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Gated

Author : Amy Christine Parker
Publisher : Ember
ISBN 13 : 0449816001
Total Pages : 370 pages
Book Rating : 4.4/5 (498 download)

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Book Synopsis Gated by : Amy Christine Parker

Download or read book Gated written by Amy Christine Parker and published by Ember. This book was released on 2014-05-27 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fast-paced, nerve-fraying contemporary thriller that questions loyalties and twists truths. Appearances can be deceiving. Lyla Hamilton is a loyal member of the Community. Her family was happy to be chosen by Pioneer to join such an lovely gated neighborhood. Here, life seems perfect. But after meeting Cody, an outsider boy, Lyla starts questioning Pioneer, her friends, her family--everything. And if there's one thing not allowed in the Community, it's doubt. As Pioneer cleverly manipulates his flock toward disaster, the real question is: Will Lyla follow her heart or follow Pioneer over the edge? From the outside looking in, it's hard to understand why anyone would join a cult. But Gated tells the story from the inside looking out, and from behind the gates things are not quite so simple. Amy Christine Parker's beautiful writing creates a chilling, utterly unique YA story. Perfect for fans of creepy thrillers and contemporary fiction alike. "A tense psychological thriller that will leave you gasping for breath as you race to the very last page." --Gretchen McNeil, author of Ten HelloGiggles.com, August 3, 2013: "When I found out that there was a YA book about cults, of course I had to read it. As it turns out, Amy Christine Parker’s Gated is an awesome, creepy book that reminds me of my favorite cult films while still being surprising." Starred Review, Kirkus Reviews, June 15, 2013: "Parker doesn’t pull punches, indicating a level of brutality that will appropriately disturb even as it successfully conveys Lyla’s complete entrapment in the Community. Compelling and not that distant from real-world cults that have ended in tragedy." Publishers Weekly, June 10, 2013: "Parker skillfully explores the mindset and inner workings of an apocalyptic cult, steadily building toward the inevitable moment of truth...As for the apocalypse itself, Parker keeps things suitably ambiguous, resulting in a complex, intriguing tale rooted in real-world events." School Library Journal, October 2013: "This well-plotted tale will allow readers a glimpse into the possible world of a doomsday cult...The language is accessible, making it a good choice for reluctant readers. After the last page is turned, the question will linger: 'Could I ever be deceived like this?'" Examiner.com "A well-rounded and thorough look into cults while still remaining entertaining throughout. I look forward to reading more of Parker's works in the future."

Gated Communities

Author : Rowland Atkinson
Publisher : Routledge
ISBN 13 : 1317998278
Total Pages : 239 pages
Book Rating : 4.3/5 (179 download)

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Book Synopsis Gated Communities by : Rowland Atkinson

Download or read book Gated Communities written by Rowland Atkinson and published by Routledge. This book was released on 2013-09-13 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This informative volume gathers contemporary accounts of the growth, influences on, and impacts of so-called gated communities, developments with walls, gates, guards and other forms of surveillance. While gated communities have become a common feature of the urban landscape in South Africa, Latin and North America, it is also clear that there is now significant interest in gated living in the European and East Asian urban context. The chapters in this book investigate issues and communities such as: gated communities in the metropolitan area of Buenos Aires, Argentina planning responses to gated communities in Canada who segregates whom? The analysis of a gated community in Mendoza, Argentina sprawl and social segregation in southern California. These illustrative chapters enable the reader to understand more about the social and economic forces that have lead to gating, the ways in which gated communities are managed, and their wider effects on both residents and those living outside the gates. This book was previously published as a special issue of the journal Housing Studies.

Gated Communities

Author : Samer Bagaeen
Publisher : Earthscan
ISBN 13 : 1849774773
Total Pages : 160 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Gated Communities by : Samer Bagaeen

Download or read book Gated Communities written by Samer Bagaeen and published by Earthscan. This book was released on 2010-02-09 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Gated Communities" presents a collection of new writings by an international and interdisciplinary group of contributors, which provides a historic, socio-political and contemporary cultural perspective of gated communities.

