Expansion and Automation of Iterative Cross-coupling: Total Synthesis of Synechoxanthin and Development of a Small Molecule Synthesizer

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (932 download)

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Book Synopsis Expansion and Automation of Iterative Cross-coupling: Total Synthesis of Synechoxanthin and Development of a Small Molecule Synthesizer by :

Download or read book Expansion and Automation of Iterative Cross-coupling: Total Synthesis of Synechoxanthin and Development of a Small Molecule Synthesizer written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Expansion of the Iterative Cross-coupling Synthesis Strategy Through Csp3 Halide Cross-coupling, Mida Boronate Synthesis, and Chan-lam Couplings

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ISBN 13 :
Total Pages : pages
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Book Synopsis Expansion of the Iterative Cross-coupling Synthesis Strategy Through Csp3 Halide Cross-coupling, Mida Boronate Synthesis, and Chan-lam Couplings by : Jenna A. Klubnick

Download or read book Expansion of the Iterative Cross-coupling Synthesis Strategy Through Csp3 Halide Cross-coupling, Mida Boronate Synthesis, and Chan-lam Couplings written by Jenna A. Klubnick and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The iterative cross-coupling strategy for small molecule synthesis has been shown to be a powerful and effective method for the synthesis of small molecules. However, this strategy was limited by current methodological limitations. Therefore, we have extended the power and application of the iterative cross-coupling strategy by the development of several new methods compatible with the iterative cross-coupling platform. We report a mild Csp3 halide 0́3 Csp2boronic acid Suzuki-Miyaura cross-coupling method amenable to fine molecule synthesis. We also report a new method for the synthesis of MIDA boronates which are sensitive to current methods. Finally, we report the extension of the entire iterative cross coupling platform to the Chan-Lam coupling to form carbon-heteroatom bonds.

Stereoselective Synthesis and Iterative Coupling of Csp3 Boronates for Automating Small Molecule Synthesis

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ISBN 13 :
Total Pages : pages
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Book Synopsis Stereoselective Synthesis and Iterative Coupling of Csp3 Boronates for Automating Small Molecule Synthesis by :

Download or read book Stereoselective Synthesis and Iterative Coupling of Csp3 Boronates for Automating Small Molecule Synthesis written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Total Synthesis of Callystatin A and Development of Trifloyl Heterocycle Cross-coupling Strategies

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ISBN 13 :
Total Pages : 550 pages
Book Rating : 4.:/5 (238 download)

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Book Synopsis Total Synthesis of Callystatin A and Development of Trifloyl Heterocycle Cross-coupling Strategies by : Neil Fred Langille

Download or read book Total Synthesis of Callystatin A and Development of Trifloyl Heterocycle Cross-coupling Strategies written by Neil Fred Langille and published by . This book was released on 2005 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Boron Reagents in Synthesis

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Publisher : ACS Symposium
ISBN 13 : 9780841231832
Total Pages : 544 pages
Book Rating : 4.2/5 (318 download)

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Book Synopsis Boron Reagents in Synthesis by : Adiel Coca

Download or read book Boron Reagents in Synthesis written by Adiel Coca and published by ACS Symposium. This book was released on 2018-02-02 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron compounds have been used extensively in organic synthesis for more than sixty years. Some of the best known reactions in synthesis, such as the Suzuki-Miyaura cross-coupling and the hydroboration reaction, involve boron compounds. Several natural products containing boron have been isolated in the last fifty years, including ionophoric macrodiolide antibiotics boromycin, borophycin, aplasmomycins A, B, and C, and tartrolons B, C, and E, as well as autoinducer-2. The study of compounds containing boronic acids for application in pharmaceuticals and materials science has grown tremendously over the last few decades. These include bortezomib, ixazomib, and tavaborole. Several more boron-based drugs are currently in clinical trials. Boron neutron capture therapy has the potential to provide a treatment for various cancers. In addition, materials bearing boronic acids are been studied as potential sensors for biological molecules, such as saccharides and glycoproteins that possess cis-1,2- or cis-1,3-diols.

