Free Radicals In The Pathogenesis Of Liver Injury

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Free Radicals in the Pathogenesis of Liver Injury

Author : Giuseppe Poli
Publisher : Pergamon
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Free Radicals in the Pathogenesis of Liver Injury by : Giuseppe Poli

Download or read book Free Radicals in the Pathogenesis of Liver Injury written by Giuseppe Poli and published by Pergamon. This book was released on 1989 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Since the first Congress on Free Radicals in Liver Injury took place in 1985, much research and development has taken place in this area of liver pathophysiology which is now considered to be of prime interest and importance in hepatology. In these Proceedings of the second Congress, held in Turin in June 1988, the most recent advances in the study of free radical mechanisms, from the organic to the molecular level in both acute and chronic liver injuries are discussed, in both experimental animals and man. The first section covers the remarkable advances that have been made in the clarification of biochemical mechanisms connecting oxidative insult to hepatocyte death. Stimulating new data on the role of free radicals and lipid peroxidation in the development of hepatocellular carcinoma and in liver regeneration appear in the second section. The papers in the third section investigate the involvement of oxidative species in the pathology of chr

Liver Pathophysiology

Author : Pablo Muriel
Publisher : Academic Press
ISBN 13 : 0128043210
Total Pages : 917 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Liver Pathophysiology by : Pablo Muriel

Download or read book Liver Pathophysiology written by Pablo Muriel and published by Academic Press. This book was released on 2017-03-02 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Free Radicals and the Liver

Author : Geza Csomos
Publisher : Springer Science & Business Media
ISBN 13 : 3642768741
Total Pages : 246 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Free Radicals and the Liver by : Geza Csomos

Download or read book Free Radicals and the Liver written by Geza Csomos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the results of the latest congress of the European Association for the Study of the Liver (EASL), this volume makes excellent reading since it explores in detail the role of free radical reactions in liver diseases. Studies in recent years using various methods have shown that free radicals play an important role in toxic liver disorders. For this reason, the current scientific knowledge is presented in this balanced, clinical portrayal. The account refers to the many observations, experiencesand evaluations that have been made both clinically and experimentally. Two major areas discussed concern the pathophysiological changes by free radicals and the therapeutic possibilities that have come to light.

The Liver

Author : Vinood Patel
Publisher : Academic Press
ISBN 13 : 0128039787
Total Pages : 370 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Liver by : Vinood Patel

Download or read book The Liver written by Vinood Patel and published by Academic Press. This book was released on 2018-01-03 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Liver: Oxidative Stress and Dietary Antioxidants takes a novel approach to the science of oxidative stress in liver disease by recognizing that diseases are multifactorial and oxidative stress is a single component. It highlights oxidative stress in relation to other processes, such as apoptosis, cell signaling and receptor mediated responses, and includes the therapeutic usage of natural antioxidants in the diet and food matrix, along with coverage of pharmacological and natural agents designed to counteract oxidative stress. Written for research scientists, gastroenterologists, food scientists, hepatologists and physicians, this trans-disciplinary guide will help advance medical sciences and enable new preventative and treatment strategies. - Provides a framework for in-depth analysis of the basic processes of oxidative stress, from molecular biology, to whole organs in relation to the liver - Bridges the trans-disciplinary divide between the basic science and mechanisms of liver disease and oxidative stress to advance medical sciences and enable preventative and treatment strategies - Contains contributions from leading national and international experts, including those from world renowned institutions

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Systems Biology of Free Radicals and Antioxidants

Author : Ismail Laher
Publisher : Springer
ISBN 13 : 9783642300172
Total Pages : 0 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Systems Biology of Free Radicals and Antioxidants by : Ismail Laher

Download or read book Systems Biology of Free Radicals and Antioxidants written by Ismail Laher and published by Springer. This book was released on 2014-06-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 290 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Drug-Induced Liver Disease

Author : Neil Kaplowitz
Publisher : CRC Press
ISBN 13 : 0203909127
Total Pages : 790 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Drug-Induced Liver Disease by : Neil Kaplowitz

Download or read book Drug-Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Free Radicals in the Pathogenesis of Alcohol Induced Liver Disease

Author : Graham Paul BUTCHER
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Free Radicals in the Pathogenesis of Alcohol Induced Liver Disease by : Graham Paul BUTCHER

Download or read book Free Radicals in the Pathogenesis of Alcohol Induced Liver Disease written by Graham Paul BUTCHER and published by . This book was released on 1991 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Free Radicals, Antioxidants, Aging and Disease

Author : Joseph A. Knight
Publisher : American Association for Clinical Chemistry, Incorporated
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Free Radicals, Antioxidants, Aging and Disease by : Joseph A. Knight

Download or read book Free Radicals, Antioxidants, Aging and Disease written by Joseph A. Knight and published by American Association for Clinical Chemistry, Incorporated. This book was released on 1999 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents information from significant peer-reviewed studies showing that increased oxidative stress has an important role in numerous medical disorders. Describes current concepts of life expectancy, the aging process, and the presence of free radicals in biological systems. Explores the relationship between free radical and increased oxidative stress in medical disorders, including atherosclerosis, ischemia/reperfusion injury, pulmonary diseases, liver and kidney disorders, cancer, and neurodegenerative disorders.

