Flow And Microreactor Technology In Medicinal Chemistry

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Flow and Microreactor Technology in Medicinal Chemistry

Author : Esther Alza
Publisher : John Wiley & Sons
ISBN 13 : 3527824618
Total Pages : 372 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Flow and Microreactor Technology in Medicinal Chemistry by : Esther Alza

Download or read book Flow and Microreactor Technology in Medicinal Chemistry written by Esther Alza and published by John Wiley & Sons. This book was released on 2022-06-13 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors—with integrated analysis of the resulting products—provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. In Flow and Microreactor Technology in Medicinal Chemistry, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. Flow and Microreactor Technology in Medicinal Chemistry readers will also find: Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists How to integrate flow synthesis with drug discovery How to perform enantioselective reactions under continuous flow conditions Flow and Microreactor Technology in Medicinal Chemistry is a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.

Flow Chemistry in Drug Discovery

Author : Jesus Alcazar
Publisher : Springer Nature
ISBN 13 : 3030855929
Total Pages : 501 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Flow Chemistry in Drug Discovery by : Jesus Alcazar

Download or read book Flow Chemistry in Drug Discovery written by Jesus Alcazar and published by Springer Nature. This book was released on 2021-12-08 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.

Flash Chemistry

Author : Jun-ichi Yoshida
Publisher : John Wiley & Sons
ISBN 13 : 0470723416
Total Pages : 244 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Flash Chemistry by : Jun-ichi Yoshida

Download or read book Flash Chemistry written by Jun-ichi Yoshida and published by John Wiley & Sons. This book was released on 2008-10-13 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Have you ever wished you could speed up your organic syntheses without losing control of the reaction? Flash Chemistry is a new concept which offers an integrated scheme for fast, controlled organic synthesis. It brings together the generation of highly reactive species and their reactions in Microsystems to enable highly controlled organic syntheses on a preparative scale in timescales of a few seconds or less. Flash Chemistry: Fast Organic Synthesis in microsystems is the first book to describe this exciting new technique, with chapters covering: an introduction to flash chemistry reaction dynamics: how fast is the act of chemical transformation, what is the rate of reaction, and what determines the selectivity of a reaction? examples of why flash chemistry is needed: the rapid construction of chemical libraries, rapid synthesis of radioactive PET probes, and on-demand rapid synthesis in industry the generation of highly reactive species through thermal, microwave, chemical, photochemical, and electrochemical activation microsystems: What are microsystems and how are they made? Why is size so important? What are the characteristic features of microsystems? conduction and control of extremely fast reactions using microsystems applications of flash chemistry in organic synthesis polymer synthesis based on flash chemistry industrial applications of flash chemistry Flash Chemistry: Fast Organic Synthesis in Microsystems is an essential introduction to anyone working in organic synthesis, process chemistry, chemical engineering and physical organic chemistry concerned with fundamental aspects of chemical reactions an d synthesis and the production of organic compounds.

Flow Chemistry in Drug Discovery

Author : Jesus Alcazar
Publisher :
ISBN 13 : 9783030855932
Total Pages : 0 pages
Book Rating : 4.8/5 (559 download)

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Book Synopsis Flow Chemistry in Drug Discovery by : Jesus Alcazar

Download or read book Flow Chemistry in Drug Discovery written by Jesus Alcazar and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.

Microreaction Technology

Author : M. Matlosz
Publisher : Springer Science & Business Media
ISBN 13 : 3642567630
Total Pages : 584 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Microreaction Technology by : M. Matlosz

Download or read book Microreaction Technology written by M. Matlosz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: IMRET 5 featured more than 80 oral and poster communications, covering the entire interdisciplinary field from design, production, modeling and characterization of microreactor devices to application of microstructured systems for production, energy and transportation, including many analytical and biological applications. A particularly strong topic was the investigation of the potential of microstructuring of reactors and systems components for process intensification. Perspectives of combining local, in situ, data acquisition with appropriate microstructuring of actuators and components within chemical and biological devices were explored in order to enhance process performance and facilitate process control.

