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Formulation Development Of Gastro Retentive Anti Diabetic Tablet
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Book Synopsis Formulation & Development of Gastro-retentive Anti-Diabetic Tablet by : Ravi Parsotambhai Gondaliya
Download or read book Formulation & Development of Gastro-retentive Anti-Diabetic Tablet written by Ravi Parsotambhai Gondaliya and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastro-retentive Tablets are primarily controlled release drug delivery systems, which gets retained in the stomach for longer period of time, thus helping in absorption of drug for the intended duration of time. This in turn improves bioavailability, reduces drug wastage, improves solubility of drugs that are less soluble at high pH environment. It also helps in achieving local delivery of drug to the stomach and proximal small intestine.
Book Synopsis Design, Development and Evaluation of Gastroretentive Drug Delivery System of Metformin Hcl by : Faria Gias Senjoti
Download or read book Design, Development and Evaluation of Gastroretentive Drug Delivery System of Metformin Hcl written by Faria Gias Senjoti and published by . This book was released on 2014 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metformin HCl, a drug from biguanide class, is the most commonly used first-line antihyperglycemic agent in the treatment of NIDDM. The major problems associated with the drug are high dose (1.5-2.0 g/day), frequent dosing due to its shorter biological half-life (1.5-4.9 hr), and low bioavailability (60%). Low bioavailability of metformin results from incomplete absorption of the drug as metformin is majorly absorbed from stomach and lower part of GIT. The study was done for the purpose of developing gastroretentive tablets of metformin HCl to prolong gastric residence time and increase drug bioavailability based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Drug-excipient incompatibility was confirmed by DSC and FTIR study. 12 mm circular bi-convex floating tablets were prepared by wet granulation method using a 10-station Rotary tablet press machine. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. Seventeen (17) trial formulations were investigated taking various compositions of polymer, NaHCO3 and SSG each at three levels. Data analysis and modeling were performed by Design expert® software (version 8.0.7.1, stat-Ease Inc., Minneapolis, MN). The optimized tablets were evaluated for weight variation, hardness, thickness, friability, moisture content, assay, in-vitro floating lag time, % swelling and surface morphology study. Furthermore, optimized tablets were stored at accelerated stability condition (40 °C and 75% RH) for 3 months. All preformulation parameters were found to be within the acceptable range. Melting peaks of metformin was visible in DSC thermogram of drug-excipients mixture, indicating that metformin was compatible with the rest of the excipients of formulation. FTIR study also confirmed the same finding. Floating lag time and duration of floating were found to be dependent on amount of gas effervescent agent (NaHCO3), swelling of polymers (HPMC and PEO) and swelling enhancer (SSG). It was found that formulation with of polymer concentration 250 mg, NaHCO3 60 mg, and SSG 50 mg fulfilled requistes of an optimum formulation. The optimized formulation was found to provide average floating lag time less than 4 minutes with a floating duration of more than 24 hours. Swelling rate of the combination of polymers was found to be rapid and linear for initial 2 hr, however it decreased thereafter and maintained the linearity until 8 hours. Combination of HPMC and PEO allowed efficient control of drug release for 12 hours. SEM figure showed the non-porous nature of tablet outer surface and little bit porous structure of inner surface before dissolution study. However, after dissolution of 2 hours and 8 hours, both surfaces turned into porous structure which allows the drug to diffuse to the surrounding medium. This also proved that the drug release occurs by diffusion. Based on accelerated stability study; optimized formulation was found to be stable for three months without any major changes in assay, dissolution profile, floating lag time and other physical properties.
Book Synopsis Liposomes in Drug Delivery by : AlexanderT. Florence
Download or read book Liposomes in Drug Delivery written by AlexanderT. Florence and published by Routledge. This book was released on 2017-10-05 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.
Book Synopsis Aulton's Pharmaceutics by : Michael E. Aulton
Download or read book Aulton's Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
Book Synopsis 3D Printing of Pharmaceuticals by : Abdul W. Basit
Download or read book 3D Printing of Pharmaceuticals written by Abdul W. Basit and published by Springer. This book was released on 2018-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Abdul W. Basit is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul’s research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the International Journal of Pharmaceutics. Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award. Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.
