Traits written by and published by . This book was released on 2017 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
