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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642998968
Total Pages : 483 pages
Book Rating : 4.6/5 (429 download)
Download or read book Erzeugung von Krankheitszuständen durch das Experiment written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1242 pages
Book Rating : 4.3/5 (91 download)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1974 with total page 1242 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Author : Karl Bartmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642728731
Total Pages : 590 pages
Book Rating : 4.6/5 (427 download)
Download or read book Antituberculosis Drugs written by Karl Bartmann and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume deals specifically with those antituberculosis drugs which passed the preclinical phase and have been or are used in the treatment of tuberculosis and other mycobacterial diseases (except leprosy) in at least some parts of the world. Despite this restriction, there are 14 such drugs, and as a result this volume has reached rather large proportions. To prevent it from becoming even larger and more unwidely, most derivatives of antituberculotics have been omitted, especially where it is claimed that they provide only better bioavailibility or tolerability. Only in the chapter on the chemotherapy of diseases due to so-called atypical mycobacteria is the clinical use of the drugs described to a certain extent. In addition to antituberculotics, also discussed are antimicrobials which have been found to be effective against these mycobacteria. The sequence in which the drugs are described is historical, reflecting not the time of discovery but rather the first clinical application. This order was selected for reasons which are now no longer relevant. In this volume less emphasis is placed on detection, biological or synthetic production of antituberculotics, and structure-activity relationships. In contrast, emphasis is put on the degree, type, and mechanism of antimyco bacterial activity, pharmacokinetics, and biotransformation in animals and man, on experimental pharmacodynamics, and on the toxicity of antituberculotics used therapeutically.
Author : Susan M. Dodd
Publisher : Springer Science & Business Media
ISBN 13 : 364279517X
Total Pages : 291 pages
Book Rating : 4.6/5 (427 download)
Download or read book Tubulointerstitial and Cystic Disease of the Kidney written by Susan M. Dodd and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over recent years, much renal research has focused on the pathology of the glomerulus, where many primary renal insults occur. However, nearly thirty years have passed since Risdon's study made the apparently anomalous observation that the extent of damage to the tubulointerstitial compartment is the major determinant of renal outcome in a variety of human glomerular diseases. This volume covers various aspects of tubulointerstitial disease, and starts with an update on cystic disease of the kidney, by Drs. WILSON and FALKENSTEIN, which includes recent experimental data on the altered properties of cystic epithelium. My own chapter gives an overview of the mechanisms of tubulo interstitial damage in progressive renal disease and includes a dis cussion of the possible role of cytokines, vasoactive peptides and peptide growth factors found over the last few years to be secreted by renal tubular cells. These comments are expanded in the contribution by Dr. WOLF and Professor NEILSON, who provide a detailed account of the cellular biology of tubulointerstitial growth. The earliest studies from the 19608 attempted to correlate histo morphometry of the tubulointerstitium with renal outcome. Dr. KHAN and Professor SINNIAH provide us with an update on mor phometric methods as applied to the kidney using new techniques. Similar techniques are employed by Dr. IVANYI and Professor OLSEN who give a detailed stereomorphological account of tubulitis both in acute allograft rejection, where its- recognition is central to the diagnosis, and in other forms of tubulointerstitial disease.
Author : E. Grundmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642807860
Total Pages : 197 pages
Book Rating : 4.6/5 (428 download)
Download or read book Special Topics in Carcinogenesis written by E. Grundmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : JUCKER
Publisher : Birkhäuser
ISBN 13 : 3034840217
Total Pages : 411 pages
Book Rating : 4.0/5 (348 download)
Download or read book Fortschritte der Arzneimittelforschung \ Progress in Drug Research \ Progrès des recherches pharmaceutiques written by JUCKER and published by Birkhäuser. This book was released on 2013-12-19 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : I.H. Page
Publisher : Springer Science & Business Media
ISBN 13 : 3642656005
Total Pages : 644 pages
Book Rating : 4.6/5 (426 download)
Download or read book Angiotensin written by I.H. Page and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of arterial hypertension is both long and short; long, since BRIGHT (1827) first related hardness of the pulse to hardness of the kidneys and hyper. trophy of the heart; short in that modern research began in the late twenties. Most of what we know of these diseases has been discovered in the past fifty years. The modern story should have begun in 1897 when an extract of kidney was shown to be pressor. But little was done with knowledge until about 1929 when the relationship of this kidney extract called "renin" to hypertension was pos· tulated. The pressor effects were, however, unlike most of those seen with sub· stances such as epinephrine or vasopressin. Plasma was required for action of renin and the active substance appeared to be protein. In 1939, it was shown that renin was not in itself a pressor substance but rather a proteolytic enzyme which produced a powerful pressor substance acting on a substrate synthesized by the liver. Later it was noted that the first definable step after the formation of this peptide was cleaving of the decapeptide which had little or no demonstrable activity, with loss of two amino acids to form the octapeptide called "angiotensin". Within a decade synthesis was achieved which made the substance available for world·wide study.