Book Synopsis Controlled Drug Delivery Systems by : Emmanuel Opara
Download or read book Controlled Drug Delivery Systems written by Emmanuel Opara and published by CRC Press. This book was released on 2020-02-28 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Book Synopsis Recent Advances in Novel Drug Carrier Systems by : Ali Demir Sezer
Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Book Synopsis Novel Formulations and Future Trends by : Amit Kumar Nayak
Download or read book Novel Formulations and Future Trends written by Amit Kumar Nayak and published by Elsevier. This book was released on 2024-03-25 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends. It discusses the most important developments in drug delivery, including important and exciting areas such as mucosal, implantable, transdermal, gastroretentive, vaccine and targeted drug delivery systems. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students. New technologies are also explored including 3D printing and computational pharmaceutics. - Explores the most recent technologies in drug delivery in detail - Contains contributions from the leading experts from academia, research, industry and regulatory agencies - Includes high quality illustrations, flow charts and tables for easy understanding of concepts - Discusses practical examples and research case studies
Book Synopsis Excipient Applications in Formulation Design and Drug Delivery by : Ajit S Narang
Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.
Book Synopsis Design of Experiments by : Lennart Eriksson
Download or read book Design of Experiments written by Lennart Eriksson and published by MKS Umetrics AB. This book was released on 2008 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Pharmaceutical Controlled Release Technology by : Donald L. Wise
Download or read book Handbook of Pharmaceutical Controlled Release Technology written by Donald L. Wise and published by CRC Press. This book was released on 2000-08-24 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!
Book Synopsis Oral Drug Absorption by : Jennifer B. Dressman
Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Book Synopsis Nanoemulsions by : Seid Mahdi Jafari
Download or read book Nanoemulsions written by Seid Mahdi Jafari and published by Academic Press. This book was released on 2018-02-24 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. - Summarizes general aspects of food nanoemulsions and their formulation - Provides detailed information on the production, application, and characterization of food nanoemulsion - Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations - Explains preparation of nanoemulsions by both low- and high-energy methods
Book Synopsis Antiepileptic Drugs by : Ali A. Asadi-Pooya
Download or read book Antiepileptic Drugs written by Ali A. Asadi-Pooya and published by Oxford University Press. This book was released on 2016 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise handbook provides up-to-date clinical guidance on effective selection, prescription, and usage of antiepileptic drugs for patients with epilepsy in various medical conditions. This text discusses choosing drugs when faced with various medical comorbidities; how to correctly prescribe, titrate, and taper drugs; how to monitor drug efficacy and side effects; how to diagnose and manage toxicity; and how antiepileptic drugs interact with other medications. This text fills an unmet need as a practical, patient-oriented reference and leads to improved patient care. This is the perfect guide for physicians looking to ensure safe practices in antiepileptic drug therapy.
Book Synopsis Handbook of Drug Administration via Enteral Feeding Tubes, 3rd edition by : Rebecca White
Download or read book Handbook of Drug Administration via Enteral Feeding Tubes, 3rd edition written by Rebecca White and published by Pharmaceutical Press. This book was released on 2015-03-11 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 400 drug monographs, this book covers the technical, practical and legal aspects that you should consider before prescribing or administering drugs via enteral feeding tubes.
Book Synopsis Optimization Methods by : Marco Cavazzuti
Download or read book Optimization Methods written by Marco Cavazzuti and published by Springer Science & Business Media. This book was released on 2012-09-11 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about optimization techniques and is subdivided into two parts. In the first part a wide overview on optimization theory is presented. Optimization is presented as being composed of five topics, namely: design of experiment, response surface modeling, deterministic optimization, stochastic optimization, and robust engineering design. Each chapter, after presenting the main techniques for each part, draws application oriented conclusions including didactic examples. In the second part some applications are presented to guide the reader through the process of setting up a few optimization exercises, analyzing critically the choices which are made step by step, and showing how the different topics that constitute the optimization theory can be used jointly in an optimization process. The applications which are presented are mainly in the field of thermodynamics and fluid dynamics due to the author's background.
Book Synopsis Managing Diabetes and Hyperglycemia in the Hospital Setting by : Boris Draznin
Download or read book Managing Diabetes and Hyperglycemia in the Hospital Setting written by Boris Draznin and published by American Diabetes Association. This book was released on 2016-05-20 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with diabetes increases annually, it is not surprising that the number of patients with diabetes who are admitted to the hospital also increases. Once in the hospital, patients with diabetes or hyperglycemia may be admitted to the Intensive Care Unit, require urgent or elective surgery, enteral or parenteral nutrition, intravenous insulin infusion, or therapies that significantly impact glycemic control (e.g., steroids). Because many clinical outcomes are influenced by the degree of glycemic control, knowledge of the best practices in inpatient diabetes management is extremely important. The field of inpatient management of diabetes and hyperglycemia has grown substantially in the last several years. This body of knowledge is summarized in this book, so it can reach the audience of hospitalists, endocrinologists, nurses and other team members who take care of hospitalized patients with diabetes and hyperglycemia.
