Essential Pharmacokinetics

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Essential Pharmacokinetics

Author : Thorsteinn Loftsson
Publisher : Academic Press
ISBN 13 : 0128014911
Total Pages : 178 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Essential Pharmacokinetics by : Thorsteinn Loftsson

Download or read book Essential Pharmacokinetics written by Thorsteinn Loftsson and published by Academic Press. This book was released on 2015-03-25 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Author : Younggil Kwon
Publisher : Springer Science & Business Media
ISBN 13 : 0306468204
Total Pages : 291 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by : Younggil Kwon

Download or read book Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists written by Younggil Kwon and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Basic Pharmacokinetics, Second Edition

Author : Mohsen A. Hedaya
Publisher : CRC Press
ISBN 13 : 1439850739
Total Pages : 599 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Basic Pharmacokinetics, Second Edition by : Mohsen A. Hedaya

Download or read book Basic Pharmacokinetics, Second Edition written by Mohsen A. Hedaya and published by CRC Press. This book was released on 2012-02-09 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Handbook of Basic Pharmacokinetics-- Including Clinical Applications

Author : Wolfgang A. Ritschel
Publisher :
ISBN 13 :
Total Pages : 616 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Handbook of Basic Pharmacokinetics-- Including Clinical Applications by : Wolfgang A. Ritschel

Download or read book Handbook of Basic Pharmacokinetics-- Including Clinical Applications written by Wolfgang A. Ritschel and published by . This book was released on 1992 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Basic Pharmacokinetics and Pharmacodynamics

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
ISBN 13 : 111819778X
Total Pages : 440 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Basic Pharmacokinetics and Pharmacodynamics by : Sara E. Rosenbaum

Download or read book Basic Pharmacokinetics and Pharmacodynamics written by Sara E. Rosenbaum and published by John Wiley & Sons. This book was released on 2012-09-10 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Basic Pharmacokinetics and Pharmacodynamics

Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
ISBN 13 : 1119143160
Total Pages : 576 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Basic Pharmacokinetics and Pharmacodynamics by : Sara E. Rosenbaum

Download or read book Basic Pharmacokinetics and Pharmacodynamics written by Sara E. Rosenbaum and published by John Wiley & Sons. This book was released on 2016-11-22 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Basic Pharmacokinetics

Author : Sunil S. Jambhekar
Publisher :
ISBN 13 : 9780857114471
Total Pages : 0 pages
Book Rating : 4.1/5 (144 download)

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Book Synopsis Basic Pharmacokinetics by : Sunil S. Jambhekar

Download or read book Basic Pharmacokinetics written by Sunil S. Jambhekar and published by . This book was released on 2023-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacokinetics: Basics to Applications

Author : Biswajit Mukherjee
Publisher : Springer Nature
ISBN 13 : 9811689504
Total Pages : 354 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Pharmacokinetics: Basics to Applications by : Biswajit Mukherjee

Download or read book Pharmacokinetics: Basics to Applications written by Biswajit Mukherjee and published by Springer Nature. This book was released on 2022-03-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

Author : Alexander A. Vinks
Publisher : Springer Science & Business Media
ISBN 13 : 0387756132
Total Pages : 466 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics by : Alexander A. Vinks

Download or read book Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics written by Alexander A. Vinks and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Pharmacokinetics Made Easy

Author : Donald J. Birkett
Publisher : McGraw Hill Professional
ISBN 13 : 9780074710722
Total Pages : 162 pages
Book Rating : 4.7/5 (17 download)

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Book Synopsis Pharmacokinetics Made Easy by : Donald J. Birkett

Download or read book Pharmacokinetics Made Easy written by Donald J. Birkett and published by McGraw Hill Professional. This book was released on 2002 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics Made Easy 1Rpresents the complex subject of pharmacokinetics in a simple, easy-to-understand manner, lending itself to a wide audience including medical practitioners, health professionals and students of pharmacology, medicine and nursing. The physiological approach adopted in the book allows clinical issues in drug therapy to be addressed, making it directly applicable to practice situations. The chapters in this book were initially published as a series of articles inAustralian Prescriberto assist practitioners in drug dosing and therapy. In this revised edition, the book has been updated according to recent developments and a new chapter called 'How to Determine the Pharmacokinetic Parameters of a Drug' added. Each chapter also has a new feature-a list of key points summarising the content to improve accessibility and understanding.