Clinical Gated Cardiac SPECT

Author : Guido Germano
Publisher : John Wiley & Sons
ISBN 13 : 0470987308
Total Pages : 384 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Clinical Gated Cardiac SPECT by : Guido Germano

Download or read book Clinical Gated Cardiac SPECT written by Guido Germano and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book will be useful for all physicians involved in cardiac imaging, whether they are in radiology, nuclear medicine, or cardiology, and should be mandatory for physicians engaged in gated cardiac SPECT. It is recommended without reservation." – from a review of the first edition in Radiology With gated cardiac SPECT now firmly established for the management of the cardiac patient, Drs. Germano and Berman bring you completely up to date with the multiple clinical applications as well as the recent technical developments of the modality. Clinical Gated Cardiac SPECT, Second Edition: covers all the available protocols describes a systematic approach for interpretation and reporting provides guidance for the recognition of artifacts includes flowcharts on the management of patients The relationship of gated cardiac SPECT to PET, MRI and CT is explored in separate chapters devoted to each modality. This book is essential reading for all clinicians involved in cardiac imaging.

Beyond Gated Communities

Author : Samer Bagaeen
Publisher : Routledge
ISBN 13 : 1317659058
Total Pages : 268 pages
Book Rating : 4.3/5 (176 download)

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Book Synopsis Beyond Gated Communities by : Samer Bagaeen

Download or read book Beyond Gated Communities written by Samer Bagaeen and published by Routledge. This book was released on 2015-06-12 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gated communities is moving away from the hard concept of a 'gated community' to the more fluid one of urban gating. The latter allows communities to be viewed through a new lens of soft boundaries, modern communication and networks of influence. The book, written by an international team of experts, builds on the research of Bagaeen and Uduku’s previous edited publication, Gated Communities (Routledge 2010) and relates recent events to trends in urban research, showing how the discussion has moved from privatised to newly collectivised spaces, which have been the focal point for events such as the Occupy London movement and the Arab Spring. Communities are now more mobilised and connected than ever, and Beyond Gated Communities shows how neighbourhoods can become part of a global network beyond their own gates. With chapters on Australia, Canada, Europe, South America, Asia, Africa and the Middle East, this is a truly international resource for scholars and students of urban studies interested in this dynamic, growing area of research.

Gated Communities in China

Author : Choon-Piew Pow
Publisher : Routledge
ISBN 13 : 113402097X
Total Pages : 225 pages
Book Rating : 4.1/5 (34 download)

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Book Synopsis Gated Communities in China by : Choon-Piew Pow

Download or read book Gated Communities in China written by Choon-Piew Pow and published by Routledge. This book was released on 2009-09-11 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the nature and dynamics of gated communities within the specificities of reform Shanghai, a city that arguably has been at the forefront of China’s new urban/consumer revolution.

Recent advances in voltage-gated sodium channels, their pharmacology and related diseases

Author : Mohamed Chahine
Publisher : Frontiers E-books
ISBN 13 : 2889191281
Total Pages : 119 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Recent advances in voltage-gated sodium channels, their pharmacology and related diseases by : Mohamed Chahine

