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Epigenetic And Genetic Mechanisms Underlying Cardiovascular Diseases And Neurodevelopmental Disorders
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Book Synopsis Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders by : Lingshan Gou
Download or read book Epigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders written by Lingshan Gou and published by Frontiers Media SA. This book was released on 2024-04-11 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease (CVD) and neurodevelopmental disorders (NDD) are both common diseases seriously affecting human health. CVD refers to a broad range of disorders including diseases affecting the vasculature, the myocardium, the heart’s electrical circuit, and congenital heart disease. NDDs are conditions affecting brain development and function, mainly characterized by impairments of cognition, communication, and motor skills. Although the heart and brain develop in spatially distinct regions, they share similar genetic factors and molecular pathways which are crucial for a precise developmental trajectory. Actually, congenital CVD survivors are at a higher risk of NDD, and whole-exome sequencing revealed a significant overlap between high-risk congenital CVD and NDD genetic variants. For CVD and NDD, the clinical presentations are heterogeneous, and the etiologies are complex. Elucidating the potential pathogenic mechanisms is good for unveiling the pathophysiology and finding the novel therapeutic target.
Book Synopsis Environmental Epigenetics by : L. Joseph Su
Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil
Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
Book Synopsis Medical Epigenetics by : Trygve Tollefsbol
Download or read book Medical Epigenetics written by Trygve Tollefsbol and published by Academic Press. This book was released on 2016-06-21 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
Book Synopsis Epigenetic Biomarkers and Diagnostics by : José Luis García-Giménez
Download or read book Epigenetic Biomarkers and Diagnostics written by José Luis García-Giménez and published by Academic Press. This book was released on 2015-12-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Book Synopsis Epigenomics, from Chromatin Biology to Therapeutics by : Krishnarao Appasani
Download or read book Epigenomics, from Chromatin Biology to Therapeutics written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2012 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts from academia, the biotechnology and pharmaceutical industries introduce biological, medical and methodological aspects of the emerging field of epigenomics.
Book Synopsis Transgenerational Epigenetics by : Trygve Tollefsbol
Download or read book Transgenerational Epigenetics written by Trygve Tollefsbol and published by Elsevier. This book was released on 2014-05-02 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies
Book Synopsis Epigenetic Mechanisms and Their Involvement in Rare Diseases by : Mojgan Rastegar
Download or read book Epigenetic Mechanisms and Their Involvement in Rare Diseases written by Mojgan Rastegar and published by Frontiers Media SA. This book was released on 2021-10-20 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Epigenetics by : Trygve Tollefsbol
Download or read book Handbook of Epigenetics written by Trygve Tollefsbol and published by Academic Press. This book was released on 2017-07-10 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
Book Synopsis Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders by : Fushun Wang
Download or read book Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders written by Fushun Wang and published by Frontiers Media SA. This book was released on 2021-08-09 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Epigenetics in Human Disease by : Trygve O. Tollefsbol
Download or read book Epigenetics in Human Disease written by Trygve O. Tollefsbol and published by Academic Press. This book was released on 2012-07-26 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
Book Synopsis Handbook of Nutrition, Diet, and Epigenetics by : Vinood B. Patel
Download or read book Handbook of Nutrition, Diet, and Epigenetics written by Vinood B. Patel and published by Springer. This book was released on 2019-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.
Book Synopsis Epigenetic Therapy with Histone Deacetylase Inhibitors: Implications for Cancer Treatment by : Christiane Pienna Soares
Download or read book Epigenetic Therapy with Histone Deacetylase Inhibitors: Implications for Cancer Treatment written by Christiane Pienna Soares and published by Frontiers Media SA. This book was released on 2021-06-02 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Unraveling Genetic Mysteries: Longevity, Genetic Engineering and Philosophy of Mind by : Edenilson Brandl
Download or read book Unraveling Genetic Mysteries: Longevity, Genetic Engineering and Philosophy of Mind written by Edenilson Brandl and published by Edenilson Brandl. This book was released on with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics is a fascinating and complex field, which reveals the secrets of the genetic code present in every living being. Through the investigation of genes and their interaction with the environment, we are able to better understand the biological processes that shape our existence. In this book, we'll explore the wonders and challenges of genetics, as well as its applications in areas such as medicine, criminal investigation, and genetic engineering. The first part of this book will take us through the intricate world of the genetics of aging and longevity. We will investigate the genetic mechanisms that determine the rate of aging of organisms and explore the possibilities of prolonging a healthy life. We'll discover how the latest research is unlocking the mysteries of aging and offering new insights into human longevity. Then we will enter the field of genetic engineering and genetically modified organisms (GMOs). We will explore the innovative techniques that allow the manipulation of DNA and the creation of organisms with specific characteristics. We'll see how this technology is revolutionizing agriculture, medicine, and industry, while raising important ethical and environmental questions. Forensic genetics will also gain prominence on our journey. We will investigate how DNA analysis has become a powerful tool in solving crimes, unraveling mysteries and assisting in the pursuit of justice. We'll discover how technological advances are revolutionizing criminal investigation and providing a deeper understanding of the genetic bonds between individuals. Entering the field of health, we will explore the genetics of neurodegenerative, cardiovascular, autoimmune and psychiatric disorders. We will understand how genes play a key role in the development of these diseases and how this understanding can open the way to more effective treatments and prevention strategies. In addition, we will investigate pharmacogenomics and precision medicine, examining how genetic individuality influences individuals' response to medications, enabling personalized and more effective treatments. We'll also cover the genetics of metabolism and obesity, sleep disorders, and the genetic implications for these conditions. The second part of this book will take us on a philosophical journey into the world of the mind. We'll explore debates about the nature of consciousness, the mind-body problem, reductionism, and dualism. We will investigate the relationship between the mind and the brain, the question of personal identity over time, and the philosophical implications of the mind in relation to artificial intelligence, free will, neuroscience, qualia, and even animal consciousness.
Book Synopsis The Interplay Between Epigenetic Regulation and Other Cellular Processes by : Kai Tang
Download or read book The Interplay Between Epigenetic Regulation and Other Cellular Processes written by Kai Tang and published by Frontiers Media SA. This book was released on 2021-07-05 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Regulatory Sequences and Human Disease by : Nadav Ahituv
Download or read book Gene Regulatory Sequences and Human Disease written by Nadav Ahituv and published by Springer Science & Business Media. This book was released on 2012-05-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Gene Regulatory Sequences and Human Disease, the Editor will introduce the different technological advances that led to this breakthrough. In addition, several examples will be provided of nucleotide variants in noncoding sequences that have been shown to be associated with various human diseases.
Book Synopsis Neurodegenerative Diseases by : Uday Kishore
Download or read book Neurodegenerative Diseases written by Uday Kishore and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