Author : H. Schneider
Publisher : Springer Science & Business Media
ISBN 13 : 3642859216
Total Pages : 381 pages
Book Rating : 4.6/5 (428 download)
Download or read book Clinical Pharmacology of Anti-Epileptic Drugs written by H. Schneider and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: "He who is faithfully analysing ... epi lepsy is doing far more than studying epilepsy" Hughlings Jackson Modifying this well-known statement by Jackson, one could say today: "He who is faithfully analysing anti-epileptic drugs is doing far more than studying anti-epileptic drugs". For these drugs not only serve to prevent epileptic fits and thus advance the treatment of epilepsy, they are also effective in the treatment of cardiac arrhythmias and trigeminal neuralgia. Furthermore, clinical pharmacologists consider anti-epi leptic drugs as model drugs in pharmacokinetics and pharmocodynamics, since reliable methods are available for their determination and their effects and side effects can be defined. The methods of estimating of drugs in body fluids provide a tool that enables us to throw light on many obscure relationships in pharmaceutical treatment. Now that we can study the pharmacokinetics and interaction of drugs in man, many hypotheses based on clinical experience alone may well be eliminated or corroborated. The grow ing body of knowledge will make us more careful about the administration of drugs in combination. Now that we can study how biological parameters interfere with drug action, we may perhaps proceed to the scientific analysis of many clinical observations that suggest the importance of such factors as age, sex, menstrual cycle, pregnancy, fever, diet, stress, sport, climate, and altitude.
Author : Harold C. Hodge
Publisher : Springer Science & Business Media
ISBN 13 : 3642655513
Total Pages : 1037 pages
Book Rating : 4.6/5 (426 download)
Download or read book Uranium · Plutonium Transplutonic Elements written by Harold C. Hodge and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than a year ago the three editors sat down at a table and worked out a set of six chapter headings which they believed might serve, in turn, for each of the three sections of this handbook. (The reader will note a similarity in order of presentation and in emphasis.) However, as our editorial plans progressed it became apparent that for each element and for the element group, there were one or two special topics appropiate for that section alone. Accordingly, in the section on uranium the common pattern holds for Chaps. 1 through 6 which include: an introduction (Chap. 1), a discussion of the physical and chemical properties (Chap. 2), experimental data on animals (Chap. 3), ex perimental data on man (Chap. 4), the rationale and development of air con centration limits to control industrial worker exposure (Chap. 5), and the prac tical problems of applying such limits in the uranium industry (Chap. 6). Chap. 7 entitled "Uranium Mining Hazards" is the subject category which is special for uranium; the chapter brings up to date the account of an important occupational hazard which was first noted by GEORGIUS AGRICOLA (1490-1555).
Author : Zdenek Deyl
Publisher : CRC Press
ISBN 13 : 1351082922
Total Pages : 449 pages
Book Rating : 4.3/5 (51 download)
Download or read book Methods In Animal Physiology written by Zdenek Deyl and published by CRC Press. This book was released on 2019-08-08 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present volume was to give an overview over different available methodological approaches. The specialists may, perhaps, object that in their particular field the level of information is superficial. However, let them look at other chapters in which different approaches are discussed and which, surely, will appear less superficial from the more general point of view. We hope, at least, that crucial references can be traced throughout the book that would enable the readers to go in more detail when desired. It can be traced throughout the book that would enable the readers to go in more detail when desired. It was really one of our ideas to draw the survey of possibilities available. If this can stimulate the readers to use ideas to draw the survey of possibilities available. If this can stimulate the readers to use other methods that those they are routinely using the goals will be met.
Author : P.S. Randall
Publisher : Springer Science & Business Media
ISBN 13 : 3642463142
Total Pages : 509 pages
Book Rating : 4.6/5 (424 download)
Download or read book Concepts in Biochemical Pharmacology written by P.S. Randall and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
Author : Library of Congress. Copyright Office
Publisher : Copyright Office, Library of Congress
ISBN 13 :
Total Pages : 1380 pages
Book Rating : 4.F/5 ( download)
Download or read book Catalog of Copyright Entries. Third Series written by Library of Congress. Copyright Office and published by Copyright Office, Library of Congress. This book was released on 1968 with total page 1380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes Part 1, Number 1: Books and Pamphlets, Including Serials and Contributions to Periodicals (January - June)
Author : G. Dallenbach-Hellweg
Publisher : Springer-Verlag
ISBN 13 : 3642684629
Total Pages : 307 pages
Book Rating : 4.6/5 (426 download)
Download or read book Ovarialtumoren written by G. Dallenbach-Hellweg and published by Springer-Verlag. This book was released on 2013-03-07 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 666 pages
Book Rating : 4.:/5 ( download)
Download or read book National Library of Medicine Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1966 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christof Stumpf
Publisher : Springer-Verlag
ISBN 13 : 3662420287
Total Pages : 328 pages
Book Rating : 4.6/5 (624 download)
Download or read book Erzeugung von Krankheitszuständen durch das Experiment written by Christof Stumpf and published by Springer-Verlag. This book was released on 2013-12-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Library of Congress. Copyright Office
Publisher :
ISBN 13 :
Total Pages : 1406 pages
Book Rating : 4.:/5 (31 download)
Download or read book Catalog of Copyright Entries, Third Series written by Library of Congress. Copyright Office and published by . This book was released on 1974 with total page 1406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The record of each copyright registration listed in the Catalog includes a description of the work copyrighted and data relating to the copyright claim (the name of the copyright claimant as given in the application for registration, the copyright date, the copyright registration number, etc.).
Author :
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.:/5 (37 download)
Download or read book Archiv für die gesamte Virusforschung written by and published by . This book was released on 1974 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