Download or read book Recent advances in voltage-gated sodium channels, their pharmacology and related diseases written by Mohamed Chahine and published by Frontiers E-books. This book was released on with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our pleasure to co-edit a Research Topic on voltage-gated sodium channels pharmacology and related diseases. We are in a process to inviting submissions of novel research article, state-of-the-art review papers and viewpoints on this topic. All the papers will follow a peer-review process according to the guidelines of Frontiers in Pharmacology. Voltage-gated sodium channel play a critical role in electrical signalling in many excitable cells such as neurons, skeletal muscle cells and cardiac myocytes. They are responsible for the initiation and the propagation of action potential, allowing integration of higher processes. They are formed by one alpha subunit that forms the pore of the channel and one or several regulatory subunits. Sodium channels are the target for local anaesthetics, antiarrhythmic drugs, and anticonvulsants. This class of ion channels is prime target to several toxins. Recently, a number of mutations in sodium channels that often results in alterations of rapid channel gating have been identified and linked to human diseases. Such channelopathies cause periodic paralysis, myotonia, long QT syndrome and other cardiac conductance disturbances, pain, hemiplegic migraine, and epilepsy. Sodium channels play also a negative role in malignant cellular proliferation, chronic pain, and other diseases. Considering these crucial physiological and pathological implications, it is not surprising that sodium channels have been and still are key targets for drug development. This Research Topic of Frontiers of Pharmacology of Ion Channels and Channelopathies will focus on this important class of ion channels how they operate, their pharmacology and their implication in diseases.

Voltage-Gated Calcium Channels

Author : Gerald Werner Zamponi
Publisher : Springer Nature
ISBN 13 : 3031088816
Total Pages : 705 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Voltage-Gated Calcium Channels by : Gerald Werner Zamponi

Download or read book Voltage-Gated Calcium Channels written by Gerald Werner Zamponi and published by Springer Nature. This book was released on 2022-11-07 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease

Author : Jörg Striessnig
Publisher : Springer Nature
ISBN 13 : 3031384377
Total Pages : 319 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease by : Jörg Striessnig

Download or read book Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease written by Jörg Striessnig and published by Springer Nature. This book was released on 2023-07-31 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

ATP-gated P2X receptors in health and disease

Author : Andrea Nistri
Publisher : Frontiers Media SA
ISBN 13 : 2889194051
Total Pages : 173 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis ATP-gated P2X receptors in health and disease by : Andrea Nistri

Download or read book ATP-gated P2X receptors in health and disease written by Andrea Nistri and published by Frontiers Media SA. This book was released on 2015-01-05 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.

Respiratory and Cardiac Gating in PET, An Issue of PET Clinics

Author : Habib Zaidi
Publisher : Elsevier Health Sciences
ISBN 13 : 1455772208
Total Pages : 260 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Respiratory and Cardiac Gating in PET, An Issue of PET Clinics by : Habib Zaidi

Download or read book Respiratory and Cardiac Gating in PET, An Issue of PET Clinics written by Habib Zaidi and published by Elsevier Health Sciences. This book was released on 2013-01-28 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of issues associated with gating studies with PET imaging are mostly unknown among practitioners of the field, which is posing a significant danger to those who undergo such studies. This is particularly true for respiratory gating examination. Topics in this issue include both basic and clinical topics, including views from radiation oncology physicians.

Molecular Mechanisms of Voltage-Gating in Ion Channels

Author : Gildas Loussouarn
Publisher : Frontiers Media SA
ISBN 13 : 2889715884
Total Pages : 163 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Molecular Mechanisms of Voltage-Gating in Ion Channels by : Gildas Loussouarn

Download or read book Molecular Mechanisms of Voltage-Gating in Ion Channels written by Gildas Loussouarn and published by Frontiers Media SA. This book was released on 2021-11-03 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fortress America

Author : Edward J. Blakely
Publisher : Brookings Institution Press
ISBN 13 : 9780815791072
Total Pages : 236 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Fortress America by : Edward J. Blakely

Download or read book Fortress America written by Edward J. Blakely and published by Brookings Institution Press. This book was released on 1997-09-01 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gated communities are a new "hot button" in many North American cities. From Boston to Los Angeles and from Miami to Toronto citizens are taking sides in the debate over whether any neighborhood should be walled and gated, preventing intrusion or inspection by outsiders. This debate has intensified since the hard cover edition of this book was published in 1997. Since then the number of gated communities has risen dramatically. In fact, new homes in over 40 percent of planned developments are gated n the West, the South, and southeastern parts of the United States. Opposition to this phenomenon is growing too. In the small and relatively homogenous town of Worcester, Massachusetts, a band of college students from Brown University and the University of Chicago picketed the Wexford Village in November of 1998 waving placards that read "Gates Divide." These students are symbolic of a much larger wave of citizens asking questions about the need for and the social values of gates that divide one portion of a community from another.

