Gas Phase Structure Characterization Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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Gas Phase Structure Characterization Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author : Anupriy
Publisher :
ISBN 13 :
Total Pages : 105 pages
Book Rating : 4.:/5 (993 download)

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Book Synopsis Gas Phase Structure Characterization Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Anupriy

Download or read book Gas Phase Structure Characterization Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Anupriy and published by . This book was released on 2016 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation investigates Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) based techniques to study the impact of molecular structure on conformation and binding energetics. A novel method to determine collison cross sectional areas using FTICR (CRAFTI), initially developed by the Dearden lab, was applied to study the conformations of molecular systems with unique structural attributes in an attempt to explore the molecular range of CRAFTI. The systems chosen for CRAFTI studies include crown-ether alkylammonium complexes and biogenic amino acids. The results were found to be consistent with expected behavior, and strongly correlated with experimental measurements made using ion mobility spectrometry (IMS) and predictions from computations. The analytical sensitivity of CRAFTI was highlighted by its ability to distinguish the normal and branched structural isomers of butylamine. Besides conformation characterization, quantitative evaluation of binding was undertaken on metal ion-cryptand complexes on the FTICR instrument using sustained off-resonance irradiation –collision-induced dissociation (SORI CID) method. Complex formation and dissociation was found to be a strong function of both guest and host sizes which impacted steric selectivity, and polarizability. The results demonstrate the ability of FTICR to simultaneously determine structure, conformation and binding thereby providing comprehensive molecular characterization.

Fundamentals and Applications of Fourier Transform Mass Spectrometry

Author : Philippe Schmitt-Kopplin
Publisher : Elsevier
ISBN 13 : 0128140143
Total Pages : 778 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fundamentals and Applications of Fourier Transform Mass Spectrometry by : Philippe Schmitt-Kopplin

Download or read book Fundamentals and Applications of Fourier Transform Mass Spectrometry written by Philippe Schmitt-Kopplin and published by Elsevier. This book was released on 2019-08-11 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis

Gas Phase Chiral Recognition, Characterization of Porous Polymer Monolith Nanospray Ionization, and the Negative Mode CRAFTI Method Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Download Gas Phase Chiral Recognition, Characterization of Porous Polymer Monolith Nanospray Ionization, and the Negative Mode CRAFTI Method Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry PDF Online Free

Author : Nannan Fang
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (55 download)

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Book Synopsis Gas Phase Chiral Recognition, Characterization of Porous Polymer Monolith Nanospray Ionization, and the Negative Mode CRAFTI Method Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Nannan Fang

Download or read book Gas Phase Chiral Recognition, Characterization of Porous Polymer Monolith Nanospray Ionization, and the Negative Mode CRAFTI Method Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Nannan Fang and published by . This book was released on 2009 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 4 deals with the application of the new CRAFTI method to negative ions. CRAFTI stands for cross-sectional areas by Fourier transform ICR. The CRAFTI technique measures collision cross sections, providing a probe of the gas phase conformations of supramolecular complexes. Our preliminary work has shown that CRAFTI is applicable to positive ions, so we further demonstrate the application of the newly-developed method to negative ions in this work.

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Investigation of Gas-phase Ions

Author : David Kage
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.:/5 (436 download)

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Book Synopsis Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Investigation of Gas-phase Ions by : David Kage

Download or read book Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Investigation of Gas-phase Ions written by David Kage and published by . This book was released on 1999 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies of gas phase ion/molecule reactions by Fourier transform ion cyclotron resonance mass spectrometry

Author : Jan C. Kleingeld
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (634 download)

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Book Synopsis Studies of gas phase ion/molecule reactions by Fourier transform ion cyclotron resonance mass spectrometry by : Jan C. Kleingeld

Download or read book Studies of gas phase ion/molecule reactions by Fourier transform ion cyclotron resonance mass spectrometry written by Jan C. Kleingeld and published by . This book was released on 1984 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gas Phase Ion/molecule Reactions as Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author : Steen Ingemann Jørgensen
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (256 download)

