Exploring The Role Of Antiviral Drugs In The Eradication Of Polio

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Exploring the Role of Antiviral Drugs in the Eradication of Polio

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180937
Total Pages : 82 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Role of Antiviral Drugs in the Eradication of Polio by : National Research Council

Download or read book Exploring the Role of Antiviral Drugs in the Eradication of Polio written by National Research Council and published by National Academies Press. This book was released on 2006-05-04 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report, is a report of a workshop in which experts evaluated whether an antiviral drug against poliovirus would be helpful in the final stages of the global polio eradication campaign. The World Health Organization currently plans to stop using oral polio vaccine three years after the detection of the last case of transmission of wild polio virus. This is because the vaccine contains live, weakened polio viruses that can spread and revert to virulence in populations that have not been immunized. Under this plan, an antiviral drug could be useful to control any polio outbreaks caused by a vaccine-derived virus that might occur after vaccination ends and the number of unimmunized people in the world steadily increases. The report recommends that planning and development of such drugs should be initiated now. It identifies several promising targets for drug development and outlines the steps needed for planning for clinical trials and regulatory approval.

Exploring the Role of Antiviral Drugs in the Eradication of Polio

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309101611
Total Pages : 82 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Role of Antiviral Drugs in the Eradication of Polio by : National Research Council

Download or read book Exploring the Role of Antiviral Drugs in the Eradication of Polio written by National Research Council and published by National Academies Press. This book was released on 2006-06-04 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report, is a report of a workshop in which experts evaluated whether an antiviral drug against poliovirus would be helpful in the final stages of the global polio eradication campaign. The World Health Organization currently plans to stop using oral polio vaccine three years after the detection of the last case of transmission of wild polio virus. This is because the vaccine contains live, weakened polio viruses that can spread and revert to virulence in populations that have not been immunized. Under this plan, an antiviral drug could be useful to control any polio outbreaks caused by a vaccine-derived virus that might occur after vaccination ends and the number of unimmunized people in the world steadily increases. The report recommends that planning and development of such drugs should be initiated now. It identifies several promising targets for drug development and outlines the steps needed for planning for clinical trials and regulatory approval.

Exploring the Role of Antiviral Drugs in the Eradication of Polio

Author : Committee on Development of a Polio Antiviral and Its Potential Role in Global Poliomyelitis Eradication
Publisher :
ISBN 13 : 9780309382069
Total Pages : 82 pages
Book Rating : 4.3/5 (82 download)

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Book Synopsis Exploring the Role of Antiviral Drugs in the Eradication of Polio by : Committee on Development of a Polio Antiviral and Its Potential Role in Global Poliomyelitis Eradication

Download or read book Exploring the Role of Antiviral Drugs in the Eradication of Polio written by Committee on Development of a Polio Antiviral and Its Potential Role in Global Poliomyelitis Eradication and published by . This book was released on 2006-05-04 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report, is a report of a workshop in which experts evaluated whether an antiviral drug against poliovirus would be helpful in the final stages of the global polio eradication campaign. The World Health Organization currently plans to stop using oral polio vaccine three years after the detection of the last case of transmission of wild polio virus. This is because the vaccine contains live, weakened polio viruses that can spread and revert to virulence in populations that have not been immunized. Under this plan, an antiviral drug could be useful to control any polio outbreaks caused by a vaccine-derived virus that might occur after vaccination ends and the number of unimmunized people in the world steadily increases. The report recommends that planning and development of such drugs should be initiated now. It identifies several promising targets for drug development and outlines the steps needed for planning for clinical trials and regulatory approval.

Exploring the Frontiers of Innovation to Tackle Microbial Threats

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309675332
Total Pages : 179 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Exploring the Frontiers of Innovation to Tackle Microbial Threats by : National Academies of Sciences, Engineering, and Medicine

Download or read book Exploring the Frontiers of Innovation to Tackle Microbial Threats written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-09-10 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: On December 4â€"5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop.

What You Need to Know about Infectious Disease

Author : Madeline Drexler
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis What You Need to Know about Infectious Disease by : Madeline Drexler

Download or read book What You Need to Know about Infectious Disease written by Madeline Drexler and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Vaccine Book

Author : Barry R. Bloom
Publisher : Academic Press
ISBN 13 : 012805400X
Total Pages : 666 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Vaccine Book by : Barry R. Bloom

Download or read book The Vaccine Book written by Barry R. Bloom and published by Academic Press. This book was released on 2016-06-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk. - Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines - Gives new ideas about future vaccines and concepts - Introduces new vaccines and concepts - Gives ideas about challenges facing public and private industrial investors in the vaccine area - Discusses the problem of declining immunization rates and vaccine hesitancy

The Picornaviruses

Author : Ellie Ehrenfeld
Publisher : American Society for Microbiology Press
ISBN 13 : 1555816037
Total Pages : 1039 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis The Picornaviruses by : Ellie Ehrenfeld

Download or read book The Picornaviruses written by Ellie Ehrenfeld and published by American Society for Microbiology Press. This book was released on 2010-09-15 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.

