Exogenous Factors In Colonic Carcinogenesis

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Exogenous Factors in Colonic Carcinogenesis

Author : W. Scheppach
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387800
Total Pages : 698 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Exogenous Factors in Colonic Carcinogenesis by : W. Scheppach

Download or read book Exogenous Factors in Colonic Carcinogenesis written by W. Scheppach and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of Falk Symposium 128, held in Würzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic carcinogenesis and its underlying genetic and environmental factors. Colorectal cancer is one of the leading causes of cancer-related death in industrialized countries. It has been recognized to be the consequence of a dynamic process leading from hyperproliferative epithelium through different classes of adenomas to invasive carcinoma. This adenoma-carcinoma sequence has been characterized on a molecular basis. Modern molecular biology has also helped to clarify the clustering of colorectal cancer within families, a phenomenon that has been known to clinicians for a long time. Thus, the pathogenesis of the two distinct familial colon cancer syndromes FAP (familial adenomatous polyposis) and HNPCC (hereditary non-polyposis colorectal cancer) is increasingly being understood. Thereby, an identification of affected people has become possible before the disease has manifested. There is also convincing evidence that the pathogenesis of sporadic colonic cancer is modulated by environmental, mainly nutritional, factors. Carcinogens seem to be far less important than the components of the `normal' human diet. It is likely that the interplay between protective and noxious dietary compounds determines the progression of the adenoma-carcinoma sequence. Additionally, a broad spectrum of drugs has been shown to affect colonic tumorigenesis, which provides the rationale for chemoprevention strategies. These issues set the scene for discussions on how genetic and environmental factors may interact in the pathogenesis of colonic cancer, contributing fresh ideas to the prevention of this most prevalent malignancy in the industrialized world.

Exogenous Factors in Colonic Carcinogenesis

Author : Wolfgang Scheppach
Publisher :
ISBN 13 : 9783933186485
Total Pages : 52 pages
Book Rating : 4.1/5 (864 download)

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Book Synopsis Exogenous Factors in Colonic Carcinogenesis by : Wolfgang Scheppach

Download or read book Exogenous Factors in Colonic Carcinogenesis written by Wolfgang Scheppach and published by . This book was released on 2002 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Asbestos

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309101697
Total Pages : 341 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Asbestos by : Institute of Medicine

Download or read book Asbestos written by Institute of Medicine and published by National Academies Press. This book was released on 2006-09-23 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: In conjunction with drafting comprehensive legislation concerning compensation for health effects related to asbestos exposure (the Fairness in Asbestos Injury Act), the Senate Committee on the Judiciary directed the Institute of Medicine to assemble the Committee on Asbestos: Selected Health Effects. This committee was charged with addressing whether asbestos exposure is causally related to adverse health consequences in addition to asbestosis, mesothelioma, and lung cancer. Asbestos: Selected Cancers presents the committee's comprehensive distillation of the peer-reviewed scientific and medical literature regarding association between asbestos and colorectal, laryngeal, esophageal, pharyngeal, and stomach cancers.

How Tobacco Smoke Causes Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Colorectal Cancer

Author : Leonard B. Saltz
Publisher : Springer Science & Business Media
ISBN 13 : 1592591604
Total Pages : 839 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Colorectal Cancer by : Leonard B. Saltz

Download or read book Colorectal Cancer written by Leonard B. Saltz and published by Springer Science & Business Media. This book was released on 2002-05-13 with total page 839 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1126 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1983 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Cancer Research

Author :
Publisher : Academic Press
ISBN 13 : 9780080562124
Total Pages : 349 pages
Book Rating : 4.5/5 (621 download)

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Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1979-11-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research

Alcohol, Tobacco and Cancer

Author : Chi-Hin Cho
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805581076
Total Pages : 642 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Alcohol, Tobacco and Cancer by : Chi-Hin Cho

Download or read book Alcohol, Tobacco and Cancer written by Chi-Hin Cho and published by Karger Medical and Scientific Publishers. This book was released on 2006-01-01 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in producing liver cancer are addressed. The second part is dedicated to the role of tobacco in lung and digestive tract cancers and to their prevention, highlighting the role of phytochemicals. More specifically, the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive properties of nicotine which are involved in the development of cancer, and the possible use of nicotine vaccine in the prevention of mortality associated with tobacco, are discussed.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetics of Colorectal Cancer

Author : John D. Potter
Publisher : Springer
ISBN 13 : 9780387095677
Total Pages : 309 pages
Book Rating : 4.0/5 (956 download)

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Book Synopsis Genetics of Colorectal Cancer by : John D. Potter

Download or read book Genetics of Colorectal Cancer written by John D. Potter and published by Springer. This book was released on 2008-12-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Novel Approaches to Colorectal Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128240792
Total Pages : 486 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Novel Approaches to Colorectal Cancer by :

Download or read book Novel Approaches to Colorectal Cancer written by and published by Academic Press. This book was released on 2021-06-18 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 1040 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2004 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Molecular Pathogenesis of Colorectal Cancer

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
ISBN 13 : 146148412X
Total Pages : 319 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Pathogenesis of Colorectal Cancer by : Kevin M. Haigis, Ph.D.

Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Autoimmune Liver Disease

Author : H.-P. Dienes
Publisher : Springer Science & Business Media
ISBN 13 : 9781402028946
Total Pages : 332 pages
Book Rating : 4.0/5 (289 download)

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Book Synopsis Autoimmune Liver Disease by : H.-P. Dienes

Download or read book Autoimmune Liver Disease written by H.-P. Dienes and published by Springer Science & Business Media. This book was released on 2005-07-12 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune processes in the liver can cause severe damage and destruction leading to cirrhosis and liver failure. The clinical spectrum of autoimmune liver disease is very wide, and diagnostic difficulties often stand at the beginning of the patient’s medical career. While in autoimmune hepatitis immunosuppressive therapy has long been shown to be life-saving, therapeutic progress is small in primary biliary cirrhosis and questionable in primary sclerosing cholangitis. New approaches to treatment will be needed in the future, but require better understanding of the pathogenesis of the underlying disease process. This book, the proceedings of Falk Symposium 142 on 'Autoimmune Liver Disease’ held in Freiburg, Germany, on 12–13 October 2004 (Part I of the Gastroenterology Week Freiburg), describes possible mechanisms of pathogenesis, discusses diagnostic criteria and takes up controversies concerning treatment options. In view of the relatively frequent manifestation of autoimmune hepatitis in childhood in particular, paediatric aspects of autoimmune liver disease, and the role of liver transplantation, are given prominence.

Bile Acid Biology and its Therapeutic Implications

Author : G. Paumgartner
Publisher : Springer Science & Business Media
ISBN 13 : 9781402028939
Total Pages : 298 pages
Book Rating : 4.0/5 (289 download)

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Book Synopsis Bile Acid Biology and its Therapeutic Implications by : G. Paumgartner

Download or read book Bile Acid Biology and its Therapeutic Implications written by G. Paumgartner and published by Springer Science & Business Media. This book was released on 2005-03-02 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world. Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics. The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

Mechanisms of Intestinal Inflammation

Author : R. Duchmann
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387879
Total Pages : 246 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Mechanisms of Intestinal Inflammation by : R. Duchmann

Download or read book Mechanisms of Intestinal Inflammation written by R. Duchmann and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.