Evidence For A Genetic Mechanism Of The Chromogranin A And Phenylethanolamine N Methyltransferase Genes In The Pathogenesis Of Hypertension In The Spontaneously Hypertensive Rat

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Evidence for a Genetic Mechanism of the Chromogranin A and Phenylethanolamine-N-methyltransferase Genes in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat

Author : Ryan Scott Friese
Publisher :
ISBN 13 : 9781109965513
Total Pages : 234 pages
Book Rating : 4.9/5 (655 download)

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Book Synopsis Evidence for a Genetic Mechanism of the Chromogranin A and Phenylethanolamine-N-methyltransferase Genes in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat by : Ryan Scott Friese

Download or read book Evidence for a Genetic Mechanism of the Chromogranin A and Phenylethanolamine-N-methyltransferase Genes in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat written by Ryan Scott Friese and published by . This book was released on 2007 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dissection of the genetic basis of human essential hypertension is greatly hindered by the inherent complexity of the disorder. Indeed, susceptibility genes are estimated to contribute ∼20-30% to development of essential hypertension, and gene actions are confounded by environmental variables, such as diet and exercise, and the diverse heterozygosity of the human population. In contrast, identification of susceptibility genes in the Spontaneously Hypertensive Rat (SHR) model of human essential hypertension is greatly enhanced by the purely genetic basis of hypertension in the SHR and the ability to strictly control the environment. The large gap in physiology between the immediate action of susceptibility genes and the ultimate development of hypertension, however, looms large, even in the SHR. The objective of the dissertation, therefore, is to identify polymorphisms within candidate genes for hypertension in the SHR that manifest as intermediate phenotypes for the ultimate hypertensive disease state. Differential expression of adrenal mRNA is proposed as a novel intermediate phenotype for hypertension in the SHR. Initially, a comparison of adrenal gene expression between the SHR rat and BPH mouse, two independent models of human essential hypertension, was performed to uncover common genetic mechanisms of hypertension across mammalian species. A diverse set of differentially expressed genes and biochemical systems within and between the SHR and BPH strains was identified, reinforcing the complexity of the disease. Next, candidate genes for hypertension in the SHR were identified using a method to integrate adrenal gene expression data with blood pressure QTL data. Seven candidate genes were identified and resequenced. Polymorphisms discovered in the promoter and/or 3'-untranslated region of the chromogranin A (Chga) and phenylethanolamine-N-methyltransferase (Pnmt ) genes were hypothesized to contribute to differential expression of Chga (1.73-fold overexpressed) and Pnmt (0.67-fold underexpressed) adrenal mRNA in the SHR. Finally, luciferase assays were used to demonstrate that promoter polymorphisms are likely to contribute to the adrenal differential mRNA expression of Chga and Pnmt in vivo. The crucial role of Chga and Pnmt in the biosynthesis and exocytosis of catecholamines makes them strong candidate genes for hypertension in the SHR. More importantly, the association of Chga and Pnmt with human essential hypertension makes them potential therapeutic targets as well.

Dissertation Abstracts International

Author :
Publisher :
ISBN 13 :
Total Pages : 1044 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disorders of Blood Pressure Regulation

Author : Adel E. Berbari
Publisher : Springer
ISBN 13 : 3319599186
Total Pages : 858 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Disorders of Blood Pressure Regulation by : Adel E. Berbari

Download or read book Disorders of Blood Pressure Regulation written by Adel E. Berbari and published by Springer. This book was released on 2018-01-25 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement. Particular emphasis is placed on review and assessment of clinical presentation, pathophysiologic mechanisms, and possible specific therapeutic options for each hypertension phenotype. Several of these phenotypes are well known and well described in the literature, such as prehypertension, white coat and masked hypertension, isolated systolic hypertension, renovascular hypertension, endocrine hypertension, pediatric hypertension, and gestational hypertension. Other hypertension phenotypes, however, are not widely recognized, being reported only in special reviews; examples include hypertension associated with renal calculus disease and other rarer causes such as Turner syndrome, herbal and medicinal compounds, and pharmacologic agents. A detailed account of the various causes of monogenic hypertension is also included. Finally, a section is devoted to general aspects of hypertension, including the significance of blood pressure indices, the natural course of untreated and treated hypertension, hypertension mechanisms, genetics, and guidelines for blood pressure control.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1416 pages
Book Rating : 4.:/5 (31 download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Medicinal Chemistry

Author : Thomas Nogrady
Publisher : Oxford University Press
ISBN 13 : 0190282967
Total Pages : 664 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Medicinal Chemistry by : Thomas Nogrady

Download or read book Medicinal Chemistry written by Thomas Nogrady and published by Oxford University Press. This book was released on 2005-08-11 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Cellular Transplantation

Author : Craig Halberstadt
Publisher : Elsevier
ISBN 13 : 0080469043
Total Pages : 699 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Cellular Transplantation by : Craig Halberstadt

Download or read book Cellular Transplantation written by Craig Halberstadt and published by Elsevier. This book was released on 2011-10-10 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation

Dorland's Dictionary of Medical Acronyms and Abbreviations

Author : Dorland
Publisher : Elsevier Health Sciences
ISBN 13 : 0323442544
Total Pages : 481 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Dorland's Dictionary of Medical Acronyms and Abbreviations by : Dorland

Download or read book Dorland's Dictionary of Medical Acronyms and Abbreviations written by Dorland and published by Elsevier Health Sciences. This book was released on 2015-07-24 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical acronyms and abbreviations offer convenience, but those countless shortcuts can often be confusing. Now a part of the popular Dorland's suite of products, this reference features thousands of terms from across various medical specialties. Its alphabetical arrangement makes for quick reference, and expanded coverage of symbols ensures they are easier to find. Effective communication plays an important role in all medical settings, so turn to this trusted volume for nearly any medical abbreviation you might encounter. - Symbols section makes it easier to locate unusual or seldom-used symbols. - Convenient alphabetical format allows you to find the entry you need more intuitively. - More than 90,000 entries and definitions. - Many new and updated entries including terminology in expanding specialties, such as Nursing; Physical, Occupational, and Speech Therapies; Transcription and Coding; Computer and Technical Fields. - New section on abbreviations to avoid, including Joint Commission abbreviations that are not to be used. - Incorporates updates suggested by the Institute for Safe Medication Practices (ISMP).

Endocrine Secrets

Author : Michael T. McDermott, MD
Publisher : Elsevier Health Sciences
ISBN 13 : 1455749753
Total Pages : 577 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Endocrine Secrets by : Michael T. McDermott, MD

Download or read book Endocrine Secrets written by Michael T. McDermott, MD and published by Elsevier Health Sciences. This book was released on 2013-04-18 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly updated Endocrine Secrets, 6th Edition continues the tradition of the highly popular Secrets Series®, offering fast answers to the most essential clinical endocrinology questions. A user-friendly Q&A format, replete with valuable pearls, tips, and memory aids, helps you to learn and study efficiently. It all adds up to a perfect concise board review or handy clinical endocrinology resource. Expedite your reference and review with a question-and-answer format that's conversational and easy to read. Zero in on key information with bulleted lists, mnemonics, practical tips from prominent endocrinologists, and "Key Points" boxes that provide a concise overview of important board-relevant content. Quickly review essential material with a chapter containing the "Top 100 Secrets" in endocrinology. Take your Secrets anywhere thanks to a convenient, pocket-sized design! Remain at the forefront of medical endocrinology with updates on new techniques and technologies, as well as changing treatment options and drug information. Equip yourself for effective practice with coverage of the most current developments in obesity management, weight loss drugs, and bariatric surgery; the newest guidelines for the pharmacological treatment of type 2 diabetes mellitus; and much more. Make use of practical tips on intensive insulin therapy, and apply evidence-based techniques to achieve appropriate glucose control in hospitalized patients and effectively manage thyroid cancer. Access the latest research concerning the benefits and risks of the wide range of osteoporosis therapies.

Pheochromocytoma

Author : Karel Pacak
Publisher : John Wiley & Sons
ISBN 13 : 0470766387
Total Pages : 184 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Pheochromocytoma by : Karel Pacak

Download or read book Pheochromocytoma written by Karel Pacak and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis. Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas – providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine. The most comprehensive book on pheochromocytoma Provides cutting edge science and clinical guidance Written by the leading names in the field Authors present their recently developed novel biochemical test for the diagnosis of Pheochromocytoma

Gastrointestinal and Colorectal Anesthesia

Author : Chandra M. Kumar
Publisher : CRC Press
ISBN 13 : 1420014064
Total Pages : 452 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Gastrointestinal and Colorectal Anesthesia by : Chandra M. Kumar

Download or read book Gastrointestinal and Colorectal Anesthesia written by Chandra M. Kumar and published by CRC Press. This book was released on 2016-04-19 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource stands as the only authoritative text to specifically focus on developments and best practices in anesthesiology for procedures affecting the gastrointestinal tract and related appendages. This book provides in-depth coverage of topics such as risk assessment, stress response, and scoring, as well as spans anesthetic trends and practi

Advanced Practice in Endocrinology Nursing

Author : Sofia Llahana
Publisher : Springer
ISBN 13 : 331999817X
Total Pages : 1337 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Advanced Practice in Endocrinology Nursing by : Sofia Llahana

Download or read book Advanced Practice in Endocrinology Nursing written by Sofia Llahana and published by Springer. This book was released on 2019-02-26 with total page 1337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society of Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.