Boronic Acids

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Publisher : John Wiley & Sons
ISBN 13 : 3527606823
Total Pages : 571 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Boronic Acids by : Dennis G. Hall

Download or read book Boronic Acids written by Dennis G. Hall and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, the whole field of organoboronic acids is presented in one comprehensive handbook. Professor Dennis Hall, a rising star within the community, covers all aspects of this important substance class, including applications in chemistry, biology and medicine. Starting with an introduction to the structure, properties, and preparation of boronic acid derivatives, together with an overview of their reactions and applications, the book goes on to look at metal-catalyzed borylation of alkanes and arenas, coupling reactions and rhodium-catalyzed additions of boronic acids to alkenes and carbonyl compounds. There follows chapters on copper-promoted C-O and C-N cross-coupling of boronic acids, recent applications in organic synthesis, as well as alpha-haloalkylboronic esters in asymmetric synthesis. Later sections deal with cycloadditions, organoboronic acids, oxazaborolidines as asymmetric inducers, and boronic acid based receptors and sensors. The whole is rounded off with experimental procedures, making this invaluable reading for organic, catalytic and medicinal chemists, as well as those working in organometallics.

Catalytic Asymmetric Synthesis

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Publisher : John Wiley & Sons
ISBN 13 : 1119736412
Total Pages : 798 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Catalytic Asymmetric Synthesis by : Takahiko Akiyama

Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.

Hydrosilylation

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Publisher : Springer Science & Business Media
ISBN 13 : 1402081723
Total Pages : 424 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Hydrosilylation by : Bogdan Marciniec

Download or read book Hydrosilylation written by Bogdan Marciniec and published by Springer Science & Business Media. This book was released on 2008-11-09 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: For fifty years, Hydrosilylation has been one of the most fundamental and elegant methods for the laboratory and industrial synthesis of organosilicon and silicon related compounds. Despite the intensive research and continued interest generated by organosilicon compounds, no comprehensive book incorporating its various aspects has been published this century. The aim of this book is to comprehensively review the advances of hydrosilylation processes since 1990. The survey of the literature published over the last two decades enables the authors to discuss the most recent aspects of hydrosilylation advances (catalytic and synthetic) and to elucidate the reaction mechanism for the given catalyst used and the reaction utilization. New catalytic pathways under optimum conditions necessary for efficient synthesis of organosilicon compounds are presented. This monograph shows the extensive development in the application of hydrosilylation in organic and asymmetric syntheses and in polymer and material science.

Enantioselective Chemical Synthesis

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Publisher :
ISBN 13 : 9781306070645
Total Pages : 328 pages
Book Rating : 4.0/5 (76 download)

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Book Synopsis Enantioselective Chemical Synthesis by : Elias J. Corey

Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by . This book was released on 2013 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules Clearly explains stereochemical synthesis in theory and practiceProvides a handy tool box for scientists wishing to understand and apply chiral chemical synthesisDescribes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages"

Encyclopedia of Controlled Drug Delivery: M-Z

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ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Encyclopedia of Controlled Drug Delivery: M-Z by : Edith Mathiowitz

Download or read book Encyclopedia of Controlled Drug Delivery: M-Z written by Edith Mathiowitz and published by . This book was released on 1999 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organotransition Metal Chemistry: From Bonding to Catalysis

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ISBN 13 :
Total Pages : 1172 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Organotransition Metal Chemistry: From Bonding to Catalysis by : John F. Hartwig

Download or read book Organotransition Metal Chemistry: From Bonding to Catalysis written by John F. Hartwig and published by . This book was released on 2010-02-10 with total page 1172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on Collman et al.'s best-selling classic book, Principles and Applications of Organotransition Metal Chemistry, Hartwig's text consists of new or thoroughly updated and restructured chapters and provides an in-depth view into mechanism, reaction scope, and applications. It covers the most important developments in the field over the last twenty years with great clarity with a selective, but thorough and authoritative coverage of the fundamentals of organometallic chemistry, the elementary reactions of these complexes, and many catalytic processes occurring through organometallic intermediates, making this the Organotransition Metal Chemistry text for a new generation of scientists.

Comprehensive Handbook on Hydrosilylation

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Publisher : Elsevier
ISBN 13 : 0080912435
Total Pages : 767 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Handbook on Hydrosilylation by : B. Marciniec

Download or read book Comprehensive Handbook on Hydrosilylation written by B. Marciniec and published by Elsevier. This book was released on 2013-10-22 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides an up-to-date account of hydrosilylation reactions and the directions in which synthetic and mechanistic studies as well as practical applications of these processes are proceeding. The book consists of two parts: the first is descriptive, presenting the catalytic, mechanistic, structural and synthetic aspects of hydrosilylation, as well as its application in organic and organosilicon chemistry. The second part, presented in tabular form sets out encyclopedic information concerning reaction conditions taken from more than 2000 papers and patents in the period 1965 - 1990.

Managing in the Modular Age

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Publisher : John Wiley & Sons
ISBN 13 : 1405141948
Total Pages : 424 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Managing in the Modular Age by : Raghu Garud

Download or read book Managing in the Modular Age written by Raghu Garud and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together seminal articles by leading scholars of technological and organizational systems, exploring the impact of 'modularity'. Modularity refers to an ability to take apart and put together differenct products and networks, or to 'mix and match' components in order to meet different user specifications. This is of key importance today where new systems such as the World Wide Web and many areas of the computer industry depend on it. The volume pulls together and defines an exciting new area of inquiry: into how our 'modular age' is reshaping the business eco-system. Includes contributions from leading scholars of technology and organization Modularity refers to an ability to take apart and put together different products and systems, or to 'mix and match' components in order to meet different user specifications. Consolidates and defines an area of inquiry that is becoming increasingly important with the development of web-based and 'network' industries. Sensitizes readers to the complexity of issues surrounding new modular products and systems created by e-business Encourages readers to make connections among different levels and disciplines. Initiates a debate around issues of modularity. Includes a commentary co-authored by the late Nobel Laureate Herbert A. Simon to whom the book is dedicated.

A Legacy in Arms

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Publisher : University of Oklahoma Press
ISBN 13 : 0806147792
Total Pages : 245 pages
Book Rating : 4.8/5 (61 download)

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Book Synopsis A Legacy in Arms by : Richard C. Rattenbury

Download or read book A Legacy in Arms written by Richard C. Rattenbury and published by University of Oklahoma Press. This book was released on 2014-10-22 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of American firearms is inseparable from the history of the United States, for firearms have played crucial roles in the nation’s founding, westward expansion, and industrial, economic, and cultural development. This history unfolds in compelling words and images in A Legacy in Arms, a volume that draws upon the collections of the National Cowboy & Western Heritage Museum in Oklahoma City to trace the business and art of gun making from the early national period to the turn of the twentieth century. With more than 200 images—almost all in full color—A Legacy in Arms not only documents the inspiration and innovation of arms makers from individual artisans to mass producers, but also describes the development of decorative expression in the gun maker’s art. In an account both entertaining and enlightening, Richard C. Rattenbury details the development of commercial arms making, from the genesis of the Kentucky rifle to the arms of such iconic manufacturers as Colt, Remington, Smith & Wesson, Sharps, Marlin, and Winchester. Into this narrative he weaves the particulars of design evolution and the impact of mass production via the “American System.” The accompanying photographs and illustrations stand as eloquent testimony to the range and richness of the gun maker's craft—and its rightful place in the story of American industry and culture.

From the American System to Mass Production, 1800-1932

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Publisher : JHU Press
ISBN 13 : 9780801831584
Total Pages : 444 pages
Book Rating : 4.8/5 (315 download)

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Book Synopsis From the American System to Mass Production, 1800-1932 by : David Hounshell

Download or read book From the American System to Mass Production, 1800-1932 written by David Hounshell and published by JHU Press. This book was released on 1984 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: David A. Houndshell's widely acclaimed history explores the American "genius for mass production" and races its origins in the nineteenth-century "American system" of manufacture. Previous writers on the American system have argued that the technical problems of mass production had been solved by armsmakers before the Civil War. Drawing upon the extensive business and manufacturing records if leading American firms, Hounshell demonstrates that the diffusion of arms production technology was neither as fast now as smooth as had been assumed. Exploring the manufacture of sewing machines and furniture, bicycles and reapers, he shows that both the expression "mass production" and the technology that lay behind it were developments of the twentieth century, attributable in large part to the Ford Motor Company. Hounshell examines the importance of individuals in the diffusion and development of production technology and the central place of marketing strategy in the success of selected American manufacturers. Whereaas Ford was the seedbed of the assembly line revolution, it was General motors that initiated a new era with its introduction of the annual model change. With the new marketing strategy, the technology of "the changeover" became of paramount importance. Hounshell chronicles how painfully Ford learned this lesson and recounts how the successful mass production of automobiles led to the establishment of an "ethos of mass production," to an era in which propoments of "Fordism" argued that mass production would solve all of America's social problems.