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Functionalized Mesoporous Silica Nanoparticles For Stimuli Responsive And Targeted Drug Delivery
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Book Synopsis Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery by : Nikola Knezevic
Download or read book Functionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery written by Nikola Knezevic and published by . This book was released on 2009 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery by : Nikola Knežević
Download or read book Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery written by Nikola Knežević and published by . This book was released on 2009 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted by :
Download or read book Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted written by and published by . This book was released on 2009 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Construction of functional supramolecular nanoassemblies has attracted great deal of attention in recent years for their wide spectrum of practical applications. Mesoporous silica nanoparticles (MSN) in particular were shown to be effective scaffolds for the construction of drug carriers, sensors and catalysts. Herein, we describe the synthesis and characterization of stimuli-responsive, controlled release MSN-based assemblies for drug delivery.
Book Synopsis Stimuli-responsive Drug Delivery Systems by : Amit Singh
Download or read book Stimuli-responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-10 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.
Book Synopsis Mesoporous Materials for Drug Delivery and Theranostics by : Valentina Cauda
Download or read book Mesoporous Materials for Drug Delivery and Theranostics written by Valentina Cauda and published by MDPI. This book was released on 2020-12-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Book Synopsis Bioresponsive Polymers by : Deepa H. Patel
Download or read book Bioresponsive Polymers written by Deepa H. Patel and published by CRC Press. This book was released on 2020-10-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.
Book Synopsis Smart Materials for Drug Delivery by : Carmen Alvarez-Lorenzo
Download or read book Smart Materials for Drug Delivery written by Carmen Alvarez-Lorenzo and published by Royal Society of Chemistry. This book was released on 2013-04-17 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart materials, which can change properties when an external stimulus is applied, can be used for the targeted drug delivery of an active molecule to a specific site in the correct dosage. Different materials such as liposomes, polymeric systems, nanomaterials and hydrogels can respond to different stimuli such as pH, temperature and light and these are all attractive for controlled release applications. With so many papers available on smart and stimuli-responsive materials for drug delivery applications it's hard to know where to start reading about this exciting topic. This two volume set brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems. With contributions from leading experts in the field, including a foreword from distinguished scientist Nicholas Peppas, The University of Texas at Austin, USA, the book will provide both an introduction to the key areas for graduate students and new researchers in the stimuli-responsive field as well as serving as a reference for those already working on fundamental materials research or drug delivery applications.
Book Synopsis Silica-coated Magnetic Nanoparticles by : Mariela A. Agotegaray
Download or read book Silica-coated Magnetic Nanoparticles written by Mariela A. Agotegaray and published by Springer. This book was released on 2017-01-04 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.
Book Synopsis Oral Lipid-Based Formulations by : David J. Hauss
Download or read book Oral Lipid-Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem
Book Synopsis Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery and Bioimaging by : Chi-An Cheng
Download or read book Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery and Bioimaging written by Chi-An Cheng and published by . This book was released on 2020 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation makes contributions to the fields of formulation and delivery of anticancer drugs, antibiotics, and imaging agents, primarily focused on engineering mesoporous silica nanoparticles (MSNs) for stimuli-responsive drug delivery. The strategies and techniques developed in this dissertation will be especially useful for achieving precision medicine or personalized medicine, which is defined as the "right drug, right dosage at right timing to right patient". Although various emerging approaches for personalized disease treatment that take individual variability into account have been developed, the necessity of delivering the desired therapeutics at the desired time to the specific site of the disease and with accurate dosage remains a challenge. Here we first review the previously reported stimuli-responsive MSNs controlled by supramolecular nanomachines for antibiotic and drug delivery. In the second part of the dissertation, we report novel MSNs-based nanoparticles engineered to be responsive to noninvasive stimuli, such as alternating magnetic