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Book Synopsis Gas Phase Ion/molecule Reactions as Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Steen Ingemann Jørgensen

Download or read book Gas Phase Ion/molecule Reactions as Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Steen Ingemann Jørgensen and published by . This book was released on 1985 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fourier transform ion cyclotron resonance

Author : Leopold J. de Koning
Publisher :
ISBN 13 :
Total Pages : 147 pages
Book Rating : 4.:/5 (631 download)

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Book Synopsis Fourier transform ion cyclotron resonance by : Leopold J. de Koning

Download or read book Fourier transform ion cyclotron resonance written by Leopold J. de Koning and published by . This book was released on 1989 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gas Phase Ion-molecule Reactions Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author : Charles William Ross
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.:/5 (314 download)

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Book Synopsis Gas Phase Ion-molecule Reactions Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Charles William Ross

Download or read book Gas Phase Ion-molecule Reactions Studied by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Charles William Ross and published by . This book was released on 1993 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Mass Spectrometry

Author :
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.7/5 (74 download)

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Book Synopsis Advances in Mass Spectrometry by :

Download or read book Advances in Mass Spectrometry written by and published by . This book was released on 2007 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gas-phase Radical Chemistry of Polypeptides in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author : Kim F. Haselmann
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (473 download)

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Book Synopsis Gas-phase Radical Chemistry of Polypeptides in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Kim F. Haselmann

Download or read book Gas-phase Radical Chemistry of Polypeptides in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Kim F. Haselmann and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Host-guest Chiral Recognition in the Gas Phase by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author : Yongjiang Liang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Host-guest Chiral Recognition in the Gas Phase by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Yongjiang Liang

Download or read book Host-guest Chiral Recognition in the Gas Phase by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Yongjiang Liang and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mass Spectrometry

Author : Marek Smoluch
Publisher : John Wiley & Sons
ISBN 13 : 1119377307
Total Pages : 450 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mass Spectrometry by : Marek Smoluch

Download or read book Mass Spectrometry written by Marek Smoluch and published by John Wiley & Sons. This book was released on 2019-07-11 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

Advances in Mass Spectrometry

Author : Zdenek Herman
Publisher :
ISBN 13 : 9781901019070
Total Pages : 103 pages
Book Rating : 4.0/5 (19 download)

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Book Synopsis Advances in Mass Spectrometry by : Zdenek Herman

Download or read book Advances in Mass Spectrometry written by Zdenek Herman and published by . This book was released on 2007 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Characterization of Protein Therapeutics using Mass Spectrometry

Author : Guodong Chen
Publisher : Springer Science & Business Media
ISBN 13 : 1441978623
Total Pages : 408 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Characterization of Protein Therapeutics using Mass Spectrometry by : Guodong Chen

Download or read book Characterization of Protein Therapeutics using Mass Spectrometry written by Guodong Chen and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Gas-phase Reactions of Amino Acids and Small Peptides as Studied in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Author : Scott R. Carr
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (385 download)

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Book Synopsis Gas-phase Reactions of Amino Acids and Small Peptides as Studied in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer by : Scott R. Carr

Download or read book Gas-phase Reactions of Amino Acids and Small Peptides as Studied in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer written by Scott R. Carr and published by . This book was released on 1997 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nucleic Acids in the Gas Phase

Author : Valérie Gabelica
Publisher : Springer
ISBN 13 : 3642548423
Total Pages : 297 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Nucleic Acids in the Gas Phase by : Valérie Gabelica

Download or read book Nucleic Acids in the Gas Phase written by Valérie Gabelica and published by Springer. This book was released on 2014-07-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation. The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.

Hydrogen Exchange Mass Spectrometry of Proteins

Author : David D. Weis
Publisher : John Wiley & Sons
ISBN 13 : 1118703731
Total Pages : 376 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Hydrogen Exchange Mass Spectrometry of Proteins by : David D. Weis

Download or read book Hydrogen Exchange Mass Spectrometry of Proteins written by David D. Weis and published by John Wiley & Sons. This book was released on 2016-01-12 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) - a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.