Morbidity and Mortality Weekly Report

Author :
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Morbidity and Mortality Weekly Report by :

Download or read book Morbidity and Mortality Weekly Report written by and published by . This book was released on 2007 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309178894
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by : National Research Council

Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-11-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Viral Proteases and Antiviral Protease Inhibitor Therapy

Author : Uwe Lendeckel
Publisher : Springer Science & Business Media
ISBN 13 : 9048123488
Total Pages : 139 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel

Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Molecular Biology of Picornaviruses

Author : Bert L. Semler
Publisher :
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Biology of Picornaviruses by : Bert L. Semler

Download or read book Molecular Biology of Picornaviruses written by Bert L. Semler and published by . This book was released on 2002 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- Up-to-date and in-depth analysis.

Jonas Salk

Author : Charlotte Jacobs
Publisher : Oxford University Press, USA
ISBN 13 : 0199334412
Total Pages : 588 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Jonas Salk by : Charlotte Jacobs

Download or read book Jonas Salk written by Charlotte Jacobs and published by Oxford University Press, USA. This book was released on 2015 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first full biography of Jonas Salk offers a complete picture of the enigmatic figure, from his early years working on an influenza vaccine--for which he never fully got credit--to his seminal creation of the Polio vaccine, up through his later work to find a cure for AIDS.

The Role of Hsp90 in Viral Replication

Author : Ron Geller
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Role of Hsp90 in Viral Replication by : Ron Geller

Download or read book The Role of Hsp90 in Viral Replication written by Ron Geller and published by . This book was released on 2008 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Considerations for viral disease eradication

Author : Stacey Knobler
Publisher : Lulu.com
ISBN 13 : 0359579353
Total Pages : 234 pages
Book Rating : 4.3/5 (595 download)

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Book Synopsis Considerations for viral disease eradication by : Stacey Knobler

Download or read book Considerations for viral disease eradication written by Stacey Knobler and published by Lulu.com. This book was released on with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disease Eradication in the 21st Century

Author : Stephen L. Cochi
Publisher : MIT Press
ISBN 13 : 0262298112
Total Pages : 333 pages
Book Rating : 4.2/5 (622 download)

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Book Synopsis Disease Eradication in the 21st Century by : Stephen L. Cochi

Download or read book Disease Eradication in the 21st Century written by Stephen L. Cochi and published by MIT Press. This book was released on 2011-09-16 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts explore the biological, social, and economic complexities of eradicating disease. Disease eradication represents the ultimate in global equity and the definitive outcome of good public health practice. Thirty years ago, the elimination of smallpox defined disease eradication as a monumental global achievement with lasting benefits for society. Today, the global commitment to eradicate polio and guinea worm and heightened interest in the potential eradication of other infectious diseases, including measles/rubella, lymphatic filariasis, onchocerciasis, and malaria, dominate public health concerns. But what does it take to eradicate a disease? This book takes a fresh look at the evolving concepts of disease eradication, influenced by scientific advances, field experience, societal issues, and economic realities. A diverse group of experts from around the world, representing a range of disciplines, examines the biological, social, political, and economic complexities of eradicating a disease. The book details lessons learned from the initiatives against polio, measles/rubella, and onchocerciasis. Further chapters examine ethical issues, the investment case, governance models, organizational and institutional arrangements, political and social factors, feasibility of eradication goals, priority setting, and the integration of disease eradication programs with existing health systems. Contributors Stephen L. Cochi, Walter R. Dowdle, Claudia I. Emerson, Kimberly M. Thompson, Radboud J. Duintjer Tebbens, Regina Rabinovich, Lesong Conteh, B. Fenton Hall, Peter A. Singer, Maya Vijayaraghavan, Damian G. Walker, Kari Stoever, Julie Jacobson, Andy Wright, Chris Maher, Bruce Aylward, Ali Jaffer Mohamed, T. Jacob John, Robert S. Scott, Robert Hall, Jeffrey Bates, Sherine Guirguis, Thomas Moran, Peter Strebel, Eric A. Ottesen, Ciro de Quadros, Linda Muller, Jai Prakash Narain, Ole Wichmann, Alan R. Hinman, Stewart Tyson, Robin Biellik, Piya Hanvoravongchai, Sandra Mounier-Jack, Valeria Oliveira Cruz, Dina Balabanova, Yayehyirad Kitaw, Tracey Koehlmoos, Sebastião Loureiro, Mitike Molla, Ha Trong Nguyen, Pierre Ongolo-Zogo, Umeda Sadykova, Harbandhu Sarma, Maria Gloria Teixeira M, Jasim Uddin, Alya Dabbagh, Ulla Kou Griffiths, Muhammad Ali Pate, John O. Gyapong, Adrian Hopkins, Dairiku Hozumi, Mwelecele Malecela

The Cutter Incident

Author : Paul A. Offit
Publisher : Yale University Press
ISBN 13 : 9780300126051
Total Pages : 262 pages
Book Rating : 4.1/5 (26 download)

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Book Synopsis The Cutter Incident by : Paul A. Offit

Download or read book The Cutter Incident written by Paul A. Offit and published by Yale University Press. This book was released on 2007-09-18 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.

Antiviral Chemotherapy

Author : D. J. Jeffries
Publisher :
ISBN 13 :
Total Pages : 614 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Antiviral Chemotherapy by : D. J. Jeffries

Download or read book Antiviral Chemotherapy written by D. J. Jeffries and published by . This book was released on 1995-07-11 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.