field (AMF) or high-intensity focused ultrasound (HIFU). AMF-responsive drug delivery demonstrates the controlled therapeutic efficacy for pancreatic cancer cells in vitro by adjusting different lengths of AMF exposure time. The HIFUresponsive MSNs provide a promising platform for magnetic resonance imaging (MRI)-guided HIFU (MRgHIFU)-stimulated cargo delivery. The change of T1 reports on the amount of released cargo which is imageable by MRI ex vivo. Both AMF-and MRgHIFU-stimulation strategies offer the potential for the spatial, temporal, and dosage control of drug delivery. In the last part, we develop an approach to achieve both high loading and high release amount of a water-insoluble antibiotic clofazimine (CFZ) carried by MSNs by using acetophenone (AP) as a chaperone molecule, solving the water insolubility problem faced when treating multidrug-resistant tuberculosis. The treatment of Mycobacterium tuberculosis infected macrophages with optimized CFZ-loaded MSNs shows good therapeutic efficacy in vitro. Finally, we develop a hollow mesoporous silica nanoparticle (HMSN) formulated near infrared (NIR) fluorophore IR-140, to realize a novel biocompatible shortwave infrared (SWIR) optical imaging contrast agent for bioimaging with a higher tissue penetration depth. The J-aggregates of IR-140 stabilized inside HMSNs showed the potential to overcome the stability, toxicity, and brightness challenges faced by common SWIR contrast agents.
Book Synopsis Polymer Modified Mesoporous Silica Nanoparticles for Controlled Drug and Protein Delivery by : Erick Yu
Download or read book Polymer Modified Mesoporous Silica Nanoparticles for Controlled Drug and Protein Delivery written by Erick Yu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery by nanoparticles has been an important, emergent field in the past decade with mesoporous silica at the forefront. With a high surface area and wide variety of modifications possible, mesoporous silica nanoparticles (MSNs) are a robust platform to load, transport and deliver molecular species, including tracer compounds, macromolecules, and anti-cancer agents. A wide variety of MSN crystalline structures were first synthesized in the 1990s and early 2000s. In the following years, advances in silane, inorganic, and organic chemistry led to “smart” drug delivery, a revolutionary method wherein contained species could be released at a desired rate. In combination with stimuli or target responsive functional groups, MSNs in recent years have shown particular promise for the therapeutic delivery of peptides, proteins, and small genetic material. To fully realize the potential for these applications, the porous structure of MSNs needs to be enlarged to accommodate larger species without compromising the overall nanoparticle structure. Additionally, due to the sensitive nature of these proteins and genetic matter, stability and prevention of structural deformation is important for their delivery into biological environments. Combining expanded pore MSNs with stimuli-responsive functional groups is currently a major focus for drug delivery. In this dissertation I report on modification of MSNs through inorganic and polymeric constituents. Using a pore-expansion process to synthesize MSNs capable of delivering proteins, specifically lysozyme (ca. 3.9 nm diameter) and bovine hemoglobin (c.a. 5.5 nm diameter), I further modified the MSNs using triblock polyethylene oxide-polypropylene-polyethylene oxide (PEO-PPO-PEO), poly(n-isopropylacrylamide) (PNIPAM), and polyethylene glycol (PEG). I show a well-controlled release of drugs and proteins with these nanoparticles. Triblock PEO-PPO-PEO copolymers function as weak surfactants, which allow them to potentially increase drug permeability through lipid bilayers that coat MSNs. The release behavior of lipid-MSNs can then be linearly fine-tuned with both the composition of the triblock copolymer and its concentration. Among the stimuli-sensitive functional groups used to modify MSNs, PNIPAM in particular has been developed significantly in the past decade as a gating molecule for both nanoparticles and porous membranes. As a thermoresponsive polymer, which changes both its surface hydrophilic/hydrophobic nature in addition to its morphology at 32 °C, PNIPAM can be applied to the MSN surface to provide a triggered release when temperatures are elevated to physiological temperatures. PNIPAM was investigated under in situ liquid atomic force microscopy at sub 80 nm grafting lengths in order to better understand and characterize its collapse behavior around nanostructured surfaces, comparable to the surface of mesoporous silica nanoparticles. Here I demonstrate that the collapse behavior occurs even at grafted lengths of 10-20 nm. However, under these conditions, the gating effect is minimal around nanostructured edges, as of those of nanopores. I further show that when PNIPAM is combined with the step-wise, template functionality of MSNs and further modified with PEG (notable for its ability to minimize non-specific binding and interactions between proteins and glass substrates), improved release delivery of loaded proteins is realized. With therapeutic peptide delivery in mind, these MSNs were tested with lysozyme and bovine hemoglobin to show their potential for delivery of both proteins and genetic material.
Book Synopsis FASTtrack Pharmaceutics by : Yvonne Perrie
Download or read book FASTtrack Pharmaceutics written by Yvonne Perrie and published by Pharmaceutical Press. This book was released on 2012 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.
Book Synopsis Nanoengineering of Biomaterials by : Sougata Jana
Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.
Book Synopsis Nanoparticles in Diagnosis, Drug Delivery and Nanotherapeutics by : Divya Bajpai Tripathy
Download or read book Nanoparticles in Diagnosis, Drug Delivery and Nanotherapeutics written by Divya Bajpai Tripathy and published by CRC Press. This book was released on 2023-12-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integration of nanotechnology with biomaterials, diagnostic tools, analytical equipment, physiotherapy kits, and drug delivery agents has resulted in nanotherapeutics illustrated as a class of medicine with potential of research and development. This book illustrates synthesis, properties, and applications of nanotherapeutics in various healthcare-related issues including treatment of cancer, Alzheimer’s disease, targeted drug delivery, anti-HIV-1 nanotherapeutics, antibacterial/antiviral agents, skin therapy, and hyperthermia. Features: Consolidates different aspects of nanoparticles such as synthesis and types of nanotherapeutics in a detailed manner Presents categorical classification of nanoparticles as therapeutics Covers the sustainability of nanotherapeutics Reviews fabrication and advancement of all categories of nanotherapeutics Discusses specific applications such as in cancer therapy, skin treatments, and targeted drug delivery This book is aimed at researchers, professionals, and senior undergraduate students in materials and medical science, biomedical engineering, and nanotechnology
Book Synopsis Stimuli-Responsive Nanocarriers by : Virendra Gajbhiye
Download or read book Stimuli-Responsive Nanocarriers written by Virendra Gajbhiye and published by Elsevier. This book was released on 2022-01-10 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems. Provides comprehensive knowledge of basic design, mechanism and construction of nanocarrier based stimuli-responsive drug releases Explores various nanocarriers characteristically used in the development of stimuli-responsive drug release systems Envisages future opportunities, challenges and implementation of nanocarrier based stimuli-responsive drug release systems in disease therapeutics
Book Synopsis Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release by : Giri Supratim
Download or read book Mesoporous Silica and Magnetic Nanoparticle Based Controlled Release written by Giri Supratim and published by LAP Lambert Academic Publishing. This book was released on 2014-01 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is one of the key technologies of twenty first century. It involves engineering with materials that have size dimension in nanometer range. As important biological entities like virus, pores of biological membranes, proteins, etc also share their sizes in the nanometer ranges; there has been an extensive application of nanotechnology in biology and biomedicine. Nanomaterial based drug delivery offers one of the most useful techniques to administer therapeutics in living cells and tissues. Mesoporous silica nanomaterials act as excellent hosts to store and deliver guest molecules. In this book, research topics on the development of mesoporous silica nanomaterials as a stimuli responsive and controlled release delivery agents have been discussed. Magnetic nanoparticles were utilized for targeting the drug delivery assembly to a site of interest and induce stimuli responsive drug release in 'proof of principle' studies. The work described in this book is expected to provide a rational approach towards designing targeted and stimuli responsive smart drug delivery systems.
Book Synopsis Immune Response to Functionalized Mesoporous Silica Nanoparticles for Targeted Drug Delivery1 by :
Download or read book Immune Response to Functionalized Mesoporous Silica Nanoparticles for Targeted Drug Delivery1 written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