Returns of Agricultural Statistics of British India and the Native State of Mysore

Author :
Publisher :
ISBN 13 :
Total Pages : 1444 pages
Book Rating : 4.:/5 (26 download)

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Book Synopsis Returns of Agricultural Statistics of British India and the Native State of Mysore by :

Download or read book Returns of Agricultural Statistics of British India and the Native State of Mysore written by and published by . This book was released on 1918 with total page 1444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Voltage-gated Calcium Channels in Developing Chicken Inner Ear Hair Cells

Author : Snežana Lević
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (72 download)

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Book Synopsis Voltage-gated Calcium Channels in Developing Chicken Inner Ear Hair Cells by : Snežana Lević

Download or read book Voltage-gated Calcium Channels in Developing Chicken Inner Ear Hair Cells written by Snežana Lević and published by . This book was released on 2006 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Conformational Changes during Potassium-Channel Gating

Author : Jakob Renhorn
Publisher : Linköping University Electronic Press
ISBN 13 : 9176853381
Total Pages : 71 pages
Book Rating : 4.1/5 (768 download)

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Book Synopsis Conformational Changes during Potassium-Channel Gating by : Jakob Renhorn

Download or read book Conformational Changes during Potassium-Channel Gating written by Jakob Renhorn and published by Linköping University Electronic Press. This book was released on 2018-04-09 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. The ability to sense voltage resides in the four voltage-sensor domains (VSDs) surrounding the central ion-conducting pore. Membrane depolarization causes the inside of the membrane to become positively charged, electrostatically repelling the positively charged fourth transmembrane segment (S4), or voltage sensor, in the VSD, causing the voltage sensor to move outwards. This motion provides necessary energy to open the pore and allow ion conductivity. Prolonged channel activation leads to alterations in the selectivity filter which cease ion conductivity, in a process called slow inactivation. In this thesis, we investigated the movement of S4 during activation of the channel. We also studied the communication between the four subunits during activation as well as the communication between the pore domain and VSD during slow inactivation. We have shown that voltage sensors move approximately 12 Å outwards during activation. The positively charged amino acid residues in S4 create temporary salt bridges with negative counter-charges in the other segments of the VSD as it moves through a membrane. We have also shown that the movement of one of the four voltage sensors can affect the movement of the neighboring voltage sensors. When at least one voltage sensor has moved to an up-position, it stabilizes other voltage sensors in the up-position, increasing the energy required for the voltage sensor to return to the down position. We have also shown reciprocal communication between the pore domain and the VSDs. Alterations in the VSD or the interface between the pore and the VSD cause changes in the rate of slow inactivation. Likewise, modifications in the pore domain cause changes to the voltage-sensor movement. This indicates communication between the pore and the VSD during slow inactivation. The information from our work could be used to find new approaches when designing channel-modifying drugs for the treatment of diseases caused by increased neuronal excitability, such as chronic pain and epilepsy.

The Voltage-gated Calcium Channels in Cat Retinal Ganglion Cell During Ontogeny

Author : Shih-Jwo Huang
Publisher :
ISBN 13 :
Total Pages : 436 pages
Book Rating : 4.:/5 (56 download)

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Book Synopsis The Voltage-gated Calcium Channels in Cat Retinal Ganglion Cell During Ontogeny by : Shih-Jwo Huang

Download or read book The Voltage-gated Calcium Channels in Cat Retinal Ganglion Cell During Ontogeny written by Shih-Jwo Huang and published by . This book was released on 1995 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: