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Author : Chin-Shan Chuang
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.F/5 ( download)
Download or read book Estimation with Resampling After Sequential Tests written by Chin-Shan Chuang and published by . This book was released on 1995 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christopher Jennison
Publisher : CRC Press
ISBN 13 : 9781584888581
Total Pages : 416 pages
Book Rating : 4.8/5 (885 download)
Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
Author :
Publisher : IMS
ISBN 13 : 9780940600669
Total Pages : 252 pages
Book Rating : 4.6/5 (6 download)
Download or read book Recent Developments in Nonparametric Inference and Probability written by and published by IMS. This book was released on 2006 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John D. Kalbfleisch
Publisher : John Wiley & Sons
ISBN 13 : 047136357X
Total Pages : 462 pages
Book Rating : 4.4/5 (713 download)
Download or read book The Statistical Analysis of Failure Time Data written by John D. Kalbfleisch and published by John Wiley & Sons. This book was released on 2002-09-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: * Contains additional discussion and examples on left truncation as well as material on more general censoring and truncation patterns. * Introduces the martingale and counting process formulation swil lbe in a new chapter. * Develops multivariate failure time data in a separate chapter and extends the material on Markov and semi Markov formulations. * Presents new examples and applications of data analysis.
Author : Gernot Wassmer
Publisher : Springer
ISBN 13 : 3319325620
Total Pages : 310 pages
Book Rating : 4.3/5 (193 download)
Download or read book Group Sequential and Confirmatory Adaptive Designs in Clinical Trials written by Gernot Wassmer and published by Springer. This book was released on 2016-07-04 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application. The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.
Author :
Publisher :
ISBN 13 :
Total Pages : 946 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jay Bartroff
Publisher : Springer Science & Business Media
ISBN 13 : 1461461146
Total Pages : 250 pages
Book Rating : 4.4/5 (614 download)
Download or read book Sequential Experimentation in Clinical Trials written by Jay Bartroff and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information. Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.
Author : J. Philip Miller
Publisher : Elsevier
ISBN 13 : 0444537384
Total Pages : 363 pages
Book Rating : 4.4/5 (445 download)
Download or read book Essential Statistical Methods for Medical Statistics written by J. Philip Miller and published by Elsevier. This book was released on 2010-11-08 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. - Contributors are internationally renowned experts in their respective areas - Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research - Methods for assessing Biomarkers, analysis of competing risks - Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs - Structural equations modelling and longitudinal data analysis
Author : Nitis Mukhopadhyay
Publisher : CRC Press
ISBN 13 : 9780824753955
Total Pages : 498 pages
Book Rating : 4.7/5 (539 download)
Download or read book Applied Sequential Methodologies written by Nitis Mukhopadhyay and published by CRC Press. This book was released on 2004-01-28 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: A technically precise yet clear presentation of modern sequential methodologies having immediate applications to practical problems in the real world, Applied Sequential Methodologies communicates invaluable techniques for data mining, agricultural science, genetics, computer simulation, finance, clinical trials, sonar signal detection, randomization, multiple comparisons, psychology, tracking, surveillance, and numerous additional areas of application. Includes more than 500 references, 165 figures and tables, and over 25 pages of subject and author indexes. Applied Sequential Methodologies brings the crucial nature of sequential approaches up to speed with recent theoretical gains, demonstrating their utility for solving real-life problems associated with Change-point detection in multichannel and distributed systems Best component selection for multivariate distributions Multistate processes Approximations for moving sums of discrete random variables Interim and terminal analyses of clinical trials Adaptive designs for longitudinal clinical trials Slope estimation in measurement-error models Tests for randomization and target tracking Appropriate count of simulation runs Stock price models Orders of genes Size and power control in multiple comparisons Authored by 33 leading scientists, this volume will greatly benefit sequential analysts, data analysts, applied statisticians, biometricians, clinical trialists, and upper-level undergraduate and graduate students in these disciplines.
Author : Weitong Wang
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.F/5 ( download)
Download or read book Adaptive Metrology and Mask Inspection written by Weitong Wang and published by . This book was released on 1998 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Max Kuhn
Publisher : CRC Press
ISBN 13 : 1351609467
Total Pages : 266 pages
Book Rating : 4.3/5 (516 download)
Download or read book Feature Engineering and Selection written by Max Kuhn and published by CRC Press. This book was released on 2019-07-25 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of developing predictive models includes many stages. Most resources focus on the modeling algorithms but neglect other critical aspects of the modeling process. This book describes techniques for finding the best representations of predictors for modeling and for nding the best subset of predictors for improving model performance. A variety of example data sets are used to illustrate the techniques along with R programs for reproducing the results.
Author : Peter H. Westfall
Publisher : John Wiley & Sons
ISBN 13 : 9780471557616
Total Pages : 382 pages
Book Rating : 4.5/5 (576 download)
Download or read book Resampling-Based Multiple Testing written by Peter H. Westfall and published by John Wiley & Sons. This book was released on 1993-01-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.
Author : Jiayang Sun
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.3/5 (91 download)
Download or read book Recent Developments in Nonparametric Inference and Probability written by Jiayang Sun and published by . This book was released on 2006 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Longbing Cao
Publisher : Springer
ISBN 13 : 3642276091
Total Pages : 368 pages
Book Rating : 4.6/5 (422 download)
Download or read book Agents and Data Mining Interaction written by Longbing Cao and published by Springer. This book was released on 2011-12-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the thoroughly refereed post-workshop proceedings of the 7th International Workshop on Agents and Data Mining Interaction, ADMI 2011, held in Taipei, Taiwan, in May 2011 in conjunction with AAMAS 2011, the 10th International Joint Conference on Autonomous Agents and Multiagent Systems. The 11 revised full papers presented were carefully reviewed and selected from 24 submissions. The papers are organized in topical sections on agents for data mining; data mining for agents; and agent mining applications.
Author : Rand R. Wilcox
Publisher : Academic Press
ISBN 13 : 012804781X
Total Pages : 812 pages
Book Rating : 4.1/5 (28 download)
Download or read book Introduction to Robust Estimation and Hypothesis Testing written by Rand R. Wilcox and published by Academic Press. This book was released on 2016-09-02 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Robust Estimating and Hypothesis Testing, 4th Editon, is a 'how-to' on the application of robust methods using available software. Modern robust methods provide improved techniques for dealing with outliers, skewed distribution curvature and heteroscedasticity that can provide substantial gains in power as well as a deeper, more accurate and more nuanced understanding of data. Since the last edition, there have been numerous advances and improvements. They include new techniques for comparing groups and measuring effect size as well as new methods for comparing quantiles. Many new regression methods have been added that include both parametric and nonparametric techniques. The methods related to ANCOVA have been expanded considerably. New perspectives related to discrete distributions with a relatively small sample space are described as well as new results relevant to the shift function. The practical importance of these methods is illustrated using data from real world studies. The R package written for this book now contains over 1200 functions. New to this edition - 35% revised content - Covers many new and improved R functions - New techniques that deal with a wide range of situations - Extensive revisions to cover the latest developments in robust regression - Covers latest improvements in ANOVA - Includes newest rank-based methods - Describes and illustrated easy to use software
Author : Meinhard Kieser
Publisher : Springer Nature
ISBN 13 : 3030495280
Total Pages : 391 pages
Book Rating : 4.0/5 (34 download)
Download or read book Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials written by Meinhard Kieser and published by Springer Nature. This book was released on 2020-11-19 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided. The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable for beginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.
Author : D. M. Titterington
Publisher :
ISBN 13 : 9780198509936
Total Pages : 404 pages
Book Rating : 4.5/5 (99 download)
Download or read book Biometrika written by D. M. Titterington and published by . This book was released on 2001 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2001 marks the centenary of Biometrika, one of the world's leading academic journals in statistical theory and methodology. In celebration of this, the book brings together two sets of papers from the journal. The first comprises seven specially commissioned articles (authors: D.R. Cox, A.C. Davison, Anthony C. Atkinson and R.A. Bailey, David Oakes, Peter Hall, T.M.F. Smith, and Howell Tong). These articles review the history of the journal and the most important contributions made by appearing in the journal in a number of important areas of statitisical activity, including general theory and methodology, surveys and time sets. In the process the papers describe the general development of statistical science during the twentieth century. The second group of ten papers are a selection of particularly seminal articles form the journal's first hundred years. The book opens with an introduction by the editors Professor D.M. Titterington and Sir David Cox.