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Author : Johan Gabrielsson
Publisher : CRC Press
ISBN 13 : 9789186274924
Total Pages : 926 pages
Book Rating : 4.2/5 (749 download)

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Book Synopsis Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by : Johan Gabrielsson

Download or read book Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition written by Johan Gabrielsson and published by CRC Press. This book was released on 2001-11-30 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

Author : Hartmut Derendorf
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496385896
Total Pages : 864 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications by : Hartmut Derendorf

Download or read book Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications written by Hartmut Derendorf and published by Lippincott Williams & Wilkins. This book was released on 2019-07-11 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Winter's Basic Clinical Pharmacokinetics

Author : Paul Beringer
Publisher : LWW
ISBN 13 : 9781496346421
Total Pages : 0 pages
Book Rating : 4.3/5 (464 download)

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Book Synopsis Winter's Basic Clinical Pharmacokinetics by : Paul Beringer

Download or read book Winter's Basic Clinical Pharmacokinetics written by Paul Beringer and published by LWW. This book was released on 2017-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help pharmacy students in clinical settings and busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among students, clinical professors, and practitioners. Part I provides a basic review of pharmacokinetic principles, with extensive explanations, graphic illustrations, and detailed algorithms. Part II explains the clinical applications of these principles to problems commonly encountered in the practice setting with specific drugs. This edition includes the latest information on the clinical use of serum drug concentrations. New case studies and examples demonstrate the application of pharmacokinetics in today's clinical practice.

Basic Pharmacokinetics

Author : Mohsen A. Hedaya
Publisher : CRC Press
ISBN 13 : 1420046721
Total Pages : 328 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Basic Pharmacokinetics by : Mohsen A. Hedaya

Download or read book Basic Pharmacokinetics written by Mohsen A. Hedaya and published by CRC Press. This book was released on 2007-04-23 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.

Essentials of Pharmacokinetics and Pharmacodynamics

Author : Thomas N. Tozer
Publisher : LWW
ISBN 13 : 9781451194425
Total Pages : 0 pages
Book Rating : 4.1/5 (944 download)

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Book Synopsis Essentials of Pharmacokinetics and Pharmacodynamics by : Thomas N. Tozer

Download or read book Essentials of Pharmacokinetics and Pharmacodynamics written by Thomas N. Tozer and published by LWW. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the fundamentals of pharmacokinetics and pharmacodynamics with the new edition of this unique text. Essentials of Pharmacokinetics and pharmacodynamics, Second Edition (formerly An Introduction to Pharmacokinetics and Pharmacodynamics), contains must-know content for students of pharmacy and medicine, people engaged in drug development and those working in drug regulatory agencies, as well as any health care professional who needs to understand the basic principles upon which quantitative decisions in drug therapy are based. This new edition provides essential information on the link between drug exposure within the body to drug response the key quantitative tools and principles of drug therapy you need to know, without extensive mathematics: up-to-date examples of currently prescribed drugs are particularly relevant to contemporary practice, and study problems in every chapter help you master the information in the text. Features more and updated study problems, including many that follow the multiple-choice format used in licensing examinations. Detailed answers are provided in an appendix to assist the reader in learning the material. The content of all chapters has been updated, and more than 60 new and improved illustrations have been added. Offers expanded content on Qualifying Events an Intravenous Bolus, Physiologic and Physicochemical Determinants of Drug Disposition; Quantifying Events Following an Extravascular Dose, and Physiologic and Physicochemical Determinants of Drug Absorption Gives greater emphasis to protein drugs and physiologic concepts, with clearly organized and updated content. Includes practice questions to reinforce your comprehension of the topics. Emphasizes the integration of basic concepts in each chapter, ensuring that the material builds on knowledge from prior chapters and is presented in the clearest way possible. Book jacket.

Drug Metabolism and Pharmacokinetics Quick Guide

Author : Siamak Cyrus Khojasteh
Publisher : Springer Science & Business Media
ISBN 13 : 1441956298
Total Pages : 214 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Drug Metabolism and Pharmacokinetics Quick Guide by : Siamak Cyrus Khojasteh

Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.