Dictionary of Medical Acronyms and Abbreviations

Author : Stanley Jablonski
Publisher : Hanley & Belfus
ISBN 13 : 9781560536512
Total Pages : pages
Book Rating : 4.5/5 (365 download)

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Book Synopsis Dictionary of Medical Acronyms and Abbreviations by : Stanley Jablonski

Download or read book Dictionary of Medical Acronyms and Abbreviations written by Stanley Jablonski and published by Hanley & Belfus. This book was released on 2004-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dictionary lists acronyms and abbreviations occurring with a reasonable frequency in the literature of medicine and the health care professions. Abbreviations and acronyms are given in capital letters, with no punctuation, and with concise definitions. The beginning sections also include symbols, genetic symbols, and the Greek alphabet and symbols.

Pharmacology and Therapeutics for Dentistry - E-Book

Author : John A. Yagiela
Publisher : Elsevier Health Sciences
ISBN 13 : 0323078249
Total Pages : 957 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Pharmacology and Therapeutics for Dentistry - E-Book by : John A. Yagiela

Download or read book Pharmacology and Therapeutics for Dentistry - E-Book written by John A. Yagiela and published by Elsevier Health Sciences. This book was released on 2010-03-12 with total page 957 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient's health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you're concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. - An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. - Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. - The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. - The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. - Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. - Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. - Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. - New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. - A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. - An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. - Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

The Adrenal Cortex

Author : Gavin P. Vinson
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Adrenal Cortex by : Gavin P. Vinson

Download or read book The Adrenal Cortex written by Gavin P. Vinson and published by . This book was released on 1992 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endocrine Hypertension

Author : Karel Pacak
Publisher :
ISBN 13 : 9781573314183
Total Pages : 0 pages
Book Rating : 4.3/5 (141 download)

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Book Synopsis Endocrine Hypertension by : Karel Pacak

Download or read book Endocrine Hypertension written by Karel Pacak and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.

Catecholamine Research

Author : Toshiharu Nagatsu
Publisher : Springer Science & Business Media
ISBN 13 : 9780306474033
Total Pages : 586 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Catecholamine Research by : Toshiharu Nagatsu

Download or read book Catecholamine Research written by Toshiharu Nagatsu and published by Springer Science & Business Media. This book was released on 2002-10-31 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of catecholamine research has not undergone comprehensive review for four years. In the interim, a tremendous amount of new information, obtained using molecular, genetic, neurochemical, and nuclear scanning techniques, has substantiated the important roles of catecholamine systems in development, cardiovascular function, psychiatric disorders, neurodegenerative diseases, and metabolism. This volume, based on the Ninth International Catecholamine Symposium, will have a substantial and lasting impact on medical science.

Neurosurgery Case Review: Questions and Answers

Author : Remi Nader
Publisher : Thieme
ISBN 13 : 1626231990
Total Pages : 1354 pages
Book Rating : 4.6/5 (262 download)

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Book Synopsis Neurosurgery Case Review: Questions and Answers by : Remi Nader

Download or read book Neurosurgery Case Review: Questions and Answers written by Remi Nader and published by Thieme. This book was released on 2020-01-30 with total page 1354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurosurgical vignettes in question and answer format provide robust prep for the ABNS oral exam! Neurosurgery Case Review: Questions and Answers, 2nd Edition by Remi Nader, Abdulrahman Sabbagh, Samer Elbabaa, Hosam Al-Jehani, Jaime Gasco, and Cristian Gragnaniello provides a robust study guide for the American Board Neurological Surgery and the Royal College of Physicians and Surgeons of Canada oral board examinations. The second edition expands on the highly successful first edition, presenting 148 cases commonly encountered by neurosurgeons in clinical practice. The cases are broadly divided into seven sections—tumor, vascular intracranial pathology, trauma, pediatric, functional, spine, and peripheral nerves. The chapters are arranged in a manner that mirrors the oral board exam. Each case includes a brief clinical scenario followed by questions on presentation, diagnosis, imaging, management, surgical detail, complications, and outcome. The presented information is backed by the latest available evidence-based references and data. Key Features: Contributions from internationally renowned neurosurgical educators Detailed answers enhance readers' knowledge and provide guidance on how to respond to questions asked in the oral board exams More than 750 high-quality images, many in full color, ensure visual understanding of key concepts Suggested readings at the end of cases offer additional study resources This is an indispensable, one-stop resource for neurosurgical residents and fellows prepping for the ABNS and Royal College oral board examinations. Neurosurgeons studying for recertification will also find this book an invaluable reference for rapid review.