Epigenetics Of Stress And Stress Disorders

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Epigenetics of Stress and Stress Disorders

Author : Nagy Youssef
Publisher : Academic Press
ISBN 13 : 0128230622
Total Pages : 422 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epigenetics of Stress and Stress Disorders by : Nagy Youssef

Download or read book Epigenetics of Stress and Stress Disorders written by Nagy Youssef and published by Academic Press. This book was released on 2022-02-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or “epidrugs. Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field

Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders

Author : Fushun Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889711536
Total Pages : 138 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders by : Fushun Wang

Download or read book Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders written by Fushun Wang and published by Frontiers Media SA. This book was released on 2021-08-09 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stress: Genetics, Epigenetics and Genomics

Author : George Fink
Publisher : Academic Press
ISBN 13 : 0128131578
Total Pages : 346 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Stress: Genetics, Epigenetics and Genomics by : George Fink

Download or read book Stress: Genetics, Epigenetics and Genomics written by George Fink and published by Academic Press. This book was released on 2020-10-24 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases.The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

Author : Tania L Roth
Publisher : Frontiers Media SA
ISBN 13 : 2889194582
Total Pages : 159 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome by : Tania L Roth

Download or read book Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome written by Tania L Roth and published by Frontiers Media SA. This book was released on 2015-04-14 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Stress Resilience

Author : Alon Chen
Publisher : Academic Press
ISBN 13 : 0128139838
Total Pages : 390 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Stress Resilience by : Alon Chen

Download or read book Stress Resilience written by Alon Chen and published by Academic Press. This book was released on 2019-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience. This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it. Approaches resilience as a process rather than as a static trait Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance Presents thorough coverage of both the genetic and environmental factors that contribute to resilience

Epigenetics and Neuroendocrinology

Author : Dietmar Spengler
Publisher : Springer
ISBN 13 : 3319299018
Total Pages : 276 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Epigenetics and Neuroendocrinology by : Dietmar Spengler

Download or read book Epigenetics and Neuroendocrinology written by Dietmar Spengler and published by Springer. This book was released on 2016-06-29 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

Epigenetics in Psychiatry

Author : Jacob Peedicayil
Publisher : Academic Press
ISBN 13 : 0128235780
Total Pages : 848 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil

Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Stress and Epigenetics in Suicide

Author : Vsevolod Rozanov
Publisher : Academic Press
ISBN 13 : 0128052864
Total Pages : 238 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Stress and Epigenetics in Suicide by : Vsevolod Rozanov

Download or read book Stress and Epigenetics in Suicide written by Vsevolod Rozanov and published by Academic Press. This book was released on 2017-02-13 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

Neuropsychiatric Disorders and Epigenetics

Author : Jacob Peedicayil
Publisher : Elsevier
ISBN 13 : 0443185174
Total Pages : 418 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Neuropsychiatric Disorders and Epigenetics by : Jacob Peedicayil

Download or read book Neuropsychiatric Disorders and Epigenetics written by Jacob Peedicayil and published by Elsevier. This book was released on 2023-09-29 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts

Neuroepigenetics and Mental Illness

Author : Bart P.F. Rutten
Publisher : Academic Press
ISBN 13 : 0128125934
Total Pages : 346 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neuroepigenetics and Mental Illness by : Bart P.F. Rutten

Download or read book Neuroepigenetics and Mental Illness written by Bart P.F. Rutten and published by Academic Press. This book was released on 2018-07-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more. Presents updated volumes comprising 15-20 chapters, allowing comprehensive coverage on a topic Uses tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter

Proximate and Evolutionary Insights Into the Epigenetics of Posttraumatic Stress Disorder

Author : Levent H. Sipahi
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (921 download)

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Book Synopsis Proximate and Evolutionary Insights Into the Epigenetics of Posttraumatic Stress Disorder by : Levent H. Sipahi

Download or read book Proximate and Evolutionary Insights Into the Epigenetics of Posttraumatic Stress Disorder written by Levent H. Sipahi and published by . This book was released on 2014 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Posttraumatic stress disorder (PTSD) is an important medical and social condition. Although the vast majority of individuals are exposed to traumatic events within their lifetime, a minority subsequently develop diagnosable PTSD. What underlies differential risk and resiliency in the face of trauma is an ongoing research and clinical question with implications for prevention and treatment. Recent work has revealed a putative role of epigenetic variation and modification - most notably DNA methylation - in the etiology of PTSD. That DNA methylation is stable, yet modifiable in response to lived experiences, makes it a strong candidate to mechanistically explain the ontogeny of PTSD by putatively linking genetic and environment effects. Here, I provide proximate and evolutionary insights into this biological capacity through three distinct, but conceptually related research projects. In the first, I compare DNA methylation longitudinally in trauma-exposed individuals with and without PTSD to reveal a complex role of epigenetic variation and modification in PTSD development. In the second, I utilize phylogenetic methods to infer and characterize the evolutionary history of genetic loci necessary for the epigenetic regulation of PTSD, revealing that this capacity may have ancient origins. In the third, I test, and fail to provide evidence for, genetic associations between PTSD risk and single nucleotide polymorphisms (SNPs) annotated to genes involved in the regulation and activity of the hypothalamic-pituitary-adrenal (HPA) axis. Taken together, these data are suggestive of an evolutionarily-conserved capacity to regulate behavior, physiology, and psychology in response to extreme traumatic experiences. I argue that this capacity is epigenetically regulated and represents an example of adaptive developmental phenotypic plasticity. This model of PTSD etiology has implications for policy, clinical practice, public health, and research.

Applied Epigenetics for Mental Health Professionals

Author : Onoriode Edeh, M.D.
Publisher : American Psychiatric Pub
ISBN 13 : 1615374132
Total Pages : 192 pages
Book Rating : 4.6/5 (153 download)

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Book Synopsis Applied Epigenetics for Mental Health Professionals by : Onoriode Edeh, M.D.

Download or read book Applied Epigenetics for Mental Health Professionals written by Onoriode Edeh, M.D. and published by American Psychiatric Pub. This book was released on 2023-11-20 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The DNA, RNA, and Histone Methylomes

Author : Stefan Jurga
Publisher : Springer Nature
ISBN 13 : 3030147924
Total Pages : 624 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The DNA, RNA, and Histone Methylomes by : Stefan Jurga

Download or read book The DNA, RNA, and Histone Methylomes written by Stefan Jurga and published by Springer Nature. This book was released on 2019-08-28 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.

Conquering Post-Traumatic Stress Disorder

Author : Victoria Lemle Beckner
Publisher : Fair Winds Press
ISBN 13 : 1616737778
Total Pages : 306 pages
Book Rating : 4.6/5 (167 download)

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Book Synopsis Conquering Post-Traumatic Stress Disorder by : Victoria Lemle Beckner

Download or read book Conquering Post-Traumatic Stress Disorder written by Victoria Lemle Beckner and published by Fair Winds Press. This book was released on 2008-09-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 13 million Americans experience Post Traumatic Stress Disorder, and one out of 13 adults will develop it in their lifetime. Recent worldwide crises and events including the Iraq war; the September 11th attacks; numerous Columbine-like events; the Catholic Church child molestation scandal; and the Katrina tragedy in New Orleans, continue to present thousands more PTSD cases each year in all age groups. This book helps victims make sense of the events that led to their illness and teaches them how to create a new reality with specific advice and action plans that put them on the road to recovery and long-term healing.

Epigenetic Mechanisms of Gene Regulation

Author : Vincenzo E. A. Russo
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Epigenetic Mechanisms of Gene Regulation by : Vincenzo E. A. Russo

Download or read book Epigenetic Mechanisms of Gene Regulation written by Vincenzo E. A. Russo and published by . This book was released on 1996 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.