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Author : Anthony D. Macknight
Publisher :
ISBN 13 : 9780783772097
Total Pages : 392 pages
Book Rating : 4.7/5 (72 download)
Download or read book Epithelial Ion and Water Transport written by Anthony D. Macknight and published by . This book was released on with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kirk L. Hamilton
Publisher : Springer Nature
ISBN 13 : 3030527808
Total Pages : 563 pages
Book Rating : 4.0/5 (35 download)
Download or read book Basic Epithelial Ion Transport Principles and Function written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2020-11-26 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.
Author : Kirk L. Hamilton
Publisher : Springer Nature
ISBN 13 : 3030554546
Total Pages : 1247 pages
Book Rating : 4.0/5 (35 download)
Download or read book Studies of Epithelial Transporters and Ion Channels written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2021-03-04 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
Author : P. A. Butcher
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (593 download)
Download or read book The Action of Noradrenaline on Epithelial Ion and Water Transport written by P. A. Butcher and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : N.K. Wills
Publisher : Springer Science & Business Media
ISBN 13 : 9400914954
Total Pages : 366 pages
Book Rating : 4.4/5 (9 download)
Download or read book Epithelial Transport written by N.K. Wills and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building from general principles, the authors clearly explain the fundamental role of epithelia in plasma electrolyte and water balance. Emphasis is placed on experimental approaches and methodology. A comprehensive glossary of terms is included.
Author : Kirk L. Hamilton
Publisher : Springer
ISBN 13 : 1493933663
Total Pages : 1015 pages
Book Rating : 4.4/5 (939 download)
Download or read book Ion Channels and Transporters of Epithelia in Health and Disease written by Kirk L. Hamilton and published by Springer. This book was released on 2015-12-14 with total page 1015 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Author : Hans H. Ussing
Publisher : Nankodo Company, Limited
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.:/5 (5 download)
Download or read book Water Transport Across Epithelia written by Hans H. Ussing and published by Nankodo Company, Limited. This book was released on 1981 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mrinalin Rao
Publisher : Biota Publishing
ISBN 13 : 1615041575
Total Pages : 118 pages
Book Rating : 4.6/5 (15 download)
Download or read book Intestinal Water and Electrolyte Transport in Health and Disease written by Mrinalin Rao and published by Biota Publishing. This book was released on 2012-01-12 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The unique architecture and physiology of the mammalian intestine, together with a tightly coordinated regulatory system, allows for the handling and absorption of as much as 9 L of fluid a day with 98% or greater efficiency. Advances in the past 40 years have made inroads into revealing the intricacies and interplay of numerous ion transporters and their modulators that are responsible for intestinal electrolyte and water transport. Studies of two devastating diseases, the virulent infectious disease cholera and the autosomal recessive disease cystic fibrosis, were largely responsible for this information explosion. These advances have been critical in the development of new therapeutic strategies to combat life-threatening diseases of varying etiologies ranging from enteric infections to cystic fibrosis and inflammatory bowel diseases. Yet, the story is far from complete, and progress needs to continue on translating information gained from reductionistic cell and tissue culture models, in vivo models, and ultimately human studies and on improving therapeutic approaches. This book reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease. Table of Contents: Overview / Epithelial Cell and Tissue Architecture / Principles of Transepithelial Electrolyte and Water Movement / Intestinal Architecture and Electrolyte Transport / Electrolyte Transporters--Pumps, Carriers, and Channels / Water Transport / Regulation / Intestinal Disorders and Advances Toward Better Treatment of Intestinal Disorders / Conclusion / References
Author : Arthur M. Jungreis
Publisher : Elsevier
ISBN 13 : 1483273873
Total Pages : 408 pages
Book Rating : 4.4/5 (832 download)
Download or read book Water Relations in Membrane Transport in Plants and Animals written by Arthur M. Jungreis and published by Elsevier. This book was released on 2013-10-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water Relations in Membrane Transport in Plants and Animals contains the presentations in a symposium dealing with Water Relations in Membranes in Plants and Animals, during the 27th Annual Fall Meeting of the American Physiological Society held at The University of Pennsylvania, 17-19 August 1976. The purpose of the symposium was to explore the common modes of water regulation in plants and animals. In these proceedings, the mechanisms employed to restrict water flow across plant and metazoan animal cells are described. Putative differences in mechanisms of water regulation retained by plant versus animal cells become inconsequential in the light of the numerous similarities: dependence upon bioelectric potentials maintained across cell membranes, energy dependence of uphill water movement, and solute coupling during water transport. The presentations can be organized into four. The first takes up specific mechanisms of water transport in plants. The second and third parts deal with specific mechanisms in invertebrates and vertebrates, respectively. The fourth part covers generalized mechanisms common to plants and animals.
Author : Charles Randall House
Publisher : Hodder Education
ISBN 13 :
Total Pages : 580 pages
Book Rating : 4.:/5 (2 download)
Download or read book Water Transport in Cells and Tissues written by Charles Randall House and published by Hodder Education. This book was released on 1974 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gheorghe Benga
Publisher : CRC Press
ISBN 13 : 1351086103
Total Pages : 300 pages
Book Rating : 4.3/5 (51 download)
Download or read book Water Transport and Biological Membranes written by Gheorghe Benga and published by CRC Press. This book was released on 2018-05-04 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main purpose of this book is to provide in-depth presentation of physical techniques for measuring water transport and their applications to a variety of biological membranes, from model membrane systems to cell membranes, and then from isolated cells to multicellular barrier systems, such as epithelia or even whole organisms. This survey of water transport in such a broad range of membrane systems will hopefully contribute to understanding of the structure-function relationships and molecular mechanisms of water permeation. Moreover, the description of various techniques, together with a review of literature will enable the readers to assess whether a technique would be useful in helping to solve his or her particular problem of research and will also expand their competence in these techniques. The book consists of two volumes.
Author : Stanley G. Schultz
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)
Download or read book Ion Transport by Epithelia written by Stanley G. Schultz and published by Raven Press (ID). This book was released on 1981 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John A. Young
Publisher : Springer
ISBN 13 : 9783642750359
Total Pages : 0 pages
Book Rating : 4.7/5 (53 download)
Download or read book Epithelial Secretion of Water and Electrolytes written by John A. Young and published by Springer. This book was released on 2011-12-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1976, when Springer-Verlag commissioned Professors Giebisch, Tosteson, and Ussing to edit what was destined to become a monumental five-volume Handbuch (" Membrane Transport in Biology," 1978 Vols I, II, III] and 1979 Vols IV A, B]), the subject of transepithelial secretion was still in its infancy. Not surprisingly, therefore, their Handbuch concentrated mainly on trans- epithelial absorption, although substantial chapters dealing with some secre- viz. "Ion Transport Across the Choroid Plexus" tory organs were included, (by E. M. Wright), "Sweat Glands" (by J. H. Thaysen), "Lacrimal Gland" (by J. H. Thaysen) and "Transport Across Insect Excretory Epithelia" (by J. P. H. Maddrell) in Volume III and "Transport in Salivary and Salt Glands" (by J. A. Young and E. W. Van Lennep), "Gastric Secretion" (by T. E. Machen and J. G. Forte), "Transport Processes in the Exocrine Pan- creas" (by I. Schulz and K. J. Ullrich), and "Transport of Ions in Liver Cells" (by M. Claret) in Volume IVB. The publication in 1977 of the seminal paper of Silva and his colleagues on the mechanism of secretion of salt and water in the salt excreting gland of the dogfish (American Journal of Physiology 233, F298-F306, 1977) provided physiologists with their first real insight into the mechanisms underlying transepithelial fluid secretion, however, and, in the ensuing years, interest in the topic has exploded as is evidenced by the numerous international symposia on exocrine secretion held since that date.
Author : Jacques Bourguet
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (9 download)
Download or read book Water and Ion Transport in Epithelia written by Jacques Bourguet and published by . This book was released on 1985 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anthony D. C. Macknight
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.F/5 ( download)
Download or read book Epithelial Ion and Water Transport written by Anthony D. C. Macknight and published by Raven Press (ID). This book was released on 1981 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shelley Fong
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (17 download)
Download or read book Computational Modelling of Fluid and Ion Transport in the Epithelial Cell written by Shelley Fong and published by . This book was released on 2018 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Secretory epithelia line organs in the human body, and exquisitely control fluid and solute transport between interior and external cavities. Dysregulation results in abnormal fluid secretion rates, leading to disease. We developed a mathematical model of a generic epithelial cell to simulate these transport processes. This system can be adapted to model transport across different epithelia - here, it was used to obtain insight into normal and pathological conditions in salivary and alveolar epithelia. Regarding saliva secretion, clinical trials have shown that irradiated parotid glands with low salivary output saw a partial restoration following transfection of aquaporin, contradicting the traditional view which predicted that fluid be absorbed out of saliva instead. To help explain this, several units of the single cell were combined into a model of the parotid duct. Model results were most aligned to experimental data when a subgroup of water permeable cells were introduced to the proximal duct, and received the majority of the transfected aquaporin. Coupled with alterations in channel expression, these changes led to increased secretion, and predicted higher bicarbonate content in the final saliva. We also fitted the generic model with characteristics of an alveolar epithelial cell, and compared against experimental observations. At baseline, it was found that the cell was absorptive, where transcellular sodium flux dominated; chloride flux was 200 times smaller. It was found that blocking the cystic fibrosis transmembrane regulator had limited impact at baseline, but was the key to the transport of fluid in both normal and edematous states. Nucleotide signalling was also incorporated into the alveolar cell model, where mechanical forces increased the rate of nucleotide secretion. We found that periodic stretch increased apical liquid volume, which led to flooding at prolonged straining beyond the range of tidal breathing. Desensitisation of purinoceptors helped prevent flooding if there were high adenosine triphosphate levels. Functional apical chloride transport was necessary for fluid secretion into the lumen. Our generic model shows that regulation of fluid transport is complex. By reproducing trends that were observed experimentally, the model could be used to highlight pathways to be exploited in the treatment of diseases induced by defective transport.
Author : Wilfred D. Stein
Publisher : Elsevier
ISBN 13 : 0124165834
Total Pages : 423 pages
Book Rating : 4.1/5 (241 download)
Download or read book Channels, Carriers, and Pumps written by Wilfred D. Stein and published by Elsevier. This book was released on 2014-12-09 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. Provides an introduction to the properties of transport proteins: channels, carriers, and pumps Presents up-to-date information on the structure of transport proteins and on their function and regulation Includes introductions to transport kinetics and to the cloning of genes that code transport proteins Furnishes a link between the experimental basis of the subject and theoretical model building