Cytochromes P450

Author : Costas Ioannides
Publisher : CRC Press
ISBN 13 : 9781439810705
Total Pages : 426 pages
Book Rating : 4.8/5 (17 download)

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Book Synopsis Cytochromes P450 by : Costas Ioannides

Download or read book Cytochromes P450 written by Costas Ioannides and published by CRC Press. This book was released on 1996-09-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicity Anticipate drug interactions Modify doses to fit the needs of patients Contributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest. This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.

Steatohepatitis (NASH and ASH)

Author : U. Leuschner
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387695
Total Pages : 410 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Steatohepatitis (NASH and ASH) by : U. Leuschner

Download or read book Steatohepatitis (NASH and ASH) written by U. Leuschner and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Symposium No. 121 on 'Steatohepatitis (NASH and ASH)', held in Den Haag, The Netherlands, on October 14-15, 2000. The histological features of what we now call non-alcoholic steatohepatitis were described as early as 1962 by the Honorary President of the Symposium, Professor Herbert Thaler, from Vienna. Others followed, and in 1980 Jürgen Ludwig, one of the speakers of this symposium, introduced the name `non-alcoholic steatohepatitis' or NASH. In a Consensus Symposium organized by the National Institute of Health (NIH) in Washington, USA, in December 1998, NASH was recognized as one of the most common liver diseases in Western countries when viral hepatitis and heavy alcohol consumption were excluded. ASH, or alcoholic steatohepatitis, is more common than NASH, since alcohol is omnipresent in Western as well as Eastern cultures. Histologically NASH and ASH are similar or even identical. Morphological findings range from fatty degeneration to inflammation and fibrosis, and may end up in liver cirrhosis. In spite of the well-defined morphological features, our knowledge of epidemiology, aetiology, and pathogenesis is full of gaps, especially for NASH. Therefore, it is the purpose of this book to show the state of the art, to discuss recent scientific data, and to suggest possible treatment strategies, hoping to stimulate clinicians as well as scientists.

Brain Aging

Author : David R. Riddle
Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis Brain Aging by : David R. Riddle

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

International Meeting on "free Radicals in Liver Injury".

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis International Meeting on "free Radicals in Liver Injury". by :

Download or read book International Meeting on "free Radicals in Liver Injury". written by and published by . This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Disease in Children

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Artificial Liver

Author : Lanjuan Li
Publisher : Springer Nature
ISBN 13 : 9811559848
Total Pages : 571 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Artificial Liver by : Lanjuan Li

Download or read book Artificial Liver written by Lanjuan Li and published by Springer Nature. This book was released on 2020-11-24 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the clinical application of artificial liver system (ALS) in hepatic failure. It has been widely used in clinics aiming to provide temporary support of liver function while maintaining extra-hepatic function in patients with liver failure. This work comprehensively summarizes the progress of livers and artificial liver, for example, the principle and implementation of Li-ALS, cell transplantation and the combined application of artificial liver and liver transplantation. It will be helpful for clinicians to implement artificial liver treatment to save the lives of patients with hepatic failure.

Hepatic Circulation

Author : W. Wayne Lautt
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615040099
Total Pages : 174 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Hepatic Circulation by : W. Wayne Lautt

Download or read book Hepatic Circulation written by W. Wayne Lautt and published by Morgan & Claypool Publishers. This book was released on 2009-11-17 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs. Table of Contents: Acknowledgements / Historical Perspectives / Overview / Fluid Exchange / Capacitance / Resistance in the Hepatic Artery / Resistance in the Venous System / Fetal and Neonatal Hepatic Circulation / In Vivo Pharmacodynamic Approaches / Nitric Oxide / Adenosine / Hepatic Nerves / Hepatic Circulation and Toxicology / Hepatorenal Syndrome / Integrative Hepatic Response to Hemorrhage / Blood Flow Regulation of Hepatocyte Proliferation / Multiple Mechanisms Maintaining a Constant Hepatic Blood Flow to Liver Mass Ratio / Pathopharmacology and Repurposing Drugs as a Research Strategy / References