Continuous-Flow Chemistry in the Research Laboratory

Author : Toma Glasnov
Publisher : Springer
ISBN 13 : 331932196X
Total Pages : 119 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Continuous-Flow Chemistry in the Research Laboratory by : Toma Glasnov

Download or read book Continuous-Flow Chemistry in the Research Laboratory written by Toma Glasnov and published by Springer. This book was released on 2016-06-01 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a short introduction to the historical background to the field, the state of the art and a brief survey of the available instrumentation and the processing techniques used. The following major areas of interest in synthetic, organic and medicinal chemistry are elaborated on: transition-metal catalyzed reactions, organocatalytic transformations, heterocyclic synthesis, and photochemical reactions. Finally, selected applications in industry are also discussed. With its ample presentation of examples from recent literature, this is an essential and reliable source of information for both experienced researchers and postgraduate newcomers to the field.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Author : Wei Zhang
Publisher : John Wiley & Sons
ISBN 13 : 0470711515
Total Pages : 769 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Green Techniques for Organic Synthesis and Medicinal Chemistry by : Wei Zhang

Download or read book Green Techniques for Organic Synthesis and Medicinal Chemistry written by Wei Zhang and published by John Wiley & Sons. This book was released on 2012-07-23 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Design and Engineering of Microreactor and Smart-Scaled Flow Processes

Author : Volker Hessel
Publisher : MDPI
ISBN 13 : 3038420387
Total Pages : 250 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Design and Engineering of Microreactor and Smart-Scaled Flow Processes by : Volker Hessel

Download or read book Design and Engineering of Microreactor and Smart-Scaled Flow Processes written by Volker Hessel and published by MDPI. This book was released on 2018-10-08 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Design and Engineering of Microreactor and Smart-Scaled Flow Processes" that was published in Processes

New Advances in Hydrogenation Processes

Author : Maryam Takht Ravanchi
Publisher : BoD – Books on Demand
ISBN 13 : 9535128698
Total Pages : 364 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis New Advances in Hydrogenation Processes by : Maryam Takht Ravanchi

Download or read book New Advances in Hydrogenation Processes written by Maryam Takht Ravanchi and published by BoD – Books on Demand. This book was released on 2017-01-25 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogen is one of the abundant elements on earth majorly in the form of water (H2O) and mainly as hydrogen gas (H2). Catalytic hydrogenation is a key reaction that has versatile applications in different industries. The main objective of this book is to bring together various applications of hydrogenation through the perspective of leading researchers in the field. This book is intended to be used as a graduate-level text book or as a practical guide for industrial engineers.

New Synthetic Technologies in Medicinal Chemistry

Author : Elizabeth Farrant
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733058
Total Pages : 176 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis New Synthetic Technologies in Medicinal Chemistry by : Elizabeth Farrant

Download or read book New Synthetic Technologies in Medicinal Chemistry written by Elizabeth Farrant and published by Royal Society of Chemistry. This book was released on 2011-10-04 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagents; microwave assisted chemistry; flow synthesis, and high throughput reaction screening.

Basics of Flow Microreactor Synthesis

Author : Jun-ichi Yoshida
Publisher : Springer
ISBN 13 : 9784431555124
Total Pages : 0 pages
Book Rating : 4.5/5 (551 download)

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Book Synopsis Basics of Flow Microreactor Synthesis by : Jun-ichi Yoshida

Download or read book Basics of Flow Microreactor Synthesis written by Jun-ichi Yoshida and published by Springer. This book was released on 2015-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in a concise form the principles and applications of flow microreactors in organic and polymer synthesis. Recently, it became possible to conduct chemical reactions in a flow reactor in laboratory synthesis. The flow microreactor enables reactions that cannot be done in batch, opening a new possibility of chemical synthesis. Extremely fast mass and heat transfer and high-resolution residence time control are responsible for the remarkable features of that process. The book is not an exhaustive compilation of all known examples of flow microreactor synthesis. Rather, it is a sampling of sufficient variety to illustrate the concept, the scope, and the current state of flow microreactor synthesis. Researchers both in academia and in industry will be interested in this book because the topics encompassed by the book are vigorously studied in many university and company laboratories today.

Small Molecule Medicinal Chemistry

Author : Werngard Czechtizky
Publisher : John Wiley & Sons
ISBN 13 : 1118771575
Total Pages : 528 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Small Molecule Medicinal Chemistry by : Werngard Czechtizky

Download or read book Small Molecule Medicinal Chemistry written by Werngard Czechtizky and published by John Wiley & Sons. This book was released on 2015-09-21 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

Early Drug Development

Author : Fabrizio Giordanetto
Publisher : John Wiley & Sons
ISBN 13 : 3527801774
Total Pages : 816 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Early Drug Development by : Fabrizio Giordanetto

Download or read book Early Drug Development written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-06-15 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Sustainable Flow Chemistry

Author : Luigi Vaccaro
Publisher : John Wiley & Sons
ISBN 13 : 3527338527
Total Pages : 336 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Sustainable Flow Chemistry by : Luigi Vaccaro

Download or read book Sustainable Flow Chemistry written by Luigi Vaccaro and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry. Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process. An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.

Microreactors in Preparative Chemistry

Author : Wladimir Reschetilowski
Publisher : John Wiley & Sons
ISBN 13 : 3527652914
Total Pages : 351 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Microreactors in Preparative Chemistry by : Wladimir Reschetilowski

Download or read book Microreactors in Preparative Chemistry written by Wladimir Reschetilowski and published by John Wiley & Sons. This book was released on 2013-09-13 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book in the field to focus on these aspects, providing extremely valuable information unavailable elsewhere for anyone seeking the practical application of microreactor technology in preparative chemistry. The topics covered branch out in three different directions. To begin with, the knowledge necessary for the preparative chemistry concerning the influence of the so-called microeffects on the reaction procedure and on mass and heat transfer as well as the surface phenomena are provided in detail. Next, practical aspects of the synthesis of various basic chemicals and fine chemicals, polymers, bioproducts and nanoparticles are discussed, including important advice for both the researcher and industrial chemist. Finally, reaction examples in microreactors whose reaction guidance are best understood are given together with universally applicable correlations as well as modeling approaches and transfer potential on related reaction systems. With its specific instructions, tips and experimental procedures for product syntheses as well as the inclusion of both the technical and theoretical background this is a must-have for beginners and experts alike working in this emerging field.

Novel Process Windows

Author : Volker Hessel
Publisher : John Wiley & Sons
ISBN 13 : 3527328580
Total Pages : 342 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Novel Process Windows by : Volker Hessel

Download or read book Novel Process Windows written by Volker Hessel and published by John Wiley & Sons. This book was released on 2015-03-23 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the concept of novel process windows, focusing on cost improvements, safety, energy and eco-efficiency throughout each step of the process. The first part presents the new reactor and process-related technologies, introducing the potential and benefit analysis. The core of the book details scenarios for unusual parameter sets and the new holistic and systemic approach to processing, while the final part analyses the implications for green and cost-efficient processing. With its practical approach, this is invaluable reading for those working in the pharmaceutical, fine chemicals, fuels and oils industries.

Continuous Pharmaceutical Processing and Process Analytical Technology

Author : Ajit S. Narang
Publisher : CRC Press
ISBN 13 : 1000804496
Total Pages : 723 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Continuous Pharmaceutical Processing and Process Analytical Technology by : Ajit S. Narang

Download or read book Continuous Pharmaceutical Processing and Process Analytical Technology written by Ajit S. Narang and published by CRC Press. This book was released on 2023-03-01 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the ‘why’ and the ‘how’, emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability. Features: Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugs Includes short stories about how some companies have adopted CM and what their drivers were and what benefits were realized Addresses economic and practical considerations, unlike many other technical books Emphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologies Highlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies